LC/MS analysis of NAD biosynthesis using stable isotope pyridine precursors.

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Published in Anal Biochem on July 15, 2002

Authors

Jason Evans1, Tao Chin Wang, Melvyn P Heyes, S P Markey

Author Affiliations

1: Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, Maryland 20892-1262, USA.

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Reduced paraquat does not exhibit MPTP-like neurotoxicity. J Anal Toxicol (1987) 0.78

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