Published in Nat Struct Biol on August 01, 2002
Biological insights from structures of two-component proteins. Annu Rev Microbiol (2009) 4.47
Diversity in chemotaxis mechanisms among the bacteria and archaea. Microbiol Mol Biol Rev (2004) 3.15
Cellular stoichiometry of the components of the chemotaxis signaling complex. J Bacteriol (2004) 3.07
Both chemotaxis and net motility greatly influence the infectivity of Vibrio cholerae. Proc Natl Acad Sci U S A (2004) 2.21
CheZ phosphatase localizes to chemoreceptor patches via CheA-short. J Bacteriol (2003) 2.15
Origins and diversification of a complex signal transduction system in prokaryotes. Sci Signal (2010) 1.98
Receiver domain structure and function in response regulator proteins. Curr Opin Microbiol (2010) 1.77
Structural analysis and solution studies of the activated regulatory domain of the response regulator ArcA: a symmetric dimer mediated by the alpha4-beta5-alpha5 face. J Mol Biol (2005) 1.76
Comparative genomic and protein sequence analyses of a complex system controlling bacterial chemotaxis. Methods Enzymol (2007) 1.46
Dynamic map of protein interactions in the Escherichia coli chemotaxis pathway. Mol Syst Biol (2009) 1.40
Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling. Nat Commun (2017) 1.39
Structural basis of response regulator dephosphorylation by Rap phosphatases. PLoS Biol (2011) 1.35
Dynamics of two Phosphorelays controlling cell cycle progression in Caulobacter crescentus. J Bacteriol (2009) 1.33
Two variable active site residues modulate response regulator phosphoryl group stability. Mol Microbiol (2008) 1.29
Synergistic regulation of competence development in Bacillus subtilis by two Rap-Phr systems. J Bacteriol (2005) 1.27
CheX is a phosphorylated CheY phosphatase essential for Borrelia burgdorferi chemotaxis. J Bacteriol (2005) 1.23
Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus. EMBO J (2005) 1.21
Negative control in two-component signal transduction by transmitter phosphatase activity. Mol Microbiol (2011) 1.20
A molecular mechanism of bacterial flagellar motor switching. J Mol Biol (2009) 1.18
Changing cellular location of CheZ predicted by molecular simulations. PLoS Comput Biol (2006) 1.17
Crystal structures of beryllium fluoride-free and beryllium fluoride-bound CheY in complex with the conserved C-terminal peptide of CheZ reveal dual binding modes specific to CheY conformation. J Mol Biol (2006) 1.14
Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate. Proc Natl Acad Sci U S A (2010) 1.11
Auxiliary phosphatases in two-component signal transduction. Curr Opin Microbiol (2010) 1.11
CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY. Mol Microbiol (2010) 1.08
Conserved mechanism for sensor phosphatase control of two-component signaling revealed in the nitrate sensor NarX. Proc Natl Acad Sci U S A (2010) 1.07
Model for Protein Concentration Gradients in the Cytoplasm. Cell Mol Bioeng (2008) 1.05
Bacterial chemotaxis: a new player in response regulator dephosphorylation. J Bacteriol (2003) 1.02
Insights into correlated motions and long-range interactions in CheY derived from molecular dynamics simulations. Biophys J (2006) 1.00
The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus. Mol Microbiol (2012) 1.00
Balls and chains--a mesoscopic approach to tethered protein domains. Biophys J (2006) 0.99
Matching biochemical reaction kinetics to the timescales of life: structural determinants that influence the autodephosphorylation rate of response regulator proteins. J Mol Biol (2009) 0.98
CheZ-mediated dephosphorylation of the Escherichia coli chemotaxis response regulator CheY: role for CheY glutamate 89. J Bacteriol (2003) 0.98
How important is the phosphatase activity of sensor kinases? Curr Opin Microbiol (2010) 0.96
Different evolutionary constraints on chemotaxis proteins CheW and CheY revealed by heterologous expression studies and protein sequence analysis. J Bacteriol (2003) 0.96
Mutations altering the N-terminal receiver domain of NRI (NtrC) That prevent dephosphorylation by the NRII-PII complex in Escherichia coli. J Bacteriol (2004) 0.93
CheX in the three-phosphatase system of bacterial chemotaxis. J Bacteriol (2007) 0.93
The diverse CheC-type phosphatases: chemotaxis and beyond. Mol Microbiol (2008) 0.93
CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated intermediate. J Bacteriol (2011) 0.92
Chemotaxis in Campylobacter jejuni. Eur J Microbiol Immunol (Bp) (2012) 0.90
Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. J Bacteriol (2003) 0.88
Molecular Mechanisms of Two-Component Signal Transduction. J Mol Biol (2016) 0.87
Protein domains and residues involved in the CheZ/CheAS interaction. J Bacteriol (2009) 0.87
A remote CheZ orthologue retains phosphatase function. Mol Microbiol (2010) 0.87
Interaction of CheY with the C-terminal peptide of CheZ. J Bacteriol (2007) 0.85
Nonconserved active site residues modulate CheY autophosphorylation kinetics and phosphodonor preference. Biochemistry (2013) 0.84
Probing Mechanistic Similarities between Response Regulator Signaling Proteins and Haloacid Dehalogenase Phosphatases. Biochemistry (2015) 0.84
Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation. MBio (2014) 0.83
Structure and activity of the flagellar rotor protein FliY: a member of the CheC phosphatase family. J Biol Chem (2013) 0.83
Action at a distance: amino acid substitutions that affect binding of the phosphorylated CheY response regulator and catalysis of dephosphorylation can be far from the CheZ phosphatase active site. J Bacteriol (2011) 0.83
Helicobacter pylori CheZ(HP) and ChePep form a novel chemotaxis-regulatory complex distinct from the core chemotaxis signaling proteins and the flagellar motor. Mol Microbiol (2015) 0.82
Differential affinity and catalytic activity of CheZ in E. coli chemotaxis. PLoS Comput Biol (2009) 0.80
Protein-protein interaction network prediction by using rigid-body docking tools: application to bacterial chemotaxis. Protein Pept Lett (2014) 0.79
Imidazole as a Small Molecule Analogue in Two-Component Signal Transduction. Biochemistry (2015) 0.79
Functional characterization of WalRK: A two-component signal transduction system from Bacillus anthracis. FEBS Open Bio (2014) 0.78
Bacterial signaling and motility: sure bets. J Bacteriol (2008) 0.78
Dynamics and activation in response regulators: the β4-α4 loop. Biomol Concepts (2012) 0.77
A Variable Active Site Residue Influences the Kinetics of Response Regulator Phosphorylation and Dephosphorylation. Biochemistry (2016) 0.76
Borrelia burgdorferi CheY2 is dispensable for chemotaxis or motility but crucial for the infectious life cycle of the spirochete. Infect Immun (2016) 0.75
Catalytic scaffolds for phosphoryl group transfer. Curr Opin Struct Biol (2016) 0.75
Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract. Proc Natl Acad Sci U S A (2017) 0.75
Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action. Elife (2016) 0.75
Last, but not least. Nat Struct Biol (2002) 0.75
Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells. J Immunol (2003) 2.81
A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection. Immunity (2003) 1.95
CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate. J Immunol (2007) 1.54
Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol (2005) 1.42
Two variable active site residues modulate response regulator phosphoryl group stability. Mol Microbiol (2008) 1.29
Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. J Immunol (2003) 1.27
Two-component signal transduction. Curr Opin Microbiol (2010) 1.23
CheX is a phosphorylated CheY phosphatase essential for Borrelia burgdorferi chemotaxis. J Bacteriol (2005) 1.23
180-W XPS GreenLight laser therapy for benign prostate hyperplasia: early safety, efficacy, and perioperative outcome after 201 procedures. Eur Urol (2011) 1.19
A search for amino acid substitutions that universally activate response regulators. Mol Microbiol (2004) 1.13
T cell receptor-like recognition of tumor in vivo by synthetic antibody fragment. PLoS One (2012) 1.05
Evidence for dynamics in proteins as a mechanism for ligand dissociation. Nat Chem Biol (2012) 1.03
Cutting edge: tumor-specific CTL are constitutively cross-armed in draining lymph nodes and transiently disseminate to mediate tumor regression following systemic CD40 activation. J Immunol (2004) 1.01
Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen. Eur J Immunol (2006) 0.98
Comparative analyses of a small molecule/enzyme interaction by multiple users of Biacore technology. Anal Biochem (2004) 0.98
Matching biochemical reaction kinetics to the timescales of life: structural determinants that influence the autodephosphorylation rate of response regulator proteins. J Mol Biol (2009) 0.98
Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution. Immunogenetics (2003) 0.98
CheZ-mediated dephosphorylation of the Escherichia coli chemotaxis response regulator CheY: role for CheY glutamate 89. J Bacteriol (2003) 0.98
Kinetic characterization of catalysis by the chemotaxis phosphatase CheZ. Modulation of activity by the phosphorylated CheY substrate. J Biol Chem (2007) 0.96
Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin. Blood (2006) 0.96
YbiV from Escherichia coli K12 is a HAD phosphatase. Proteins (2005) 0.95
High affinity xenoreactive TCR:MHC interaction recruits CD8 in absence of binding to MHC. J Immunol (2003) 0.95
Peptidic termini play a significant role in TCR recognition. J Immunol (2002) 0.91
Single MHC mutation eliminates enthalpy associated with T cell receptor binding. J Mol Biol (2007) 0.90
Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. J Bacteriol (2003) 0.88
Measurement of response regulator autodephosphorylation rates spanning six orders of magnitude. Methods Enzymol (2010) 0.88
Dendritic cells can be rapidly expanded ex vivo and safely administered in patients with metastatic breast cancer. Cancer Immunol Immunother (2004) 0.87
A link between dimerization and autophosphorylation of the response regulator PhoB. J Biol Chem (2013) 0.86
Nonconserved active site residues modulate CheY autophosphorylation kinetics and phosphodonor preference. Biochemistry (2013) 0.84
Action at a distance: amino acid substitutions that affect binding of the phosphorylated CheY response regulator and catalysis of dephosphorylation can be far from the CheZ phosphatase active site. J Bacteriol (2011) 0.83
Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex. J Am Chem Soc (2011) 0.83
Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production. Immunology (2005) 0.82
An agent-based model of signal transduction in bacterial chemotaxis. PLoS One (2010) 0.81
Accurate structure prediction of peptide-MHC complexes for identifying highly immunogenic antigens. Mol Immunol (2013) 0.80
Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II. Eur J Immunol (2008) 0.80
Francisella tularensis RipA protein topology and identification of functional domains. J Bacteriol (2012) 0.79
Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance. Transpl Immunol (2013) 0.76
Extragenic suppressor mutations in ΔripA disrupt stability and function of LpxA. BMC Microbiol (2014) 0.75
Sense and sensibility in bacteria. VIIIth International Conference on Bacterial Locomotion and Sensory Transduction. EMBO Rep (2005) 0.75