Published in J Neurosci on June 01, 2002
Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury. Nat Med (2010) 2.45
Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII. J Physiol (2004) 2.11
Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. J Neurosci (2007) 2.00
NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents. Nat Neurosci (2011) 1.65
Chloride regulation in the pain pathway. Brain Res Rev (2008) 1.55
Regulation of K-Cl cotransport: from function to genes. J Membr Biol (2004) 1.52
Cation-chloride cotransporters in neuronal development, plasticity and disease. Nat Rev Neurosci (2014) 1.50
Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron (2012) 1.50
Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci (2010) 1.50
Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J Neurosci (2011) 1.47
Loose ligation of the sciatic nerve is associated with TrkB receptor-dependent decreases in KCC2 protein levels in the ipsilateral spinal dorsal horn. Pain (2007) 1.29
Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain. J Neurosci (2012) 1.26
Brain injury impairs dentate gyrus inhibitory efficacy. Neurobiol Dis (2006) 1.23
Knocking down of the KCC2 in rat hippocampal neurons increases intracellular chloride concentration and compromises neuronal survival. J Physiol (2011) 1.22
Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters. Pain (2008) 1.18
Excitatory GABA: How a Correct Observation May Turn Out to be an Experimental Artifact. Front Pharmacol (2012) 1.14
Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever! Front Cell Neurosci (2012) 1.12
The role of cation-dependent chloride transporters in neuropathic pain following spinal cord injury. Mol Pain (2008) 1.11
Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. BMC Genomics (2007) 1.09
Reorganization of inhibitory synaptic circuits in rodent chronically injured epileptogenic neocortex. Cereb Cortex (2010) 1.09
Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation. J Biol Chem (2009) 1.04
Spatial and temporal dynamics in the ionic driving force for GABA(A) receptors. Neural Plast (2011) 1.01
Dual personality of GABA/glycine-mediated depolarizations in immature spinal cord. Proc Natl Acad Sci U S A (2007) 1.01
GABA(A) Receptor Dynamics and Constructing GABAergic Synapses. Front Mol Neurosci (2008) 0.97
The action of BDNF on GABA(A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons. J Physiol (2003) 0.96
Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons. J Cell Biol (2006) 0.95
Development of spontaneous miniature EPSCs in mouse AVCN neurons during a critical period of afferent-dependent neuron survival. J Neurophysiol (2006) 0.95
Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors. J Biol Chem (2009) 0.94
Presynaptic GABAA receptors facilitate GABAergic transmission to dopaminergic neurons in the ventral tegmental area of young rats. J Physiol (2007) 0.93
Cortical inhibition, pH and cell excitability in epilepsy: what are optimal targets for antiepileptic interventions? J Physiol (2012) 0.93
Bradykinin decreases K(+) and increases Cl(-) conductances in vagal afferent neurones of the guinea pig. J Physiol (2004) 0.92
Mechanisms of GABAergic homeostatic plasticity. Neural Plast (2011) 0.92
Altered GABA signaling in early life epilepsies. Neural Plast (2011) 0.92
Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording. Mol Brain (2009) 0.91
GABA(A) receptors in normal development and seizures: friends or foes? Curr Neuropharmacol (2008) 0.90
GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas. Exp Neurol (2008) 0.89
Genetics studies indicate that neural induction and early neuronal maturation are disturbed in autism. Front Cell Neurosci (2014) 0.89
Is birth a critical period in the pathogenesis of autism spectrum disorders? Nat Rev Neurosci (2015) 0.87
Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. Neuroscience (2012) 0.84
Identification of pharmacological targets in amyotrophic lateral sclerosis through genomic analysis of deregulated genes and pathways. Curr Genomics (2012) 0.84
Excitatory actions of GABA in the intact neonatal rodent hippocampus in vitro. Front Cell Neurosci (2013) 0.83
Functional consequences of the disturbances in the GABA-mediated inhibition induced by injuries in the cerebral cortex. Neural Plast (2011) 0.82
The role of GABA in the regulation of GnRH neurons. Front Neurosci (2014) 0.81
Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters. Front Cell Neurosci (2015) 0.81
Hippocampus and epilepsy: Findings from human tissues. Rev Neurol (Paris) (2015) 0.80
Calcium-activated chloride current expression in axotomized sensory neurons: what for? Front Mol Neurosci (2012) 0.78
Mechanisms of intrinsic epileptogenesis in human gelastic seizures with hypothalamic hamartoma. CNS Neurosci Ther (2014) 0.77
Cell-attached recordings of responses evoked by photorelease of GABA in the immature cortical neurons. Front Cell Neurosci (2013) 0.76
Amino acid transporter (VIAAT, VGLUT2) and chloride cotransporter (KCC1, KCC2 and NKCC1) expression in the vestibular nuclei of intact and labyrinthectomized rat. Exp Brain Res (2007) 0.76
Reactive Neurogenesis and Down-Regulation of the Potassium-Chloride Cotransporter KCC2 in the Cochlear Nuclei after Cochlear Deafferentation. Front Pharmacol (2016) 0.75
Effects of essential amino acid deficiency: down-regulation of KCC2 and the GABAA receptor; disinhibition in the anterior piriform cortex. J Neurochem (2013) 0.75
Bumetanide promotes neural precursor cell regeneration and dendritic development in the hippocampal dentate gyrus in the chronic stage of cerebral ischemia. Neural Regen Res (2016) 0.75
Research on ionic homeostatic equilibrium may change our view about epilepsy. Clinics (Sao Paulo) (2013) 0.75
Brain Derived Neurotrophic Factor Modification of Epileptiform Burst Discharges in a Temporal Lobe Epilepsy Model. Basic Clin Neurosci (2016) 0.75
Abnormal chloride homeostasis in the substancia nigra pars reticulata contributes to locomotor deficiency in a model of acute liver injury. PLoS One (2013) 0.75
Chloride Co-transporter NKCC1 Inhibitor Bumetanide Enhances Neurogenesis and Behavioral Recovery in Rats After Experimental Stroke. Mol Neurobiol (2016) 0.75
Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med (2009) 3.32
De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy. Nat Genet (2008) 2.98
Cl- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1. J Physiol (2004) 2.42
Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models. J Virol (2004) 1.97
Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study. Acta Neuropathol (2003) 1.72
Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J Biol Chem (2008) 1.65
Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease. FASEB J (2004) 1.51
A comparative study of localization of heat shock protein 27 and heat shock protein 72 in the developmental and degenerative intervertebral discs. Spine (Phila Pa 1976) (2002) 1.44
Extensive distribution of glial cytoplasmic inclusions in an autopsied case of multiple system atrophy with a prolonged 18-year clinical course. Neuropathology (2011) 1.41
Functional changes in piriform cortex pyramidal neurons in the chronic methamphetamine-treated rat. Gen Physiol Biophys (2014) 1.38
Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay. Am J Hum Genet (2010) 1.35
Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain. Brain Res Dev Brain Res (2002) 1.32
Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. Neuro Oncol (2013) 1.29
Difference in binocularity and ocular dominance plasticity between GABAergic and excitatory cortical neurons. J Neurosci (2010) 1.29
Transgenic expression of enhanced green fluorescent protein enables direct visualization for physiological studies of vasopressin neurons and isolated nerve terminals of the rat. Endocrinology (2004) 1.28
De Novo mutations in GNAO1, encoding a Gαo subunit of heterotrimeric G proteins, cause epileptic encephalopathy. Am J Hum Genet (2013) 1.27
Expression of VEGF and its receptor genes in intracranial schwannomas. J Neurooncol (2007) 1.26
Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene. Eur J Neurosci (2006) 1.26
GABA-A receptors regulate neocortical neuronal migration in vitro and in vivo. Cereb Cortex (2006) 1.18
Discovery of a novel type of autophagy targeting RNA. Autophagy (2013) 1.17
Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy. Lung Cancer (2012) 1.17
GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J Neurosci (2004) 1.17
Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation. Acta Neuropathol (2009) 1.16
Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. Int J Cancer (2008) 1.16
Induction of NMDA and GABAA receptor-mediated Ca2+ oscillations with KCC2 mRNA downregulation in injured facial motoneurons. J Neurophysiol (2002) 1.15
Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation. Glia (2010) 1.14
Distinctions between pituicytoma and ordinary pilocytic astrocytoma. Case report. J Neurosurg (2003) 1.13
Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama study. Hypertension (2011) 1.12
Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever! Front Cell Neurosci (2012) 1.12
A case of hereditary diffuse leukoencephalopathy with axonal spheroids caused by a de novo mutation in CSF1R masquerading as primary progressive multiple sclerosis. Mult Scler (2013) 1.12
Intradural, extramedullary spinal Ewing's sarcoma in childhood. J Clin Neurosci (2003) 1.12
Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex. Cereb Cortex (2006) 1.09
Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J (2002) 1.08
Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro. J Neurochem (2008) 1.07
Quinoline derivatives are therapeutic candidates for transmissible spongiform encephalopathies. J Virol (2004) 1.07
Layer-specific expression of Cl- transporters and differential [Cl-]i in newborn rat cortex. Neuroreport (2002) 1.06
alpha 2-Adrenoceptor-mediated presynaptic modulation of GABAergic transmission in mechanically dissociated rat ventrolateral preoptic neurons. J Neurophysiol (2003) 1.06
Kinetic properties of Cl uptake mediated by Na+-dependent K+-2Cl cotransport in immature rat neocortical neurons. J Neurosci (2007) 1.05
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. Sci Transl Med (2012) 1.04
Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma. Clin Cancer Res (2011) 1.03
Brain-type creatine kinase activates neuron-specific K+-Cl- co-transporter KCC2. J Neurochem (2005) 1.02
CD59 blocks not only the insertion of C9 into MAC but inhibits ion channel formation by homologous C5b-8 as well as C5b-9. J Physiol (2002) 1.02
Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain. Acta Neuropathol (2002) 1.02
Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer. Lung Cancer (2011) 1.01
Allelic losses of chromosome 10 in glioma tissues detected by quantitative single-strand conformation polymorphism analysis. Clin Chem (2006) 1.00
Reappraisal of aquaporin-4 astrocytopathy in Asian neuromyelitis optica and multiple sclerosis patients. Brain Pathol (2011) 0.99
Quantitative analysis of neurofibrillary pathology in a general population to reappraise neuropathological criteria for senile dementia of the neurofibrillary tangle type (tangle-only dementia): the Hisayama Study. Neuropathology (2006) 0.99
Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons. J Neurosci (2004) 0.98
The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor. Lung Cancer (2011) 0.96
Developmental changes in KCC1, KCC2 and NKCC1 mRNAs in the rat cerebellum. Brain Res Dev Brain Res (2002) 0.96
Direct uptake and degradation of DNA by lysosomes. Autophagy (2013) 0.96
Downregulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells. Oncol Rep (2013) 0.96
Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant. Neurochem Int (2006) 0.96
Interaction of neuron-specific K+-Cl- cotransporter, KCC2, with brain-type creatine kinase. FEBS Lett (2004) 0.96
Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies. J Gen Virol (2004) 0.95
Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. Brain Cell Biol (2009) 0.94
Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons. J Physiol (2003) 0.94
PACAP/PAC1 autocrine system promotes proliferation and astrogenesis in neural progenitor cells. Glia (2007) 0.94
Aquaporin-4 astrocytopathy in Baló's disease. Acta Neuropathol (2010) 0.94
Adenosine A1 receptor-mediated presynaptic inhibition of GABAergic transmission in immature rat hippocampal CA1 neurons. J Neurophysiol (2003) 0.94
Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis. Acta Neuropathol (2002) 0.93
The Na(+)/H(+) exchanger is a major pH regulator in GABAergic presynaptic nerve terminals synapsing onto rat CA3 pyramidal neurons. J Neurochem (2006) 0.92
Experimental investigation of nanoparticle dispersion by beads milling with centrifugal bead separation. J Colloid Interface Sci (2006) 0.92
Type A1 but not type A2 botulinum toxin decreases the grip strength of the contralateral foreleg through axonal transport from the toxin-treated foreleg of rats. J Pharmacol Sci (2011) 0.92
Quantitative digital assessment of MGMT immunohistochemical expression in glioblastoma tissue. Brain Tumor Pathol (2011) 0.91
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease. Curr Alzheimer Res (2013) 0.91
Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation. Acta Neuropathol (2007) 0.91
Results of a long-term follow-up after neuroendoscopic biopsy procedure and third ventriculostomy in patients with intracranial germinomas. J Neurosurg (2007) 0.91
Eosinophilic myelitis associated with atopic diathesis: a combined neuroimaging and histopathological study. Acta Neuropathol (2002) 0.91
Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia. J Immunol (2009) 0.91
Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice. Am J Pathol (2006) 0.91
Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies. J Neurochem (2006) 0.91
Complement C5a receptor-mediated signaling may be involved in neurodegeneration in Alzheimer's disease. J Immunol (2003) 0.91
Functional roles of presynaptic GABA(A) receptors on glycinergic nerve terminals in the rat spinal cord. J Physiol (2002) 0.91
Amygdala kindling induces upregulation of mRNA for NKCC1, a Na(+), K(+)-2Cl(-) cotransporter, in the rat piriform cortex. Neurosci Res (2002) 0.90
Discrete flexoelectric polarizations and biaxial subphases with periodicities other than three and four layers in chiral smectic liquid crystals frustrated between ferroelectricity and antiferroelectricity. Phys Rev E Stat Nonlin Soft Matter Phys (2005) 0.90
The effects of volatile anesthetics on synaptic and extrasynaptic GABA-induced neurotransmission. Brain Res Bull (2012) 0.90
Differentiating primary CNS lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion-weighted imaging, and ¹⁸F-fluorodeoxyglucose positron emission tomography. Neuroradiology (2012) 0.90
Alpha 1-adrenoceptor-activated cation currents in neurones acutely isolated from rat cardiac parasympathetic ganglia. J Physiol (2003) 0.90
Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification. Oncol Rep (2012) 0.90
A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas. Neuropathology (2003) 0.90
Intraneuronal amyloid beta42 enhanced by heating but counteracted by formic acid. J Neurosci Methods (2006) 0.89
Accumulation of beta- and gamma-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse. Brain Res (2004) 0.89
Increased clusterin (apolipoprotein J) expression in human and mouse brains infected with transmissible spongiform encephalopathies. Acta Neuropathol (2001) 0.89
Characterization of the biological functions of a transcription factor, c-myc intron binding protein 1 (MIBP1). J Biochem (2002) 0.89
Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study. J Am Geriatr Soc (2011) 0.89
Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells. Invest Ophthalmol Vis Sci (2008) 0.89
Cellular distribution of NDRG1 protein in the rat kidney and brain during normal postnatal development. J Histochem Cytochem (2003) 0.89
Taurine inhibits K+-Cl- cotransporter KCC2 to regulate embryonic Cl- homeostasis via with-no-lysine (WNK) protein kinase signaling pathway. J Biol Chem (2012) 0.89
Statin therapy reduces inflammatory markers in hypercholesterolemic patients with high baseline levels. J Atheroscler Thromb (2010) 0.89
Effects of ethanol on GABA(A) receptors in GABAergic and glutamatergic presynaptic nerve terminals. J Pharmacol Exp Ther (2012) 0.88
Circadian rhythm in intracellular Cl(-) activity of acutely dissociated neurons of suprachiasmatic nucleus. Am J Physiol Cell Physiol (2002) 0.88
Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies. Acta Neuropathol (2002) 0.88