Published in Bioorg Med Chem Lett on February 09, 2006
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Evolutionary dynamics of local pandemic H1N1/2009 influenza virus lineages revealed by whole-genome analysis. J Virol (2011) 1.55
Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis. Crit Care (2014) 1.48
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A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet (2011) 1.43
High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo. Cancer Res (2011) 1.34
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Evolutionary pathways of the pandemic influenza A (H1N1) 2009 in the UK. PLoS One (2011) 1.31
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Development of tridentate iron chelators: from desferrithiocin to ICL670. Curr Med Chem (2003) 1.21
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease. Mol Neurodegener (2010) 1.18
A cathepsin K inhibitor reduces breast cancer induced osteolysis and skeletal tumor burden. Cancer Res (2007) 1.15
Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. J Med Chem (2004) 1.10
Molecular epidemiology of rotaviral infection in South Indian children with acute diarrhea from 1995-1996 to 1998-1999. J Med Virol (2002) 1.10
Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett (2005) 1.09
The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro. Bone (2004) 1.06
Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands. J Med Chem (2005) 1.05
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An exploratory study of the association between reactive attachment disorder and attachment narratives in early school-age children. J Child Psychol Psychiatry (2009) 1.03
The impact of maternal psychopathology on child-mother attachment. Arch Womens Ment Health (2009) 1.02
SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity. Bioorg Med Chem Lett (2004) 1.01
2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem (2007) 1.01
Service and wider societal costs of very young children with autism in the UK. J Autism Dev Disord (2012) 1.01
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Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach. Anal Biochem (2003) 1.00
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands. J Med Chem (2003) 0.98
A rapid method for identifying diversity within PCR amplicons using a heteroduplex mobility assay and synthetic polynucleotides: application to characterisation of dsRNA elements associated with Cryptosporidium. J Microbiol Methods (2003) 0.96
Conversational behaviour of children with Asperger syndrome and conduct disorder. J Child Psychol Psychiatry (2002) 0.96
The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). J Bone Miner Res (2004) 0.96
Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain. Pain (2002) 0.95
Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity. Bioorg Med Chem Lett (2005) 0.94
Restricted and repetitive behaviors in autism spectrum disorders and typical development: cross-sectional and longitudinal comparisons. J Autism Dev Disord (2014) 0.94
Autism spectrum disorder profile in neurofibromatosis type I. J Autism Dev Disord (2015) 0.93
Treatment mechanism in the MRC preschool autism communication trial: implications for study design and parent-focussed therapy for children. J Child Psychol Psychiatry (2014) 0.93
Reactive attachment disorder following early maltreatment: systematic evidence beyond the institution. J Abnorm Child Psychol (2013) 0.93
Community maturity, species saturation and the variant diversity-productivity relationships in grasslands. Ecol Lett (2006) 0.92
Characterisation of norovirus strains in rural Ghanaian children with acute diarrhoea. J Med Virol (2006) 0.92
Methods for the detection and characterisation of noroviruses associated with outbreaks of gastroenteritis: outbreaks occurring in the north-west of England during two norovirus seasons. J Med Virol (2004) 0.91
Prevention of strain-related osteopenia in aseptic loosening of hip prostheses using perioperative bisphosphonate. J Orthop Res (2008) 0.90
Do larger studies find smaller effects? The example of studies for the prevention of conduct disorder. Eur Child Adolesc Psychiatry (2008) 0.90
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis. Bioorg Med Chem Lett (2004) 0.89
Evaluation of a one-tube RT-PCR system for detection of enteroviruses. J Clin Virol (2002) 0.88
Call for a quality standard for sequence-based assays in clinical microbiology: necessity for quality assessment of sequences used in microbial identification and typing. J Clin Microbiol (2010) 0.87
The Social Communication Intervention Project: a randomized controlled trial of the effectiveness of speech and language therapy for school-age children who have pragmatic and social communication problems with or without autism spectrum disorder. Int J Lang Commun Disord (2012) 0.87
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors. Bioorg Med Chem Lett (2002) 0.87
HepSEQ: International Public Health Repository for Hepatitis B. Nucleic Acids Res (2006) 0.86
The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588. Bioorg Med Chem (2013) 0.86
Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE). J Med Chem (2006) 0.85
Towards regional, error-bounded landscape carbon storage estimates for data-deficient areas of the world. PLoS One (2012) 0.85
Social communication disorder outside autism? A diagnostic classification approach to delineating pragmatic language impairment, high functioning autism and specific language impairment. J Child Psychol Psychiatry (2013) 0.85
Brief report: mediation of treatment effect in a communication intervention for pre-school children with autism. J Autism Dev Disord (2012) 0.85
Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors. Mol Neurodegener (2010) 0.85
Crohn's disease, hepatosplenic T-cell lymphoma and no biological therapy: are we barking up the wrong tree? Inflamm Bowel Dis (2009) 0.84
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II. Bioorg Med Chem Lett (2010) 0.84
Novel scaffold for cathepsin K inhibitors. Bioorg Med Chem Lett (2007) 0.83
Attachment narratives and behavioral and emotional symptoms in an ethnically diverse, at-risk sample. J Am Acad Child Adolesc Psychiatry (2008) 0.82
ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans. Bone (2011) 0.82
A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg Med Chem Lett (2006) 0.82
Molecular epidemiological analysis of Cryptosporidium isolates from humans and animals by using a heteroduplex mobility assay and nucleic acid sequencing based on a small double-stranded RNA element. J Clin Microbiol (2003) 0.82
Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem (2005) 0.82
The transmission of risk to children from mothers with schizophrenia: a developmental psychopathology model. Clin Psychol Rev (2007) 0.81
New chemotypes for cathepsin K inhibitors. Bioorg Med Chem Lett (2008) 0.81
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Bioorg Med Chem Lett (2009) 0.81
Arylaminoethyl amides as novel non-covalent cathepsin K inhibitors. J Med Chem (2002) 0.81
Infant neural sensitivity to dynamic eye gaze relates to quality of parent-infant interaction at 7-months in infants at risk for autism. J Autism Dev Disord (2015) 0.81
Discovery and profiling of a selective and efficacious Syk inhibitor. J Med Chem (2015) 0.80
Quantifying peer interactions for research and clinical use: the Manchester Inventory for Playground Observation. Res Dev Disabil (2011) 0.79
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg Med Chem Lett (2009) 0.79
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett (2005) 0.78
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I. Bioorg Med Chem Lett (2010) 0.78
1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: a novel series of potent calcium-sensing receptor antagonists. J Med Chem (2010) 0.78
Cost effectiveness of proton pump inhibitors in gastro-oesophageal reflux disease without oesophagitis: comparison of on-demand esomeprazole with conventional omeprazole strategies. Pharmacoeconomics (2002) 0.78
Effect of the combination of docetaxel, zoledronic acid, and a COX-2 inhibitor on the growth of human breast cancer cell lines. Am J Clin Oncol (2003) 0.77
Secure attachment promotes the development of effortful control in boys. Attach Hum Dev (2015) 0.77
2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors. Bioorg Med Chem Lett (2010) 0.77
Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors. Bioorg Med Chem Lett (2009) 0.77
Predictors of parent-child interaction style in dyads with autism. Res Dev Disabil (2013) 0.77
The effect of inpatient care on measured Health Needs in children and adolescents. J Child Psychol Psychiatry (2009) 0.77
Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children. J Autism Dev Disord (2015) 0.77