|
1
|
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex.
|
J Virol
|
2002
|
6.69
|
|
2
|
Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons.
|
J Virol
|
2003
|
5.41
|
|
3
|
Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection.
|
Radiology
|
2003
|
4.13
|
|
4
|
An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A.
|
J Biol Chem
|
2001
|
3.91
|
|
5
|
Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes.
|
J Virol
|
2004
|
3.39
|
|
6
|
Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C.
|
Proc Natl Acad Sci U S A
|
2007
|
3.13
|
|
7
|
Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection.
|
J Virol
|
2006
|
3.10
|
|
8
|
Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate.
|
J Biol Chem
|
2003
|
2.94
|
|
9
|
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation.
|
PLoS Pathog
|
2010
|
2.91
|
|
10
|
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.
|
J Biol Chem
|
2004
|
2.71
|
|
11
|
T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection.
|
J Virol
|
2005
|
2.58
|
|
12
|
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.
|
Hepatology
|
2007
|
2.25
|
|
13
|
Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.
|
Proc Natl Acad Sci U S A
|
2010
|
2.19
|
|
14
|
Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution.
|
Hepatology
|
2006
|
1.96
|
|
15
|
Binding of hepatitis C virus-like particles derived from infectious clone H77C to defined human cell lines.
|
J Virol
|
2002
|
1.84
|
|
16
|
APOBEC-mediated interference with hepadnavirus production.
|
Hepatology
|
2005
|
1.82
|
|
17
|
Malignant ascites: systematic review and guideline for treatment.
|
Eur J Cancer
|
2006
|
1.78
|
|
18
|
Immunodominance and functional alterations of tumor-associated antigen-specific CD8+ T-cell responses in hepatocellular carcinoma.
|
Hepatology
|
2014
|
1.76
|
|
19
|
Membrane association of hepatitis C virus nonstructural proteins and identification of the membrane alteration that harbors the viral replication complex.
|
Antiviral Res
|
2003
|
1.76
|
|
20
|
Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.
|
J Virol
|
2005
|
1.74
|
|
21
|
Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfate interaction.
|
J Virol
|
2006
|
1.71
|
|
22
|
Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis.
|
Am J Gastroenterol
|
2002
|
1.70
|
|
23
|
Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice.
|
Gastroenterology
|
2003
|
1.66
|
|
24
|
End-of-life care in hospital: current practice and potentials for improvement.
|
J Pain Symptom Manage
|
2007
|
1.65
|
|
25
|
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.
|
Proc Natl Acad Sci U S A
|
2008
|
1.62
|
|
26
|
Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection.
|
Hepatology
|
2005
|
1.61
|
|
27
|
The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment.
|
J Virol
|
2002
|
1.56
|
|
28
|
Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver.
|
J Virol
|
2006
|
1.52
|
|
29
|
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.
|
J Clin Invest
|
2009
|
1.46
|
|
30
|
Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis.
|
Cancer
|
2005
|
1.42
|
|
31
|
Comment on "Inhibition of hepatitis B virus replication by APOBEC3G".
|
Science
|
2004
|
1.41
|
|
32
|
Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model.
|
Gastroenterology
|
2008
|
1.40
|
|
33
|
Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B.
|
J Virol
|
2009
|
1.37
|
|
34
|
Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner.
|
J Immunol
|
2008
|
1.36
|
|
35
|
Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA.
|
J Virol
|
2004
|
1.36
|
|
36
|
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication.
|
J Virol
|
2004
|
1.36
|
|
37
|
Pathogenesis of hepatocellular carcinoma.
|
Eur J Gastroenterol Hepatol
|
2005
|
1.30
|
|
38
|
Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C.
|
J Virol
|
2004
|
1.29
|
|
39
|
Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency.
|
J Virol
|
2011
|
1.28
|
|
40
|
Targeted therapy for hepatocellular carcinoma.
|
Nat Rev Gastroenterol Hepatol
|
2009
|
1.27
|
|
41
|
Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H.
|
J Gen Virol
|
2008
|
1.25
|
|
42
|
Molecular virology of hepatitis C virus (HCV): 2006 update.
|
Int J Med Sci
|
2006
|
1.24
|
|
43
|
Virological and immunological determinants of intrahepatic virus-specific CD8+ T-cell failure in chronic hepatitis C virus infection.
|
Hepatology
|
2008
|
1.24
|
|
44
|
Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference.
|
Hepatology
|
2009
|
1.24
|
|
45
|
Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia.
|
Am J Gastroenterol
|
2002
|
1.22
|
|
46
|
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase.
|
J Biol Chem
|
2001
|
1.19
|
|
47
|
Hepatitis C: molecular virology and antiviral targets.
|
Trends Mol Med
|
2002
|
1.17
|
|
48
|
Hepatitis C virus-induced hepatocarcinogenesis.
|
J Hepatol
|
2009
|
1.17
|
|
49
|
Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion.
|
Gastroenterology
|
2008
|
1.16
|
|
50
|
Central role of a serine phosphorylation site within duck hepatitis B virus core protein for capsid trafficking and genome release.
|
J Biol Chem
|
2003
|
1.15
|
|
51
|
Quantitative promoter methylation analysis of hepatocellular carcinoma, cirrhotic and normal liver.
|
Int J Cancer
|
2008
|
1.15
|
|
52
|
Scavenger receptor class B type I and hepatitis C virus infection of primary tupaia hepatocytes.
|
J Virol
|
2005
|
1.14
|
|
53
|
Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.
|
PLoS Pathog
|
2010
|
1.13
|
|
54
|
Selenium levels in patients with hepatitis C virus-related chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma: a pilot study.
|
Hepatology
|
2013
|
1.13
|
|
55
|
Comprehensive analysis of the alpha-fetoprotein-specific CD8+ T cell responses in patients with hepatocellular carcinoma.
|
Hepatology
|
2008
|
1.12
|
|
56
|
Uptake and presentation of hepatitis C virus-like particles by human dendritic cells.
|
Blood
|
2005
|
1.11
|
|
57
|
Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection.
|
J Clin Invest
|
2002
|
1.11
|
|
58
|
Effective strategies for management of hypertension after vascular endothelial growth factor signaling inhibition therapy: results from a phase II randomized, factorial, double-blind study of Cediranib in patients with advanced solid tumors.
|
J Clin Oncol
|
2009
|
1.10
|
|
59
|
Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes.
|
J Hepatol
|
2005
|
1.09
|
|
60
|
Adaptive immune responses to hepatitis C virus: from viral immunobiology to a vaccine.
|
Biol Chem
|
2008
|
1.09
|
|
61
|
Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells.
|
J Virol
|
2008
|
1.09
|
|
62
|
Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26).
|
J Immunol
|
2012
|
1.08
|
|
63
|
EGFR and HER2 expression in advanced biliary tract cancer.
|
World J Gastroenterol
|
2009
|
1.08
|
|
64
|
Analysis of molecular pathways in sporadic neuroendocrine tumors of the gastro-entero-pancreatic system.
|
Int J Cancer
|
2007
|
1.06
|
|
65
|
Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis.
|
Proc Natl Acad Sci U S A
|
2005
|
1.05
|
|
66
|
Treatment of unresectable cholangiocarcinoma: conventional transarterial chemoembolization compared with drug eluting bead-transarterial chemoembolization and systemic chemotherapy.
|
Eur J Gastroenterol Hepatol
|
2012
|
1.04
|
|
67
|
HBV life cycle and novel drug targets.
|
Hepatol Int
|
2011
|
1.03
|
|
68
|
The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival.
|
Hepatology
|
2011
|
1.02
|
|
69
|
Do religious or spiritual beliefs influence bereavement? A systematic review.
|
Palliat Med
|
2007
|
1.01
|
|
70
|
Parallel expansion of human virus-specific FoxP3- effector memory and de novo-generated FoxP3+ regulatory CD8+ T cells upon antigen recognition in vitro.
|
J Immunol
|
2007
|
1.00
|
|
71
|
Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes.
|
Hepatology
|
2003
|
1.00
|
|
72
|
Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.
|
Lancet
|
2009
|
0.99
|
|
73
|
Four minutes for a patient, twenty seconds for a relative - an observational study at a university hospital.
|
BMC Health Serv Res
|
2010
|
0.97
|
|
74
|
Activation of dendritic cells by local ablation of hepatocellular carcinoma.
|
J Hepatol
|
2005
|
0.97
|
|
75
|
Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo.
|
Gastroenterology
|
2012
|
0.96
|
|
76
|
Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival.
|
Hepatology
|
2003
|
0.95
|
|
77
|
Reversal of drug resistance of hepatocellular carcinoma cells by adenoviral delivery of anti-MDR1 ribozymes.
|
Hepatology
|
2002
|
0.93
|
|
78
|
Peripherally acting opioid antagonists in the treatment of opiate-related constipation: a systematic review.
|
J Pain Symptom Manage
|
2007
|
0.93
|
|
79
|
Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes.
|
Hepatology
|
2005
|
0.92
|
|
80
|
EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesis.
|
Cancer Sci
|
2010
|
0.92
|
|
81
|
Diarrhea predicts a positive response to sorafenib in patients with advanced hepatocellular carcinoma.
|
Hepatology
|
2012
|
0.91
|
|
82
|
Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies.
|
J Virol
|
2013
|
0.89
|
|
83
|
Host cell responses induced by hepatitis C virus binding.
|
Hepatology
|
2006
|
0.89
|
|
84
|
Immunoregulation of dendritic and T cells by alpha-fetoprotein in patients with hepatocellular carcinoma.
|
J Hepatol
|
2004
|
0.88
|
|
85
|
Advances in prevention and diagnosis of hepatocellular carcinoma.
|
Expert Rev Gastroenterol Hepatol
|
2008
|
0.88
|
|
86
|
Acute Mycoplasma pneumoniae infection presenting as cholestatic hepatitis.
|
J Clin Microbiol
|
2003
|
0.87
|
|
87
|
CD161(+)CD4(+) T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and IFN-γ.
|
Front Immunol
|
2012
|
0.87
|
|
88
|
Lack of ex vivo peripheral and intrahepatic α-fetoprotein-specific CD4+ responses in hepatocellular carcinoma.
|
Int J Cancer
|
2011
|
0.87
|
|
89
|
The tupaia model for the study of hepatitis B virus: direct infection and HBV genome transduction of primary tupaia hepatocytes.
|
Methods Mol Med
|
2004
|
0.87
|
|
90
|
Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential.
|
J Hepatol
|
2012
|
0.86
|
|
91
|
CD40 inhibits replication of hepatitis C virus in primary human hepatocytes by c-Jun N terminal kinase activation independent from the interferon pathway.
|
Hepatology
|
2013
|
0.86
|
|
92
|
Conserved determinants for membrane association of nonstructural protein 5A from hepatitis C virus and related viruses.
|
J Virol
|
2006
|
0.86
|
|
93
|
Locoregional therapy for cholangiocarcinoma.
|
Curr Opin Gastroenterol
|
2013
|
0.85
|
|
94
|
Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.
|
PLoS Pathog
|
2012
|
0.85
|
|
95
|
Translation of stable hepadnaviral mRNA cleavage fragments induced by the action of phosphorothioate-modified antisense oligodeoxynucleotides.
|
Nucleic Acids Res
|
2005
|
0.84
|
|
96
|
Role of host genetic factors in the outcome of hepatitis C virus infection.
|
Viruses
|
2009
|
0.84
|
|
97
|
Characterization of nonstructural protein membrane anchor deletion mutants expressed in the context of the hepatitis C virus polyprotein.
|
J Virol
|
2005
|
0.83
|
|
98
|
Evolving therapies in the treatment of hepatocellular carcinoma.
|
Biologics
|
2008
|
0.83
|
|
99
|
Differential antigen specificity of hepatitis C virus-specific interleukin 17- and interferon γ-producing CD8(+) T cells during chronic infection.
|
J Infect Dis
|
2012
|
0.83
|
|
100
|
Palliative cancer care: an epidemiologic study.
|
J Clin Oncol
|
2011
|
0.83
|
|
101
|
Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81.
|
World J Gastroenterol
|
2009
|
0.83
|
|
102
|
Gene therapy for malignant liver disease.
|
Expert Opin Biol Ther
|
2002
|
0.83
|
|
103
|
Hepatitis B or hepatitis C and human immunodeficiency virus infection.
|
J Hepatol
|
2005
|
0.83
|
|
104
|
VEGF Trap for the treatment of malignant ascites.
|
Lancet Oncol
|
2011
|
0.82
|
|
105
|
Immunotherapy of murine hepatocellular carcinoma by alpha-fetoprotein DNA vaccination combined with adenovirus-mediated chemokine and cytokine expression.
|
Hum Gene Ther
|
2008
|
0.82
|
|
106
|
Virus-specific CD4+ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific upregulation of CD154.
|
J Hepatol
|
2010
|
0.82
|
|
107
|
The transcription factor c-Jun protects against liver damage following activated β-Catenin signaling.
|
PLoS One
|
2012
|
0.82
|
|
108
|
Identification of naturally processed hepatitis C virus-derived major histocompatibility complex class I ligands.
|
PLoS One
|
2012
|
0.82
|
|
109
|
Absence of viral escape within a frequently recognized HLA-A26-restricted CD8+ T-cell epitope targeting the functionally constrained hepatitis C virus NS5A/5B cleavage site.
|
J Gen Virol
|
2007
|
0.81
|
|
110
|
Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase.
|
J Virol
|
2010
|
0.81
|
|
111
|
Molecular characteristics and predictors of survival in patients with malignant neuroendocrine tumors.
|
Int J Cancer
|
2008
|
0.81
|
|
112
|
The hepatitis C virus NS5A protein and response to interferon alpha: mutational analyses in patients with chronic HCV genotype 3a infection from India.
|
Med Microbiol Immunol
|
2006
|
0.81
|
|
113
|
Transgenic mice replicating hepatitis B virus but lacking expression of the major HBsAg.
|
J Med Virol
|
2008
|
0.81
|
|
114
|
Analysis of bulk and virus-specific CD8+ T cells reveals advanced differentiation of CD8+ T cells in patients with common variable immunodeficiency.
|
Clin Immunol
|
2011
|
0.80
|
|
115
|
Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles.
|
J Innate Immun
|
2009
|
0.80
|
|
116
|
Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics of the liver.
|
BMC Gastroenterol
|
2009
|
0.80
|
|
117
|
Tracking cccDNA in chronic HBV infection.
|
Hepatology
|
2004
|
0.79
|
|
118
|
Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection.
|
J Gen Virol
|
2009
|
0.79
|
|
119
|
DDB treatment of patients with chronic hepatitis.
|
Hepatology
|
2004
|
0.79
|
|
120
|
Methylnaltrexone: the evidence for its use in the management of opioid-induced constipation.
|
Core Evid
|
2010
|
0.79
|
|
121
|
Reversible autonomic dysfunction during antiviral treatment in patients with chronic hepatitis C virus infection: Anti-HCV therapy and autonomic function.
|
Hepat Mon
|
2011
|
0.79
|
|
122
|
A mouse model of oral-esophageal carcinogenesis.
|
Onkologie
|
2005
|
0.79
|
|
123
|
Differential transcriptional regulation of human telomerase in a cellular model representing important genetic alterations in esophageal squamous carcinogenesis.
|
Carcinogenesis
|
2005
|
0.79
|
|
124
|
A novel target of hepatitis B virus mutations: splicing of surface RNA.
|
Hepatology
|
2005
|
0.78
|
|
125
|
Phosphodiesterase 5 inhibitors lower both portal and pulmonary pressure in portopulmonary hypertension: a case report.
|
J Med Case Rep
|
2007
|
0.78
|
|
126
|
A primer on the molecular virology of hepatitis C.
|
Liver Int
|
2004
|
0.77
|
|
127
|
Human hepatitis B virus production in avian cells is characterized by enhanced RNA splicing and the presence of capsids containing shortened genomes.
|
PLoS One
|
2012
|
0.77
|
|
128
|
Analysis of molecular pathways in neuroendocrine cancers of the gastroenteropancreatic system.
|
Ann N Y Acad Sci
|
2004
|
0.77
|
|
129
|
Out of control: hepatitis B reactivation by transarterial treatment of hepatocellular carcinoma.
|
J Hepatol
|
2004
|
0.76
|
|
130
|
Hypothyroidism in patients with hepatocellular carcinoma treated by transarterial chemoembolization.
|
Hepatology
|
2008
|
0.76
|
|
131
|
Recent developments in target identification against hepatitis C virus.
|
Expert Opin Ther Targets
|
2004
|
0.76
|
|
132
|
Stable human lymphoblastoid cell lines constitutively expressing hepatitis C virus proteins.
|
J Gen Virol
|
2005
|
0.76
|
|
133
|
New ways of interfering with HCV replication.
|
Hepatology
|
2003
|
0.75
|
|
134
|
Clinical response to Auron Misheil Therapy in a man with advanced multifocal hepatocellular carcinoma: A case report.
|
J Med Case Rep
|
2011
|
0.75
|
|
135
|
[What contribution makes DNA sequencing in clinical practice? - before widespread application DNA sequencing has to be optimized].
|
Dtsch Med Wochenschr
|
2014
|
0.75
|
|
136
|
Induction of anti-hepatitis B virus immune responses through DNA immunization.
|
Methods Mol Med
|
2004
|
0.75
|
|
137
|
A severe case of odynophagia.
|
BMJ
|
2011
|
0.75
|
|
138
|
Evolving treatments of virus-associated HCC: new targets and drugs.
|
Front Biosci (Schol Ed)
|
2010
|
0.75
|
|
139
|
[Elevated liver enzymes].
|
MMW Fortschr Med
|
2010
|
0.75
|
|
140
|
[Viral hepatitis].
|
Ther Umsch
|
2011
|
0.75
|
|
141
|
[Hepatitis 2004: an update].
|
Ther Umsch
|
2004
|
0.75
|
|
142
|
Of mice and men: a small animal model of hepatitis C virus replication.
|
Hepatology
|
2002
|
0.75
|
|
143
|
Cis-preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex.
|
Hepatology
|
2002
|
0.75
|
|
144
|
Psychosomatic liaison service in medicine - need for psychotherapeutic interventions and their realisation.
|
Swiss Med Wkly
|
2002
|
0.75
|
|
145
|
|
Dtsch Med Wochenschr
|
2016
|
0.75
|