Published in Trends Biochem Sci on July 01, 2002
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol (2008) 5.19
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev (2003) 5.10
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31
Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J (2003) 3.58
Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway. Cell (2013) 3.49
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol Mol Biol Rev (2006) 3.30
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A (2003) 3.28
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci U S A (2008) 3.13
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle (2009) 3.05
FOXOs, cancer and regulation of apoptosis. Oncogene (2008) 3.02
The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A (2002) 2.93
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev (2008) 2.61
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet (2009) 2.34
Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev (2005) 2.30
Notch tumor suppressor function. Oncogene (2008) 2.26
C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci U S A (2003) 2.25
Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J (2006) 2.18
FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A. Cell Signal (2006) 2.12
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12
Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal (2010) 1.94
BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism. J Exp Med (2006) 1.93
Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol (2003) 1.92
The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol (2009) 1.91
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell (2008) 1.88
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet (2011) 1.82
Control of cyclin G2 mRNA expression by forkhead transcription factors: novel mechanism for cell cycle control by phosphoinositide 3-kinase and forkhead. Mol Cell Biol (2004) 1.76
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
Functional interaction between FOXO3a and ATM regulates DNA damage response. Nat Cell Biol (2008) 1.58
Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol (2006) 1.58
Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains. Mol Biol Cell (2008) 1.57
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev (2014) 1.57
Retracted FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma. J Cell Biol (2005) 1.51
SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell (2008) 1.48
Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad. J Biol Chem (2004) 1.48
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J (2010) 1.45
The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45
Nuclear calcium signalling in the regulation of brain function. Nat Rev Neurosci (2013) 1.44
Deubiquitinating enzymes as novel anticancer targets. Future Oncol (2007) 1.43
Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Res (2007) 1.38
PP2A regulates the pro-apoptotic activity of FOXO1. J Biol Chem (2008) 1.36
FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Mol Cell Biol (2009) 1.35
Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. J Clin Invest (2004) 1.34
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. Curr Genomics (2007) 1.33
Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia. Clin Cancer Res (2010) 1.30
Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis. Breast Cancer Res (2008) 1.30
Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell (2010) 1.29
LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins. Cancer Res (2008) 1.28
A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes Dev (2010) 1.27
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes (2008) 1.26
Differential regulation of Foxo3a target genes in erythropoiesis. Mol Cell Biol (2007) 1.26
FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats. Diabetes (2009) 1.25
Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med (2011) 1.25
Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest. Exp Cell Res (2006) 1.22
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. J Cell Biol (2005) 1.22
FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. PLoS Pathog (2012) 1.22
CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med (2004) 1.20
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO J (2008) 1.20
Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. J Biol Chem (2008) 1.20
Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab (2013) 1.19
Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal (2012) 1.19
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death. Mol Cell Biol (2004) 1.18
Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation. Oncogene (2011) 1.16
Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling. Mol Biol Cell (2007) 1.14
Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region. Biochemistry (2008) 1.14
Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor. J Mol Signal (2008) 1.13
Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. Mol Cell Biol (2005) 1.12
Why target PIM1 for cancer diagnosis and treatment? Future Oncol (2010) 1.12
The interactions of flavonoids within neuronal signalling pathways. Genes Nutr (2007) 1.11
Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen. J Immunol (2008) 1.11
FoxO, autophagy, and cardiac remodeling. J Cardiovasc Transl Res (2010) 1.11
LY294002 and rapamycin co-operate to inhibit T-cell proliferation. Br J Pharmacol (2005) 1.11
Synaptic activity and nuclear calcium signaling protect hippocampal neurons from death signal-associated nuclear translocation of FoxO3a induced by extrasynaptic N-methyl-D-aspartate receptors. J Biol Chem (2010) 1.09
FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol. J Biol Chem (2009) 1.07
Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival. Genome Biol (2007) 1.07
Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. BMC Cancer (2011) 1.06
FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol. Mol Cell Biochem (2009) 1.05
Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target. PLoS One (2009) 1.05
FOXO1 plays an essential role in apoptosis of retinal pericytes. Mol Vis (2010) 1.04
The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma. Toxicol Sci (2009) 1.03
Isotretinoin and FoxO1: A scientific hypothesis. Dermatoendocrinol (2011) 1.02
Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. J Gerontol A Biol Sci Med Sci (2012) 1.02
Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. Infect Immun (2008) 1.02
Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells. Nat Immunol (2009) 1.01
An overview of stress response and hypometabolic strategies in Caenorhabditis elegans: conserved and contrasting signals with the mammalian system. Int J Biol Sci (2010) 1.01
Apoptosis in gingival overgrowth tissues. J Dent Res (2007) 1.01
Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J Biol Chem (2013) 1.00
Involvement of the up-regulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress. J Biol Chem (2012) 1.00
Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells. Front Biosci (Elite Ed) (2011) 1.00
Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1. J Cell Biol (2005) 1.00
Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. Lab Invest (2009) 0.99
Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a. Endocrinology (2008) 0.98
Characterization of the promoters of Epsilon glutathione transferases in the mosquito Anopheles gambiae and their response to oxidative stress. Biochem J (2005) 0.97
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. Development (2009) 0.97
Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells. J Cereb Blood Flow Metab (2006) 0.97
Resistance to transforming growth factor β-mediated tumor suppression in melanoma: are multiple mechanisms in place? Carcinogenesis (2010) 0.97
p75NTR-dependent modulation of cellular handling of reactive oxygen species. J Neurochem (2009) 0.97
Polarised expression of FoxB and FoxQ2 genes during development of the hydrozoan Clytia hemisphaerica. Dev Genes Evol (2006) 0.97
DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road. Antioxid Redox Signal (2010) 0.97
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol (2002) 4.85
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell (2008) 3.38
Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science (2011) 3.29
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol (2002) 3.20
Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J Cell Biol (2003) 3.15
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol (2010) 2.26
Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A (2009) 2.04
Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments. Dev Cell (2012) 1.77
Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun (2011) 1.59
The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase. Dev Cell (2012) 1.55
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. PLoS One (2010) 1.50
Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One (2008) 1.43
A TPR domain-containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B. J Cell Biol (2013) 1.38
Evolution and function of the mitotic checkpoint. Dev Cell (2012) 1.38
Release of Mps1 from kinetochores is crucial for timely anaphase onset. J Cell Biol (2010) 1.33
Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation. J Cell Biol (2013) 1.31
Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy. Cancer Res (2010) 1.26
A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes. EMBO J (2010) 1.18
Preventing aneuploidy: the contribution of mitotic checkpoint proteins. Biochim Biophys Acta (2008) 1.14
Mps1 promotes rapid centromere accumulation of Aurora B. EMBO Rep (2012) 0.97
Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase. Chromosoma (2014) 0.95
Improving depth in phosphoproteomics by using a strong cation exchange-weak anion exchange-reversed phase multidimensional separation approach. Anal Chem (2011) 0.90
Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases. PLoS One (2013) 0.88
Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a. J Lipid Res (2003) 0.88
Universal quantitative kinase assay based on diagonal SCX chromatography and stable isotope dimethyl labeling provides high-definition kinase consensus motifs for PKA and human Mps1. J Proteome Res (2013) 0.86
APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. J Cell Sci (2015) 0.75