Published in Curr Opin Microbiol on March 06, 2010
Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR. PLoS Pathog (2011) 2.15
Molecular strategies for phosphorylation-mediated regulation of response regulator activity. Curr Opin Microbiol (2010) 1.90
Spatial organization in bacterial chemotaxis. EMBO J (2010) 1.62
The aspartate-less receiver (ALR) domains: distribution, structure and function. PLoS Pathog (2015) 1.43
Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics. FASEB J (2011) 1.36
The response regulator SypE controls biofilm formation and colonization through phosphorylation of the syp-encoded regulator SypA in Vibrio fischeri. Mol Microbiol (2012) 1.30
Negative control in two-component signal transduction by transmitter phosphatase activity. Mol Microbiol (2011) 1.20
Structure of the response regulator PhoP from Mycobacterium tuberculosis reveals a dimer through the receiver domain. Biochemistry (2011) 1.13
CheV: CheW-like coupling proteins at the core of the chemotaxis signaling network. Trends Microbiol (2010) 1.09
A structural model of anti-anti-σ inhibition by a two-component receiver domain: the PhyR stress response regulator. Mol Microbiol (2010) 1.06
Involvement of WalK (VicK) phosphatase activity in setting WalR (VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells. Mol Microbiol (2012) 1.03
Structural basis of a protein partner switch that regulates the general stress response of α-proteobacteria. Proc Natl Acad Sci U S A (2012) 1.00
Anti-adaptors provide multiple modes for regulation of the RssB adaptor protein. Genes Dev (2013) 0.99
Structural basis for sigma factor mimicry in the general stress response of Alphaproteobacteria. Proc Natl Acad Sci U S A (2012) 0.98
Response regulator heterodimer formation controls a key stage in Streptomyces development. PLoS Genet (2014) 0.96
Signal transduction in histidine kinases: insights from new structures. Structure (2015) 0.95
Segmental motions, not a two-state concerted switch, underlie allostery in CheY. Structure (2012) 0.94
Regulation of virulence by the RevR response regulator in Clostridium perfringens. Infect Immun (2011) 0.93
A Phosphosignaling Adaptor Primes the AAA+ Protease ClpXP to Drive Cell Cycle-Regulated Proteolysis. Mol Cell (2015) 0.89
Identification of the amino acids essential for LytSR-mediated signal transduction in Staphylococcus aureus and their roles in biofilm-specific gene expression. Mol Microbiol (2015) 0.88
Promoter recognition and activation by the global response regulator CbrB in Pseudomonas aeruginosa. J Bacteriol (2011) 0.88
Molecular Mechanisms of Two-Component Signal Transduction. J Mol Biol (2016) 0.87
A remote CheZ orthologue retains phosphatase function. Mol Microbiol (2010) 0.87
Structural insights into the regulatory mechanism of the response regulator RocR from Pseudomonas aeruginosa in cyclic Di-GMP signaling. J Bacteriol (2012) 0.87
Evidence against the "Y-T coupling" mechanism of activation in the response regulator NtrC. J Mol Biol (2014) 0.87
A link between dimerization and autophosphorylation of the response regulator PhoB. J Biol Chem (2013) 0.86
The diguanylate cyclase GcbA facilitates Pseudomonas aeruginosa biofilm dispersion by activating BdlA. J Bacteriol (2014) 0.86
The residue threonine 82 of DevR (DosR) is essential for DevR activation and function in Mycobacterium tuberculosis despite its atypical location. J Bacteriol (2011) 0.86
Structural basis of a physical blockage mechanism for the interaction of response regulator PmrA with connector protein PmrD from Klebsiella pneumoniae. J Biol Chem (2013) 0.85
Structure of the pilus assembly protein TadZ from Eubacterium rectale: implications for polar localization. Mol Microbiol (2012) 0.85
Nonconserved active site residues modulate CheY autophosphorylation kinetics and phosphodonor preference. Biochemistry (2013) 0.84
The extracytoplasmic linker peptide of the sensor protein SaeS tunes the kinase activity required for staphylococcal virulence in response to host signals. PLoS Pathog (2015) 0.83
The sensory histidine kinases TorS and EvgS tend to form clusters in Escherichia coli cells. PLoS One (2013) 0.83
The Nla28S/Nla28 two-component signal transduction system regulates sporulation in Myxococcus xanthus. J Bacteriol (2012) 0.83
The atypical response regulator protein ChxR has structural characteristics and dimer interface interactions that are unique within the OmpR/PhoB subfamily. J Biol Chem (2011) 0.83
Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation. MBio (2014) 0.83
Lactoferricin B inhibits the phosphorylation of the two-component system response regulators BasR and CreB. Mol Cell Proteomics (2011) 0.82
The pathogenicity island encoded PvrSR/RcsCB regulatory network controls biofilm formation and dispersal in Pseudomonas aeruginosa PA14. Mol Microbiol (2013) 0.82
Identification of YsrT and evidence that YsrRST constitute a unique phosphorelay system in Yersinia enterocolitica. J Bacteriol (2010) 0.82
Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens. Virulence (2014) 0.81
Atypical OmpR/PhoB subfamily response regulator GlnR of actinomycetes functions as a homodimer, stabilized by the unphosphorylated conserved Asp-focused charge interactions. J Biol Chem (2014) 0.81
Structure-function studies of DNA binding domain of response regulator KdpE reveals equal affinity interactions at DNA half-sites. PLoS One (2012) 0.81
AccR is a master regulator involved in carbon catabolite repression of the anaerobic catabolism of aromatic compounds in Azoarcus sp. CIB. J Biol Chem (2013) 0.81
Intra- and interprotein phosphorylation between two-hybrid histidine kinases controls Myxococcus xanthus developmental progression. J Biol Chem (2012) 0.81
Purification, crystallization and preliminary X-ray crystallographic analysis of the receiver and stalk domains (PA3346RS) of the response regulator PA3346 from Pseudomonas aeruginosa PAO1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.80
Identification of Regions in the Receiver Domain of the ETHYLENE RESPONSE1 Ethylene Receptor of Arabidopsis Important for Functional Divergence. Plant Physiol (2015) 0.80
The Eukaryotic-Like Ser/Thr Kinase PrkC Regulates the Essential WalRK Two-Component System in Bacillus subtilis. PLoS Genet (2015) 0.80
Phosphoryl Group Flow within the Pseudomonas aeruginosa Pil-Chp Chemosensory System: DIFFERENTIAL FUNCTION OF THE EIGHT PHOSPHOTRANSFERASE AND THREE RECEIVER DOMAINS. J Biol Chem (2016) 0.79
Found: the elusive ANTAR transcription antiterminator. PLoS Genet (2012) 0.79
Ligand-induced folding of a two-component signaling receiver domain. Biochemistry (2015) 0.79
Imidazole as a Small Molecule Analogue in Two-Component Signal Transduction. Biochemistry (2015) 0.79
DNA-affinity-purified chip (DAP-chip) method to determine gene targets for bacterial two component regulatory systems. J Vis Exp (2014) 0.78
Interactions of the CpxA sensor kinase and cognate CpxR response regulator from Yersinia pseudotuberculosis. BMC Res Notes (2012) 0.78
5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus. Antimicrob Agents Chemother (2012) 0.78
Nuclear magnetic resonance structure and dynamics of the response regulator Sma0114 from Sinorhizobium meliloti. Biochemistry (2012) 0.78
Missense substitutions reflecting regulatory control of transmitter phosphatase activity in two-component signalling. Mol Microbiol (2013) 0.78
An alternate route to phosphorylating DegU of Bacillus subtilis using acetyl phosphate. BMC Microbiol (2015) 0.77
The Pseudomonas aeruginosa AlgZR two-component system coordinates multiple phenotypes. Front Cell Infect Microbiol (2014) 0.77
Interaction of the RcsB Response Regulator with Auxiliary Transcription Regulators in Escherichia coli. J Biol Chem (2015) 0.77
The VieB auxiliary protein negatively regulates the VieSA signal transduction system in Vibrio cholerae. BMC Microbiol (2015) 0.76
Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. PLoS Biol (2016) 0.76
Experimental Analysis of Functional Variation within Protein Families: Receiver Domain Autodephosphorylation Kinetics. J Bacteriol (2016) 0.76
Characterization of a temperature-responsive two component regulatory system from the Antarctic archaeon, Methanococcoides burtonii. Sci Rep (2016) 0.75
The YsrS Paralog DygS Has the Capacity To Activate Expression of the Yersinia enterocolitica Ysa Type III Secretion System. J Bacteriol (2016) 0.75
Cross Talk Inhibition Nullified by a Receiver Domain Missense Substitution. J Bacteriol (2015) 0.75
Use of restrained molecular dynamics to predict the conformations of phosphorylated receiver domains in two-component signaling systems. Proteins (2016) 0.75
To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators. Mol Microbiol (2016) 0.75
Contrasting roles of dynamics in protein allostery: NMR and structural studies of CheY and the third PDZ domain from PSD-95. Biophys Rev (2015) 0.75
Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. Mol Microbiol (2017) 0.75
The atypical response regulator AtvR is a new player in Pseudomonas aeruginosa response to hypoxia and virulence. Infect Immun (2017) 0.75
Two-state allosteric behavior in a single-domain signaling protein. Science (2001) 6.07
Phosphorylation of bacterial response regulator proteins by low molecular weight phospho-donors. Proc Natl Acad Sci U S A (1992) 4.88
Structural conservation in the CheY superfamily. Biochemistry (1993) 3.55
Transmitter and receiver modules in bacterial signaling proteins. Proc Natl Acad Sci U S A (1988) 3.28
Structure and catalytic mechanism of the E. coli chemotaxis phosphatase CheZ. Nat Struct Biol (2002) 2.60
Roles of the highly conserved aspartate and lysine residues in the response regulator of bacterial chemotaxis. J Biol Chem (1991) 2.58
Diversity of structure and function of response regulator output domains. Curr Opin Microbiol (2010) 2.17
Crystal structure of activated CheY. Comparison with other activated receiver domains. J Biol Chem (2001) 2.17
Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family. J Biol Chem (2006) 2.10
Divalent metal ion binding to the CheY protein and its significance to phosphotransfer in bacterial chemotaxis. Biochemistry (1990) 2.07
Manipulation of intracellular magnesium content in polymyxin B nonapeptide-sensitized Escherichia coli by ionophore A23187. J Bacteriol (1985) 1.91
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Kinetic comparison of the specificity of the vancomycin resistance VanSfor two response regulators, VanR and PhoB. Biochemistry (1996) 1.74
Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima. Structure (2002) 1.68
Switched or not?: the structure of unphosphorylated CheY bound to the N terminus of FliM. J Bacteriol (2006) 1.56
C-terminal DNA binding stimulates N-terminal phosphorylation of the outer membrane protein regulator OmpR from Escherichia coli. Proc Natl Acad Sci U S A (1999) 1.55
Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate states. J Mol Biol (2002) 1.54
Conformational coupling in the chemotaxis response regulator CheY. Proc Natl Acad Sci U S A (2001) 1.53
A distinct meta-active conformation in the 1.1-A resolution structure of wild-type ApoCheY. J Biol Chem (2001) 1.52
Phosphorylation-independent activity of atypical response regulators of Helicobacter pylori. J Bacteriol (2005) 1.46
Proposed signal transduction role for conserved CheY residue Thr87, a member of the response regulator active-site quintet. J Bacteriol (1998) 1.41
Physiologically relevant small phosphodonors link metabolism to signal transduction. Curr Opin Microbiol (2010) 1.35
Self-guided Langevin dynamics study of regulatory interactions in NtrC. Proteins (2009) 1.32
Markers of fitness in a successful enzyme superfamily. Curr Opin Struct Biol (2009) 1.31
Structure of an atypical orphan response regulator protein supports a new phosphorylation-independent regulatory mechanism. J Biol Chem (2007) 1.30
Phosphotransfer in Rhodobacter sphaeroides chemotaxis. J Mol Biol (2002) 1.29
Two variable active site residues modulate response regulator phosphoryl group stability. Mol Microbiol (2008) 1.29
Rapid phosphotransfer to CheY from a CheA protein lacking the CheY-binding domain. Biochemistry (2000) 1.29
Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator. Proc Natl Acad Sci U S A (2009) 1.29
Two-component signaling circuit structure and properties. Curr Opin Microbiol (2010) 1.27
Catalytic mechanism of phosphorylation and dephosphorylation of CheY: kinetic characterization of imidazole phosphates as phosphodonors and the role of acid catalysis. Biochemistry (1997) 1.22
Kinetic characterization of CheY phosphorylation reactions: comparison of P-CheA and small-molecule phosphodonors. Biochemistry (1999) 1.21
Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation. J Mol Biol (2008) 1.20
The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state. Proc Natl Acad Sci U S A (2008) 1.19
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics. Curr Opin Microbiol (2009) 1.17
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Kinetics of CheY phosphorylation by small molecule phosphodonors. FEBS Lett (1999) 1.14
Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system. Biochemistry (2005) 1.14
Identical phosphatase mechanisms achieved through distinct modes of binding phosphoprotein substrate. Proc Natl Acad Sci U S A (2010) 1.11
Phosphorylation-independent activation of the atypical response regulator NblR. Microbiology (2008) 1.11
An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS. Mol Microbiol (2007) 1.06
Activation mechanism of a signaling protein at atomic resolution from advanced computations. J Am Chem Soc (2007) 1.06
NMR structure of the pseudo-receiver domain of CikA. Protein Sci (2007) 1.06
Nuclear magnetic resonance spectroscopy reveals the functional state of the signalling protein CheY in vivo in Escherichia coli. Mol Microbiol (2003) 1.05
Segmented transition pathway of the signaling protein nitrogen regulatory protein C. J Mol Biol (2009) 1.03
Pivotal roles for the receiver domain in the mechanism of action of the response regulator RamR of Streptomyces coelicolor. J Mol Biol (2005) 0.99
Matching biochemical reaction kinetics to the timescales of life: structural determinants that influence the autodephosphorylation rate of response regulator proteins. J Mol Biol (2009) 0.98
A novel "four-component" two-component signal transduction mechanism regulates developmental progression in Myxococcus xanthus. J Biol Chem (2009) 0.97
Mutations altering the N-terminal receiver domain of NRI (NtrC) That prevent dephosphorylation by the NRII-PII complex in Escherichia coli. J Bacteriol (2004) 0.93
Pathways for conformational change in nitrogen regulatory protein C from discrete path sampling. J Phys Chem B (2008) 0.91
1H, 15N, and 13C backbone chemical shift assignments, secondary structure, and magnesium-binding characteristics of the Bacillus subtilis response regulator, Spo0F, determined by heteronuclear high-resolution NMR. Protein Sci (1995) 0.91
Crystallographic and biochemical studies of DivK reveal novel features of an essential response regulator in Caulobacter crescentus. J Biol Chem (2002) 0.91
Coarse-grained dynamics of the receiver domain of NtrC: fluctuations, correlations and implications for allosteric cooperativity. Proteins (2008) 0.86
Phosphorylation and binding interactions of CheY studied by use of Badan-labeled protein. Biochemistry (2004) 0.84