Published in J Biol Chem on July 07, 2011
G-quadruplexes in viruses: function and potential therapeutic applications. Nucleic Acids Res (2014) 0.95
U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence. Biochemistry (2014) 0.92
Mechanism of HIV-1 RNA dimerization in the central region of the genome and significance for viral evolution. J Biol Chem (2013) 0.78
Physical properties of Rous Sarcoma Virus RNA. Proc Natl Acad Sci U S A (1968) 8.26
Helix formation by guanylic acid. Proc Natl Acad Sci U S A (1962) 6.77
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell (2001) 6.50
Retroviral recombination and reverse transcription. Science (1990) 6.27
G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res (2006) 5.84
A sodium-potassium switch in the formation of four-stranded G4-DNA. Nature (1990) 5.35
RNA packaging. Curr Top Microbiol Immunol (1996) 4.88
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science (2004) 4.87
Dynamics of HIV-1 recombination in its natural target cells. Proc Natl Acad Sci U S A (2004) 4.37
G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Angew Chem Int Ed Engl (2004) 4.20
G-quartet structures in telomeric DNA. Annu Rev Biophys Biomol Struct (1994) 3.53
High rate of recombination throughout the human immunodeficiency virus type 1 genome. J Virol (2000) 3.09
Evidence for interstrand quadruplex formation in the dimerization of human immunodeficiency virus 1 genomic RNA. Proc Natl Acad Sci U S A (1993) 3.02
Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanism. Prog Nucleic Acid Res Mol Biol (2005) 2.98
Dimerization of human immunodeficiency virus (type 1) RNA: stimulation by cations and possible mechanism. Nucleic Acids Res (1991) 2.94
Four-stranded nucleic acid structures 25 years later: from guanosine gels to telomer DNA. J Biomol Struct Dyn (1990) 2.62
Template-directed pausing of DNA synthesis by HIV-1 reverse transcriptase during polymerization of HIV-1 sequences in vitro. J Biol Chem (1993) 2.26
The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA. Cell (1993) 2.23
Mode of dimerization of HIV-1 genomic RNA. Biochemistry (1993) 2.18
Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure. Proc Natl Acad Sci U S A (1996) 2.17
Transactivation of the minus-strand DNA transfer by nucleocapsid protein during reverse transcription of the retroviral genome. EMBO J (1994) 2.16
Sequence-specific binding of human immunodeficiency virus type 1 nucleocapsid protein to short oligonucleotides. J Virol (1998) 2.14
Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures. Biochemistry (1992) 1.88
Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis. Biochemistry (1996) 1.83
Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine tract. J Virol (1996) 1.83
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
G-quartet-dependent recognition between the FMRP RGG box and RNA. RNA (2003) 1.54
Retroviral nucleocapsid protein-metal ion interactions: folding and sequence variants. Proc Natl Acad Sci U S A (1990) 1.53
Strand transfer events during HIV-1 reverse transcription. Virus Res (2008) 1.51
Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus. PLoS Pathog (2009) 1.45
Human replication protein A unfolds telomeric G-quadruplexes. Nucleic Acids Res (2006) 1.43
Trans-activation of the 5' to 3' viral DNA strand transfer by nucleocapsid protein during reverse transcription of HIV1 RNA. C R Acad Sci III (1993) 1.42
On the conservative nature of intragenic recombination. Proc Natl Acad Sci U S A (2005) 1.37
A high affinity binding site for the HIV-1 nucleocapsid protein. Nucleic Acids Res (1997) 1.29
The structure of HIV-1 genomic RNA in the gp120 gene determines a recombination hot spot in vivo. J Biol Chem (2004) 1.24
Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis. J Virol (2003) 1.24
The kissing hairpin sequence promotes recombination within the HIV-I 5' leader region. J Biol Chem (2001) 1.24
The HIV-1 repeated sequence R as a robust hot-spot for copy-choice recombination. Nucleic Acids Res (2001) 1.15
Role of post-transcriptional modifications of primer tRNALys,3 in the fidelity and efficacy of plus strand DNA transfer during HIV-1 reverse transcription. J Biol Chem (1999) 1.14
Genome-wide analyses of recombination prone regions predict role of DNA structural motif in recombination. PLoS One (2009) 1.14
Copy-choice recombination by reverse transcriptases: reshuffling of genetic markers mediated by RNA chaperones. Proc Natl Acad Sci U S A (2000) 1.13
Mutagenicity and pausing of HIV reverse transcriptase during HIV plus-strand DNA synthesis. Nucleic Acids Res (1994) 1.13
Unfolding of DNA quadruplexes induced by HIV-1 nucleocapsid protein. Nucleic Acids Res (2005) 1.12
Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination. J Biol Chem (2003) 1.07
Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism. J Biol Chem (2002) 1.06
Identification of a preferred region for recombination and mutation in HIV-1 gag. Virology (2004) 1.02
Polyamide nucleic acid targeted to the primer binding site of the HIV-1 RNA genome blocks in vitro HIV-1 reverse transcription. Biochemistry (1998) 0.98
Comparison of the genetic recombination rates of human immunodeficiency virus type 1 in macrophages and T cells. J Virol (2005) 0.98
G-quartets direct assembly of HIV-1 nucleocapsid protein along single-stranded DNA. Nucleic Acids Res (2003) 0.94
A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro. J Biol Chem (2009) 0.88
Architecture and secondary structure of an entire HIV-1 RNA genome. Nature (2009) 6.12
Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. J Clin Invest (2005) 5.00
High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states. PLoS Biol (2008) 4.40
Flap endonuclease 1: a central component of DNA metabolism. Annu Rev Biochem (2004) 3.16
Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J Biol Chem (2004) 3.10
Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs. J Biol Chem (2004) 3.01
Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. J Virol (2007) 2.95
Cleavage specificity of Saccharomyces cerevisiae flap endonuclease 1 suggests a double-flap structure as the cellular substrate. J Biol Chem (2002) 2.06
Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors. J Biol Chem (2001) 1.91
The interaction of APOBEC3G with human immunodeficiency virus type 1 nucleocapsid inhibits tRNA3Lys annealing to viral RNA. J Virol (2007) 1.74
On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing. J Biol Chem (2004) 1.72
Lagging strand replication proteins in genome stability and DNA repair. Chem Rev (2006) 1.71
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. J Biol Chem (2004) 1.63
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
Efficiency of human immunodeficiency virus type 1 postentry infection processes: evidence against disproportionate numbers of defective virions. J Virol (2007) 1.59
The protein components and mechanism of eukaryotic Okazaki fragment maturation. Crit Rev Biochem Mol Biol (2003) 1.57
Nucleocapsid protein function in early infection processes. Virus Res (2008) 1.53
Strand transfer events during HIV-1 reverse transcription. Virus Res (2008) 1.51
Interactions of murine APOBEC3 and human APOBEC3G with murine leukemia viruses. J Virol (2008) 1.50
Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site. J Mol Biol (2004) 1.49
The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. Proc Natl Acad Sci U S A (2004) 1.49
Human immunodeficiency virus type 1 nucleocapsid zinc-finger mutations cause defects in reverse transcription and integration. Virology (2006) 1.48
Nucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteins. Nucleic Acids Res (2006) 1.47
Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides. Nucleic Acids Res (2006) 1.47
Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome. Proc Natl Acad Sci U S A (2010) 1.46
Pif1 helicase directs eukaryotic Okazaki fragments toward the two-nuclease cleavage pathway for primer removal. J Biol Chem (2008) 1.43
Specific zinc-finger architecture required for HIV-1 nucleocapsid protein's nucleic acid chaperone function. Proc Natl Acad Sci U S A (2002) 1.42
A role for dNTP binding of human immunodeficiency virus type 1 reverse transcriptase in viral mutagenesis. Biochemistry (2004) 1.41
Subtle alterations of the native zinc finger structures have dramatic effects on the nucleic acid chaperone activity of human immunodeficiency virus type 1 nucleocapsid protein. J Virol (2002) 1.39
Reconstituted Okazaki fragment processing indicates two pathways of primer removal. J Biol Chem (2006) 1.38
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes. Nucleic Acids Res (2013) 1.37
Dna2p helicase/nuclease is a tracking protein, like FEN1, for flap cleavage during Okazaki fragment maturation. J Biol Chem (2004) 1.34
Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone function. J Mol Biol (2006) 1.32
Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA. PLoS One (2012) 1.30
Pif1 helicase lengthens some Okazaki fragment flaps necessitating Dna2 nuclease/helicase action in the two-nuclease processing pathway. J Biol Chem (2009) 1.27
Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2008) 1.24
Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis. J Virol (2003) 1.24
Retroviral nucleocapsid proteins display nonequivalent levels of nucleic acid chaperone activity. J Virol (2008) 1.24
Evidence that DNA damage detection machinery participates in DNA repair. Cell Cycle (2005) 1.23
Reduced dNTP binding affinity of 3TC-resistant M184I HIV-1 reverse transcriptase variants responsible for viral infection failure in macrophage. J Biol Chem (2008) 1.23
Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways. Mol Cell Biol (2004) 1.23
Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Mol Cell Biol (2004) 1.22
Real-time PCR analysis of HIV-1 replication post-entry events. Methods Mol Biol (2009) 1.22
Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27. Blood (2006) 1.21
Elimination of protease activity restores efficient virion production to a human immunodeficiency virus type 1 nucleocapsid deletion mutant. J Virol (2003) 1.21
Flap endonuclease 1. Annu Rev Biochem (2013) 1.21
Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates. J Biol Chem (2009) 1.18
Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1. J Virol (2007) 1.18
The effects of estrogen-responsive element- and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ER alpha and ER beta. Mol Endocrinol (2002) 1.18
Okazaki fragment metabolism. Cold Spring Harb Perspect Biol (2013) 1.17
Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis. J Mol Biol (2005) 1.16
Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex. J Biol Chem (2006) 1.15
Mechanistic understanding of an altered fidelity simian immunodeficiency virus reverse transcriptase mutation, V148I, identified in a pig-tailed macaque. J Biol Chem (2003) 1.13
Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect. J Biol Chem (2008) 1.12
Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion. J Biol Chem (2003) 1.10
Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threading. J Biol Chem (2010) 1.09
Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain. J Virol (2009) 1.09
GTP is the primary activator of the anti-HIV restriction factor SAMHD1. J Biol Chem (2013) 1.09
Eukaryotic lagging strand DNA replication employs a multi-pathway mechanism that protects genome integrity. J Biol Chem (2010) 1.08
Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function. RNA Biol (2010) 1.08
Comparison of SIV and HIV-1 genomic RNA structures reveals impact of sequence evolution on conserved and non-conserved structural motifs. PLoS Pathog (2013) 1.08
Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex. J Biol Chem (2009) 1.08
Dimeric RNA recognition regulates HIV-1 genome packaging. PLoS Pathog (2013) 1.07
Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination. J Biol Chem (2003) 1.07
AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. J Biol Chem (2002) 1.07
Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism. J Biol Chem (2002) 1.06
Mutations in human immunodeficiency virus type 1 nucleocapsid protein zinc fingers cause premature reverse transcription. J Virol (2008) 1.05
Flap endonuclease 1 efficiently cleaves base excision repair and DNA replication intermediates assembled into nucleosomes. Mol Cell (2002) 1.05
DNA ligase I competes with FEN1 to expand repetitive DNA sequences in vitro. J Biol Chem (2002) 1.04
Differing roles of the N- and C-terminal zinc fingers in human immunodeficiency virus nucleocapsid protein-enhanced nucleic acid annealing. J Biol Chem (2003) 1.04
A guanosine-centric mechanism for RNA chaperone function. Science (2013) 1.03
Cofactors for human immunodeficiency virus type 1 cDNA integration in vitro. J Virol (2003) 1.03
Steps of the acceptor invasion mechanism for HIV-1 minus strand strong stop transfer. J Biol Chem (2003) 1.02
Identification of a preferred region for recombination and mutation in HIV-1 gag. Virology (2004) 1.02
Anti-HIV host factor SAMHD1 regulates viral sensitivity to nucleoside reverse transcriptase inhibitors via modulation of cellular deoxyribonucleoside triphosphate (dNTP) levels. J Biol Chem (2013) 1.02
Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications. Virology (2010) 1.01
Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo. J Virol (2002) 1.01
Differences in the abilities of estrogen receptors to integrate activation functions are critical for subtype-specific transcriptional responses. Mol Endocrinol (2002) 1.00
Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia. Am J Physiol Lung Cell Mol Physiol (2006) 1.00
C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism. J Biol Chem (2009) 0.99
Frequent incorporation of ribonucleotides during HIV-1 reverse transcription and their attenuated repair in macrophages. J Biol Chem (2012) 0.99
The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability. Virology (2011) 0.99
Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H. J Biol Chem (2002) 0.98
Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure. J Biol Chem (2004) 0.98
Flap endonuclease disengages Dna2 helicase/nuclease from Okazaki fragment flaps. J Biol Chem (2006) 0.98
Transmission electron microscopy reveals an optimal HIV-1 nucleocapsid aggregation with single-stranded nucleic acids and the mature HIV-1 nucleocapsid protein. J Mol Biol (2006) 0.98
Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates. Nucleic Acids Res (2009) 0.97
HIV-1 protease and reverse transcriptase control the architecture of their nucleocapsid partner. PLoS One (2007) 0.97
Reduced dNTP interaction of human immunodeficiency virus type 1 reverse transcriptase promotes strand transfer. J Biol Chem (2006) 0.97
An alternative pathway for Okazaki fragment processing: resolution of fold-back flaps by Pif1 helicase. J Biol Chem (2010) 0.97
HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein. Virology (2008) 0.96
Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2009) 0.96
Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4. J Virol (2005) 0.96
Binding of estrogen receptor beta to estrogen response element in situ is independent of estradiol and impaired by its amino terminus. Mol Endocrinol (2005) 0.95
Molecular basis of therapeutic strategies for breast cancer. Curr Drug Targets Immune Endocr Metabol Disord (2005) 0.95