Published in Genome Res on July 01, 2004
Global analysis of X-chromosome dosage compensation. J Biol (2006) 3.78
Aneuploidy: cells losing their balance. Genetics (2008) 3.48
Submicroscopic deletion in patients with Williams-Beuren syndrome influences expression levels of the nonhemizygous flanking genes. Am J Hum Genet (2006) 3.18
Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines. Proc Natl Acad Sci U S A (2012) 2.20
Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci (2010) 2.08
Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. Am J Hum Genet (2007) 2.06
Ohnologs in the human genome are dosage balanced and frequently associated with disease. Proc Natl Acad Sci U S A (2010) 2.02
Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21. Eur J Hum Genet (2008) 1.90
Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance. Am J Hum Genet (2007) 1.86
Gene copy-number alterations: a cost-benefit analysis. Cell (2013) 1.79
Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart. Genome Biol (2005) 1.64
Chromosomal instability and cancer: a complex relationship with therapeutic potential. J Clin Invest (2012) 1.62
Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. Mamm Genome (2011) 1.47
A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet (2010) 1.42
Understanding the basis for Down syndrome phenotypes. PLoS Genet (2006) 1.41
New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol (2012) 1.36
Single cell sequencing reveals low levels of aneuploidy across mammalian tissues. Proc Natl Acad Sci U S A (2014) 1.34
Trisomy 21 and early brain development. Trends Neurosci (2011) 1.28
Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy. BMC Genomics (2007) 1.24
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Hum Mol Genet (2009) 1.20
Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21. BMC Med Genet (2006) 1.19
A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks. Genome Biol (2007) 1.19
Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays. BMC Genomics (2004) 1.16
Down syndrome: the brain in trisomic mode. Nat Rev Neurosci (2012) 1.10
Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis (2011) 1.09
Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes. Proc Natl Acad Sci U S A (2005) 1.08
Profiling expression changes caused by a segmental aneuploid in maize. BMC Genomics (2008) 1.08
The power of comparative and developmental studies for mouse models of Down syndrome. Mamm Genome (2007) 1.07
The use of mouse models to understand and improve cognitive deficits in Down syndrome. Dis Model Mech (2011) 1.05
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res (2010) 1.05
Gene expression variation in Down's syndrome mice allows prioritization of candidate genes. Genome Biol (2007) 1.04
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. BMC Genomics (2006) 1.04
Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model. J Neurochem (2009) 1.01
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural Plast (2012) 1.00
Transcriptome-wide survey of mouse CNS-derived cells reveals monoallelic expression within novel gene families. PLoS One (2012) 1.00
Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes. BMC Genomics (2011) 1.00
Impairment of circulating endothelial progenitors in Down syndrome. BMC Med Genomics (2010) 0.99
Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet (2011) 0.97
Global DNA hypermethylation in down syndrome placenta. PLoS Genet (2013) 0.95
Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci (2011) 0.95
Discovery of novel serum biomarkers for prenatal Down syndrome screening by integrative data mining. PLoS One (2009) 0.94
Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks. BMC Genomics (2014) 0.93
Meiotic behavior of aneuploid chromatin in mouse models of Down syndrome. Chromosoma (2009) 0.92
Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes. Dev Neurosci (2011) 0.92
Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening. PLoS One (2011) 0.91
Gene-dosage effects in Down syndrome and trisomic mouse models. Genome Biol (2004) 0.89
Expression evolution facilitated the convergent neofunctionalization of a sodium channel gene. Mol Biol Evol (2014) 0.86
Aneuploidy causes tissue-specific qualitative changes in global gene expression patterns in maize. Plant Physiol (2009) 0.86
Differential expression of genes mapping to recurrently abnormal chromosomal regions characterize neuroblastic tumours with distinct ploidy status. BMC Med Genomics (2008) 0.86
A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes. Genome Biol (2010) 0.86
Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade. J Alzheimers Dis (2012) 0.85
The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model. PLoS Genet (2012) 0.85
Environmental enrichment rescues postnatal neurogenesis defect in the male and female Ts65Dn mouse model of Down syndrome. Dev Neurosci (2011) 0.84
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med (2011) 0.84
Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice. J Comp Neurol (2014) 0.83
The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome. Am J Med Genet A (2015) 0.83
Identification of Inverse Regulator-a (Inr-a) as Synonymous with Pre-mRNA Cleavage Complex II Protein (Pcf11) in Drosophila. G3 (Bethesda) (2012) 0.82
Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic "Down syndrome" mice. Am J Med Genet A (2009) 0.82
Mechanisms of x chromosome dosage compensation. J Genomics (2015) 0.82
Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome. BMC Med Genomics (2013) 0.81
Genome-wide expression analysis in Down syndrome: insight into immunodeficiency. PLoS One (2012) 0.80
Gene expression analysis of induced pluripotent stem cells from aneuploid chromosomal syndromes. BMC Genomics (2013) 0.80
Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Transl Med (2013) 0.80
The cognitive phenotype of Down syndrome: insights from intracellular network analysis. NeuroRx (2006) 0.80
Genetic dissection of the Down syndrome critical region. Hum Mol Genet (2015) 0.79
A novel procedure for genotyping of single nucleotide polymorphisms in trisomy with genomic DNA and the invader assay. Nucleic Acids Res (2008) 0.79
Apoptosis screening of human chromosome 21 proteins reveals novel cell death regulators. Mol Biol Rep (2009) 0.79
Hard-Wired Control of Bacterial Processes by Chromosomal Gene Location. Trends Microbiol (2016) 0.79
Trisomy 21 and facial developmental instability. Am J Phys Anthropol (2013) 0.79
Molecular and cellular alterations in Down syndrome: toward the identification of targets for therapeutics. Neural Plast (2012) 0.78
Expression profiling of drug response--from genes to pathways. Dialogues Clin Neurosci (2006) 0.77
Quantitative proteomic analysis of amniocytes reveals potentially dysregulated molecular networks in Down syndrome. Clin Proteomics (2013) 0.77
Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome. Curr Alzheimer Res (2016) 0.77
No Evidence for Mutations that Deregulate GARS-AIRS-GART Protein Levels in Children with Down Syndrome. Indian J Clin Biochem (2012) 0.77
Facts and artifacts in studies of gene expression in aneuploids and sex chromosomes. Chromosoma (2014) 0.77
Epigenetic dysregulation in the developing Down syndrome cortex. Epigenetics (2016) 0.75
Integrated miRNA and mRNA expression profiling in fetal hippocampus with Down syndrome. J Biomed Sci (2016) 0.75
Genes and Small RNA Transcripts Exhibit Dosage-Dependent Expression Pattern in Maize Copy-Number Alterations. Genetics (2016) 0.75
Evaluation of reference genes for gene expression in red-tailed phascogale (Phascogale calura) liver, lung, small intestine and spleen. PeerJ (2016) 0.75
Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential. PLoS One (2016) 0.75
Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models. Epigenomics (2016) 0.75
Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55
The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner. Cell (1988) 7.72
Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell (2000) 6.92
Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays. Proc Natl Acad Sci U S A (2001) 6.07
Extension and integration of the gene ontology (GO): combining GO vocabularies with external vocabularies. Genome Res (2002) 5.67
Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell (2002) 5.64
A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat Genet (1995) 4.95
Human chromosome 21 gene expression atlas in the mouse. Nature (2002) 4.36
The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho. J Cell Biol (1997) 3.28
A gene expression map of human chromosome 21 orthologues in the mouse. Nature (2002) 2.76
RED2, a brain-specific member of the RNA-specific adenosine deaminase family. J Biol Chem (1996) 2.64
DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum Mol Genet (1998) 2.24
Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain. Genomics (2003) 2.19
Transcriptome analysis of human autosomal trisomy. Hum Mol Genet (2002) 1.90
Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome. Prog Clin Biol Res (1990) 1.84
Analysis of autosomal dosage compensation involving the alcohol dehydrogenase locus in Drosophila melanogaster. Genetics (1990) 1.80
Too much of a good thing: mechanisms of gene action in Down syndrome. Trends Genet (2001) 1.72
Automated image analysis for array hybridization experiments. Bioinformatics (2001) 1.66
Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones. Proc Natl Acad Sci U S A (1995) 1.63
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Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Cytogenet Cell Genet (2001) 1.52
The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals. Genome Res (2000) 1.40
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The promoter of the long variant of collagen XVIII, the precursor of endostatin, contains liver-specific regulatory elements. Hepatology (2000) 0.90
Developmental expression of the SH3BGR gene, mapping to the Down syndrome heart critical region. Mech Dev (2000) 0.90
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Mutation analysis of SYNJ1: a possible candidate gene for chromosome 21q22-linked bipolar disorder. Mol Psychiatry (2001) 0.86
Quantification of expression and methylation of the Igf2r imprinted gene in segmental trisomic mouse model. Genomics (2003) 0.86
Mapping of eight testis-specific genes to mouse chromosomes. Genomics (1997) 0.83
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
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A human protein-protein interaction network: a resource for annotating the proteome. Cell (2005) 18.97
Transcriptome analysis by strand-specific sequencing of complementary DNA. Nucleic Acids Res (2009) 9.40
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet (2005) 6.91
The genome of a songbird. Nature (2010) 5.90
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol (2011) 4.84
Dissecting the genomic complexity underlying medulloblastoma. Nature (2012) 4.77
Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry. Nat Genet (2002) 4.64
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27
Melanopsin is required for non-image-forming photic responses in blind mice. Science (2003) 4.22
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature (2004) 3.69
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities. Genet Med (2011) 3.51
Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet (2011) 3.43
Prediction of alternative isoforms from exon expression levels in RNA-Seq experiments. Nucleic Acids Res (2010) 3.36
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. Mol Cell (2004) 3.26
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
American College of Medical Genetics standards and guidelines for interpretation and reporting of postnatal constitutional copy number variants. Genet Med (2011) 3.22
The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells (2010) 3.17
Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell (2013) 3.08
Automated Gene Ontology annotation for anonymous sequence data. Nucleic Acids Res (2003) 3.02
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The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res (2012) 2.94
Construction and analysis of a human-chimpanzee comparative clone map. Science (2002) 2.83
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ConsensusPathDB--a database for integrating human functional interaction networks. Nucleic Acids Res (2008) 2.77
A gene expression map of human chromosome 21 orthologues in the mouse. Nature (2002) 2.76
Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature (2008) 2.71
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Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Res (2010) 2.61
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A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A (2007) 2.50
Starch as a major integrator in the regulation of plant growth. Proc Natl Acad Sci U S A (2009) 2.47
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c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell (2005) 2.30
Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules. Mol Biol Cell (2007) 2.30
Targeted high throughput sequencing in clinical cancer settings: formaldehyde fixed-paraffin embedded (FFPE) tumor tissues, input amount and tumor heterogeneity. BMC Med Genomics (2011) 2.24
A comparison of oligonucleotide and cDNA-based microarray systems. Physiol Genomics (2004) 2.21
On the origin of the chordate central nervous system: expression of onecut in the sea urchin embryo. Evol Dev (2004) 2.19
Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells. Stem Cells (2006) 2.18
MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy. J Cell Mol Med (2009) 2.12
Somatic mutation profiles of MSI and MSS colorectal cancer identified by whole exome next generation sequencing and bioinformatics analysis. PLoS One (2010) 2.10
Characterizing the mouse ES cell transcriptome with Illumina sequencing. Genomics (2008) 2.09
A prospective evaluation of pain associated with stone passage, stents, and stent removal using a visual analog scale. Urology (2013) 2.05
Genome-wide massively parallel sequencing of formaldehyde fixed-paraffin embedded (FFPE) tumor tissues for copy-number- and mutation-analysis. PLoS One (2009) 2.04
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Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1. Cancer Res (2003) 1.93
Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells (2006) 1.88
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med (2005) 1.88
Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate. Science (2010) 1.86
TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem Biophys Res Commun (2007) 1.84
An efficient and economic enhancer mix for PCR. Biochem Biophys Res Commun (2006) 1.82
Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum Mol Genet (2003) 1.80
A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint. Science (2006) 1.76
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Identification of metabolic and biomass QTL in Arabidopsis thaliana in a parallel analysis of RIL and IL populations. Plant J (2007) 1.74
Genetic analysis of the mouse brain proteome. Nat Genet (2002) 1.73
Alternative pathways as mechanism for the negative effects associated with overexpression of superoxide dismutase. J Theor Biol (2005) 1.71
Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Sci Transl Med (2013) 1.70
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New evidence for genome-wide duplications at the origin of vertebrates using an amphioxus gene set and completed animal genomes. Genome Res (2003) 1.65