Published in Mamm Genome on May 01, 2002
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature (2008) 2.71
Cardiac syndrome X and endothelial dysfunction: new concepts in prognosis and treatment. Am J Med (2006) 2.33
Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome. Genome Res (2004) 2.29
Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1. Cancer Res (2003) 1.93
Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum Mol Genet (2003) 1.80
Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Sci Transl Med (2013) 1.70
Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population. Circ Cardiovasc Genet (2012) 1.57
Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice. Hum Mol Genet (2007) 1.57
Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proc Natl Acad Sci U S A (2006) 1.47
The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J Neurosci (2009) 1.46
Understanding the basis for Down syndrome phenotypes. PLoS Genet (2006) 1.41
Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet (2002) 1.39
Genetic determinants influencing the response to injury, inflammation, and sepsis. Shock (2005) 1.35
Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Res (2006) 1.31
Trisomy 21 and early brain development. Trends Neurosci (2011) 1.28
Development and validation of the Arizona Cognitive Test Battery for Down syndrome. J Neurodev Disord (2010) 1.15
Down syndrome: from understanding the neurobiology to therapy. J Neurosci (2010) 1.13
Genetic contribution to the septic response in a mouse model. Shock (2002) 1.08
Perinatal loss of Ts65Dn Down syndrome mice. Genetics (2005) 1.05
Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer. Jpn J Cancer Res (2002) 1.05
The use of mouse models to understand and improve cognitive deficits in Down syndrome. Dis Model Mech (2011) 1.05
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes. Genome Biol (2007) 1.04
A quantitative trait loci analysis to map genes involved in lipopolysaccharide-induced inflammatory response: identification of macrophage scavenger receptor 1 as a candidate gene. J Immunol (2006) 1.02
Effects of aneuploidy on skull growth in a mouse model of Down syndrome. J Anat (2007) 1.02
An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects. Am J Hum Genet (2012) 1.01
A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. Mech Dev (2008) 1.01
PCR prescreen for genotyping the Ts65Dn mouse model of Down syndrome. Biotechniques (2010) 0.98
Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression. Mol Cancer (2005) 0.94
Comparative genomic sequence analysis of the human chromosome 21 Down syndrome critical region. Genome Res (2002) 0.94
Differential effects of trisomy on brain shape and volume in related aneuploid mouse models. Am J Med Genet A (2007) 0.93
Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome. Cancer Res (2011) 0.93
Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009. Proc Am Thorac Soc (2009) 0.92
The effects of piracetam on cognitive performance in a mouse model of Down's syndrome. Physiol Behav (2002) 0.91
A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome. Prog Brain Res (2012) 0.87
Microstructure of trabecular bone in a mouse model for Down syndrome. Anat Rec (Hoboken) (2007) 0.85
Down syndrome: national conference on patient registries, research databases, and biobanks. Mol Genet Metab (2011) 0.85
Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic "Down syndrome" mice. Am J Med Genet A (2009) 0.82
IL-10 plasma levels are elevated after LPS injection in splenectomized A/J mice. J Surg Res (2005) 0.82
Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatment. J Neurosci (2013) 0.81
Protection from lethal endotoxic shock after testosterone depletion is linked to chromosome X. Shock (2005) 0.81
Increased male reproductive success in Ts65Dn "Down syndrome" mice. Mamm Genome (2010) 0.80
Allelic Interaction between CRELD1 and VEGFA in the Pathogenesis of Cardiac Atrioventricular Septal Defects. AIMS Genet (2014) 0.80
Trisomy 21 and facial developmental instability. Am J Phys Anthropol (2013) 0.79
Sex differences in improved efficacy of doxorubicin chemotherapy in Cbr1+/- mice. Anticancer Drugs (2012) 0.78
Morphological integration of soft-tissue facial morphology in Down Syndrome and siblings. Am J Phys Anthropol (2011) 0.78
Long-range chromosomal engineering is more efficient in vitro than in vivo. Transgenic Res (2005) 0.78
Assessing cognitive improvement in people with Down syndrome: important considerations for drug-efficacy trials. Handb Exp Pharmacol (2015) 0.78
Functional genomics: a time and place for every gene. Nature (2002) 0.75
Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene. Genomics (2002) 0.75