Published in J Med Chem on June 06, 2002
Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arterioscler Thromb Vasc Biol (2008) 1.64
Cathepsin K inhibitors for osteoporosis and potential off-target effects. Expert Opin Investig Drugs (2009) 1.26
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation. Structure (2005) 2.78
miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol (2011) 2.61
A new social communication intervention for children with autism: pilot randomised controlled treatment study suggesting effectiveness. J Child Psychol Psychiatry (2004) 2.59
A global perspective on trends in nature-based tourism. PLoS Biol (2009) 2.58
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib. J Biol Chem (2008) 2.09
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO J (2008) 1.99
Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov (2008) 1.95
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. ChemMedChem (2006) 1.90
Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res (2003) 1.83
Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival. J Bone Miner Res (2003) 1.82
Diversity of noroviruses cocirculating in the north of England from 1998 to 2001. J Clin Microbiol (2004) 1.65
Risk factors for suicide completion in borderline personality disorder: a case-control study of cluster B comorbidity and impulsive aggression. J Clin Psychiatry (2007) 1.58
Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis. J Natl Cancer Inst (2007) 1.56
The conceptualization and measurement of therapeutic alliance: an empirical review. Clin Psychol Rev (2008) 1.56
Evolutionary dynamics of local pandemic H1N1/2009 influenza virus lineages revealed by whole-genome analysis. J Virol (2011) 1.55
Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis. Crit Care (2014) 1.48
Autism and other psychiatric comorbidity in neurofibromatosis type 1: evidence from a population-based study. Dev Med Child Neurol (2012) 1.47
Pheochromocytoma and paraganglioma in children: a review of medical and surgical management at a tertiary care center. Pediatrics (2006) 1.45
Primary hyperparathyroidism surgical management since the introduction of minimally invasive parathyroidectomy: Mayo Clinic experience. Arch Surg (2005) 1.45
Molecular basis of coiled-coil formation. Proc Natl Acad Sci U S A (2007) 1.44
An examination of DSM-IV depressive symptoms and risk for suicide completion in major depressive disorder: a psychological autopsy study. J Affect Disord (2006) 1.44
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet (2011) 1.43
High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo. Cancer Res (2011) 1.34
Public health value of next-generation DNA sequencing of enterohemorrhagic Escherichia coli isolates from an outbreak. J Clin Microbiol (2012) 1.31
Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK. PLoS One (2011) 1.31
Quality of interaction between at-risk infants and caregiver at 12-15 months is associated with 3-year autism outcome. J Child Psychol Psychiatry (2012) 1.27
Parent-infant interaction in infant siblings at risk of autism. Res Dev Disabil (2012) 1.22
A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjug Chem (2002) 1.19
Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site. Biochim Biophys Acta (2010) 1.16
A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden. Cancer Res (2007) 1.15
FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation. J Med Chem (2010) 1.14
Molecular epidemiology of rotaviral infection in South Indian children with acute diarrhea from 1995-1996 to 1998-1999. J Med Virol (2002) 1.10
The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. Angew Chem Int Ed Engl (2003) 1.09
Amino-acid-type selective isotope labeling of proteins expressed in Baculovirus-infected insect cells useful for NMR studies. J Biomol NMR (2003) 1.09
Efficient uniform isotope labeling of Abl kinase expressed in Baculovirus-infected insect cells. J Biomol NMR (2005) 1.08
The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro. Bone (2004) 1.06
Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13. J Med Chem (2009) 1.06
NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors. Proc Natl Acad Sci U S A (2013) 1.03
Neurofibromatosis type 1 and autism spectrum disorder. Pediatrics (2013) 1.03
An exploratory study of the association between reactive attachment disorder and attachment narratives in early school-age children. J Child Psychol Psychiatry (2009) 1.03
The impact of maternal psychopathology on child-mother attachment. Arch Womens Ment Health (2009) 1.02
Library design for fragment based screening. Curr Top Med Chem (2005) 1.02
Service and wider societal costs of very young children with autism in the UK. J Autism Dev Disord (2012) 1.01
2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem (2007) 1.01
Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists. Bioorg Med Chem (2011) 0.98
A rapid method for identifying diversity within PCR amplicons using a heteroduplex mobility assay and synthetic polynucleotides: application to characterisation of dsRNA elements associated with Cryptosporidium. J Microbiol Methods (2003) 0.96
Conversational behaviour of children with Asperger syndrome and conduct disorder. J Child Psychol Psychiatry (2002) 0.96
Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis. J Med Chem (2004) 0.96
The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). J Bone Miner Res (2004) 0.96
Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain. Pain (2002) 0.95
Control-group study of an intervention training program for youth suicide prevention. Suicide Life Threat Behav (2007) 0.94
Control of intrinsically disordered stathmin by multisite phosphorylation. J Biol Chem (2006) 0.94
Restricted and repetitive behaviors in autism spectrum disorders and typical development: cross-sectional and longitudinal comparisons. J Autism Dev Disord (2014) 0.94
Autism spectrum disorder profile in neurofibromatosis type I. J Autism Dev Disord (2015) 0.93
Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for children. J Child Psychol Psychiatry (2014) 0.93
Thermodynamics of the Op18/stathmin-tubulin interaction. J Biol Chem (2003) 0.93
Reactive attachment disorder following early maltreatment: systematic evidence beyond the institution. J Abnorm Child Psychol (2013) 0.93
Is the goal of mastication reached in young dentates, aged dentates and aged denture wearers? Br J Nutr (2007) 0.92
Characterisation of norovirus strains in rural Ghanaian children with acute diarrhoea. J Med Virol (2006) 0.92
Stabilization of branched oligosaccharides: Lewis(x) benefits from a nonconventional C-H···O hydrogen bond. J Am Chem Soc (2013) 0.92
Methods for the detection and characterisation of noroviruses associated with outbreaks of gastroenteritis: outbreaks occurring in the north-west of England during two norovirus seasons. J Med Virol (2004) 0.91
Prevention of strain-related osteopenia in aseptic loosening of hip prostheses using perioperative bisphosphonate. J Orthop Res (2008) 0.90
Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases. Future Med Chem (2014) 0.90
Do larger studies find smaller effects? The example of studies for the prevention of conduct disorder. Eur Child Adolesc Psychiatry (2008) 0.90
Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib. Biomol NMR Assign (2008) 0.89
Time efficient detection of protein-ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment. J Biomol NMR (2009) 0.89
Evaluation of a one-tube RT-PCR system for detection of enteroviruses. J Clin Virol (2002) 0.88
Preorganization of the Bioactive Conformation of Sialyl Lewis(X) Analogues Correlates with Their Affinity to E-Selectin. Angew Chem Int Ed Engl (2001) 0.88
A simple protocol for amino acid type selective isotope labeling in insect cells with improved yields and high reproducibility. J Biomol NMR (2011) 0.88
Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor. Bioorg Med Chem (2008) 0.87
The Social Communication Intervention Project: a randomized controlled trial of the effectiveness of speech and language therapy for school-age children who have pragmatic and social communication problems with or without autism spectrum disorder. Int J Lang Commun Disord (2012) 0.87
Call for a quality standard for sequence-based assays in clinical microbiology: necessity for quality assessment of sequences used in microbial identification and typing. J Clin Microbiol (2010) 0.87
HepSEQ: International Public Health Repository for Hepatitis B. Nucleic Acids Res (2006) 0.86
A pseudo-TEP repair of an incarcerated obturator hernia. Int J Surg Case Rep (2011) 0.86
Dipeptide nitrile inhibitors of cathepsin K. Bioorg Med Chem Lett (2006) 0.86
One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Arthritis Rheum (2003) 0.86
Adolescent suicide in Quebec and prior utilization of medical services. Can J Public Health (2004) 0.86
Pre-organization of the core structure of E-selectin antagonists. Chemistry (2011) 0.85
Social communication disorder outside autism? A diagnostic classification approach to delineating pragmatic language impairment, high functioning autism and specific language impairment. J Child Psychol Psychiatry (2013) 0.85
Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation. J Med Chem (2010) 0.85
A Readily Available, Highly Potent E-Selectin Antagonist. Angew Chem Int Ed Engl (2001) 0.85
Towards regional, error-bounded landscape carbon storage estimates for data-deficient areas of the world. PLoS One (2012) 0.85
Brief report: mediation of treatment effect in a communication intervention for pre-school children with autism. J Autism Dev Disord (2012) 0.85
Crohn's disease, hepatosplenic T-cell lymphoma and no biological therapy: are we barking up the wrong tree? Inflamm Bowel Dis (2009) 0.84
Outcomes in women diagnosed with borderline personality disorder in adolescence. J Can Acad Child Adolesc Psychiatry (2011) 0.83
Nanomolar E-selectin antagonists with prolonged half-lives by a fragment-based approach. J Am Chem Soc (2013) 0.83
Extraction and analysis of intact glucosinolates--a validated pressurized liquid extraction/liquid chromatography-mass spectrometry protocol for Isatis tinctoria, and qualitative analysis of other cruciferous plants. J Chromatogr A (2007) 0.83
Youth and young adult suicide: a study of life trajectory. J Psychiatr Res (2011) 0.83
Attachment narratives and behavioral and emotional symptoms in an ethnically diverse, at-risk sample. J Am Acad Child Adolesc Psychiatry (2008) 0.82
Stress-induced somatization in spouses of deployed and nondeployed servicemen. J Am Acad Nurse Pract (2009) 0.82
Design, synthesis and evaluation of monovalent ligands for the asialoglycoprotein receptor (ASGP-R). Bioorg Med Chem (2009) 0.82
Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides. Chembiochem (2012) 0.82
Completed suicides among Quebec adolescents involved with juvenile justice and child welfare services. Suicide Life Threat Behav (2004) 0.82