Published in J Med Chem on June 20, 2002
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother (2007) 1.54
Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz (2009) 1.41
Identification of a new class of nonpeptidic inhibitors of cruzain. J Am Chem Soc (2008) 1.26
Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies. Open Med Chem J (2011) 1.22
2-Cyclo-heptyl-idene-N-phenyl-hydrazine-carbo-thio-amide. Acta Crystallogr Sect E Struct Rep Online (2014) 1.05
Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett (2008) 1.02
A role for the root cap in root branching revealed by the non-auxin probe naxillin. Nat Chem Biol (2012) 0.97
Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry (2007) 0.93
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia (2014) 0.92
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi. Antimicrob Agents Chemother (2010) 0.87
Synthesis, spectroscopic, and antimicrobial studies on bivalent zinc and mercury complexes of 2-formylpyridine thiosemicarbazone. Bioinorg Chem Appl (2009) 0.84
Computational identification of uncharacterized cruzain binding sites. PLoS Negl Trop Dis (2010) 0.83
Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella. Antimicrob Agents Chemother (2011) 0.83
Microwave assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones. Tetrahedron Lett (2009) 0.83
Antimalarial activity of thiosemicarbazones and purine derived nitriles. Bioorg Med Chem Lett (2009) 0.79
Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB. PLoS One (2013) 0.78
Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L. ACS Med Chem Lett (2012) 0.77
Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrob Agents Chemother (2015) 0.76
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L. Bioorg Med Chem (2015) 0.75
Structural and antitrypanosomal data of different carbasones of piperitone. Data Brief (2016) 0.75
Theoretical and experimental studies of vibrational spectra and thermodynamical analysis of 3'-bromopropiophenone and 4'-bromo-3-chloropropiophenone. J Mol Model (2010) 0.75
Synthetic mammalian prions. Science (2004) 7.35
The genome of the blood fluke Schistosoma mansoni. Nature (2009) 5.94
Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol (2003) 4.24
Evidence for assembly of prions with left-handed beta-helices into trimers. Proc Natl Acad Sci U S A (2004) 3.64
GPCRDB information system for G protein-coupled receptors. Nucleic Acids Res (2003) 3.34
Automated extraction of mutation data from the literature: application of MuteXt to G protein-coupled receptors and nuclear hormone receptors. Bioinformatics (2004) 3.03
Pathway complexity of prion protein assembly into amyloid. J Biol Chem (2002) 2.96
Structural studies of the scrapie prion protein by electron crystallography. Proc Natl Acad Sci U S A (2002) 2.91
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes. Proc Natl Acad Sci U S A (2006) 2.69
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett (2003) 2.54
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol (2004) 2.47
Invasion of skin by Schistosoma cercariae. Trends Parasitol (2002) 2.44
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med (2012) 2.39
Drug discovery and development for neglected parasitic diseases. Nat Chem Biol (2006) 2.31
Strain-specified characteristics of mouse synthetic prions. Proc Natl Acad Sci U S A (2005) 2.25
Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med (2007) 2.15
Protease-sensitive synthetic prions. PLoS Pathog (2010) 2.14
Searching for new antimalarial therapeutics amongst known drugs. Chem Biol Drug Des (2006) 2.10
Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. J Virol (2004) 2.07
From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis. Acta Trop (2010) 2.01
Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A (2009) 1.97
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A (2005) 1.91
Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. Am J Trop Med Hyg (2009) 1.87
A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. J Biol Chem (2006) 1.82
Co-evolutionary analysis reveals insights into protein-protein interactions. J Mol Biol (2002) 1.77
Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis (2009) 1.74
Dominant-negative inhibition of prion replication in transgenic mice. Proc Natl Acad Sci U S A (2002) 1.65
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. Nat Biotechnol (2004) 1.63
Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei. Chem Biol Drug Des (2006) 1.61
A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. J Biol Chem (2004) 1.57
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem (2010) 1.54
Proteomic analysis of Schistosoma mansoni cercarial secretions. Mol Cell Proteomics (2005) 1.54
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother (2007) 1.54
Genes contributing to prion pathogenesis. J Gen Virol (2008) 1.51
A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. J Immunol (2010) 1.51
Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol (2005) 1.51
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem (2004) 1.49
Automatic extraction of protein point mutations using a graph bigram association. PLoS Comput Biol (2007) 1.48
Molecular phylogeny and evolution of the plant-specific seven-transmembrane MLO family. J Mol Evol (2003) 1.45
Combined endostatin and TRAIL gene transfer suppresses human hepatocellular carcinoma growth and angiogenesis in nude mice. Cancer Biol Ther (2009) 1.43
IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient. Sci Transl Med (2010) 1.42
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrob Agents Chemother (2010) 1.41
A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem (2004) 1.41
A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis (2011) 1.39
Blood 'n' guts: an update on schistosome digestive peptidases. Trends Parasitol (2004) 1.35
RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. PLoS Negl Trop Dis (2008) 1.35
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Mol Biochem Parasitol (2003) 1.34
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett (2009) 1.33
Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem (2008) 1.32
RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl Trop Dis (2010) 1.32
Potent inhibition of scrapie prion replication in cultured cells by bis-acridines. Proc Natl Acad Sci U S A (2003) 1.32
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl Trop Dis (2010) 1.30
Host pathogen protein interactions predicted by comparative modeling. Protein Sci (2007) 1.29
Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. PLoS Negl Trop Dis (2009) 1.29
Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13. Cancer Res (2002) 1.26
Identification of a new class of nonpeptidic inhibitors of cruzain. J Am Chem Soc (2008) 1.26
Cell division modulates prion accumulation in cultured cells. Proc Natl Acad Sci U S A (2007) 1.25
Differential use of protease families for invasion by schistosome cercariae. Biochimie (2007) 1.24
Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. J Biol Chem (2002) 1.22
A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrob Agents Chemother (2013) 1.22
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrob Agents Chemother (2010) 1.22
Gene expression patterns during adaptation of a helminth parasite to different environmental niches. Genome Biol (2007) 1.20
Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Immunol (2009) 1.20
Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. J Biol Chem (2007) 1.19
Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem (2009) 1.18
Bilateral uterine artery chemoembolization with methotrexate for cesarean scar pregnancy. Am J Obstet Gynecol (2012) 1.17
A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One (2009) 1.17
Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol (2009) 1.17
Proteomic analysis of skin invasion by blood fluke larvae. PLoS Negl Trop Dis (2008) 1.16
Differential regulation of elastic fiber formation by fibulin-4 and -5. J Biol Chem (2009) 1.16
Expression of tumor necrosis factor alpha-induced protein 3 mRNA in peripheral blood mononuclear cells negatively correlates with disease severity in psoriasis vulgaris. Clin Vaccine Immunol (2012) 1.15
Global identification of peptidase specificity by multiplex substrate profiling. Nat Methods (2012) 1.14
The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A (2005) 1.14
Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. PLoS Negl Trop Dis (2010) 1.14
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog (2012) 1.13
Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis (2012) 1.12
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett (2005) 1.11
Tissue-specific expression of TIPE2 provides insights into its function. Mol Immunol (2010) 1.10
Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Mol Biochem Parasitol (2002) 1.09
Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas. Cancer Immunol Immunother (2011) 1.08
Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett (2006) 1.07