Published in JAMA on July 22, 2002
Federal Study of Adherence to Medications in the Elderly (FAME) | NCT00393419
Additional KIF6 Risk Offers Better Adherence to Statins (AKROBATS) | NCT01068834
Discontinuation of statins in routine care settings: a cohort study. Ann Intern Med (2013) 5.87
Risk of incident diabetes among patients treated with statins: population based study. BMJ (2013) 5.40
Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the american heart association. Circulation (2011) 5.26
Why don't diabetes patients achieve recommended risk factor targets? Poor adherence versus lack of treatment intensification. J Gen Intern Med (2008) 3.99
Coronary Heart Disease Mortality Declines in the United States From 1979 Through 2011: Evidence for Stagnation in Young Adults, Especially Women. Circulation (2015) 3.56
Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the American Heart Association. J Am Coll Cardiol (2011) 2.89
New prescription medication gaps: a comprehensive measure of adherence to new prescriptions. Health Serv Res (2009) 2.63
Revisiting Rose: strategies for reducing coronary heart disease. BMJ (2006) 2.53
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Cost-effectiveness of providing full drug coverage to increase medication adherence in post-myocardial infarction Medicare beneficiaries. Circulation (2008) 2.42
Independent pharmacist prescribing in Canada. Can Pharm J (Ott) (2012) 2.20
Effectiveness and efficiency of different guidelines on statin treatment for preventing deaths from coronary heart disease: modelling study. BMJ (2006) 2.03
Suboptimal statin adherence and discontinuation in primary and secondary prevention populations. J Gen Intern Med (2004) 2.01
The placebo response in medicine: minimize, maximize or personalize? Nat Rev Drug Discov (2013) 2.00
Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J (2015) 1.92
Socioeconomic gradient in use of statins among Danish patients: population-based cross-sectional study. Br J Clin Pharmacol (2005) 1.89
Creating a conversation: insights from the development of a decision aid. PLoS Med (2007) 1.77
Sociodemographic variations in the contribution of secondary drug prevention to stroke survival at middle and older ages: cohort study. BMJ (2009) 1.73
Racial/Ethnic and gender gaps in the use of and adherence to evidence-based preventive therapies among elderly Medicare Part D beneficiaries after acute myocardial infarction. Circulation (2013) 1.68
Predictors of nonadherence to statins: a systematic review and meta-analysis. Ann Pharmacother (2010) 1.66
Income-based drug coverage in British Columbia: the impact on access to medicines. Healthc Policy (2006) 1.59
The clinical implications of ageing for rational drug therapy. Eur J Clin Pharmacol (2008) 1.56
Treatment Options for Statin-Associated Muscle Symptoms. Dtsch Arztebl Int (2015) 1.55
The 2003 Canadian recommendations for dyslipidemia management: revisions are needed. CMAJ (2005) 1.49
Multiple health behaviours: overview and implications. J Public Health (Oxf) (2012) 1.46
Trends in adherence to secondary prevention medications in elderly post-myocardial infarction patients. Pharmacoepidemiol Drug Saf (2008) 1.45
Determinants of medication adherence to antihypertensive medications among a Chinese population using Morisky Medication Adherence Scale. PLoS One (2013) 1.37
Adherence to cardioprotective medications and mortality among patients with diabetes and ischemic heart disease. BMC Cardiovasc Disord (2006) 1.35
Persistence and determinants of statin therapy among middle-aged patients for primary and secondary prevention. Br J Clin Pharmacol (2005) 1.29
Patient medication adherence: measures in daily practice. Oman Med J (2011) 1.29
How do we improve patient compliance and adherence to long-term statin therapy? Curr Atheroscler Rep (2013) 1.20
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol (2013) 1.17
Long-term medication adherence after myocardial infarction: experience of a community. Am J Med (2009) 1.14
Long term persistence with statin treatment in daily medical practice. Heart (2004) 1.13
Interventions to improve adherence to lipid lowering medication. Cochrane Database Syst Rev (2004) 1.12
Investigating factors associated with adherence behaviour in patients with chronic myeloid leukemia: an observational patient-centered outcome study. Br J Cancer (2012) 1.11
Reducing Medication Costs to Prevent Cardiovascular Disease: A Community Guide Systematic Review. Prev Chronic Dis (2015) 1.11
Study protocol: the Adherence and Intensification of Medications (AIM) study--a cluster randomized controlled effectiveness study. Trials (2010) 1.11
Impact of better adherence to statin agents in the primary prevention of coronary artery disease. Eur J Clin Pharmacol (2009) 1.11
Impact of adherence to statins on coronary artery disease in primary prevention. Br J Clin Pharmacol (2007) 1.11
Use of statins and beta-blockers after acute myocardial infarction according to income and education. J Epidemiol Community Health (2007) 1.09
Adherence to cardiovascular medications: lessons learned and future directions. Prog Cardiovasc Dis (2013) 1.08
Oral bisphosphonate compliance and persistence: a matter of choice? Osteoporos Int (2010) 1.07
Factors associated with adherence to drug therapy: a population-based study. Eur J Clin Pharmacol (2007) 1.06
Adherence to statin or aspirin or both in patients with established cardiovascular disease: exploring healthy behaviour vs. drug effects and 10-year follow-up of outcome. Br J Clin Pharmacol (2008) 1.06
Persistence and determinants of statin therapy among middle-aged patients free of cardiovascular disease. Eur J Clin Pharmacol (2005) 1.05
Purchasing prescription drugs in Canada: hang together or hang separately. Healthc Policy (2011) 1.05
Patient compliance based on genetic medicine: a literature review. J Community Genet (2013) 1.04
Drug development and use in the elderly: search for the right dose and dosing regimen (Parts I and II). Br J Clin Pharmacol (2004) 1.02
Cost-related nonadherence by medication type among Medicare Part D beneficiaries with diabetes. Med Care (2013) 1.02
Optimizing medication adherence: an ongoing opportunity to improve outcomes after kidney transplantation. Clin J Am Soc Nephrol (2010) 1.00
Recent developments in secondary prevention and cardiac rehabilitation after acute myocardial infarction. BMJ (2004) 0.98
Patient and Partner Feedback Reports to Improve Statin Medication Adherence: A Randomized Control Trial. J Gen Intern Med (2016) 0.97
Medication adherence in heart failure. Heart Fail Rev (2007) 0.97
Unintentional Continuation of Medications Intended for Acute Illness After Hospital Discharge: A Population-Based Cohort Study. J Gen Intern Med (2016) 0.96
Do patients' expectations influence their use of medications? Qualitative study. Can Fam Physician (2008) 0.96
Evidence-based cardiovascular care in the community: a population-based cross-sectional study. BMC Fam Pract (2004) 0.95
Impact of reducing dosing frequency on adherence to oral therapies: a literature review and meta-analysis. Patient Prefer Adherence (2013) 0.95
Molecular sources of residual cardiovascular risk, clinical signals, and innovative solutions: relationship with subclinical disease, undertreatment, and poor adherence: implications of new evidence upon optimizing cardiovascular patient outcomes. Vasc Health Risk Manag (2013) 0.94
Elderly patients' adherence to statin therapy. JAMA (2002) 0.94
Results of a national survey on OTC medicines, Part 2: Do pharmacists support switching prescription agents to over-the-counter status? Can Pharm J (Ott) (2012) 0.94
Family practice patients' adherence to statin medications. Can Fam Physician (2007) 0.94
Antihypertensive Medications Adherence Among Nigerian Hypertensive Subjects in a Specialist Clinic Compared to a General Outpatient Clinic. Ann Med Health Sci Res (2015) 0.93
Facilitating Clinical Research through the Health Information Exchange: Lipid Control as an Example. AMIA Annu Symp Proc (2010) 0.93
Improving the physician-patient cardiovascular risk dialogue to improve statin adherence. BMC Fam Pract (2009) 0.93
Statin underuse and low prevalence of LDL-C control among U.S. adults at high risk of coronary heart disease. Am J Med Sci (2014) 0.93
Primary medication non-adherence after discharge from a general internal medicine service. PLoS One (2013) 0.92
Promoting knowledge of statins in patients with low health literacy using an audio booklet. Patient Prefer Adherence (2011) 0.92
Whom are we treating with lipid-lowering drugs? Are we following the guidelines? Evidence from a population-based study: the Tromso study 2001. Eur J Clin Pharmacol (2004) 0.92
A "hot" topic in dyslipidemia management--"how to beat a flush": optimizing niacin tolerability to promote long-term treatment adherence and coronary disease prevention. Mayo Clin Proc (2010) 0.91
Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: a cohort study. BMC Cardiovasc Disord (2011) 0.91
Two Randomized Controlled Pilot Trials of Social Forces to Improve Statin Adherence among Patients with Diabetes. J Gen Intern Med (2016) 0.91
Barriers to detecting and treating hypercholesterolaemia in patients with ischaemic heart disease: primary care perceptions. Br J Gen Pract (2005) 0.90
Tailored Information and Automated Reminding to Improve Medication Adherence in Spanish- and English-Speaking Elders Treated for Memory Impairment. Clin Gerontol (2012) 0.90
n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial. Vasc Med (2013) 0.89
Initiation and persistence to statin treatment in patients with diabetes receiving glucose-lowering medications 1997- 2006. Open Cardiovasc Med J (2009) 0.89
Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials. BMC Cardiovasc Disord (2014) 0.88
Adherence to pharmacotherapy and medication-related beliefs in patients with hypertension in Lima, Peru. PLoS One (2014) 0.88
Discontinuation and switching of therapy after initiation of lipid-lowering drugs: the effects of comorbidities and patient characteristics. Br J Clin Pharmacol (2003) 0.87
Changes in adherence to statins and subsequent lipid profiles during and following breast cancer treatment. Breast Cancer Res Treat (2013) 0.87
Predictive patterns of early medication adherence in renal transplantation. Transplantation (2014) 0.87
Association of vitamin D and incident statin induced myalgia--a retrospective cohort study. PLoS One (2014) 0.86
Use of evidence-based cardiac prevention therapy among outpatients with atrial fibrillation. Am J Med (2013) 0.86
The roles of past behavior and health beliefs in predicting medication adherence to a statin regimen. Patient Prefer Adherence (2012) 0.86
Is concordance the primrose path to health? BMJ (2003) 0.86
Pattern of statin use in southern italian primary care: can prescription databases be used for monitoring long-term adherence to the treatment? PLoS One (2014) 0.85
Reasons for (non)compliance with intervention following identification of 'high-risk' status in the NHS Health Check programme. J Public Health (Oxf) (2014) 0.85
Statin use in adults at high risk of cardiovascular disease mortality: cross-sectional analysis of baseline data from The Irish Longitudinal Study on Ageing (TILDA). BMJ Open (2015) 0.85
Assessment of adherence to cardiovascular medicines in rural population: An observational study in patients attending a tertiary care hospital. Indian J Pharmacol (2016) 0.85
Cholesterol levels and statin use in patients with coronary heart disease treated in primary care settings. Prev Chronic Dis (2005) 0.84
Medication adherence is associated with having a caregiver among cardiac patients. Ann Behav Med (2013) 0.84
Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study. Pharm Pract (Granada) (2014) 0.84
Use of statin therapy to reduce cardiovascular risk in older patients. Curr Gerontol Geriatr Res (2010) 0.84
Health and Economic Implications of National Treatment Coverage for Cardiovascular Disease in India: Cost-Effectiveness Analysis. Circ Cardiovasc Qual Outcomes (2015) 0.83
Persistence with statin therapy in Hungary. Arch Med Sci (2013) 0.83
Underuse of lipid-lowering drugs and factors associated with poor adherence: a real practice analysis in Italy. Eur J Clin Pharmacol (2005) 0.83
Secondary prevention by enhancing adherence in diabetic patients. Int J Prev Med (2010) 0.83
Statin therapy in patients with acute coronary syndrome: low-density lipoprotein cholesterol goal attainment and effect of statin potency. Ther Clin Risk Manag (2015) 0.83
Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med (2006) 10.58
Atrial fibrillation in patients with cryptogenic stroke. N Engl J Med (2014) 6.73
Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet (2006) 6.64
Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model. JAMA (2003) 6.39
A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ (2009) 6.21
A multicenter study of the coding accuracy of hospital discharge administrative data for patients admitted to cardiac care units in Ontario. Am Heart J (2002) 4.65
Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis. Lancet (2006) 4.42
Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study. Ann Intern Med (2013) 4.35
Comparison of coding of heart failure and comorbidities in administrative and clinical data for use in outcomes research. Med Care (2005) 4.30
Drug-drug interactions among elderly patients hospitalized for drug toxicity. JAMA (2003) 4.00
Warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis. Circulation (2014) 3.78
Atypical antipsychotics and risk of cerebrovascular accidents. Am J Psychiatry (2004) 3.71
Lipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradox. JAMA (2004) 3.61
Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation (2009) 3.55
Assessing the association of appropriateness of coronary revascularization and clinical outcomes for patients with stable coronary artery disease. J Am Coll Cardiol (2012) 3.45
Effect of socioeconomic status on treatment and mortality after stroke. Stroke (2002) 3.44
Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulated. Stroke (2008) 3.14
The risk of hip fracture after initiating antihypertensive drugs in the elderly. Arch Intern Med (2012) 3.10
Prognosis and determinants of survival in patients newly hospitalized for heart failure: a population-based study. Arch Intern Med (2002) 3.09
Risk-treatment mismatch in the pharmacotherapy of heart failure. JAMA (2005) 3.05
Socioeconomic status and mortality after acute myocardial infarction. Ann Intern Med (2006) 3.02
Rhythm versus rate control therapy and subsequent stroke or transient ischemic attack in patients with atrial fibrillation. Circulation (2012) 2.96
Comparing hierarchical modeling with traditional logistic regression analysis among patients hospitalized with acute myocardial infarction: should we be analyzing cardiovascular outcomes data differently? Am Heart J (2003) 2.88
Deriving ethnic-specific BMI cutoff points for assessing diabetes risk. Diabetes Care (2011) 2.87
Impact of hospital nursing care on 30-day mortality for acute medical patients. J Adv Nurs (2007) 2.85
Use of fibrates in the United States and Canada. JAMA (2011) 2.82
The frequency and characteristics of dietary supplement recalls in the United States. JAMA Intern Med (2013) 2.81
Prevalence, predictors, and outcomes of primary nonadherence after acute myocardial infarction. Circulation (2008) 2.76
Automated variable selection methods for logistic regression produced unstable models for predicting acute myocardial infarction mortality. J Clin Epidemiol (2004) 2.69
Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005. JAMA (2010) 2.61
Care and outcomes of patients newly hospitalized for heart failure in the community treated by cardiologists compared with other specialists. Circulation (2003) 2.61
Gaps in the evaluation and monitoring of new pharmaceuticals: proposal for a different approach. CMAJ (2003) 2.59
Administrative Data Feedback for Effective Cardiac Treatment: AFFECT, a cluster randomized trial. JAMA (2005) 2.54
Reader's guide to critical appraisal of cohort studies: 1. Role and design. BMJ (2005) 2.43
Nephrologist follow-up improves all-cause mortality of severe acute kidney injury survivors. Kidney Int (2013) 2.42
Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies. Circulation (2009) 2.40
The use of the propensity score for estimating treatment effects: administrative versus clinical data. Stat Med (2005) 2.31
Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction. Clin Chim Acta (2007) 2.31
Improved outcomes with early collaborative care of ambulatory heart failure patients discharged from the emergency department. Circulation (2010) 2.29
IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke. Circulation (2011) 2.29
Effectiveness of virtual reality using Wii gaming technology in stroke rehabilitation: a pilot randomized clinical trial and proof of principle. Stroke (2010) 2.28
Sex differences in carotid endarterectomy outcomes: results from the Ontario Carotid Endarterectomy Registry. Stroke (2003) 2.28
Continuity of care and patient outcomes after hospital discharge. J Gen Intern Med (2004) 2.26
Comparison of provincial prescription drug plans and the impact on patients' annual drug expenditures. CMAJ (2008) 2.23
The potential economic impact of restricted access to angiotensin-receptor blockers. CMAJ (2011) 2.22
Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysis. Circulation (2011) 2.17
Trends in risk factors for cardiovascular disease in Canada: temporal, socio-demographic and geographic factors. CMAJ (2009) 2.16
Population trends in BMD testing, treatment, and hip and wrist fracture rates: are the hip fracture projections wrong? J Bone Miner Res (2004) 2.15
Effect of cardiac and noncardiac conditions on survival after defibrillator implantation. J Am Coll Cardiol (2007) 2.15
Bundle branch block patterns and long-term outcomes in heart failure. Int J Cardiol (2010) 2.07
Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure. Circulation (2006) 2.05
Cardiovascular complications and mortality after diabetes diagnosis for South Asian and Chinese patients: a population-based cohort study. Diabetes Care (2013) 2.04
Prevalence and extent of obstructive coronary artery disease among patients undergoing elective coronary catheterization in New York State and Ontario. JAMA (2013) 2.03
Use of niacin in the United States and Canada. JAMA Intern Med (2013) 2.02
Long-term trends in use of and expenditures for cardiovascular medications in Canada. CMAJ (2009) 2.02
The striking effect of the Heart Outcomes Prevention Evaluation (HOPE) on ramipril prescribing in Ontario. CMAJ (2003) 1.94
Association between total duration of breastfeeding and iron deficiency. Pediatrics (2013) 1.93
Life expectancy after an index hospitalization for patients with heart failure: a population-based study. Am Heart J (2008) 1.92
Lifetime analysis of hospitalizations and survival of patients newly admitted with heart failure. Circ Heart Fail (2012) 1.92
New fibrate use and acute renal outcomes in elderly adults: a population-based study. Ann Intern Med (2012) 1.91
Comparison of cardiovascular risk profiles among ethnic groups using population health surveys between 1996 and 2007. CMAJ (2010) 1.85
Use of ezetimibe in the United States and Canada. N Engl J Med (2008) 1.85
Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study. BMJ (2005) 1.84
Cardiovascular disease and hypertension risk in living kidney donors: an analysis of health administrative data in Ontario, Canada. Transplantation (2008) 1.83
Early deaths in patients with heart failure discharged from the emergency department: a population-based analysis. Circ Heart Fail (2010) 1.83
Temporal trends in the use of percutaneous coronary intervention and coronary artery bypass surgery in New York State and Ontario. Circulation (2010) 1.82
Sex differences in implantable cardioverter-defibrillator outcomes: findings from a prospective defibrillator database. Ann Intern Med (2012) 1.80
Regional differences in process of care and outcomes for older acute myocardial infarction patients in the United States and Ontario, Canada. Circulation (2006) 1.78
Diuretic dose and long-term outcomes in elderly patients with heart failure after hospitalization. Am Heart J (2010) 1.76
Geography and service supply do not explain socioeconomic gradients in angiography use after acute myocardial infarction. CMAJ (2003) 1.76
Readers guide to critical appraisal of cohort studies: 3. Analytical strategies to reduce confounding. BMJ (2005) 1.76
Impact of the choice of benchmark on the conclusions of hospital report cards. Am Heart J (2004) 1.72
Hospitalization rates and length of stay for cardiovascular conditions in Canada, 1994 to 1999. Can J Cardiol (2003) 1.71
Emergency department triage of acute myocardial infarction patients and the effect on outcomes. Ann Emerg Med (2009) 1.71
Inpatient smoking-cessation counseling and all-cause mortality in patients with acute myocardial infarction. Am Heart J (2007) 1.69
The identification and development of Canadian coronary artery bypass graft surgery quality indicators. J Thorac Cardiovasc Surg (2005) 1.68
The effect of a charted history of depression on emergency department triage and outcomes in patients with acute myocardial infarction. CMAJ (2011) 1.66
Atypical antipsychotics and parkinsonism. Arch Intern Med (2005) 1.66
Impaired renal function modifies the risk of severe hypoglycaemia among users of insulin but not glyburide: a population-based nested case-control study. Nephrol Dial Transplant (2010) 1.65
Population rates of cardiac catheterization and yield of high-risk coronary artery disease. CMAJ (2005) 1.64
Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure. J Card Fail (2003) 1.64
The relationship between cow's milk and stores of vitamin D and iron in early childhood. Pediatrics (2012) 1.64
Time-related mortality for women after coronary artery bypass graft surgery: a population-based study. J Thorac Cardiovasc Surg (2004) 1.62
How many arterial grafts are enough? A population-based study of midterm outcomes. J Thorac Cardiovasc Surg (2006) 1.62
Factors explaining the under-use of reperfusion therapy among ideal patients with ST-segment elevation myocardial infarction. Eur Heart J (2006) 1.62
Meta-analysis: effects of percutaneous coronary intervention versus medical therapy on angina relief. Ann Intern Med (2010) 1.62
Waiting times, revascularization modality, and outcomes after acute myocardial infarction at hospitals with and without on-site revascularization facilities in Canada. J Am Coll Cardiol (2003) 1.58
Relation between cardiac troponin I and mortality in acute decompensated heart failure. Am Heart J (2007) 1.58
Predictors of short-term complications after implantable cardioverter-defibrillator replacement: results from the Ontario ICD Database. Circ Arrhythm Electrophysiol (2011) 1.58
Recent trends in cardiovascular complications among men and women with and without diabetes. Diabetes Care (2006) 1.57
Rescue angioplasty or repeat fibrinolysis after failed fibrinolytic therapy for ST-segment myocardial infarction: a meta-analysis of randomized trials. J Am Coll Cardiol (2007) 1.56
Neighborhood income and stroke care and outcomes. Neurology (2012) 1.56
Trends in cardiovascular drug utilization and drug expenditures in Canada between 1996 and 2001. Can J Cardiol (2003) 1.56
Relationship between preventability of death after coronary artery bypass graft surgery and all-cause risk-adjusted mortality rates. Circulation (2008) 1.56
Autoregression as a means of assessing the strength of seasonality in a time series. Popul Health Metr (2003) 1.55
Trends in heart failure outcomes and pharmacotherapy: 1992 to 2000. Am J Med (2004) 1.55