Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

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Published in Proc Natl Acad Sci U S A on May 14, 2007

Authors

Qi Chen1, Michael Graham Espey, Andrew Y Sun, Je-Hyuk Lee, Murali C Krishna, Emily Shacter, Peter L Choyke, Chaya Pooput, Kenneth L Kirk, Garry R Buettner, Mark Levine

Author Affiliations

1: Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Associated clinical trials:

Study of High Dose Intravenous (IV) Ascorbic Acid in Measurable Solid Tumor Disease | NCT01125449

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