Published in Protein Eng on June 01, 2002
Differential use of signal peptides and membrane domains is a common occurrence in the protein output of transcriptional units. PLoS Genet (2006) 1.12
Cross-linking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J Neurochem (2007) 1.08
Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4. J Chem Inf Model (2010) 1.05
Molecular targets and mechanisms for ethanol action in glycine receptors. Pharmacol Ther (2010) 1.03
Normal-mode analysis of the glycine alpha1 receptor by three separate methods. J Chem Inf Model (2007) 0.96
Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation. Proc Natl Acad Sci U S A (2010) 0.93
Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics. Pharmacol Rev (2014) 0.90
Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. J Biol Chem (2008) 0.90
Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor. Anesthesiology (2013) 0.90
Charge scan reveals an extended region at the intracellular end of the GABA receptor pore that can influence ion selectivity. J Gen Physiol (2007) 0.87
The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling. Pharmaceuticals (Basel) (2010) 0.75
Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor. Front Mol Neurosci (2016) 0.75
Methoxyflurane metabolism and renal dysfunction: clinical correlation in man. Anesthesiology (1971) 2.39
Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci U S A (2000) 2.24
Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol (2001) 2.01
Evidence for a common binding cavity for three general anesthetics within the GABAA receptor. J Neurosci (2001) 2.00
Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesth Analg (1997) 1.80
Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc Natl Acad Sci U S A (1998) 1.76
Chronic exposure to anesthetic gases in the operating room. Anesthesiology (1971) 1.73
A unitary theory of anesthesia based on lateral phase separations in nerve membranes. Anesthesiology (1977) 1.40
Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics) Anesth Analg (1998) 1.28
The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers. Proc Natl Acad Sci U S A (1975) 1.17
Letter: Oxidized cytochrome P-450. Magnetic circular dichroism evidence for thiolate ligation in the substrate-bound form. Implications for the catalytic mechanism. J Am Chem Soc (1976) 1.15
Pressure-induced elevation of phase transition temperature in dipalmitoylphosphatidylcholine bilayers. An electron spin resonance measurement of the enthalpy of phase transition. Biochim Biophys Acta (1974) 1.14
Effects of pressure and anesthetics on conduction and synaptic transmission. J Pharmacol Exp Ther (1975) 1.10
Pressure reversal of inhalation anesthetic-induced disorder in spin-labeled phospholipid vesicles. Biochim Biophys Acta (1973) 1.08
The effect of two inhalation anesthetics on the order of spin-labeled phospholipid vesicles. Biochim Biophys Acta (1973) 1.07
Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol. Br J Pharmacol (2000) 1.07
Localization of molecular halothane in phospholipid bilayer model nerve membranes. Anesthesiology (1976) 1.05
Structural elements involved in activation of the gamma-aminobutyric acid type A (GABAA) receptor. Biochem Soc Trans (2004) 1.03
Magnetic circular dichroism studies. XXV. A preliminary investigation of microsomal cytochromes. Proc Natl Acad Sci U S A (1974) 1.01
Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues. ACS Chem Neurosci (2010) 1.00
Urinary metabolites of halothane in man. Anesthesiology (1975) 0.97
Reductive metabolism of carbon tetrachloride by human cytochromes P-450 reconstituted in phospholipid vesicles: mass spectral identification of trichloromethyl radical bound to dioleoyl phosphatidylcholine. Proc Natl Acad Sci U S A (1982) 0.96
Sites of volatile anesthetic action on kainate (Glutamate receptor 6) receptors. J Biol Chem (1998) 0.90
In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent. Cancer Res (1989) 0.90
Production of 5- and 15-hydroperoxyeicosatetraenoic acid from arachidonic acid by halothane-free radicals generated by UV-irradiation. Anesthesiology (1984) 0.90
Concentration measures of volatile anesthetics in the aqueous phase using calcium sensitive electrodes. J Neurosci Methods (1998) 0.90
Pressure reversal of anesthesia: the extent of small-molecule exclusion from spin-labeled phospholipid model membranes. Anesthesiology (1973) 0.90
1-Chloro-2,2,2-trifluoroethyl radical: Formation from halothane by human cytochrome P-450 in reconstituted vesicles and binding to phospholipids. Biochem Biophys Res Commun (1981) 0.89
Electron spin resonance studies with the volatile anesthetics on phospholipid model membranes. Ann N Y Acad Sci (1973) 0.88
Magnetic circular dichroism of ferrous carbonyl adducts of cytochromes P-450 and P-420 and their synthetic models: further evidence for mercaptide as the fifth ligand to iron. Proc Natl Acad Sci U S A (1976) 0.86
The anesthetic potencies of alkanethiols for rats: relevance to theories of narcosis. Anesth Analg (2000) 0.85
Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis. Anesth Analg (1999) 0.85
The effect of pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers. Biochim Biophys Acta (1974) 0.85
Letter: Chloroperoxidase. Evidence for P-450 type heme environment from magnetic circular dichroism spectroscopy. J Am Chem Soc (1976) 0.85
Molecular modeling of ligand-gated ion channels: progress and challenges. Int Rev Neurobiol (2001) 0.85
Nerve membrane lipid fluidity: opposing effects of high pressure and ethanol. Undersea Biomed Res (1979) 0.84
The membrane volume occupied by anesthetic molecules: a reinterpretation of the erythrocyte expansion data. Biochim Biophys Acta (1977) 0.83
Reconstitution of cytochrome P-450 and cytochrome P-450 reductase into phosphatidylcholine-phosphatidylethanolamine bilayers: characterization of structure and metabolic activity. Mol Pharmacol (1979) 0.83
Asymmetric antagonistic effects of an inhalation anesthetic and high pressure on the phase transition temperature of dipalmitoyl phosphatidic acid bilayers. Biochim Biophys Acta (1980) 0.83
Magnetic circular dichroism of purified forms of rabbit liver cytochromes P-450 and P-420. Biochemistry (1978) 0.82
Binding of halothane-free radicals to fatty acids following UV irradiation. Anesthesiology (1982) 0.82
Leukotriene B4 metabolism by hepatic cytochrome P-450. Biochem Biophys Res Commun (1983) 0.82
Halothane stereoisomers: lack of stereospecificity in two model systems. Anesthesiology (1973) 0.82
Volatile metabolites and decomposition products of halothane in man. Anesthesiology (1979) 0.81
Conversion of leukotriene A4 to leukotriene B4: catalysis by human liver microsomes under anaerobic conditions. Arch Biochem Biophys (1987) 0.81
Intramolecular determination of primary kinetic isotope effects in hydroxylations catalyzed by cytochrome P-450. Biochem Biophys Res Commun (1976) 0.80
Actions of fluorinated alkanols on GABA(A) receptors: relevance to theories of narcosis. Anesth Analg (1999) 0.80
Toxicity of calcium ionophore A23187 in monolayers of hypoxic hepatocytes. Toxicol Appl Pharmacol (1987) 0.80
The compression-ordering and solubility-disordering effects of high pressure gases on phospholipid bilayers. Life Sci (1976) 0.80
Magnetic circular dichroism studies XXXV. A comparison of cytochromes P-450 and P-448. Proc Natl Acad Sci U S A (1974) 0.80
Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes. Anesthesiology (1988) 0.80
Pressure-induced changes in the molecular organization of a lipid-peptide complex: polymyxin binding to phosphatidic acid membranes. Biochim Biophys Acta (1980) 0.80
Toxicity of 1,2-dibromoethane in primary hepatocyte monolayer cultures: lack of dependence on oxygen concentration. Toxicol Appl Pharmacol (1988) 0.79
Lipid-protein interactions as determinants of activation or inhibition by cytochrome b5 of cytochrome P-450-mediated oxidations. J Biol Chem (1982) 0.79
Hypoxia potentiates killing of hepatocyte monolayers by leukotrienes, hydroperoxyeicosatetraenoic acids, or calcium ionophore A23187. Biochim Biophys Acta (1984) 0.79
Evidence for leukotriene A4 as an intermediate in the conversion of 5-HPETE to leukotriene B4 catalyzed by cytochrome P-450. Biochem Biophys Res Commun (1983) 0.79
Oxygen concentration-dependent metabolism of leukotriene B4 by hepatocyte monolayers. Biochim Biophys Acta (1986) 0.79
Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart. Anesth Analg (1999) 0.79
Association of cytochrome b5 and cytochrome P-450 reductase with cytochrome P-450 in the membrane of reconstituted vesicles. J Biol Chem (1982) 0.79
An improved monobromobimane assay for glutathione utilizing tris- (2-carboxyethyl)phosphine as the reductant. Anal Biochem (1999) 0.78
Metabolism of isoflurane in Fischer 344 rats and man. Anesthesiology (1974) 0.78
Leukotriene D4 increases extravascular lung water in the dog. Circ Shock (1987) 0.78
Is there light at the end of the tunnel? Anesth Analg (1985) 0.78
Effect of clinical concentrations of halothane on phospholipid-cholesterol membrane fluidity. Mol Pharmacol (1978) 0.78
Toxicity of styrene vapor in hepatocyte monolayers at low oxygen tensions. Environ Health Perspect (1990) 0.77
Toxicity of t-butylhydroperoxide in hepatocyte monolayers exposed to hypoxia and reoxygenation. In Vitro Cell Dev Biol (1987) 0.77
Intramolecular determination of substituent effects in hydroxylations catalyzed by cytochrome P-450. Mol Pharmacol (1977) 0.77
Formation of free radical intermediates during nitrous oxide metabolism by human intestinal contents. Biochem Pharmacol (1980) 0.77
A unitary theory of anesthesia based on lateral phase separations in nerve membranes [proceedings]. Biophys J (1977) 0.77
Conversion of 5-hydroperoxyeicosatetraenoic acid into leukotriene B4 by rat hepatocytes: a novel cellular source for leukotriene B4. Mol Pharmacol (1988) 0.76
Reductive metabolism of halothane by human and rabbit cytochrome P-450. Binding of 1-chloro-2,2,2-trifluoroethyl radical to phospholipids. Mol Pharmacol (1982) 0.76
Antagonism of membrane compression effects by high pressure gas mixtures in a phospholipid bilayer system. Life Sci (1978) 0.75
Perturbations of peptide-induced lateral phase separations in phosphatidic acid bilayers by the inhalation anesthetic methoxyflurane. Mol Pharmacol (1981) 0.75
Binding of anti-trifluoroacetyl antibodies to isolated hepatocytes observed by digital fluorescence microscopy. Biochem Biophys Res Commun (1994) 0.75
Phospholipid interactions with cytochrome P-450 in reconstituted vesicles. Preference for negatively-charged phosphatidic acid. Biochim Biophys Acta (1981) 0.75
Spin trap evidence for production of superoxide radical anions by purified NADPH-cytochrome P-450 reductase. Biochem Biophys Res Commun (1981) 0.75
Direct chemical ionization mass spectrometry of underivatized arachidonic acid metabolites: application to leukotriene biosynthesis. Basic Life Sci (1988) 0.75
Editorial: The applicability of membrane models to studies of the mechanism of anesthetic action. Anesthesiology (1974) 0.75
Phospholipid transfer between vesicles. Dependence on presence of cytochrome P-450 and phosphatidylcholine-phosphatidylethanolamine ratio. Biochim Biophys Acta (1982) 0.75
Luciferase as a model for the site of inhaled anesthetic action. Anesth Analg (2001) 0.75
Magnetic circular dichroism studies of non-iron "hyper" porphyrin complexes as models for reduced + CO cytochrome P-450. J Am Chem Soc (1977) 0.75
Expression of bcl-2 inhibits cellular radical generation. Free Radic Res (1996) 0.75
Quantification of 5- and 15-HPETE's by direct chemical ionization mass spectrometry. Free Radic Biol Med (1987) 0.75
Nuclear translocation of heat shock protein 72 in liver cells of halothane-exposed rats. Biochem Biophys Res Commun (1994) 0.75
Leukotriene biosynthesis: direct chemical ionization mass spectrometry of underivatized arachidonic acid metabolites. Biomed Environ Mass Spectrom (1988) 0.75
Time course of 72-kilodalton heat shock protein induction and appearance of trifluoroacetyl adducts in livers of halothane-exposed rats. Mol Pharmacol (1994) 0.75
Interaction of hypoxia and carbon tetrachloride toxicity in hepatocyte monolayers. Exp Mol Pathol (1989) 0.75
Impurities in 14 C-labeled halothane. Anesthesiology (1972) 0.75
Biodegradation of inhalation anesthetics. Clin Anesth (1975) 0.75
Metabolism of nitrous oxide by human and rat intestinal contents. Anesthesiology (1980) 0.75
Equilibrium of 1% halothane with components of the central nervous system. Anesth Analg (1985) 0.75
Effect of alcohol on expression of heat shock protein 73 in monolayers of hepatocytes from alcohol-exposed rats. Biochem Biophys Res Commun (1994) 0.75
Low-level binding of halothane metabolites to rat liver histones in vivo. Anesthesiology (1981) 0.75