Published in J Biol Chem on November 29, 2006
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science (2009) 4.45
The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol (2011) 3.07
Targeting SphK1 as a new strategy against cancer. Curr Drug Targets (2008) 1.91
Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J Biol Chem (2007) 1.74
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest (2012) 1.54
Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. Mediators Inflamm (2016) 1.46
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. FASEB J (2008) 1.43
Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. Oncogene (2011) 1.38
Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol (2011) 1.34
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res (2009) 1.25
Sphingosine-1-phosphate and modulation of vascular tone. Cardiovasc Res (2009) 1.19
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med (2012) 1.16
Lymphangiogenesis: a new player in cancer progression. World J Gastroenterol (2010) 1.15
G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J (2008) 1.14
Sphingosine 1-phosphate signalling. Development (2014) 1.14
Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. J Lipid Res (2008) 1.13
Regulation and functions of sphingosine kinases in the brain. Biochim Biophys Acta (2008) 1.11
The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids. Eur J Pharmacol (2009) 1.10
Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol (2010) 1.09
Export of sphingosine-1-phosphate and cancer progression. J Lipid Res (2014) 1.09
Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS One (2012) 1.06
Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-beta/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. J Biol Chem (2008) 1.06
Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. J Biol Chem (2009) 1.04
Noncanonical transforming growth factor beta signaling in scleroderma fibrosis. Curr Opin Rheumatol (2009) 1.03
Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells. PLoS One (2011) 0.99
Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. Biochem Biophys Res Commun (2009) 0.95
The expression of sphingosine kinase-1 in head and neck carcinoma. Cells Tissues Organs (2010) 0.95
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem (2011) 0.95
Ceramide signaling in cancer and stem cells. Future Lipidol (2008) 0.92
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opin Ther Targets (2009) 0.91
Multiple roles for sphingolipids in steroid hormone biosynthesis. Subcell Biochem (2008) 0.91
A fluorescent plate reader assay for ceramide kinase. Anal Biochem (2007) 0.91
Sphingosine kinase regulation and cardioprotection. Cardiovasc Res (2008) 0.90
Roles of sphingosine-1-phosphate signaling in angiogenesis. World J Biol Chem (2010) 0.90
Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteries. Pharmacol Res (2010) 0.90
Determination of sphingosine kinase activity for cellular signaling studies. Anal Chem (2008) 0.89
Nuclear sphingolipid metabolism. Annu Rev Physiol (2011) 0.89
A lipid binding domain in sphingosine kinase 2. Biochem Biophys Res Commun (2009) 0.88
Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond. Anticancer Agents Med Chem (2011) 0.88
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing. Exp Cell Res (2009) 0.87
Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin. PLoS One (2012) 0.85
The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines. Curr Pharm Des (2012) 0.84
Phospholipids: "greasing the wheels" of humoral immunity. Biochim Biophys Acta (2012) 0.84
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats. Pain (2011) 0.83
The interplay between bioactive sphingolipids and steroid hormones. Steroids (2010) 0.81
The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation. Arthritis Res Ther (2014) 0.80
S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. Biochim Biophys Acta (2012) 0.80
Sphingosine kinase localization in the control of sphingolipid metabolism. Adv Enzyme Regul (2010) 0.80
High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2. Mol Cell Biochem (2014) 0.78
The genetics of feed conversion efficiency traits in a commercial broiler line. Sci Rep (2015) 0.77
Cloning and characterization of rat sphingosine kinase 1 with an N-terminal extension. Biochem Biophys Res Commun (2007) 0.76
Mouse Sphingosine Kinase 1a Is Negatively Regulated through Conventional PKC-Dependent Phosphorylation at S373 Residue. PLoS One (2015) 0.76
Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1. Front Pharmacol (2016) 0.76
Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. PLoS Biol (2017) 0.75
Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein Expression. J Biol Chem (2015) 0.75
Recent advances in biomarkers and potential targeted therapies in head and neck squamous cell carcinoma. ISRN Surg (2012) 0.75
Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease. Biomed Res Int (2015) 0.75
Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease. Sci Rep (2017) 0.75
Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. Expert Opin Ther Targets (2017) 0.75
Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol (2003) 9.29
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science (2009) 4.45
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature (2010) 3.59
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell (2012) 3.24
The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol (2011) 3.07
Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol (2011) 2.97
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem (2005) 2.64
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim Biophys Acta (2006) 2.62
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta (2002) 2.53
Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. J Exp Med (2004) 2.44
Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem (2002) 2.42
Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol (2005) 2.39
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc Natl Acad Sci U S A (2006) 2.39
Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem (2003) 2.36
A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood (2008) 2.22
Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol Metab (2007) 2.00
The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett (2003) 1.98
Targeting SphK1 as a new strategy against cancer. Curr Drug Targets (2008) 1.91
Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res (2007) 1.82
Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta (2009) 1.76
Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem (2010) 1.74
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp Cell Res (2002) 1.69
Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett (2005) 1.69
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J Biol Chem (2005) 1.67
Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol (2010) 1.67
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov (2013) 1.66
Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity. Circ Res (2003) 1.54
Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res (2009) 1.54
Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J Biol Chem (2007) 1.54
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J Cell Biol (2002) 1.51
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J (2010) 1.49
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem (2003) 1.47
Sphingosine-1-phosphate: dual messenger functions. FEBS Lett (2002) 1.44
Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. FASEB J (2008) 1.43
Sphingosine kinases: a novel family of lipid kinases. Prog Nucleic Acid Res Mol Biol (2002) 1.43
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood (2006) 1.41
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J Cell Biol (2005) 1.40
The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Mol Cell Biol (2005) 1.38
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res (2008) 1.34
Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. Blood (2008) 1.33
Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. J Lipid Res (2008) 1.30
Generation and metabolism of bioactive sphingosine-1-phosphate. J Cell Biochem (2004) 1.28
Pleiotropic actions of sphingosine-1-phosphate. Prog Lipid Res (2003) 1.27
Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Mol Cell Biol (2008) 1.22
Sphingosine-1-phosphate and lipid phosphohydrolases. Biochim Biophys Acta (2002) 1.20
Sphingosine 1-phosphate signaling: providing cells with a sense of direction. Trends Cell Biol (2002) 1.20
Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. J Biol Chem (2007) 1.19
Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. J Exp Med (2010) 1.19
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. J Allergy Clin Immunol (2012) 1.15
Regulation and functions of sphingosine kinases in the brain. Biochim Biophys Acta (2008) 1.11
EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells. FASEB J (2007) 1.11
Is tail vein injection a relevant breast cancer lung metastasis model? J Thorac Dis (2013) 1.11
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. J Cell Biol (2004) 1.10
Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB J (2012) 1.09
Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells. J Biol Chem (2008) 1.08
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol Cell Biol (2006) 1.07
Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. J Biol Chem (2004) 1.06
Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood (2005) 1.05
Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacol Ther (2007) 1.04
Characterization of murine sphingosine-1-phosphate phosphohydrolase. J Biol Chem (2001) 1.04
Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells. FEBS Lett (2007) 1.04
A rapid and sensitive method to measure secretion of sphingosine-1-phosphate. Methods Enzymol (2007) 1.04
An improved syngeneic orthotopic murine model of human breast cancer progression. Breast Cancer Res Treat (2014) 1.03
Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. J Biol Chem (2002) 1.01
The roles of sphingosine-1-phosphate in asthma. Mol Immunol (2002) 1.01
Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor. Mol Pharmacol (2006) 0.99
Aminoacylase 1 is a sphingosine kinase 1-interacting protein. FEBS Lett (2004) 0.99
Development of small-molecule inhibitors of sphingosine-1-phosphate signaling. Pharmacol Ther (2011) 0.98
Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells. J Biol Chem (2002) 0.97
Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. Prostaglandins Other Lipid Mediat (2005) 0.96
Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. J Neurochem (2009) 0.94
Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. FEBS Lett (2010) 0.94
Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis. J Neurosci Res (2002) 0.93
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage. J Biol Chem (2011) 0.93
Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. Mol Cancer Res (2008) 0.91
The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. Biochemistry (2003) 0.90
Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. FASEB J (2009) 0.89
Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo. Methods Enzymol (2007) 0.87
Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. FASEB J (2007) 0.86
Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. Circ Res (2007) 0.85
Targeting sphingosine-1-phosphate in hematologic malignancies. Anticancer Agents Med Chem (2011) 0.85
Bacterial translocation up-regulates GTP-cyclohydrolase I in mesenteric vasculature of cirrhotic rats. Hepatology (2003) 0.85
Sphingosine-1-phosphate synthesis and functions in mast cells. Future Lipidol (2008) 0.84
The fate of intravenously administered tetrahydrobiopterin and its implications for heterologous gene therapy of phenylketonuria. Mol Genet Metab (2004) 0.84
A specific ceramide kinase assay to measure cellular levels of ceramide. Anal Biochem (2003) 0.83
Modulation of adaptive immune responses by sphingosine-1-phosphate. Semin Cell Dev Biol (2004) 0.80
The potential of histone deacetylase inhibitors in Niemann - Pick type C disease. FEBS J (2013) 0.80