Published in Nat Immunol on July 01, 2002
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol (2007) 3.57
Zinc is a novel intracellular second messenger. J Cell Biol (2007) 2.46
Mast cells and mastocytosis. Blood (2008) 2.32
The tyrosine kinase network regulating mast cell activation. Immunol Rev (2009) 2.29
Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91
Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol (2005) 1.91
Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells. J Cell Biol (2005) 1.80
Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J Leukoc Biol (2010) 1.73
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med (2014) 1.59
Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 1.53
New insights on mast cell activation via the high affinity receptor for IgE. Adv Immunol (2008) 1.51
Regulation of mast cell responses in health and disease. Crit Rev Immunol (2011) 1.50
E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling. J Leukoc Biol (2012) 1.47
Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med (2004) 1.47
Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med (2004) 1.44
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med (2003) 1.42
Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation. Nat Commun (2017) 1.39
Mechanisms of mast cell signaling in anaphylaxis. J Allergy Clin Immunol (2009) 1.34
G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation. Immunol Lett (2007) 1.33
Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol (2005) 1.31
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis. J Cell Biol (2003) 1.28
The multiple roles of phosphoinositide 3-kinase in mast cell biology. Trends Immunol (2008) 1.27
Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev (2009) 1.25
Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol (2005) 1.25
The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood (2007) 1.24
Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells. Cell Signal (2007) 1.21
Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. Blood (2007) 1.21
The long and arduous road to CRAC. Cell Calcium (2007) 1.21
The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. J Exp Med (2003) 1.21
Regulation of Ca2+ signaling with particular focus on mast cells. Crit Rev Immunol (2009) 1.20
Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity (2009) 1.17
Understanding the mechanisms of anaphylaxis. Curr Opin Allergy Clin Immunol (2008) 1.16
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. J Immunol (2007) 1.16
An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med (2006) 1.15
Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor. Blood (2005) 1.14
Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release. Cell Signal (2008) 1.12
Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab (2010) 1.12
Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase. Mol Cell Biol (2004) 1.09
Mast cell chemotaxis - chemoattractants and signaling pathways. Front Immunol (2012) 1.07
Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness. J Exp Med (2006) 1.05
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol (2012) 1.03
Adapters in the organization of mast cell signaling. Immunol Rev (2009) 1.03
Immunoglobulin E receptor signaling and asthma. J Biol Chem (2011) 1.02
Impaired degranulation but enhanced cytokine production after Fc epsilonRI stimulation of diacylglycerol kinase zeta-deficient mast cells. J Exp Med (2006) 1.02
Regulation of mast cell survival and function by tuberous sclerosis complex 1. Blood (2012) 1.01
Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells. Mol Cell Biol (2006) 1.01
Receptor signaling in immune cell development and function. Immunol Res (2011) 0.98
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 0.97
Uncovering new complexities in mast cell signaling. Nat Immunol (2002) 0.97
Amplification mechanisms for the enhancement of antigen-mediated mast cell activation. Immunol Res (2009) 0.96
IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species. J Immunol (2008) 0.95
Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Mol Cell Biol (2004) 0.95
Cytoskeleton in mast cell signaling. Front Immunol (2012) 0.93
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice. J Immunol (2011) 0.93
Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. Prostaglandins Other Lipid Mediat (2008) 0.92
The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells. J Biol Chem (2010) 0.92
Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med (2005) 0.92
Inhibitory effect of carotenoids on the degranulation of mast cells via suppression of antigen-induced aggregation of high affinity IgE receptors. J Biol Chem (2009) 0.91
The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling. Front Immunol (2012) 0.90
Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants. FEBS Lett (2010) 0.90
Mast cell biology: introduction and overview. Adv Exp Med Biol (2011) 0.89
A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells. Immunity (2013) 0.89
Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. J Exp Med (2009) 0.89
Basophils and autoreactive IgE in the pathogenesis of systemic lupus erythematosus. Curr Allergy Asthma Rep (2011) 0.89
CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells. J Immunol (2011) 0.88
Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580. Clin Exp Immunol (2004) 0.88
LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes? J Leukoc Biol (2010) 0.88
Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/alpha 10-nicotinic receptors. J Immunol (2010) 0.88
Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. Mol Cell Biol (2010) 0.87
Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation. Br J Pharmacol (2008) 0.87
Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling. Mol Cell Biol (2014) 0.86
Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation. Mol Cell Biol (2011) 0.86
Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction. Mol Immunol (2009) 0.85
Streptochlorin suppresses allergic dermatitis and mast cell activation via regulation of Lyn/Fyn and Syk signaling pathways in cellular and mouse models. PLoS One (2013) 0.85
PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability. Blood (2011) 0.84
Mast cells at the host-pathogen interface: host-protection versus immune evasion in leishmaniasis. Clin Exp Immunol (2004) 0.84
Cutting edge: persistence of increased mast cell numbers in tissues links dermatitis to enhanced airway disease in a mouse model of atopy. J Immunol (2011) 0.83
The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J Immunol (2013) 0.83
Fyn promotes proliferation, differentiation, survival and function of osteoclast lineage cells. J Cell Biochem (2010) 0.83
DJ-1 regulates mast cell activation and IgE-mediated allergic responses. J Allergy Clin Immunol (2012) 0.83
Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production. J Biol Chem (2011) 0.83
Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1. Immunity (2011) 0.82
Immunoglobulin E induces VEGF production in mast cells and potentiates their pro-tumorigenic actions through a Fyn kinase-dependent mechanism. J Hematol Oncol (2013) 0.82
Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulation. J Immunol (2010) 0.82
Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood. Epigenetics (2015) 0.82
Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. Exp Mol Med (2009) 0.82
A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor. J Immunol (2009) 0.81
Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells. J Biol Chem (2014) 0.81
DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation. J Exp Med (2014) 0.80
Cross-linking of FcepsilonRI causes Ca2+ mobilization via a sphingosine kinase pathway in a clathrin-dependent manner. Cell Calcium (2009) 0.80
Shp2 activates Fyn and Ras to regulate RBL-2H3 mast cell activation following FcεRI aggregation. PLoS One (2012) 0.80
The adaptor 3BP2 is required for early and late events in FcεRI signaling in human mast cells. J Immunol (2012) 0.80
Inhibition of the antigen-induced activation of rodent mast cells by putative Janus kinase 3 inhibitors WHI-P131 and WHI-P154 in a Janus kinase 3-independent manner. Br J Pharmacol (2005) 0.80
Selective, α2β1 integrin-dependent secretion of il-6 by connective tissue mast cells. J Innate Immun (2011) 0.80
Fyn deficiency promotes a preferential increase in subcutaneous adipose tissue mass and decreased visceral adipose tissue inflammation. Diabetes (2013) 0.80
Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells for anti-allergic activity. BMC Complement Altern Med (2015) 0.79
Kinetic proofreading of ligand-FcepsilonRI interactions may persist beyond LAT phosphorylation. J Immunol (2007) 0.79
An Interaction Library for the FcεRI Signaling Network. Front Immunol (2014) 0.79
The Vibrio cholerae cytolysin promotes activation of mast cell (T helper 2) cytokine production. Cell Microbiol (2007) 0.79
The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions. Cell Commun Signal (2013) 0.79
Maternal and child undernutrition: global and regional exposures and health consequences. Lancet (2008) 26.44
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol (2006) 7.89
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature (2010) 7.50
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 5.99
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A (2006) 5.69
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell (2002) 5.44
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum (2002) 4.98
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med (2009) 4.97
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol (2002) 4.89
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77
Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med (2014) 4.70
Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood (2007) 4.50
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol (2011) 3.91
Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr (2002) 3.88
Improvement of child survival in Mexico: the diagonal approach. Lancet (2006) 3.87
Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A (2006) 3.66
Janus kinases in immune cell signaling. Immunol Rev (2009) 3.60
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood (2007) 3.33
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. Nat Genet (2010) 3.24
Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24
Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med (2010) 3.24
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science (2003) 3.19
Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev (2004) 3.18
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol (2005) 3.15
Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum (2007) 3.06
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science (2002) 3.05
Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat Immunol (2004) 2.94
Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol (2003) 2.93
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity (2009) 2.93
The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity (2007) 2.83
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med (2008) 2.72
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity (2010) 2.70
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med (2006) 2.70
The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev (2003) 2.62
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol (2011) 2.59
Markers for detergent-resistant lipid rafts occupy distinct and dynamic domains in native membranes. Mol Biol Cell (2004) 2.50
Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity (2012) 2.47
Th17 cells: a new fate for differentiating helper T cells. Immunol Res (2008) 2.45
STATs shape the active enhancer landscape of T cell populations. Cell (2012) 2.45
Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling. Protein Sci (2007) 2.44
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med (2004) 2.44
T(H)-17 differentiation: of mice and men. Nat Immunol (2007) 2.40
TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol (2012) 2.37
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature (2013) 2.36
A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science (2002) 2.35
The tyrosine kinase network regulating mast cell activation. Immunol Rev (2009) 2.29
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J (2002) 2.26
The Janus kinases (Jaks). Genome Biol (2004) 2.18
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. Nat Struct Mol Biol (2006) 2.10
Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu Rev Immunol (2012) 2.06
Therapeutic targeting of Janus kinases. Immunol Rev (2008) 2.03
The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol (2004) 2.01
CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity (2008) 1.95
Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor. Immunity (2011) 1.93
Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat Immunol (2009) 1.92
Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83
Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med (2007) 1.83
Role of Grb2 in EGF-stimulated EGFR internalization. J Cell Sci (2002) 1.82
Molecular phylogeny within type I cytokines and their cognate receptors. Immunity (2003) 1.79
The LAT story: a tale of cooperativity, coordination, and choreography. Cold Spring Harb Perspect Biol (2010) 1.77
Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochem Biophys Res Commun (2008) 1.76
The functional plasticity of T cell subsets. Nat Rev Immunol (2009) 1.74
Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J Leukoc Biol (2010) 1.73
STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci U S A (2002) 1.69
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature (2008) 1.68
Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. J Virol (2007) 1.67
Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea. J Pediatr Gastroenterol Nutr (2007) 1.66
Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol (2002) 1.64
Helper T cell diversity and plasticity. Curr Opin Immunol (2012) 1.63
Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Mol Biol Cell (2008) 1.63
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev (2010) 1.61
Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med (2012) 1.61
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood (2014) 1.58
STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease. Immunity (2012) 1.56
Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol (2006) 1.55
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. J Biol Chem (2005) 1.55
Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico. Food Nutr Bull (2010) 1.55
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation. J Biol Chem (2008) 1.54
Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 1.53
Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences. Biochemistry (2004) 1.52
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med (2005) 1.49