Patricia S Doyle

Author PubWeight™ 12.14^‹?›

Rank	Title	Journal	Year	PubWeight™‹?›
1	Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.	J Med Chem	2002	1.64
2	Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.	Antimicrob Agents Chemother	2010	1.41
3	Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.	PLoS Negl Trop Dis	2009	1.29
4	Identification of a new class of nonpeptidic inhibitors of cruzain.	J Am Chem Soc	2008	1.26
5	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.	J Med Chem	2010	1.04
6	Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.	Bioorg Med Chem Lett	2007	1.00
7	Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.	J Med Chem	2010	1.00
8	Metal compounds for the treatment of parasitic diseases.	J Inorg Biochem	2008	0.98
9	Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.	Beilstein J Org Chem	2013	0.95
10	In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.	PLoS Negl Trop Dis	2010	0.93
11	Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.	Antimicrob Agents Chemother	2007	0.86