PubRank

Peter M Colman

Author PubWeight™ 52.64‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005 13.59
2 Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A 2007 3.41
3 BCL-2 family antagonists for cancer therapy. Nat Rev Drug Discov 2008 3.24
4 To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions. Mol Cell 2008 2.97
5 Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell 2013 2.75
6 Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III. J Mol Biol 2004 2.33
7 A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol 2008 2.04
8 The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity 2012 1.89
9 Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol 2013 1.68
10 Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain. J Am Chem Soc 2011 1.49
11 A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak. Mol Cell 2007 1.47
12 High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl 2009 1.34
13 Structural studies of the resistance of influenza virus neuramindase to inhibitors. J Med Chem 2002 1.20
14 Modelling the structure of the fusion protein from human respiratory syncytial virus. Protein Eng 2002 1.17
15 Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J Biol Chem 2009 1.09
16 Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes. Proc Natl Acad Sci U S A 2011 1.09
17 Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design. Chembiochem 2011 1.04
18 Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins. J Biol Chem 2009 1.03
19 Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem 2011 1.02
20 Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1. PLoS Pathog 2010 1.02
21 Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine. J Mol Biol 2009 0.95
22 Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum. Acta Crystallogr D Biol Crystallogr 2005 0.88
23 Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms. J Mol Biol 2006 0.86
24 Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins. Structure 2011 0.86
25 Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. J Med Chem 2013 0.86
26 Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins. J Virol 2012 0.82
27 Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza. Angew Chem Int Ed Engl 2003 0.78
28 De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization. J Med Chem 2014 0.78