Published in Prog Nucleic Acid Res Mol Biol on January 01, 2002
Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J (2008) 1.78
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J Biol Chem (2007) 1.74
Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol (2010) 1.67
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J Cell Biol (2005) 1.40
Regulation and functions of sphingosine kinases in the brain. Biochim Biophys Acta (2008) 1.11
Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. Lab Invest (2010) 1.06
Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. PLoS One (2011) 1.05
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorg Med Chem (2011) 1.03
Sphinganine-1-phosphate attenuates both hepatic and renal injury induced by hepatic ischemia and reperfusion in mice. Shock (2010) 1.00
Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood (2013) 0.94
Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. Eukaryot Cell (2005) 0.93
Unraveling the complexities of sphingosine-1-phosphate function: the mast cell model. Prostaglandins Other Lipid Mediat (2008) 0.92
The glucocorticoid receptor signalling in breast cancer. J Cell Mol Med (2007) 0.92
Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int (2012) 0.91
Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system. Br J Pharmacol (2011) 0.90
Sphingosine-1-phosphate transporters as targets for cancer therapy. Biomed Res Int (2014) 0.89
Interleukin-11 protects against renal ischemia and reperfusion injury. Am J Physiol Renal Physiol (2012) 0.89
Effect of alkyl chain length on sphingosine kinase 2 selectivity. Bioorg Med Chem Lett (2012) 0.88
Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res (2007) 0.88
Effect of sphingosine kinase 1 inhibition on blood pressure. FASEB J (2012) 0.86
Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance. Int J Mol Sci (2014) 0.84
Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. PLoS One (2013) 0.84
Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3. Am J Physiol Cell Physiol (2008) 0.83
Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. PLoS One (2012) 0.83
Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2008) 0.82
Isoflurane protects against human endothelial cell apoptosis by inducing sphingosine kinase-1 via ERK MAPK. Int J Mol Sci (2012) 0.82
A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. Am J Physiol Renal Physiol (2012) 0.81
Sphingolipids as cell fate regulators in lung development and disease. Apoptosis (2015) 0.81
MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2. Oncotarget (2016) 0.80
STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. World J Gastroenterol (2014) 0.80
Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons. J Cell Mol Med (2016) 0.78
High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2. Mol Cell Biochem (2014) 0.78
Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. Mol Microbiol (2013) 0.78
Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. Oncotarget (2016) 0.78
MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2. Cancer Cell Int (2017) 0.77
Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. Oncotarget (2016) 0.77
Inhibition of sphingosine kinase prevents lipopolysaccharide-induced preterm birth and suppresses proinflammatory responses in a murine model. Am J Pathol (2015) 0.77
Sphingosine kinase: a novel putative target for the prevention of infection-triggered preterm birth. Obstet Gynecol Int (2013) 0.77
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. J Immunol (2013) 0.76
"Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. Int J Mol Sci (2017) 0.75
Comparative analysis of the effects of a sphingosine kinase inhibitor to temozolomide and radiation treatment on glioblastoma cell lines. Cancer Biol Ther (2017) 0.75
Sphingosine kinase 1 expression enhances colon tumor growth. J Transl Med (2017) 0.75
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol (2003) 9.29
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science (2009) 4.45
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature (2010) 3.59
Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol (2005) 3.59
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell (2012) 3.24
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem (2004) 3.22
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc Natl Acad Sci U S A (2012) 3.12
The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol (2011) 3.07
Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol (2011) 2.97
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther (2008) 2.96
Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. Nature (2003) 2.77
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem (2005) 2.64
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim Biophys Acta (2006) 2.62
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta (2002) 2.53
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med (2004) 2.44
Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem (2002) 2.42
Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol (2005) 2.39
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A (2006) 2.39
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem (2003) 2.36
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood (2008) 2.22
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev (2010) 2.10
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci (2005) 2.07
Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol Metab (2007) 2.00
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett (2003) 1.98
Targeting SphK1 as a new strategy against cancer. Curr Drug Targets (2008) 1.91
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res (2007) 1.82
Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology (2015) 1.81
Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta (2009) 1.76
Functions of the multifaceted family of sphingosine kinases and some close relatives. J Biol Chem (2006) 1.76
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem (2003) 1.76
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem (2010) 1.74
Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. J Biol Chem (2002) 1.73
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp Cell Res (2002) 1.69
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett (2005) 1.69
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J Biol Chem (2005) 1.67
Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol (2010) 1.67
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov (2013) 1.66
The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development (2003) 1.57
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res (2009) 1.54
Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res (2003) 1.54
Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J Biol Chem (2007) 1.54
OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Mol Pharmacol (2008) 1.52
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol (2002) 1.51
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J (2010) 1.49
Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Mol Cancer Ther (2008) 1.48
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem (2003) 1.47
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem (2003) 1.47
Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. Oncogene (2004) 1.44
Sphingosine-1-phosphate: dual messenger functions. FEBS Lett (2002) 1.44
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Res (2010) 1.43
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. FASEB J (2008) 1.43
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med (2003) 1.42
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood (2006) 1.41
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J Cell Biol (2005) 1.40
The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J Pharmacol Exp Ther (2007) 1.40