MicroRNAs in gene regulation: when the smallest governs it all.

PubWeight™: 1.76‹?› | Rank: Top 3%

🔗 View Article (PMC 1559927)

Published in J Biomed Biotechnol on January 01, 2006

Authors

Dominique L Ouellet1, Marjorie P Perron, Lise-Andrée Gobeil, Pierre Plante, Patrick Provost

Author Affiliations

1: Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUL, Ste-Foy, Quebec, Canada.

Articles citing this

miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments. Nucleic Acids Res (2009) 2.90

Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol (2009) 2.26

MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proc Natl Acad Sci U S A (2007) 2.16

Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element. Nucleic Acids Res (2008) 2.03

MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem (2008) 1.86

MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders. Curr Genomics (2009) 1.60

MicroRNA expression in Alzheimer blood mononuclear cells. Gene Regul Syst Bio (2007) 1.43

Protein interactions and complexes in human microRNA biogenesis and function. Front Biosci (2008) 1.33

MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord. J Neurosci (2010) 1.10

Protein components of the microRNA pathway and human diseases. Methods Mol Biol (2009) 1.07

AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes. J Interferon Cytokine Res (2008) 1.04

Regulatory RNAs: future perspectives in diagnosis, prognosis, and individualized therapy. Methods Mol Biol (2007) 1.03

Ariadne: a database search engine for identification and chemical analysis of RNA using tandem mass spectrometry data. Nucleic Acids Res (2009) 1.00

Prediction of guide strand of microRNAs from its sequence and secondary structure. BMC Bioinformatics (2009) 0.99

Novel HIV-1 therapeutics through targeting altered host cell pathways. Expert Opin Biol Ther (2009) 0.94

Hypothesis: a role for fragile X mental retardation protein in mediating and relieving microRNA-guided translational repression? J Biomed Biotechnol (2006) 0.92

Involvement of microRNA lethal-7a in the regulation of embryo implantation in mice. PLoS One (2012) 0.89

Heterogeneity of microRNAs expression in cervical cancer cells: over-expression of miR-196a. Int J Clin Exp Pathol (2014) 0.87

RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis. Front Mol Neurosci (2013) 0.87

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. Biochim Biophys Acta (2008) 0.86

Predicted functional RNAs within coding regions constrain evolutionary rates of yeast proteins. PLoS One (2008) 0.86

Emergence of a complex relationship between HIV-1 and the microRNA pathway. Methods Mol Biol (2009) 0.86

Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease. Int J Clin Exp Pathol (2015) 0.85

Profiles of extracellular miRNAs in the aqueous humor of glaucoma patients assessed with a microarray system. Sci Rep (2014) 0.85

Regulation of human Dicer by the resident ER membrane protein CLIMP-63. Nucleic Acids Res (2012) 0.84

Small RNA cloning. Methods Mol Biol (2010) 0.83

Common genetic variants in pre-microRNAs and risk of breast cancer in the North Indian population. Ecancermedicalscience (2014) 0.83

Vitamin D and microRNAs in bone. Crit Rev Eukaryot Gene Expr (2013) 0.83

MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA. J Neurochem (2013) 0.80

A polymerase chain reaction-based cloning strategy applicable to functional microRNA studies. Anal Biochem (2008) 0.79

Mmu-miR-193 is involved in embryo implantation in mouse uterus by regulating GRB7 gene expression. Reprod Sci (2013) 0.78

Controlled expression of functional miR-122 with a ligand inducible expression system. BMC Biotechnol (2010) 0.78

Modulation of microRNA Activity by Semi-microRNAs. Front Genet (2012) 0.78

Do we eat gene regulators? Commun Integr Biol (2012) 0.77

Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus. Reprod Sci (2013) 0.77

Detection and quantitative analysis of small RNAs by PCR. Methods Mol Biol (2010) 0.76

Refractoriness of hepatitis C virus internal ribosome entry site to processing by Dicer in vivo. J Negat Results Biomed (2009) 0.75

MicroRNAs in Breast Cancer -Our Initial Results. Balkan J Med Genet (2012) 0.75

MicroRNAs and PIWI-interacting RNAs in oncology. Oncol Lett (2016) 0.75

MiR-181a influences the cognitive function of epileptic rats induced by pentylenetetrazol. Int J Clin Exp Pathol (2015) 0.75

MicroRNAs that target RGS5. Iran J Basic Med Sci (2015) 0.75

RNA interference in head and neck oncology. Oncol Lett (2016) 0.75

Articles cited by this

(truncated to the top 100)

MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56

MicroRNA expression profiles classify human cancers. Nature (2005) 69.12

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62

Prediction of mammalian microRNA targets. Cell (2003) 53.70

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature (2005) 48.95

Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31

miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25

Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75

The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49

Human MicroRNA targets. PLoS Biol (2004) 34.51

An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell (1993) 33.79

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26

c-Myc-regulated microRNAs modulate E2F1 expression. Nature (2005) 31.81

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature (2005) 31.60

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science (2001) 31.33

RAS is regulated by the let-7 microRNA family. Cell (2005) 30.24

MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05

The microRNA Registry. Nucleic Acids Res (2004) 29.45

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A (2004) 28.29

RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell (2001) 25.86

MicroRNA targets in Drosophila. Genome Biol (2003) 23.59

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 23.17

Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86

Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14

miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A (2005) 21.51

MicroRNA genes are transcribed by RNA polymerase II. EMBO J (2004) 20.65

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32

A uniform system for microRNA annotation. RNA (2003) 20.28

MicroRNA maturation: stepwise processing and subcellular localization. EMBO J (2002) 19.47

A species of small antisense RNA in posttranscriptional gene silencing in plants. Science (1999) 19.34

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev (2002) 19.24

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature (2000) 19.15

Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res (2004) 18.86

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res (2005) 18.58

MicroRNA-directed cleavage of HOXB8 mRNA. Science (2004) 18.33

The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev (2003) 17.64

Vertebrate microRNA genes. Science (2003) 17.42

Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res (2003) 17.13

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04

Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science (2005) 16.84

Nuclear export of microRNA precursors. Science (2003) 16.59

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10

Dicer is essential for mouse development. Nat Genet (2003) 15.87

MicroRNA expression in zebrafish embryonic development. Science (2005) 15.52

Argonaute2, a link between genetic and biochemical analyses of RNAi. Science (2001) 15.32

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell (2005) 15.26

Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63

Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59

Insertion sequences. Microbiol Mol Biol Rev (1998) 14.03

Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science (2005) 13.84

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J (2001) 12.88

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell (1997) 12.87

Identification of virus-encoded microRNAs. Science (2004) 12.56

Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans. Science (2001) 11.86

High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer (2004) 11.79

The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev (2004) 11.58

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA (2004) 11.52

MicroRNAs regulate brain morphogenesis in zebrafish. Science (2005) 11.16

RNA silencing in plants. Nature (2004) 11.12

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell (2000) 10.92

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans. Plant Cell (1990) 10.56

A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res (2005) 10.46

New microRNAs from mouse and human. RNA (2003) 10.35

ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell (2001) 10.20

A combined computational-experimental approach predicts human microRNA targets. Genes Dev (2004) 9.82

Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res (2005) 9.80

Genomic targets of the human c-Myc protein. Genes Dev (2003) 9.67

RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem (2001) 9.66

R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science (2003) 9.53

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell (2005) 9.35

Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell (2005) 9.27

Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell (2005) 9.01

RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73

A cellular microRNA mediates antiviral defense in human cells. Science (2005) 8.48

The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR. Genes Dev (2004) 8.42

Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA (2004) 8.31

Single processing center models for human Dicer and bacterial RNase III. Cell (2004) 8.19

A protein sensor for siRNA asymmetry. Science (2004) 7.77

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61

A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat Struct Mol Biol (2005) 7.49

Sequence requirements for micro RNA processing and function in human cells. RNA (2003) 7.46

Small interfering RNA-induced transcriptional gene silencing in human cells. Science (2004) 7.29

Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol (2005) 7.23

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature (2005) 7.12

Articles by these authors

The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81

Botulinum toxin type a is a safe and effective treatment for neurogenic urinary incontinence: results of a single treatment, randomized, placebo controlled 6-month study. J Urol (2005) 2.68

Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol (2009) 2.26

Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles. Blood (2013) 2.10

Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element. Nucleic Acids Res (2008) 2.03

Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs. J Biomed Biotechnol (2006) 2.02

MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem (2008) 1.86

Testicular cancer variations in time and space in Europe. Eur Urol (2006) 1.67

[Partial nephrectomy by selective renal parenchymal clamping using a new clamp]. Prog Urol (2007) 1.45

Impact of diagnostic delay in testis cancer: results of a large population-based study. Eur Urol (2007) 1.44

[Efficacy and safety of Pelvicol in the vaginal treatment of prolapse]. Prog Urol (2006) 1.42

Retroperitoneoscopic adrenalectomy: comparison of retrograde and antegrade approach among a series of 279 cases. Urology (2013) 1.40

Conservative management of small testicular tumors relative to carcinoma in situ prevalence. J Urol (2005) 1.39

Protein interactions and complexes in human microRNA biogenesis and function. Front Biosci (2008) 1.33

ago1 and dcr1, two core components of the RNA interference pathway, functionally diverge from rdp1 in regulating cell cycle events in Schizosaccharomyces pombe. Mol Biol Cell (2003) 1.28

Polyorchidism: presentation of 2 cases, review of the literature and a new management strategy. Urol Int (2008) 1.20

The repertoire and features of human platelet microRNAs. PLoS One (2012) 1.19

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc Natl Acad Sci U S A (2006) 1.12

Protein components of the microRNA pathway and human diseases. Methods Mol Biol (2009) 1.07

Resistance of human hepatitis delta virus RNAs to dicer activity. J Virol (2003) 1.04

Regulatory RNAs: future perspectives in diagnosis, prognosis, and individualized therapy. Methods Mol Biol (2007) 1.03

A multicenter study of the morbidity of radical cystectomy in select elderly patients with bladder cancer. J Urol (2002) 0.97

Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview. Transpl Int (2007) 0.96

The Saccharomyces cerevisiae Arf3 protein is involved in actin cable and cortical patch formation. FEMS Yeast Res (2007) 0.93

Functional testicular evaluation using PET/CT with 18F-fluorodeoxyglucose. Eur J Nucl Med Mol Imaging (2011) 0.93

Hypothesis: a role for fragile X mental retardation protein in mediating and relieving microRNA-guided translational repression? J Biomed Biotechnol (2006) 0.92

Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells. Clin Cancer Res (2011) 0.92

Molecular cloning and functional characterization of mouse coactosin-like protein. Biochem Biophys Res Commun (2002) 0.91

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102. Biochem J (2009) 0.90

Long-term efficacy of two cycles of BEP regimen in high-risk stage I nonseminomatous testicular germ cell tumors with embryonal carcinoma and/or vascular invasion. Eur Urol (2004) 0.89

Fertility after testicular cancer treatments: results of a large multicenter study. Cancer (2004) 0.88

Emergence of a complex relationship between HIV-1 and the microRNA pathway. Methods Mol Biol (2009) 0.86

Detection of human Dicer and Argonaute 2 catalytic activity. Methods Mol Biol (2011) 0.86

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain. Biochim Biophys Acta (2008) 0.86

Regulation of human Dicer by the resident ER membrane protein CLIMP-63. Nucleic Acids Res (2012) 0.84

Current knowledge of MicroRNAs and noncoding RNAs in virus-infected cells. Methods Mol Biol (2010) 0.84

Regulation of host gene expression by HIV-1 TAR microRNAs. Retrovirology (2013) 0.83

Alteration of the platelet transcriptome in chronic kidney disease. Thromb Haemost (2012) 0.83

Erectile dysfunction in end-stage liver disease men. J Sex Med (2009) 0.82

Ejaculatory function after permanent 125I prostate brachytherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys (2009) 0.82

Open partial nephrectomy with selective renal parenchymal control: a new reliable clamp. Urology (2006) 0.81

Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe. Front Biosci (2008) 0.81

Effects of pathogen reduction systems on platelet microRNAs, mRNAs, activation, and function. Platelets (2014) 0.81

Elevated Abundance, Size, and MicroRNA Content of Plasma Extracellular Vesicles in Viremic HIV-1+ Patients: Correlations With Known Markers of Disease Progression. J Acquir Immune Defic Syndr (2015) 0.81

Fluorescent ligands of the bradykinin B1 receptors: pharmacologic characterization and application to the study of agonist-induced receptor translocation and cell surface receptor expression. J Pharmacol Exp Ther (2009) 0.81

[Retroperitoneal laparoscopic surgery for phaeochromocytoma: analysis of morbidity and haemodynamic instability]. Prog Urol (2007) 0.81

[Treatment of bladder outlet obstruction secondary to suburethral tape by section of the tape]. Prog Urol (2006) 0.80

Midodrine improves orgasm in spinal cord-injured men: the effects of autonomic stimulation. J Sex Med (2008) 0.80

NMR structure of human coactosin-like protein. J Biomol NMR (2004) 0.79

A polymerase chain reaction-based cloning strategy applicable to functional microRNA studies. Anal Biochem (2008) 0.79

Modulation of microRNA Activity by Semi-microRNAs. Front Genet (2012) 0.78

Synchronous epidermoid cyst and mature teratoma of the testis: an unusual association. Urol Int (2007) 0.78

Azoospermic HIV-1 infected patients wishing to have children: proposed strategy to reduce HIV-1 transmission risk during sperm retrieval and intracytoplasmic sperm injection: Case Report. Hum Reprod (2007) 0.78

Oral midodrine for prostaglandin e1 induced priapism in spinal cord injured patients. J Urol (2009) 0.77

Refractoriness of hepatitis C virus internal ribosome entry site to processing by Dicer in vivo. J Negat Results Biomed (2009) 0.75

[Linguistic validation of the "Brief Index of Sexual Functioning for Women"]. Prog Urol (2006) 0.75

[Fertility before and after treatment of patients with Leydig cell tumour]. Prog Urol (2007) 0.75

[Epidural abscess after prostatic biopsies]. Prog Urol (2005) 0.75

[Non-deferential male contraception: review of the literature]. Prog Urol (2007) 0.75

[Vasectomy and vas deferens contraceptive surgery: legal and technical aspects]. Prog Urol (2007) 0.75

Comparison of red blood cell volume distribution curves and phase-contrast microscopy in localization of the origin of hematuria. Urology (2003) 0.75

[Systematic planning of technical training in urologic surgery: methodologic trial]. Prog Urol (2002) 0.75

[Urological consequences of pudendal nerve trauma during orthopedic surgery: review and practical advice]. Prog Urol (2002) 0.75

Lethal posttraumatic rupture of a pheochromocytoma: lesson from a postmortem diagnosis. Urol Int (2007) 0.75

[Severe (RTOG grades 3 or 4) long-term complications of adjuvant radiotherapy after total prostatectomy]. Prog Urol (2006) 0.75

[Can urinary corpuscular volume using automated hematology contribute the diagnostic etiology of hematuric microscopy?]. Prog Urol (2002) 0.75