Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMC 2772996)

Published in Immunity on April 09, 2009

Authors

Nicolas Charles1, Wendy T Watford, Haydeé L Ramos, Lars Hellman, Hans C Oettgen, Gregorio Gomez, John J Ryan, John J O'Shea, Juan Rivera

Author Affiliations

1: Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA.

Articles citing this

Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med (2010) 3.24

Protective and pathological roles of mast cells and basophils. Nat Rev Immunol (2013) 1.54

Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis. Immunity (2011) 1.15

Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal (2012) 1.11

Development, regulation and functional capacities of Th17 cells. Semin Immunopathol (2010) 1.10

Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10

Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol (2012) 1.03

Adapters in the organization of mast cell signaling. Immunol Rev (2009) 1.03

Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. J Immunol (2009) 0.95

A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood (2013) 0.95

Basophils and autoreactive IgE in the pathogenesis of systemic lupus erythematosus. Curr Allergy Asthma Rep (2011) 0.89

Basophils, IgE, and autoantibody-mediated kidney disease. J Immunol (2011) 0.88

Interrogation of sphingosine-1-phosphate receptor 2 function in vivo reveals a prominent role in the recovery from IgE and IgG-mediated anaphylaxis with minimal effect on its onset. Immunol Lett (2013) 0.83

Cutting edge: persistence of increased mast cell numbers in tissues links dermatitis to enhanced airway disease in a mouse model of atopy. J Immunol (2011) 0.83

Basophil-derived IL-4 plays versatile roles in immunity. Semin Immunopathol (2016) 0.82

Understanding the roles of basophils: breaking dawn. Immunology (2012) 0.81

New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol (2016) 0.81

Human cord blood derived immature basophils show dual characteristics, expressing both basophil and eosinophil associated proteins. PLoS One (2012) 0.80

Role of basophils in the pathogenesis of minimal change nephrotic syndrome: A literature review. Exp Ther Med (2014) 0.80

Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms. J Biol Chem (2012) 0.79

IL-3 contributes to development of lupus nephritis in MRL/lpr mice. Kidney Int (2015) 0.79

Optimizing the GATA-3 position weight matrix to improve the identification of novel binding sites. BMC Genomics (2012) 0.79

A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data. BMC Bioinformatics (2015) 0.78

Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. J Leukoc Biol (2013) 0.78

Role of basophils in rheumatoid arthritis (Review). Exp Ther Med (2015) 0.78

The deleterious role of basophils in systemic lupus erythematosus. Curr Opin Immunol (2013) 0.77

Signaling pathways critical for allergic airway inflammation. Curr Opin Allergy Clin Immunol (2010) 0.76

Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. J Immunol (2013) 0.76

Concurrent exposure to microbial products and food antigens triggers initiation of food allergy. N Am J Med Sci (2009) 0.75

Basophils contribute to pristane-induced Lupus-like nephritis model. Sci Rep (2017) 0.75

Articles cited by this

A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61

Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science (1988) 7.96

A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization. J Immunol (1980) 6.69

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A (2001) 4.76

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol (2002) 3.60

Basophils enhance immunological memory responses. Nat Immunol (2008) 3.35

Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice. J Immunol (1989) 3.20

The role of Th1/Th2 polarization in mucosal immunity. Nat Med (2002) 3.19

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell (1995) 3.17

Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity (2008) 3.11

Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc Natl Acad Sci U S A (1977) 3.07

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity (1995) 2.50

GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors. Cell Res (2006) 2.40

Role of Th1 and Th17 cells in organ-specific autoimmunity. J Autoimmun (2008) 2.35

Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity (2005) 2.19

SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity (2004) 2.18

Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91

Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum (2005) 1.74

Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med (2007) 1.68

Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity (2004) 1.63

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice. J Clin Invest (1989) 1.62

Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc Natl Acad Sci U S A (1989) 1.59

Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid. Blood (2008) 1.59

Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol (2004) 1.40

Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses. J Immunol (2007) 1.26

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol (2005) 1.25

Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells. J Immunol (2005) 1.24

Human basophils: mediator release and cytokine production. Adv Immunol (2001) 1.20

MMCP-8, the first lineage-specific differentiation marker for mouse basophils. Elevated numbers of potent IL-4-producing and MMCP-8-positive cells in spleens of malaria-infected mice. Eur J Immunol (2000) 1.19

Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J Immunol (2005) 1.11

Syk deficiency in nonreleaser basophils. J Allergy Clin Immunol (1999) 1.09

The tyrosine kinases p53/56lyn and p72syk are differentially expressed at the protein level but not at the messenger RNA level in nonreleasing human basophils. Am J Respir Cell Mol Biol (2000) 1.04

Innate lymphocyte and dendritic cell cross-talk: a key factor in the regulation of the immune response. Clin Exp Immunol (2008) 1.01

Genetic evidence for Lyn as a negative regulator of IL-4 signaling. J Immunol (1999) 0.97

Increased expression of genes linked to FcepsilonRI Signaling and to cytokine and chemokine production in Lyn-deficient mast cells. J Immunol (2005) 0.96

Histamine release from the basophils of control and asthmatic subjects and a comparison of gene expression between "releaser" and "nonreleaser" basophils. J Immunol (2007) 0.95

Receptor cross-linking and histamine release. I. The quantitative dependence of basophil degranulation on the number of receptor doublets. J Immunol (1979) 0.93

A comparison of inflammatory mediators released by basophils of asthmatic and control subjects in response to high-affinity IgE receptor aggregation. Int Arch Allergy Immunol (2007) 0.88

Helminth infections and allergic diseases: from the Th2 paradigm to regulatory networks. Clin Rev Allergy Immunol (2004) 0.88

Promising immunotherapies with Th1-related cytokines against infectious diseases. J Infect Chemother (2003) 0.86

Articles by these authors

Maternal and child undernutrition: global and regional exposures and health consequences. Lancet (2008) 26.44

Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol (2006) 7.89

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling. Nature (2010) 7.50

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 5.99

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A (2006) 5.69

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum (2002) 4.98

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95

IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem (2007) 4.77

Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood (2007) 4.50

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol (2011) 3.91

Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr (2002) 3.88

Improvement of child survival in Mexico: the diagonal approach. Lancet (2006) 3.87

Stat5a/b are essential for normal lymphoid development and differentiation. Proc Natl Acad Sci U S A (2006) 3.66

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol (2002) 3.60

Janus kinases in immune cell signaling. Immunol Rev (2009) 3.60

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity (2010) 3.52

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. Blood (2007) 3.33

Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24

Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med (2010) 3.24

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor. Science (2003) 3.19

Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev (2004) 3.18

IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol (2005) 3.15

Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum (2007) 3.06

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science (2002) 3.05

Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol (2003) 2.93

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity (2009) 2.93

The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity (2007) 2.83

CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J Exp Med (2008) 2.72

Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity (2010) 2.70

T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med (2006) 2.70

The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev (2003) 2.62

Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol (2011) 2.59

Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity (2012) 2.47

Th17 cells: a new fate for differentiating helper T cells. Immunol Res (2008) 2.45

STATs shape the active enhancer landscape of T cell populations. Cell (2012) 2.45

Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med (2004) 2.44

T(H)-17 differentiation: of mice and men. Nat Immunol (2007) 2.40

TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol (2012) 2.37

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature (2013) 2.36

The tyrosine kinase network regulating mast cell activation. Immunol Rev (2009) 2.29

KRAB zinc finger proteins: an analysis of the molecular mechanisms governing their increase in numbers and complexity during evolution. Mol Biol Evol (2002) 2.27

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J (2002) 2.26

The Janus kinases (Jaks). Genome Biol (2004) 2.18

Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection. Cell Host Microbe (2008) 2.15

Dioxins: an overview. Environ Res (2006) 2.11

Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu Rev Immunol (2012) 2.06

Therapeutic targeting of Janus kinases. Immunol Rev (2008) 2.03

The ins and outs of IgE-dependent mast-cell exocytosis. Trends Immunol (2004) 2.01

CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity (2008) 1.95

Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat Immunol (2009) 1.92

Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87

Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med (2007) 1.83

Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res (2012) 1.81

Molecular phylogeny within type I cytokines and their cognate receptors. Immunity (2003) 1.79

The functional plasticity of T cell subsets. Nat Rev Immunol (2009) 1.74

Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J Leukoc Biol (2010) 1.73

The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol (2008) 1.73

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest (2002) 1.73

GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Circulation (2012) 1.71

A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity (2013) 1.71

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation. Proc Natl Acad Sci U S A (2002) 1.69

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature (2008) 1.68

Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circ Res (2013) 1.67

Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea. J Pediatr Gastroenterol Nutr (2007) 1.66

Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol (2002) 1.64

Helper T cell diversity and plasticity. Curr Opin Immunol (2012) 1.63

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev (2010) 1.61

Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med (2012) 1.61

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3. Blood (2014) 1.58

STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease. Immunity (2012) 1.56

IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. J Biol Chem (2005) 1.55

Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico. Food Nutr Bull (2010) 1.55

Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection. J Immunol (2008) 1.53

Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 1.53

Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity (2004) 1.53

Stat5 expression is critical for mast cell development and survival. Blood (2003) 1.48

E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling. J Leukoc Biol (2012) 1.47

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol (2011) 1.47

A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. J Biol Chem (2004) 1.47