A multicenter, double-blind, randomized, placebo-controlled study of the efficacy and safety of botulinum toxin type A in the treatment of glabellar lines.

PubWeight™: 1.39‹?› | Rank: Top 10%

🔗 View Article (PMID 12063480)

Published in J Am Acad Dermatol on June 01, 2002

Authors

J Alastair Carruthers1, Nicholas J Lowe, M Alan Menter, John Gibson, Marian Nordquist, Julie Mordaunt, Patricia Walker, Nina Eadie, BOTOX Glabellar Lines I Study Group

Author Affiliations

1: Vancouver Hospital, Vancouver, British Columbia, Canada.

Associated clinical trials:

Efficacy and Safety of a New Botulinum Toxin Type A for Treatment of Facial Expression Lines | NCT01180348

Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study | NCT01529788

Duration of Botox Using OLD Versus COLD for Treatment of Glabellar Lines | NCT05083286

Articles citing this

A double-blind, randomized, placebo-controlled, two-dose comparative study of botulinum toxin type A for treating glabellar lines in Japanese subjects. Aesthetic Plast Surg (2008) 1.50

A Phase III Study of IncobotulinumtoxinA in the Treatment of Glabellar Frown Lines. J Clin Aesthet Dermatol (2011) 1.08

Differential characteristics of incobotulinumtoxinA and its use in the management of glabellar frown lines. Clin Pharmacol (2013) 0.87

Onset, longevity, and patient satisfaction with incobotulinumtoxinA for the treatment of glabellar frown lines: a single-arm, prospective clinical study. Clin Interv Aging (2013) 0.85

Botulinum toxins for facial lines: a concise review. Dermatol Ther (Heidelb) (2012) 0.84

The Practical Use of AbobotulinumtoxinA in Aesthetics. Aesthet Surg J (2017) 0.83

AbobotulinumtoxinA: A 25-Year History. Aesthet Surg J (2017) 0.82

Duration of action of abobotulinumtoxina and onabotulinumtoxina: a randomized, double-blind study using a contralateral frontalis model. J Clin Aesthet Dermatol (2011) 0.81

Botulinum toxin type A for the management of glabellar rhytids. Clin Cosmet Investig Dermatol (2010) 0.80

Onset and duration of effect of incobotulinumtoxinA, onabotulinumtoxinA, and abobotulinumtoxinA in the treatment of glabellar frown lines: a randomized, double-blind study. Clin Cosmet Investig Dermatol (2013) 0.79

Complications of minimally invasive cosmetic procedures: prevention and management. J Cutan Aesthet Surg (2012) 0.79

Characterizing the Lateral Border of the Frontalis for Safe and Effective Injection of Botulinum Toxin. Aesthet Surg J (2015) 0.77

The changed image of botulinum toxin. BMJ (2002) 0.76

Exaggeration of wrinkles after botulinum toxin injection for forehead horizontal lines. Ann Dermatol (2011) 0.75

IncobotulinumtoxinA use in aesthetic indications in daily practice: a European multicenter, noninterventional, retrospective study. Clin Cosmet Investig Dermatol (2015) 0.75

Selection and preference for botulinum toxins in the management of photoaging and facial lines: patient and physician considerations. Patient Prefer Adherence (2010) 0.75

IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations. Clin Cosmet Investig Dermatol (2015) 0.75

Use of Botulinum Neurotoxin in Ophthalmology. Turk J Ophthalmol (2016) 0.75

Botulinum toxin type a for the treatment of hyperkinetic lines of the face. J Maxillofac Oral Surg (2012) 0.75

Impact on facial rejuvenation with dermatological preparations. Clin Interv Aging (2009) 0.75

Wrinkles. BMJ Clin Evid (2014) 0.75

Articles by these authors

Modernising medical careers, medical training application service, and the postgraduate medical education and training board: time for the emperors to don their clothes. Lancet (2007) 3.12

Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma. Blood (2003) 2.31

Botulinum toxin type A (BOTOX) for the prophylactic treatment of chronic daily headache: a randomized, double-blind, placebo-controlled trial. Headache (2005) 2.16

Salvage second hematopoietic cell transplantation in myeloma. Biol Blood Marrow Transplant (2013) 1.80

Neuro-ophthalmology of invasive fungal sinusitis: 14 consecutive patients and a review of the literature. Clin Experiment Ophthalmol (2013) 1.70

CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis. Blood (2012) 1.65

Myeloid derived suppressor cells are numerically, functionally and phenotypically different in patients with multiple myeloma. Leuk Lymphoma (2014) 1.60

Clinical response to adalimumab treatment in patients with moderate to severe psoriasis: double-blind, randomized controlled trial and open-label extension study. J Am Acad Dermatol (2006) 1.58

Outcome of lower-intensity allogeneic transplantation in non-Hodgkin lymphoma after autologous transplantation failure. Biol Blood Marrow Transplant (2011) 1.57

Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne. J Am Acad Dermatol (2004) 1.53

Recognition, diagnosis, and treatment of primary focal hyperhidrosis. J Am Acad Dermatol (2004) 1.51

Global TravEpiNet: a national consortium of clinics providing care to international travelers--analysis of demographic characteristics, travel destinations, and pretravel healthcare of high-risk US international travelers, 2009-2011. Clin Infect Dis (2011) 1.51

Autologous or allogeneic stem cell transplantation in patients with Waldenstrom's macroglobulinemia. Biol Blood Marrow Transplant (2006) 1.49

Regional distribution of wall thickness and failure properties of human abdominal aortic aneurysm. J Biomech (2005) 1.49

Cultural similarities and differences in medical professionalism: a multi-region study. Med Educ (2012) 1.44

OnabotulinumtoxinA treatment of mild glabellar lines in repose. Dermatol Surg (2010) 1.40

Unrelated donor reduced-intensity allogeneic hematopoietic stem cell transplantation for relapsed and refractory Hodgkin lymphoma. Biol Blood Marrow Transplant (2009) 1.28

Conditioning regimens for allotransplants for diffuse large B-cell lymphoma: myeloablative or reduced intensity? Blood (2012) 1.23

The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease. Thorax (2012) 1.22

Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells. Blood (2009) 1.21

Botulinum toxin type A in the treatment of primary axillary hyperhidrosis: a 52-week multicenter double-blind, randomized, placebo-controlled study of efficacy and safety. J Am Acad Dermatol (2007) 1.21

Race and outcomes of autologous hematopoietic cell transplantation for multiple myeloma. Biol Blood Marrow Transplant (2009) 1.14

Spinal leptomeningeal lymphoma presenting as pseudotumor syndrome. J Neuroophthalmol (2013) 1.13

Double-blind, placebo-controlled study of the safety and efficacy of botulinum toxin type A for patients with glabellar lines. Plast Reconstr Surg (2003) 1.09

Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial. Arch Dermatol (2002) 1.07

Unrelated umbilical cord blood transplant for adult acute lymphoblastic leukemia in first and second complete remission: a comparison with allografts from adult unrelated donors. Haematologica (2013) 1.07

Lower branch coherent states in shear flows: transition and control. Phys Rev Lett (2007) 1.07

Comment on "Profiling oil sands mixtures from industrial developments and natural groundwaters for source identification". Environ Sci Technol (2014) 1.06

The use of photodynamic therapy in dermatology: results of a consensus conference. J Drugs Dermatol (2006) 1.03

A comparison of allogeneic and autologous bone marrow transplantation for lymphoblastic lymphoma. Blood (2002) 1.03

Quality-of-life issues in psoriasis and psoriatic arthritis: outcome measures and therapies from a dermatological perspective. J Am Acad Dermatol (2006) 1.03

Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation. Cancer Res (2004) 1.01

Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol (2003) 1.01

Either interleukin-12 or interferon-gamma can correct the dendritic cell defect induced by transforming growth factor beta in patients with myeloma. Br J Haematol (2004) 1.00

Prognostically significant cytotoxic T cell clones are stimulated after thalidomide therapy in patients with multiple myeloma. Leuk Lymphoma (2009) 1.00

Autologous transplantation for diffuse aggressive non-Hodgkin lymphoma in first relapse or second remission. Biol Blood Marrow Transplant (2004) 1.00

The impact of immigration on child health: experimental evidence from a migration lottery program. Econ Inq (2012) 0.99

Medical training in the UK: sleepwalking to disaster. Lancet (2007) 0.99

Regulatory T cells and multiple myeloma. Clin Lymphoma Myeloma (2008) 0.98

Double-blind, randomized, placebo-controlled, dose-response study of the safety and efficacy of botulinum toxin type A in subjects with crow's feet. Dermatol Surg (2005) 0.96

Photodynamic therapy with methyl aminolevulinate for primary nodular basal cell carcinoma: results of two randomized studies. Int J Dermatol (2009) 0.96

Early failure of frontline rituximab-containing chemo-immunotherapy in diffuse large B cell lymphoma does not predict futility of autologous hematopoietic cell transplantation. Biol Blood Marrow Transplant (2014) 0.95

REFINE-1, a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial With ATX-101, an Injectable Drug for Submental Fat Reduction. Dermatol Surg (2016) 0.94

Treatment of recurrent Sweet's syndrome with coexisting rheumatoid arthritis with the tumor necrosis factor antagonist etanercept. J Am Acad Dermatol (2006) 0.94

Impact of pretransplantation conditioning regimens on outcomes of allogeneic transplantation for chemotherapy-unresponsive diffuse large B cell lymphoma and grade III follicular lymphoma. Biol Blood Marrow Transplant (2013) 0.93

Fludarabine, cytarabine, granulocyte-colony stimulating factor and amsacrine: an effective salvage therapy option for acute myeloid leukemia at first relapse. Leuk Lymphoma (2012) 0.92

Migration and mental health: Evidence from a natural experiment. J Health Econ (2009) 0.92

Training in oral disease, diagnosis and treatment for medical students and doctors in the United Kingdom. Br J Oral Maxillofac Surg (2005) 0.92

Allogeneic hematopoietic cell transplantation for chemotherapy-unresponsive mantle cell lymphoma: a cohort analysis from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant (2013) 0.92

Frequent genetic differences between matched primary and metastatic breast cancer provide an approach to identification of biomarkers for disease progression. Eur J Hum Genet (2010) 0.92

Interferon-alpha in the treatment of multiple myeloma. Curr Drug Targets (2011) 0.90

Effect of obesity on outcomes after autologous hematopoietic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant (2011) 0.90

Outcome of patients with IgD and IgM multiple myeloma undergoing autologous hematopoietic stem cell transplantation: a retrospective CIBMTR study. Clin Lymphoma Myeloma Leuk (2010) 0.90

3D photography and lip filler: a novel assay. J Cosmet Laser Ther (2007) 0.89

Comparisons among botulinum toxins: an evidence-based review. Plast Reconstr Surg (2008) 0.89

A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles. J Am Acad Dermatol (2010) 0.88

Preliminary benchmarking of appropriate sanctions for lapses in undergraduate professionalism in the health professions. Med Teach (2011) 0.87

Donor characteristics affecting graft failure, graft-versus-host disease, and survival after unrelated donor transplantation with reduced-intensity conditioning for hematologic malignancies. Biol Blood Marrow Transplant (2011) 0.87

Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection. Parasitol Res (2003) 0.87

Safety and tolerability of onabotulinumtoxinA in the treatment of facial lines: a meta-analysis of individual patient data from global clinical registration studies in 1678 participants. J Am Acad Dermatol (2009) 0.87

Comparison of twin and autologous transplants for multiple myeloma. Biol Blood Marrow Transplant (2008) 0.87

Transformation and progression of Waldenström's macroglobulinemia following cladribine therapy in two cases: natural evolution or iatrogenic causation? Am J Hematol (2006) 0.86

Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks. J Am Acad Dermatol (2003) 0.86

A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice. PLoS Negl Trop Dis (2010) 0.85

Phenotyping primitive plasma cells. Br J Haematol (2002) 0.85

Alternate donor hematopoietic cell transplantation (HCT) in non-Hodgkin lymphoma using lower intensity conditioning: a report from the CIBMTR. Biol Blood Marrow Transplant (2011) 0.85

Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection. Proc Natl Acad Sci U S A (2011) 0.85

Combining systemic retinoids with biologic agents for moderate to severe psoriasis. Int J Dermatol (2008) 0.84

Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection. Infect Immun (2009) 0.84

Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state. Leuk Lymphoma (2013) 0.84

Facial aesthetics: achieving the natural, relaxed look. J Cosmet Laser Ther (2007) 0.84

Botulinum toxin types A and B: comparison of efficacy, duration, and dose-ranging studies for the treatment of facial rhytides and hyperhidrosis. Clin Dermatol (2004) 0.84

The use of thalidomide in myeloma therapy as an effective anticancer drug. Curr Cancer Drug Targets (2006) 0.84

Current systemic therapies for psoriasis: where are we now? J Am Acad Dermatol (2003) 0.84

Expression of trypanotolerance in N'Dama x Boran crosses under field challenge in relation to N'Dama genome content. BMC Proc (2011) 0.83

Comparable outcomes in nonsecretory and secretory multiple myeloma after autologous stem cell transplantation. Biol Blood Marrow Transplant (2008) 0.83

Botulinum toxin type A in the treatment of bilateral primary axillary hyperhidrosis: efficacy and duration with repeated treatments. Dermatol Surg (2003) 0.83

Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background. BMC Genomics (2010) 0.83

A phase I safety and pharmacokinetic study of ATX-101: injectable, synthetic deoxycholic acid for submental contouring. J Drugs Dermatol (2015) 0.83

The management of dental patients taking new generation oral anticoagulants. Prim Dent J (2014) 0.83

Reducing TNF receptor 2+ regulatory T cells via the combined action of azacitidine and the HDAC inhibitor, panobinostat for clinical benefit in acute myeloid leukemia patients. Clin Cancer Res (2013) 0.83

Recombinant tumor necrosis factor alpha does not inhibit the growth of African trypanosomes in axenic cultures. Infect Immun (2002) 0.82

Fasciculations and cramps: how benign? Report of four cases progressing to ALS. J Neurol (2010) 0.82

Methotrexate and psoriasis in the era of new biologic agents. J Am Acad Dermatol (2004) 0.82

Treatment of coexisting bullous pemphigoid and psoriasis with the tumor necrosis factor antagonist etanercept. J Am Acad Dermatol (2006) 0.81

A novel method to evaluate residence time in humans using a nonpenetrating fluorescent tracer. Invest Ophthalmol Vis Sci (2002) 0.81

Pre-exposure rabies vaccination among US international travelers: findings from the global TravEpiNet consortium. Vector Borne Zoonotic Dis (2013) 0.81

Autologous haematopoietic cell transplantation for non-Hodgkin lymphoma with secondary CNS involvement. Br J Haematol (2013) 0.80

Clonal cytotoxic T cells in myeloma. Leuk Lymphoma (2003) 0.80

Effect of esomeprazole versus placebo on pulmonary exacerbations in cystic fibrosis. BMC Pulm Med (2014) 0.79

The treatment of psoriasis and psoriatic arthritis with etanercept: practical considerations on monotherapy, combination therapy, and safety. Dermatol Clin (2004) 0.79

The biology and cytogenetics of multiple myeloma. Rev Clin Exp Hematol (2002) 0.79

Excellent outcomes for adolescents and adults with acute lymphoblastic leukemia and lymphoma without allogeneic stem cell transplant: the FRALLE-93 pediatric protocol. Leuk Lymphoma (2014) 0.79

Botulinum toxin type A gives adjunctive benefit to periorbital laser resurfacing. J Cosmet Laser Ther (2004) 0.79

Trogocytosis generates acquired regulatory T cells adding further complexity to the dysfunctional immune response in multiple myeloma. Oncoimmunology (2012) 0.79

Diagnosis of a naturally occurring dual infection of layer chickens with fowlpox virus and gallid herpesvirus 1 (infectious laryngotracheitis virus). Avian Pathol (2010) 0.79

Influence of age and histology on outcome in adult non-Hodgkin lymphoma patients undergoing autologous hematopoietic cell transplantation (HCT): a report from the Center For International Blood & Marrow Transplant Research (CIBMTR). Biol Blood Marrow Transplant (2008) 0.79