PubRank

Robert J Gorelick

Author PubWeight™ 93.88‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Architecture and secondary structure of an entire HIV-1 RNA genome. Nature 2009 6.12
2 Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J Clin Invest 2005 5.00
3 High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states. PLoS Biol 2008 4.40
4 Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs. J Biol Chem 2004 3.01
5 Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. J Virol 2007 2.95
6 Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors. J Biol Chem 2001 1.91
7 Human immunodeficiency virus type 1 nucleocapsid zn(2+) fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA. J Virol 2003 1.84
8 The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA. J Virol 2007 1.74
9 Efficiency of human immunodeficiency virus type 1 postentry infection processes: evidence against disproportionate numbers of defective virions. J Virol 2007 1.59
10 Nucleocapsid protein function in early infection processes. Virus Res 2008 1.53
11 Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses. J Virol 2008 1.50
12 Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site. J Mol Biol 2004 1.49
13 Human immunodeficiency virus type 1 nucleocapsid zinc-finger mutations cause defects in reverse transcription and integration. Virology 2006 1.48
14 Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins. Nucleic Acids Res 2006 1.47
15 Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides. Nucleic Acids Res 2006 1.47
16 Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome. Proc Natl Acad Sci U S A 2010 1.46
17 Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone function. Proc Natl Acad Sci U S A 2002 1.42
18 Subtle alterations of the native zinc finger structures have dramatic effects on the nucleic acid chaperone activity of human immunodeficiency virus type 1 nucleocapsid protein. J Virol 2002 1.39
19 Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes. Nucleic Acids Res 2013 1.37
20 Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function. J Mol Biol 2006 1.32
21 Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA. PLoS One 2012 1.30
22 Retroviral nucleocapsid proteins display nonequivalent levels of nucleic acid chaperone activity. J Virol 2008 1.24
23 Real-time PCR analysis of HIV-1 replication post-entry events. Methods Mol Biol 2009 1.22
24 Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27. Blood 2006 1.21
25 Elimination of protease activity restores efficient virion production to a human immunodeficiency virus type 1 nucleocapsid deletion mutant. J Virol 2003 1.21
26 Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1. J Virol 2007 1.18
27 Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis. J Mol Biol 2005 1.16
28 Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain. J Virol 2009 1.09
29 Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function. RNA Biol 2010 1.08
30 Comparison of SIV and HIV-1 genomic RNA structures reveals impact of sequence evolution on conserved and non-conserved structural motifs. PLoS Pathog 2013 1.08
31 Dimeric RNA recognition regulates HIV-1 genome packaging. PLoS Pathog 2013 1.07
32 Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination. J Biol Chem 2003 1.07
33 Mutations in human immunodeficiency virus type 1 nucleocapsid protein zinc fingers cause premature reverse transcription. J Virol 2008 1.05
34 Differing roles of the N- and C-terminal zinc fingers in human immunodeficiency virus nucleocapsid protein-enhanced nucleic acid annealing. J Biol Chem 2003 1.04
35 Cofactors for human immunodeficiency virus type 1 cDNA integration in vitro. J Virol 2003 1.03
36 A guanosine-centric mechanism for RNA chaperone function. Science 2013 1.03
37 Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications. Virology 2010 1.01
38 Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo. J Virol 2002 1.01
39 C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism. J Biol Chem 2009 0.99
40 The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability. Virology 2011 0.99
41 Transmission electron microscopy reveals an optimal HIV-1 nucleocapsid aggregation with single-stranded nucleic acids and the mature HIV-1 nucleocapsid protein. J Mol Biol 2006 0.98
42 HIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partner. PLoS One 2007 0.97
43 Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4. J Virol 2005 0.96
44 HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein. Virology 2008 0.96
45 G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA. Nucleic Acids Res 2003 0.94
46 Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins. J Virol 2005 0.94
47 Human T-cell lymphotropic virus type 1 nucleocapsid protein-induced structural changes in transactivation response DNA hairpin measured by single-molecule fluorescence resonance energy transfer. J Virol 2008 0.94
48 Studies on the restriction of murine leukemia viruses by mouse APOBEC3. PLoS One 2012 0.92
49 Nucleotide excision repair and template-independent addition by HIV-1 reverse transcriptase in the presence of nucleocapsid protein. J Biol Chem 2006 0.91
50 Structure/function mapping of amino acids in the N-terminal zinc finger of the human immunodeficiency virus type 1 nucleocapsid protein: residues responsible for nucleic acid helix destabilizing activity. Biochemistry 2006 0.90
51 Femtomole SHAPE reveals regulatory structures in the authentic XMRV RNA genome. J Am Chem Soc 2011 0.90
52 Zinc finger-dependent HIV-1 nucleocapsid protein-TAR RNA interactions. Nucleic Acids Res 2003 0.89
53 Single DNA molecule stretching measures the activity of chemicals that target the HIV-1 nucleocapsid protein. Anal Biochem 2006 0.88
54 Structure and dynamics of the HIV-1 frameshift element RNA. Biochemistry 2014 0.87
55 Aromatic residue mutations reveal direct correlation between HIV-1 nucleocapsid protein's nucleic acid chaperone activity and retroviral replication. Virus Res 2012 0.86
56 Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein. Nucleic Acids Res 2009 0.86
57 Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein. J Virol 2003 0.84
58 A succession of mechanisms stimulate efficient reconstituted HIV-1 minus strand strong stop DNA transfer. Biochemistry 2009 0.83
59 A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA. Virus Res 2012 0.83
60 Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication. Nucleic Acids Res 2013 0.83
61 Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA. J Biochem 2003 0.82
62 Characterization of human immunodeficiency virus type 1 (HIV-1) containing mutations in the nucleocapsid protein at a putative HIV-1 protease cleavage site. Virology 2006 0.81
63 Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: implications for genomic RNA packaging. J Virol 2013 0.81
64 Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities. Retrovirology 2015 0.80
65 Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific site. J Mol Biol 2009 0.80
66 An immature retroviral RNA genome resembles a kinetically trapped intermediate state. J Virol 2014 0.80
67 Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication. Virology 2008 0.80
68 HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation. J Biol Chem 2011 0.78
69 Blocking premature reverse transcription fails to rescue the HIV-1 nucleocapsid-mutant replication defect. Retrovirology 2011 0.78
70 TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4(+) T-cells with no measurable effect on susceptibility to SIV infection. Virology 2010 0.78
71 Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5'-terminal genomic RNA fragments: a paradigm for RNA removal reactions in HIV-1 reverse transcription. Virus Res 2012 0.78
72 Molecular determinants of HIV-1 NCp7 chaperone activity in maturation of the HIV-1 dimerization initiation site. Nucleic Acids Res 2012 0.77
73 HIV-1 nucleocapsid proteins as molecular chaperones for tetramolecular antiparallel G-quadruplex formation. J Am Chem Soc 2013 0.75
74 Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature 2016 0.75