Published in Clin Cancer Res on June 01, 2002
Mechanisms of Taxol resistance related to microtubules. Oncogene (2003) 3.16
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res (2009) 3.14
ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours. Br J Cancer (2004) 1.88
Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res (2010) 1.45
Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. Br J Cancer (2006) 1.29
Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors. Breast Cancer Res (2009) 1.26
Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer. Br J Cancer (2005) 1.22
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol Cell Biol (2005) 1.13
High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients. Oncologist (2012) 0.99
The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. Cancer Res (2011) 0.97
Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells. Br J Cancer (2004) 0.97
Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells. J Vet Sci (2009) 0.95
Low ERK phosphorylation in cancer-associated fibroblasts is associated with tamoxifen resistance in pre-menopausal breast cancer. PLoS One (2012) 0.95
ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics. World J Surg Oncol (2012) 0.91
Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation. Am J Pathol (2003) 0.91
Activation of the EGFR/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands. Br J Cancer (2010) 0.91
Phosphorylated AKT and MAPK expression in primary tumours and in corresponding metastases and clinical outcome in colorectal cancer patients receiving irinotecan-cetuximab. J Transl Med (2012) 0.91
PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture. Breast Cancer Res (2009) 0.90
Expression profile analysis of long noncoding RNA in HER-2-enriched subtype breast cancer by next-generation sequencing and bioinformatics. Onco Targets Ther (2016) 0.88
BMP9 inhibits proliferation and metastasis of HER2-positive SK-BR-3 breast cancer cells through ERK1/2 and PI3K/AKT pathways. PLoS One (2014) 0.87
Complex interactions between the components of the PI3K/AKT/mTOR pathway, and with components of MAPK, JAK/STAT and Notch-1 pathways, indicate their involvement in meningioma development. Virchows Arch (2014) 0.87
ΔNp63α regulates Erk signaling via MKP3 to inhibit cancer metastasis. Oncogene (2012) 0.86
Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: optimising EGFR-targeted treatment options. Br J Cancer (2007) 0.86
Phase I/II study of sorafenib with anastrozole in patients with hormone receptor positive aromatase inhibitor resistant metastatic breast cancer. Breast Cancer Res Treat (2010) 0.86
Expression of SLP-2 was associated with invasion of esophageal squamous cell carcinoma. PLoS One (2013) 0.84
Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin. Oncogene (2013) 0.82
Prognostic and predictive value of Phospho-p44/42 and pAKT in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy. World J Surg Oncol (2013) 0.81
Relationships between signaling pathway usage and sensitivity to a pathway inhibitor: examination of trametinib responses in cultured breast cancer lines. PLoS One (2014) 0.81
Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk. PLoS One (2013) 0.79
GRP78 regulates sensitivity of human colorectal cancer cells to DNA targeting agents. Cytotechnology (2014) 0.79
Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells. J Oncol (2010) 0.79
Imbalanced expression of mitogen-activated protein kinase phosphatase-1 and phosphorylated extracellular signal-regulated kinases in lung squamous cell carcinoma. J Zhejiang Univ Sci B (2011) 0.78
The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence. Oncotarget (2015) 0.78
Expression of pERK and pAKT in human astrocytomas: correlation with IDH1-R132H presence, vascular endothelial growth factor, microvascular characteristics and clinical outcome. Virchows Arch (2011) 0.77
Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells. BMC Cancer (2015) 0.76
Inflammatory breast cancer: high incidence of detection of mixed human cytomegalovirus genotypes associated with disease pathogenesis. Front Oncol (2014) 0.76
MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model. Mol Cancer Ther (2015) 0.76
Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Sci Rep (2015) 0.75
Potassium-3-beta-hydroxy-20-oxopregn-5-en-17-alpha-yl sulfate: a novel inhibitor of 78 kDa glucose-regulated protein. Onco Targets Ther (2016) 0.75
Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells. Mol Cancer (2017) 0.75
DUSP1 promoter methylation in peripheral blood leukocyte is associated with triple-negative breast cancer risk. Sci Rep (2017) 0.75
Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway. Cell Death Dis (2016) 0.75
The potential role of extracellular regulatory kinase in the survival of patients with early stage adenocarcinoma. J Thorac Dis (2014) 0.75
Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer. Oncotarget (2016) 0.75
miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer. Sci Rep (2016) 0.75
Skp2 regulates subcellular localization of PPARγ by MEK signaling pathways in human breast cancer. Int J Mol Sci (2013) 0.75
Reduced miR-550a-3p leads to breast cancer initiation, growth, and metastasis by increasing levels of ERK1 and 2. Oncotarget (2016) 0.75
Associations between clinicopathological prognostic factors and pAkt, pMAPK and topoisomerase II expression in breast cancer. Int J Clin Exp Med (2014) 0.75
Luteolin induces apoptosis in vitro through suppressing the MAPK and PI3K signaling pathways in gastric cancer. Oncol Lett (2017) 0.75
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet (2002) 3.89
Reframing medical education to support professional identity formation. Acad Med (2014) 3.40
"Intrinsic Roles" rather than "armour": renaming the "non-medical expert roles" of the CanMEDS framework to match their intent. Adv Health Sci Educ Theory Pract (2011) 2.41
Mammographic density is related to stroma and stromal proteoglycan expression. Breast Cancer Res (2003) 2.37
Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLoS One (2009) 2.36
Why medical students should learn how to teach. Med Teach (2007) 2.31
Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer. Breast Cancer Res (2011) 2.25
Medical competence: the interplay between individual ability and the health care environment. Med Teach (2010) 2.09
The Prohibitins: emerging roles in diverse functions. J Cell Mol Med (2006) 1.81
Orienting teaching toward the learning process. Acad Med (2004) 1.77
The autophagy protein LC3A correlates with hypoxia and is a prognostic marker of patient survival in clear cell ovarian cancer. J Pathol (2012) 1.72
Writing for publication in medical education: the benefits of a faculty development workshop and peer writing group. Med Teach (2008) 1.71
Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer. Clin Cancer Res (2003) 1.67
Are Canadian General Internal Medicine training program graduates well prepared for their future careers? BMC Med Educ (2006) 1.65
CD20+ tumor-infiltrating lymphocytes have an atypical CD27- memory phenotype and together with CD8+ T cells promote favorable prognosis in ovarian cancer. Clin Cancer Res (2012) 1.64
Prohibitin: a potential target for new therapeutics. Trends Mol Med (2005) 1.60
Effect of the ACGME duty hours restrictions on surgical residents and faculty: a systematic review. Acad Med (2011) 1.60
Faculty development for teaching and evaluating professionalism: from programme design to curriculum change. Med Educ (2005) 1.60
The current state of musculoskeletal clinical skills teaching for preclerkship medical students. J Rheumatol (2008) 1.58
Which pedagogical principles should clinical teachers know? Teachers and education experts disagree. Disagreement on important pedagogical principles. Med Teach (2009) 1.52
Targeting the EGFR pathway for cancer therapy. Curr Med Chem (2006) 1.48
S100 proteins and their influence on pro-survival pathways in cancer. Biochem Cell Biol (2004) 1.37
Clinical significance of estrogen receptor phosphorylation. Endocr Relat Cancer (2011) 1.33
Multiple mini-interviews versus traditional interviews: stakeholder acceptability comparison. Med Educ (2009) 1.31
A schematic representation of the professional identity formation and socialization of medical students and residents: a guide for medical educators. Acad Med (2015) 1.31
Competency-based medical education: implications for undergraduate programs. Med Teach (2010) 1.28
Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer. Clin Cancer Res (2003) 1.23
Psoriasin interacts with Jab1 and influences breast cancer progression. Cancer Res (2003) 1.20
Surveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer. Clin Cancer Res (2013) 1.18
BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene. Cancer Res (2005) 1.15
Clonal evolution of high-grade serous ovarian carcinoma from primary to recurrent disease. J Pathol (2012) 1.15
Influence of evolution in tumor biobanking on the interpretation of translational research. Cancer Epidemiol Biomarkers Prev (2008) 1.15
The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer. Cancer Res (2005) 1.15
Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer. PLoS One (2008) 1.14
S100A7 and the progression of breast cancer. Breast Cancer Res (2004) 1.14
Necrosis and hypoxia in invasive breast carcinoma. Breast Cancer Res Treat (2003) 1.12
Tumor cell expression of HLA-DM associates with a Th1 profile and predicts improved survival in breast carcinoma patients. Int Immunol (2006) 1.11
Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium. Cancer Res (2002) 1.10
Characteristic profiles among students and junior doctors with specific career preferences. BMC Med Educ (2013) 1.10
Management and leadership development programs for the medical community at McGill University. Mcgill J Med (2006) 1.10
The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours. J Pathol (2004) 1.08
Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen. Clin Cancer Res (2004) 1.07
Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides. Nucleic Acids Res (2009) 1.07
Psoriasin (S100A7) expression is altered during skin tumorigenesis. BMC Dermatol (2003) 1.06
Estrogen receptor-alpha phosphorylated at Ser118 is present at the promoters of estrogen-regulated genes and is not altered due to HER-2 overexpression. Cancer Res (2006) 1.05
Identification of new human coding steroid receptor RNA activator isoforms. Biochem Biophys Res Commun (2003) 1.04
S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast. Breast Cancer Res (2004) 1.04
Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in tissue microarrays of ERalpha positive human breast carcinomas. Breast Cancer Res Treat (2008) 1.03
Intermittent hypoxia induces proteasome-dependent down-regulation of estrogen receptor alpha in human breast carcinoma. Clin Cancer Res (2004) 1.03
Permission to contact (PTC)--a strategy to enhance patient engagement in translational research. Biopreserv Biobank (2013) 1.03
Analysis of gene expression in ductal carcinoma in situ of the breast. Clin Cancer Res (2002) 1.01
Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target. J Steroid Biochem Mol Biol (2007) 0.98
Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer? Endocr Relat Cancer (2006) 0.98
Defining the key roles and competencies of the clinician-educator of the 21st century: a national mixed-methods study. Acad Med (2014) 0.98
Coming of age as communicators: differences in the implementation of common communications skills training in four residency programmes. Med Educ (2007) 0.97
Timing of consent for the research use of surgically removed tissue: is postoperative consenting acceptable? Cancer (2009) 0.97
Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype. Virchows Arch (2009) 0.96
Phospho-serine-118 estrogen receptor-alpha detection in human breast tumors in vivo. Clin Cancer Res (2004) 0.96
The Resident-as-Teacher: It's More Than Just About Student Learning. J Grad Med Educ (2011) 0.95
Biospecimen use correlates with emerging techniques in cancer research: impact on planning future biobanks. Biopreserv Biobank (2012) 0.95
Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer. Breast Cancer Res Treat (2006) 0.94
Impact of a Permission to Contact (PTC) platform on biobank enrollment and efficiency. Biopreserv Biobank (2013) 0.93
RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer. BMC Cancer (2002) 0.93
Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis. BMC Cancer (2005) 0.92
A phosphorylation code for oestrogen receptor-alpha predicts clinical outcome to endocrine therapy in breast cancer. Endocr Relat Cancer (2010) 0.92
The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivo. J Steroid Biochem Mol Biol (2009) 0.91
Death related to albendazole-induced pancytopenia: case report and review. Am J Trop Med Hyg (2005) 0.90
Assessment of multiple different estrogen receptor-beta antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditions. Breast Cancer Res Treat (2006) 0.90
Pediatric crisis resource management training improves emergency medicine trainees' perceived ability to manage emergencies and ability to identify teamwork errors. Pediatr Emerg Care (2014) 0.90
Spontaneous mammary tumors differ widely in their inherent sensitivity to adoptively transferred T cells. Cancer Res (2007) 0.90
Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouse. DNA Cell Biol (2006) 0.90
Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer. Cancer Lett (2009) 0.89
What are the biggest challenges and opportunities for biorepositories in the next three to five years? Biopreserv Biobank (2010) 0.89
When the learning environment is suboptimal: exploring medical students' perceptions of "mistreatment". Acad Med (2014) 0.89