Published in Annu Rev Neurosci on March 20, 2002
A microRNA array reveals extensive regulation of microRNAs during brain development. RNA (2003) 9.76
A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev (2002) 6.10
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron (2008) 3.97
Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci (2010) 3.73
Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron (2008) 3.14
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell (2010) 3.08
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. J Neurophysiol (2008) 2.46
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol (2012) 2.42
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes. Genes Dev (2005) 2.38
The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development. Proc Natl Acad Sci U S A (2004) 2.34
Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics (2007) 2.30
Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr Opin Pharmacol (2008) 2.29
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A (2007) 2.10
The state of synapses in fragile X syndrome. Neuroscientist (2009) 2.07
Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations. RNA (2002) 2.06
Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs. J Biomed Biotechnol (2006) 2.02
The active FMR1 promoter is associated with a large domain of altered chromatin conformation with embedded local histone modifications. Proc Natl Acad Sci U S A (2006) 2.00
Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein. Proc Natl Acad Sci U S A (2004) 1.99
Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles. Proc Natl Acad Sci U S A (2004) 1.96
RNA transport and local control of translation. Annu Rev Cell Dev Biol (2005) 1.96
Toward fulfilling the promise of molecular medicine in fragile X syndrome. Annu Rev Med (2011) 1.96
Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice. Proc Natl Acad Sci U S A (2008) 1.91
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proc Natl Acad Sci U S A (2007) 1.91
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J Biol Chem (2008) 1.87
MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem (2008) 1.86
Fragile X mental retardation protein regulates translation by binding directly to the ribosome. Mol Cell (2014) 1.83
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
The fragile X mental retardation protein and group I metabotropic glutamate receptors regulate levels of mRNA granules in brain. Proc Natl Acad Sci U S A (2005) 1.74
Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice. J Neurosci (2008) 1.72
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome. Proc Natl Acad Sci U S A (2005) 1.70
The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits. J Neurosci (2009) 1.60
Mechanisms of RNA-mediated disease. J Biol Chem (2008) 1.59
On BC1 RNA and the fragile X mental retardation protein. Proc Natl Acad Sci U S A (2008) 1.56
Dendritic BC1 RNA in translational control mechanisms. J Cell Biol (2005) 1.45
Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome. J Neurosci (2008) 1.42
The fragile X mental retardation protein has nucleic acid chaperone properties. Nucleic Acids Res (2004) 1.42
Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. Nat Neurosci (2011) 1.36
A mouse model of the human Fragile X syndrome I304N mutation. PLoS Genet (2009) 1.36
Protein interactions and complexes in human microRNA biogenesis and function. Front Biosci (2008) 1.33
Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. J Neurosci (2011) 1.32
Signals, synapses, and synthesis: how new proteins control plasticity. Front Neural Circuits (2009) 1.31
RNA protein interaction in neurons. Annu Rev Neurosci (2013) 1.31
Ras and Rap signaling in synaptic plasticity and mental disorders. Neuroscientist (2010) 1.29
Ionotropic glutamate receptors & CNS disorders. CNS Neurol Disord Drug Targets (2008) 1.27
Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci (2010) 1.24
SCA8 repeat expansion: large CTA/CTG repeat alleles are more common in ataxic patients, including those with SCA6. Am J Hum Genet (2003) 1.24
C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD. Acta Neuropathol (2014) 1.22
Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models. Front Synaptic Neurosci (2010) 1.18
An origin of DNA replication in the promoter region of the human fragile X mental retardation (FMR1) gene. Mol Cell Biol (2006) 1.16
Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry (2012) 1.14
Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes. Mol Biol Cell (2007) 1.10
Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome. Psychoneuroendocrinology (2011) 1.10
The shape of the human language-ready brain. Front Psychol (2014) 1.10
The cationic porphyrin TMPyP4 destabilizes the tetraplex form of the fragile X syndrome expanded sequence d(CGG)n. Nucleic Acids Res (2003) 1.09
Fragile X Mental Retardation Protein is Involved in Protein Synthesis-Dependent Collapse of Growth Cones Induced by Semaphorin-3A. Front Neural Circuits (2009) 1.08
Interactions of the G quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family. Nucleic Acids Res (2007) 1.08
Protein components of the microRNA pathway and human diseases. Methods Mol Biol (2009) 1.07
Fragile X mental retardation protein interactions with the microtubule associated protein 1B RNA. RNA (2008) 1.07
A distinct DNA-methylation boundary in the 5'- upstream sequence of the FMR1 promoter binds nuclear proteins and is lost in fragile X syndrome. Am J Hum Genet (2009) 1.05
A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell (2014) 1.04
A simple, high-throughput assay for Fragile X expanded alleles using triple repeat primed PCR and capillary electrophoresis. J Mol Diagn (2010) 1.01
Transcranial magnetic stimulation provides means to assess cortical plasticity and excitability in humans with fragile x syndrome and autism spectrum disorder. Front Synaptic Neurosci (2010) 1.00
microRNAs: tiny regulators of synapse function in development and disease. J Cell Mol Med (2008) 0.98
CAG repeat RNA as an auxiliary toxic agent in polyglutamine disorders. RNA Biol (2011) 0.97
Neuronal autophagy and neurodevelopmental disorders. Exp Neurobiol (2013) 0.96
Compressed Genotyping. IEEE Trans Inf Theory (2010) 0.95
The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior. J Neurosci (2008) 0.95
AGG interruptions in (CGG)(n) DNA repeat tracts modulate the structure and thermodynamics of non-B conformations in vitro. Biochemistry (2010) 0.95
Limbic epileptogenesis in a mouse model of fragile X syndrome. Cereb Cortex (2008) 0.94
Genetic modifiers of dFMR1 encode RNA granule components in Drosophila. Genetics (2009) 0.94
Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected]. PLoS One (2012) 0.94
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders. Brain Res (2014) 0.93
The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis. Mol Biol Cell (2005) 0.93
Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology. Brain Res (2011) 0.92
Hypothesis: a role for fragile X mental retardation protein in mediating and relieving microRNA-guided translational repression? J Biomed Biotechnol (2006) 0.92
FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control. Proc Natl Acad Sci U S A (2013) 0.91
Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue. Biogerontology (2009) 0.91
Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate. J Biol Chem (2010) 0.90
Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos. Proc Natl Acad Sci U S A (2006) 0.90
dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition. Development (2010) 0.89
The development of cortical columns: role of Fragile X mental retardation protein. J Physiol (2009) 0.89
FMRP interacts with G-quadruplex structures in the 3'-UTR of its dendritic target Shank1 mRNA. RNA Biol (2014) 0.89
Induced pluripotent stem cells to model and treat neurogenetic disorders. Neural Plast (2012) 0.88
Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology (2014) 0.88
Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model. Genes Dev (2014) 0.86
Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome. Gene Ther (2009) 0.86
Substitution of critical isoleucines in the KH domains of Drosophila fragile X protein results in partial loss-of-function phenotypes. Genetics (2006) 0.85
Recombinant bacterial expression and purification of human fragile X mental retardation protein isoform 1. Protein Expr Purif (2010) 0.85
Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. PLoS One (2011) 0.84
Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase. J Med Chem (2013) 0.83
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies. PLoS Genet (2013) 0.83
Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndrome. Behav Brain Res (2013) 0.83
Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms. PLoS Genet (2012) 0.83
SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One (2013) 0.82
Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus. Learn Mem (2011) 0.82
Distribution of CGG repeat sizes within the fragile X mental retardation 1 (FMR1) homologue in a non-human primate population. Hum Genet (2003) 0.82
Expression of fragile X mental retardation protein within the vocal control system of developing and adult male zebra finches. Neuroscience (2008) 0.81
The mGluR theory of fragile X mental retardation. Trends Neurosci (2004) 8.88
Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc Natl Acad Sci U S A (2002) 6.45
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron (2008) 6.26
Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci (2004) 4.69
An evidence-based approach to establish the functional and clinical significance of copy number variants in intellectual and developmental disabilities. Genet Med (2011) 3.51
Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome. Neuron (2007) 3.17
The pathophysiology of fragile x syndrome. Annu Rev Genomics Hum Genet (2007) 2.85
RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron (2003) 2.81
Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia. Am J Hum Genet (2010) 2.70
Phosphorylation influences the translation state of FMRP-associated polyribosomes. Hum Mol Genet (2003) 2.66
RNA and microRNAs in fragile X mental retardation. Nat Cell Biol (2004) 2.63
Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Hum Mol Genet (2007) 2.55
Age-associated DNA methylation in pediatric populations. Genome Res (2012) 2.53
Relative burden of large CNVs on a range of neurodevelopmental phenotypes. PLoS Genet (2011) 2.46
Molecular mechanisms of fragile X syndrome: a twenty-year perspective. Annu Rev Pathol (2011) 2.39
Microdeletions of 3q29 confer high risk for schizophrenia. Am J Hum Genet (2010) 2.38
The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development. Proc Natl Acad Sci U S A (2004) 2.34
Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling. Mol Cell (2011) 2.27
Replication stress induces tumor-like microdeletions in FHIT/FRA3B. Proc Natl Acad Sci U S A (2007) 2.27
Incidence of fragile X syndrome by newborn screening for methylated FMR1 DNA. Am J Hum Genet (2009) 2.12
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A (2007) 2.10
Replication stress induces genome-wide copy number changes in human cells that resemble polymorphic and pathogenic variants. Am J Hum Genet (2009) 2.07
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat Chem Biol (2008) 2.04
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. J Neurosci (2007) 2.02
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome. J Neurosci (2010) 1.89
S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J Biol Chem (2008) 1.87
Local RNA translation at the synapse and in disease. J Neurosci (2011) 1.83
Fragile X syndrome. Eur J Hum Genet (2008) 1.81
Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. Sci Transl Med (2012) 1.72
Transcription, translation and fragile X syndrome. Curr Opin Genet Dev (2006) 1.72
New insights into fragile X syndrome: from molecules to neurobehaviors. Trends Biochem Sci (2003) 1.68
Signatures of founder effects, admixture, and selection in the Ashkenazi Jewish population. Proc Natl Acad Sci U S A (2010) 1.64
Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome. Am J Hum Genet (2002) 1.59
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet (2012) 1.52
Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nat Neurosci (2007) 1.46
Microarray-based mutation detection in the dystrophin gene. Hum Mutat (2008) 1.39
Physiological identification of human transcripts translationally regulated by a specific microRNA. Hum Mol Genet (2005) 1.39
Hemizygous mutations in SNAP29 unmask autosomal recessive conditions and contribute to atypical findings in patients with 22q11.2DS. J Med Genet (2012) 1.33
Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nat Cell Biol (2013) 1.27
The unstable repeats--three evolving faces of neurological disease. Neuron (2013) 1.26
New perspectives on the biology of fragile X syndrome. Curr Opin Genet Dev (2012) 1.23
A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels. Blood (2007) 1.22
Mosaic FMR1 deletion causes fragile X syndrome and can lead to molecular misdiagnosis: a case report and review of the literature. Am J Med Genet A (2008) 1.21
Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum. Hum Mol Genet (2012) 1.21
Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males. Am J Med Genet A (2010) 1.16
Neurogenetics: advancing the "next-generation" of brain research. Neuron (2010) 1.16
Fragile X protein functions with lgl and the par complex in flies and mice. Dev Cell (2005) 1.14
The fragile X mental retardation protein, FMRP, recognizes G-quartets. Ment Retard Dev Disabil Res Rev (2004) 1.14
Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice. BMC Genomics (2014) 1.03
Fragile X syndrome: an update and review for the primary pediatrician. Clin Pediatr (Phila) (2005) 1.01
Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation. PLoS Genet (2007) 0.99
Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus. BMC Med Genet (2013) 0.97
Gene expression profiles in a transgenic animal model of fragile X syndrome. Neurobiol Dis (2002) 0.96
Array-based FMR1 sequencing and deletion analysis in patients with a fragile X syndrome-like phenotype. PLoS One (2010) 0.93
Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity. J Neurochem (2004) 0.89
Neuroscience: fragile dopamine. Nature (2008) 0.87
Empirical evaluation of oligonucleotide probe selection for DNA microarrays. PLoS One (2010) 0.84
Molecular diagnosis of Beckwith-Wiedemann syndrome using quantitative methylation-sensitive polymerase chain reaction. Genet Med (2006) 0.82
Toward pluripotency by reprogramming: mechanisms and application. Protein Cell (2013) 0.81
Development and characterization of antibodies that immunoprecipitate the FMR1 protein. Methods Mol Biol (2003) 0.79
Genomic tics in tourette syndrome. Biol Psychiatry (2012) 0.75
The human genome: a diamond in the rough. Curr Opin Genet Dev (2012) 0.75