Published in Science on May 17, 2002
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Opening and closing of the bacterial RNA polymerase clamp. Science (2012) 1.73
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Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. PLoS Biol (2010) 1.69
A chaperone network controls the heat shock response in E. coli. Genes Dev (2004) 1.63
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Structure and function of the initially transcribing RNA polymerase II-TFIIB complex. Nature (2012) 1.48
RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. Mol Cell Biol (2004) 1.46
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Still looking for the magic spot: the crystallographically defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulation. J Mol Biol (2008) 1.44
Real-time footprinting of DNA in the first kinetically significant intermediate in open complex formation by Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A (2007) 1.44
Organization of an activator-bound RNA polymerase holoenzyme. Mol Cell (2008) 1.39
The structure of a transcribing T7 RNA polymerase in transition from initiation to elongation. Science (2008) 1.39
The interaction between sigma70 and the beta-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation. Proc Natl Acad Sci U S A (2005) 1.38
T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site. Proc Natl Acad Sci U S A (2010) 1.38
An intersubunit contact stimulating transcription initiation by E coli RNA polymerase: interaction of the alpha C-terminal domain and sigma region 4. Genes Dev (2003) 1.38
TFB1 or TFB2 is sufficient for Thermococcus kodakaraensis viability and for basal transcription in vitro. J Mol Biol (2006) 1.36
Photo-cross-linking of a purified preinitiation complex reveals central roles for the RNA polymerase II mobile clamp and TFIIE in initiation mechanisms. Mol Cell Biol (2004) 1.32
Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase. Mol Cell (2008) 1.31
Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction. Nucleic Acids Res (2010) 1.30
Prevalence of RNA polymerase stalling at Escherichia coli promoters after open complex formation. Mol Microbiol (2008) 1.30
Central role of the RNA polymerase trigger loop in intrinsic RNA hydrolysis. Proc Natl Acad Sci U S A (2010) 1.29
Structures of RNA polymerase-antibiotic complexes. Curr Opin Struct Biol (2009) 1.28
Dissection of recognition determinants of Escherichia coli sigma32 suggests a composite -10 region with an 'extended -10' motif and a core -10 element. Mol Microbiol (2009) 1.27
Fine structure of the promoter-sigma region 1.2 interaction. Proc Natl Acad Sci U S A (2008) 1.23
Interactions between the Rhodobacter sphaeroides ECF sigma factor, sigma(E), and its anti-sigma factor, ChrR. J Mol Biol (2004) 1.23
The effects of upstream DNA on open complex formation by Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A (2004) 1.22
Multiscale spatial organization of RNA polymerase in Escherichia coli. Biophys J (2013) 1.20
Sequential recognition of two distinct sites in sigma(S) by the proteolytic targeting factor RssB and ClpX. EMBO J (2003) 1.20
Mutational analysis of Escherichia coli sigma28 and its target promoters reveals recognition of a composite -10 region, comprised of an 'extended -10' motif and a core -10 element. Mol Microbiol (2009) 1.19
RNA polymerase mutants defective in the initiation of transcription-coupled DNA repair. Nucleic Acids Res (2005) 1.19
Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA. J Mol Biol (2008) 1.17
Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J Biol Chem (2014) 1.17
Structural and mechanistic basis for the inhibition of Escherichia coli RNA polymerase by T7 Gp2. Mol Cell (2012) 1.17
Molecular mechanism of transcription inhibition by phage T7 gp2 protein. J Mol Biol (2011) 1.16
The bacteriophage lambda Q antiterminator protein contacts the beta-flap domain of RNA polymerase. Proc Natl Acad Sci U S A (2008) 1.16
Sigma factors for cyanobacterial transcription. Gene Regul Syst Bio (2009) 1.16
Mutations enabling displacement of tryptophan by 4-fluorotryptophan as a canonical amino acid of the genetic code. Genome Biol Evol (2014) 1.16
A nexus for gene expression-molecular mechanisms of Spt5 and NusG in the three domains of life. J Mol Biol (2012) 1.16
The structure of a transcription activation subcomplex reveals how σ(70) is recruited to PhoB promoters. EMBO J (2011) 1.15
Functional interaction between TFIIB and the Rpb2 subunit of RNA polymerase II: implications for the mechanism of transcription initiation. Mol Cell Biol (2004) 1.15
6S RNA binding to Esigma(70) requires a positively charged surface of sigma(70) region 4.2. Mol Microbiol (2009) 1.13
A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme. Proc Natl Acad Sci U S A (2004) 1.13
Plant sigma factors and their role in plastid transcription. Plant Cell Rep (2007) 1.12
Region 1.2 of the RNA polymerase sigma subunit controls recognition of the -10 promoter element. EMBO J (2007) 1.12
A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding. Chem Biol (2008) 1.11
Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4. J Mol Biol (2007) 1.10
A critical role of downstream RNA polymerase-promoter interactions in the formation of initiation complex. J Biol Chem (2011) 1.10
Elongation complexes of Thermus thermophilus RNA polymerase that possess distinct translocation conformations. Nucleic Acids Res (2006) 1.09
Probing DNA binding, DNA opening, and assembly of a downstream clamp/jaw in Escherichia coli RNA polymerase-lambdaP(R) promoter complexes using salt and the physiological anion glutamate. Biochemistry (2010) 1.07
A structural model of anti-anti-σ inhibition by a two-component receiver domain: the PhyR stress response regulator. Mol Microbiol (2010) 1.06
Conformational heterogeneity in RNA polymerase observed by single-pair FRET microscopy. Biophys J (2006) 1.06
Transcriptional control in the prereplicative phase of T4 development. Virol J (2010) 1.05
The -11A of promoter DNA and two conserved amino acids in the melting region of sigma70 both directly affect the rate limiting step in formation of the stable RNA polymerase-promoter complex, but they do not necessarily interact. Nucleic Acids Res (2007) 1.05
One-step DNA melting in the RNA polymerase cleft opens the initiation bubble to form an unstable open complex. Proc Natl Acad Sci U S A (2010) 1.05
RNA-mediated destabilization of the sigma(70) region 4/beta flap interaction facilitates engagement of RNA polymerase by the Q antiterminator. Mol Cell (2006) 1.04
Initial events in bacterial transcription initiation. Biomolecules (2015) 1.04
Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases. Nucleic Acids Res (2006) 1.04
Loss of the Rpb4/Rpb7 subcomplex in a mutant form of the Rpb6 subunit shared by RNA polymerases I, II, and III. Mol Cell Biol (2003) 1.03
Conserved region 2.1 of Escherichia coli heat shock transcription factor sigma32 is required for modulating both metabolic stability and transcriptional activity. J Bacteriol (2004) 1.03
Distance-restrained docking of rifampicin and rifamycin SV to RNA polymerase using systematic FRET measurements: developing benchmarks of model quality and reliability. Biophys J (2004) 1.03
Escherichia coli RNA polymerase recognition of a sigma70-dependent promoter requiring a -35 DNA element and an extended -10 TGn motif. J Bacteriol (2006) 1.03
Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife (2015) 1.02
The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site. EMBO J (2010) 1.02
Archaeal RNA polymerase. Curr Opin Struct Biol (2009) 1.02
Association of RNA polymerase with transcribed regions in Escherichia coli. Proc Natl Acad Sci U S A (2004) 1.02
Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters. Mol Syst Biol (2013) 1.02
Control of the timing of promoter escape and RNA catalysis by the transcription factor IIb fingertip. J Biol Chem (2008) 1.02
Structural and biochemical bases for the redox sensitivity of Mycobacterium tuberculosis RslA. J Mol Biol (2010) 1.02
Mutational analysis of sigma70 region 4 needed for appropriation by the bacteriophage T4 transcription factors AsiA and MotA. J Mol Biol (2006) 1.01
RNA polymerase II transcription: structure and mechanism. Biochim Biophys Acta (2012) 1.01
Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution. Proc Natl Acad Sci U S A (2009) 1.01
Structural basis of a protein partner switch that regulates the general stress response of α-proteobacteria. Proc Natl Acad Sci U S A (2012) 1.00
Transcription of the T4 late genes. Virol J (2010) 1.00
Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex. Science (2002) 6.17
Structure of the bacterial RNA polymerase promoter specificity sigma subunit. Mol Cell (2002) 4.22
Bacterial RNA polymerases: the wholo story. Curr Opin Struct Biol (2003) 4.12
Structure and function of the transcription elongation factor GreB bound to bacterial RNA polymerase. Cell (2003) 3.14
Catabolite activator protein: DNA binding and transcription activation. Curr Opin Struct Biol (2004) 2.91
Structural basis for promoter-10 element recognition by the bacterial RNA polymerase σ subunit. Cell (2011) 2.82
Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA. Mol Cell (2003) 2.50
Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Cell (2010) 2.50
The structural basis for promoter -35 element recognition by the group IV sigma factors. PLoS Biol (2006) 2.18
Structural basis for bacterial transcription-coupled DNA repair. Cell (2006) 2.16
Marking and measuring single microtubules by PRC1 and kinesin-4. Cell (2013) 1.86
A conserved structural module regulates transcriptional responses to diverse stress signals in bacteria. Mol Cell (2007) 1.76
Sigma and RNA polymerase: an on-again, off-again relationship? Mol Cell (2005) 1.74
Structural basis of transcriptional pausing in bacteria. Cell (2013) 1.71
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase. EMBO J (2005) 1.71
Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. PLoS Biol (2010) 1.69
Structure of a ternary transcription activation complex. Mol Cell (2004) 1.68
Molecular evolution of multisubunit RNA polymerases: sequence analysis. J Mol Biol (2009) 1.67
Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation. Mol Cell (2004) 1.61
Structure of microcin J25, a peptide inhibitor of bacterial RNA polymerase, is a lassoed tail. J Am Chem Soc (2003) 1.56
Regulation of bacterial RNA polymerase sigma factor activity: a structural perspective. Curr Opin Microbiol (2008) 1.52
Region 4 of sigma as a target for transcription regulation. Mol Microbiol (2003) 1.50
Bacterial sigma factors: a historical, structural, and genomic perspective. Annu Rev Microbiol (2014) 1.49
Utilization of variably spaced promoter-like elements by the bacterial RNA polymerase holoenzyme during early elongation. Mol Microbiol (2010) 1.48
Molecular evolution of multisubunit RNA polymerases: structural analysis. J Mol Biol (2009) 1.45
Protein-protein and protein-DNA interactions of sigma70 region 4 involved in transcription activation by lambdacI. J Mol Biol (2002) 1.42
Structure and function of lineage-specific sequence insertions in the bacterial RNA polymerase beta' subunit. J Mol Biol (2005) 1.41
Autoregulation of a bacterial sigma factor explored by using segmental isotopic labeling and NMR. Proc Natl Acad Sci U S A (2002) 1.36
Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1. Proc Natl Acad Sci U S A (2013) 1.35
Structure of the filamentous phage pIV multimer by cryo-electron microscopy. J Mol Biol (2003) 1.34
How to switch off a histidine kinase: crystal structure of Geobacillus stearothermophilus KinB with the inhibitor Sda. J Mol Biol (2008) 1.33
Crystal structure of the Bacillus stearothermophilus anti-sigma factor SpoIIAB with the sporulation sigma factor sigmaF. Cell (2002) 1.32
Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction. Nucleic Acids Res (2010) 1.30
Structure and function of CarD, an essential mycobacterial transcription factor. Proc Natl Acad Sci U S A (2013) 1.25
Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center. Proc Natl Acad Sci U S A (2008) 1.16
Genomic resources for songbird research and their use in characterizing gene expression during brain development. Proc Natl Acad Sci U S A (2007) 1.13
Crystal structure of Thermus aquaticus Gfh1, a Gre-factor paralog that inhibits rather than stimulates transcript cleavage. J Mol Biol (2005) 1.11
Initiation of transcription-coupled repair characterized at single-molecule resolution. Nature (2012) 1.10
Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4. J Mol Biol (2007) 1.10
Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. J Bacteriol (2012) 1.10
The bacterial transcription repair coupling factor. Curr Opin Struct Biol (2007) 1.06
Crystal structures of the ADP and ATP bound forms of the Bacillus anti-sigma factor SpoIIAB in complex with the anti-anti-sigma SpoIIAA. J Mol Biol (2004) 1.05
Crystal structure of bacteriophage lambda cII and its DNA complex. Mol Cell (2005) 1.04
Recombinant Thermus aquaticus RNA polymerase for structural studies. J Mol Biol (2006) 1.01
Crystal structure of Escherichia coli Rnk, a new RNA polymerase-interacting protein. J Mol Biol (2008) 0.99
Rapid isolation and identification of bacteriophage T4-encoded modifications of Escherichia coli RNA polymerase: a generic method to study bacteriophage/host interactions. J Proteome Res (2008) 0.98
Promoter melting triggered by bacterial RNA polymerase occurs in three steps. Proc Natl Acad Sci U S A (2010) 0.97
An altered-specificity DNA-binding mutant of Escherichia coli sigma70 facilitates the analysis of sigma70 function in vivo. Mol Microbiol (2005) 0.95
Disulfide cross-linking indicates that FlgM-bound and free sigma28 adopt similar conformations. Proc Natl Acad Sci U S A (2006) 0.94
Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein. Cell (2012) 0.92
Derepression of bacterial transcription-repair coupling factor is associated with a profound conformational change. J Mol Biol (2010) 0.91
Identification of the gate regions in the primary structure of the secretin pIV. Mol Microbiol (2010) 0.91
A novel method for the production of in vivo-assembled, recombinant Escherichia coli RNA polymerase lacking the α C-terminal domain. Protein Sci (2011) 0.89
Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.89
Temporal regulation of gene expression of the Thermus thermophilus bacteriophage P23-45. J Mol Biol (2010) 0.88
Crystal structure of the in vivo-assembled Bacillus subtilis Spx/RNA polymerase alpha subunit C-terminal domain complex. J Struct Biol (2009) 0.87
Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone. Biochemistry (2010) 0.86
Noninvasive detection of pulmonary tissue destruction in a mouse model of emphysema using hyperpolarized 129Xe MRS under spontaneous respiration. Magn Reson Med (2010) 0.84
Crystallographic analysis of Thermus aquaticus RNA polymerase holoenzyme and a holoenzyme/promoter DNA complex. Methods Enzymol (2003) 0.84
Crystal structure of the bacteriophage T4 late-transcription coactivator gp33 with the β-subunit flap domain of Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A (2011) 0.83
Phage-encoded inhibitor of Staphylococcus aureus transcription exerts context-dependent effects on promoter function in a modified Escherichia coli-based transcription system. J Bacteriol (2013) 0.82
Promoter recognition by bacterial alternative sigma factors: the price of high selectivity? Genes Dev (2009) 0.81
RNA-Seq reveals differential gene expression in Staphylococcus aureus with single-nucleotide resolution. PLoS One (2013) 0.80
The 2.7 Å resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr (2010) 0.79
Crystallographic analysis of an RNA polymerase σ-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.77
Biochemical insights into the function of phage G1 gp67 in Staphylococcus aureus. Bacteriophage (2013) 0.76
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