Published in N Engl J Med on July 20, 2006
Epidemiology and risk profile of heart failure. Nat Rev Cardiol (2010) 4.88
Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation (2009) 3.55
Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction. Circ Heart Fail (2010) 3.01
Progression of left ventricular diastolic dysfunction and risk of heart failure. JAMA (2011) 2.86
Association of the metabolic syndrome with pulmonary venous hypertension. Chest (2009) 2.75
Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol (2012) 2.56
Longitudinal changes in ejection fraction in heart failure patients with preserved and reduced ejection fraction. Circ Heart Fail (2012) 2.53
Heart failure and chronic obstructive pulmonary disease: diagnostic pitfalls and epidemiology. Eur J Heart Fail (2009) 2.51
Death in heart failure: a community perspective. Circ Heart Fail (2008) 2.46
Patterns of weight change preceding hospitalization for heart failure. Circulation (2007) 2.45
Epidemiology and clinical course of heart failure with preserved ejection fraction. Eur J Heart Fail (2010) 2.35
Incident heart failure prediction in the elderly: the health ABC heart failure score. Circ Heart Fail (2008) 2.33
Exercise training in patients with heart failure and preserved ejection fraction: meta-analysis of randomized control trials. Circ Heart Fail (2014) 2.30
Outcomes in ambulatory chronic systolic and diastolic heart failure: a propensity score analysis. Am Heart J (2006) 2.10
Effect of Selective Heart Rate Slowing in Heart Failure With Preserved Ejection Fraction. Circulation (2015) 2.02
Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin. Circulation (2015) 1.96
Lifetime analysis of hospitalizations and survival of patients newly admitted with heart failure. Circ Heart Fail (2012) 1.92
Multidimensional Prognostic Index based on a comprehensive geriatric assessment predicts short-term mortality in older patients with heart failure. Circ Heart Fail (2009) 1.83
Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging (2013) 1.82
A contemporary appraisal of the heart failure epidemic in Olmsted County, Minnesota, 2000 to 2010. JAMA Intern Med (2015) 1.79
The prognostic significance of respiratory rate in patients with pneumonia: a retrospective analysis of data from 705,928 hospitalized patients in Germany from 2010-2012. Dtsch Arztebl Int (2014) 1.79
Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum. Circulation (2011) 1.78
A longitudinal study of left ventricular function and structure from CKD to ESRD: the CRIC study. Clin J Am Soc Nephrol (2013) 1.72
Canadian Cardiovascular Society Consensus Conference recommendations on heart failure update 2007: Prevention, management during intercurrent illness or acute decompensation, and use of biomarkers. Can J Cardiol (2007) 1.70
Prognostic Importance of Impaired Systolic Function in Heart Failure With Preserved Ejection Fraction and the Impact of Spironolactone. Circulation (2015) 1.64
Baseline characteristics of patients in the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial. Circ Heart Fail (2012) 1.62
Outcomes in patients with heart failure treated in hospitals with varying admission rates: population-based cohort study. BMJ Qual Saf (2014) 1.61
Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies. Circ Res (2014) 1.56
A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: results of the Home-HF study. Eur J Heart Fail (2009) 1.55
Orthostatic hypotension as a risk factor for incident heart failure: the atherosclerosis risk in communities study. Hypertension (2012) 1.54
Resistive and pulsatile arterial load as predictors of left ventricular mass and geometry: the multi-ethnic study of atherosclerosis. Hypertension (2014) 1.54
Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community. Eur Heart J (2012) 1.53
Prognostic value of cardiopulmonary exercise testing in heart failure with preserved ejection fraction. The Henry Ford HospITal CardioPulmonary EXercise Testing (FIT-CPX) project. Am Heart J (2016) 1.47
Association of chronic kidney disease with abnormal cardiac mechanics and adverse outcomes in patients with heart failure and preserved ejection fraction. Eur J Heart Fail (2015) 1.47
beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. Sci Signal (2010) 1.45
Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study. Eur J Heart Fail (2012) 1.43
Cardiac structure and function in heart failure with preserved ejection fraction: baseline findings from the echocardiographic study of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial. Circ Heart Fail (2013) 1.40
One-Year Outcomes After Transcatheter Insertion of an Interatrial Shunt Device for the Management of Heart Failure With Preserved Ejection Fraction. Circ Heart Fail (2016) 1.39
Rationale and design of a multicenter echocardiographic study to assess the relationship between cardiac structure and function and heart failure risk in a biracial cohort of community-dwelling elderly persons: the Atherosclerosis Risk in Communities study. Circ Cardiovasc Imaging (2013) 1.37
Predictors of new-onset heart failure: differences in preserved versus reduced ejection fraction. Circ Heart Fail (2012) 1.35
Prevalence, clinical phenotype, and outcomes associated with normal B-type natriuretic peptide levels in heart failure with preserved ejection fraction. Am J Cardiol (2012) 1.28
Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction. J Am Coll Cardiol (2014) 1.27
Diastolic heart failure--a common and lethal condition by any name. N Engl J Med (2006) 1.27
Mechanisms of impaired calcium handling underlying subclinical diastolic dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol (2007) 1.25
Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction. Am Heart J (2012) 1.24
Prevalence and prognosis of asymptomatic left ventricular diastolic dysfunction in ambulatory patients with coronary heart disease. Am J Cardiol (2007) 1.18
Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study. Cardiovasc Diabetol (2010) 1.16
The relationship between systolic blood pressure on admission and mortality in older patients with heart failure. Eur J Heart Fail (2010) 1.12
Understanding the epidemic of heart failure: past, present, and future. Curr Heart Fail Rep (2014) 1.12
Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. J Am Coll Cardiol (2012) 1.12
The emerging epidemic of heart failure with preserved ejection fraction. Curr Heart Fail Rep (2013) 1.11
Maximum potential benefit of implantable defibrillators in preventing sudden death after hospital admission because of heart failure. CMAJ (2009) 1.10
Predictive value of beat-to-beat QT variability index across the continuum of left ventricular dysfunction: competing risks of noncardiac or cardiovascular death and sudden or nonsudden cardiac death. Circ Arrhythm Electrophysiol (2012) 1.09
The heart failure epidemic. Int J Environ Res Public Health (2010) 1.07
Developing therapies for heart failure with preserved ejection fraction: current state and future directions. JACC Heart Fail (2014) 1.07
Atrial fibrillation in congestive heart failure. Heart Fail Clin (2010) 1.07
Cardiac structure and function and prognosis in heart failure with preserved ejection fraction: findings from the echocardiographic study of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) Trial. Circ Heart Fail (2014) 1.06
Early detection of myocardial dysfunction and heart failure. Nat Rev Cardiol (2010) 1.06
Diastolic myofilament dysfunction in the failing human heart. Pflugers Arch (2011) 1.05
Changes in cardiac physiology after severe burn injury. J Burn Care Res (2011) 1.04
Heart failure with preserved ejection fraction in the elderly: scope of the problem. Heart Fail Rev (2012) 1.04
The disconnect between phase II and phase III trials of drugs for heart failure. Nat Rev Cardiol (2013) 1.03
Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. Circ Res (2014) 1.03
Diastolic dysfunction and mortality in early severe sepsis and septic shock: a prospective, observational echocardiography study. Crit Ultrasound J (2012) 1.02
Reliability of peak exercise testing in patients with heart failure with preserved ejection fraction. Am J Cardiol (2012) 1.00
Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways. J Am Heart Assoc (2013) 1.00
Cardio-renal syndromes: a systematic approach for consensus definition and classification. Heart Fail Rev (2012) 0.99
Age, increased left ventricular mass, and lower regional myocardial perfusion are related to greater extent of myocardial dyssynchrony in asymptomatic individuals: the multi-ethnic study of atherosclerosis. Circulation (2009) 0.99
Epidemiology, pathophysiology, and prognosis of heart failure in the elderly. Heart Fail Clin (2007) 0.98
Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure. Eur Heart J (2009) 0.98
The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction. J Am Heart Assoc (2013) 0.98
Heart failure in South Asia. Curr Cardiol Rev (2013) 0.97
Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction. Eur Heart J (2012) 0.96
Digoxin and reduction of heart failure hospitalization in chronic systolic and diastolic heart failure. Am J Cardiol (2008) 0.96
Patient selection in heart failure with preserved ejection fraction clinical trials. J Am Coll Cardiol (2015) 0.95
Rationale and design of the Karolinska-Rennes (KaRen) prospective study of dyssynchrony in heart failure with preserved ejection fraction. Eur J Heart Fail (2009) 0.95
Heart failure with preserved ejection fraction in African Americans: The ARIC (Atherosclerosis Risk In Communities) study. JACC Heart Fail (2013) 0.95
Heart failure with preserved ejection fraction. Glob Cardiol Sci Pract (2012) 0.94
Patterns of comorbidity in older adults with heart failure: the Cardiovascular Research Network PRESERVE study. J Am Geriatr Soc (2013) 0.93
Elastin overexpression by cell-based gene therapy preserves matrix and prevents cardiac dilation. J Cell Mol Med (2012) 0.93
Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction. Circ Heart Fail (2014) 0.93
Heart failure with preserved ejection fraction in the elderly: scope of the problem. J Mol Cell Cardiol (2015) 0.93
Secular trends of heart failure among US male physicians. Am Heart J (2007) 0.92
Enhanced resistance to permeability transition in interfibrillar cardiac mitochondria in dogs: effects of aging and long-term aldosterone infusion. Am J Physiol Heart Circ Physiol (2012) 0.92
Mechanisms of the cardiorenal syndromes. Nat Rev Nephrol (2009) 0.91
Diastolic dysfunction, cardiovascular aging, and the anesthesiologist. Anesthesiol Clin (2009) 0.91
Clinical variables affecting survival in patients with decompensated diastolic versus systolic heart failure. Clin Res Cardiol (2009) 0.91
The restoration of chronotropic competence in heart failure patients with normal ejection fraction (RESET) study: rationale and design. J Card Fail (2009) 0.91
Classification of diastolic function with phase-contrast cardiac magnetic resonance imaging: validation with echocardiography and age-related reference values. Clin Res Cardiol (2014) 0.91
Cystatin C concentration as a predictor of systolic and diastolic heart failure. J Card Fail (2008) 0.90
Cardiorenal syndrome in heart failure: a cardiologist's perspective. Can J Cardiol (2008) 0.90
Innate regeneration in the aging heart: healing from within. Mayo Clin Proc (2013) 0.89
Role of physical training in heart failure with preserved ejection fraction. Curr Heart Fail Rep (2012) 0.89
Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism. J Appl Physiol (1985) (2011) 0.89
Myocardial fibrosis induced by exposure to subclinical lipopolysaccharide is associated with decreased miR-29c and enhanced NOX2 expression in mice. PLoS One (2014) 0.89
Diastolic dysfunction is an independent predictor of cardiovascular events in incident dialysis patients with preserved systolic function. PLoS One (2015) 0.88
Office management of patients with diastolic heart failure. CMAJ (2009) 0.88
Left ventricular dysfunction as a risk factor for cardiovascular and noncardiovascular hospitalizations in African Americans. Am Heart J (2010) 0.88
Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med (2004) 11.44
Impracticability of informed consent in the Registry of the Canadian Stroke Network. N Engl J Med (2004) 9.85
Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet (2006) 6.64
Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model. JAMA (2003) 6.39
Adherence with statin therapy in elderly patients with and without acute coronary syndromes. JAMA (2002) 6.30
A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ (2009) 6.21
Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women. JAMA (2011) 5.33
A modification of the Elixhauser comorbidity measures into a point system for hospital death using administrative data. Med Care (2009) 5.13
Metformin use and all-cause and prostate cancer-specific mortality among men with diabetes. J Clin Oncol (2013) 4.75
Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study. BMJ (2010) 4.73
A multicenter study of the coding accuracy of hospital discharge administrative data for patients admitted to cardiac care units in Ontario. Am Heart J (2002) 4.65
Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort study. BMJ (2009) 4.44
Proportion of hospital readmissions deemed avoidable: a systematic review. CMAJ (2011) 4.37
Comparison of coding of heart failure and comorbidities in administrative and clinical data for use in outcomes research. Med Care (2005) 4.30
Reader's guide to critical appraisal of cohort studies: 2. Assessing potential for confounding. BMJ (2005) 3.94
Effect of age on stroke prevention therapy in patients with atrial fibrillation: the atrial fibrillation investigators. Stroke (2009) 3.89
Warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis. Circulation (2014) 3.78
Propensity score methods gave similar results to traditional regression modeling in observational studies: a systematic review. J Clin Epidemiol (2005) 3.76
Derivation and validation of an index to predict early death or unplanned readmission after discharge from hospital to the community. CMAJ (2010) 3.60
Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation (2009) 3.55
A multinational cohort study of in-center daily hemodialysis and patient survival. Kidney Int (2012) 3.47
Assessing the association of appropriateness of coronary revascularization and clinical outcomes for patients with stable coronary artery disease. J Am Coll Cardiol (2012) 3.45
Effect of socioeconomic status on treatment and mortality after stroke. Stroke (2002) 3.44
State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail (2008) 3.35
The PLAN score: a bedside prediction rule for death and severe disability following acute ischemic stroke. Arch Intern Med (2012) 3.26
Epidural anaesthesia and survival after intermediate-to-high risk non-cardiac surgery: a population-based cohort study. Lancet (2008) 3.22
Effect of discharge summary availability during post-discharge visits on hospital readmission. J Gen Intern Med (2002) 3.21
Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulated. Stroke (2008) 3.14
The risk of hip fracture after initiating antihypertensive drugs in the elderly. Arch Intern Med (2012) 3.10
Prognosis and determinants of survival in patients newly hospitalized for heart failure: a population-based study. Arch Intern Med (2002) 3.09
Effectiveness of public report cards for improving the quality of cardiac care: the EFFECT study: a randomized trial. JAMA (2009) 3.08
Risk-treatment mismatch in the pharmacotherapy of heart failure. JAMA (2005) 3.05
Socioeconomic status and mortality after acute myocardial infarction. Ann Intern Med (2006) 3.02
Levothyroxine dose and risk of fractures in older adults: nested case-control study. BMJ (2011) 2.97
Rhythm versus rate control therapy and subsequent stroke or transient ischemic attack in patients with atrial fibrillation. Circulation (2012) 2.96
National trends in rates of death and hospital admissions related to acute myocardial infarction, heart failure and stroke, 1994-2004. CMAJ (2009) 2.89
Comparing hierarchical modeling with traditional logistic regression analysis among patients hospitalized with acute myocardial infarction: should we be analyzing cardiovascular outcomes data differently? Am Heart J (2003) 2.88
Deriving ethnic-specific BMI cutoff points for assessing diabetes risk. Diabetes Care (2011) 2.87
Impact of hospital nursing care on 30-day mortality for acute medical patients. J Adv Nurs (2007) 2.85
Use of fibrates in the United States and Canada. JAMA (2011) 2.82
Prevalence, predictors, and outcomes of primary nonadherence after acute myocardial infarction. Circulation (2008) 2.76
Automated variable selection methods for logistic regression produced unstable models for predicting acute myocardial infarction mortality. J Clin Epidemiol (2004) 2.69
A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med (2004) 2.68
Association of temporal trends in risk factors and treatment uptake with coronary heart disease mortality, 1994-2005. JAMA (2010) 2.61
Care and outcomes of patients newly hospitalized for heart failure in the community treated by cardiologists compared with other specialists. Circulation (2003) 2.61
Administrative Data Feedback for Effective Cardiac Treatment: AFFECT, a cluster randomized trial. JAMA (2005) 2.54
Effectiveness and safety of drug-eluting stents in Ontario. N Engl J Med (2007) 2.50
Association of hospital spending intensity with mortality and readmission rates in Ontario hospitals. JAMA (2012) 2.47
Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies. Circulation (2009) 2.40
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med (2003) 2.38
Outcomes and processes of care related to preoperative medical consultation. Arch Intern Med (2010) 2.34
The use of the propensity score for estimating treatment effects: administrative versus clinical data. Stat Med (2005) 2.31
Effects of contemporary troponin assay sensitivity on the utility of the early markers myoglobin and CKMB isoforms in evaluating patients with possible acute myocardial infarction. Clin Chim Acta (2007) 2.31
Survival after implantable cardioverter-defibrillator implantation in the elderly. Circulation (2013) 2.30
Improved outcomes with early collaborative care of ambulatory heart failure patients discharged from the emergency department. Circulation (2010) 2.29
IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke. Circulation (2011) 2.29
Sex differences in carotid endarterectomy outcomes: results from the Ontario Carotid Endarterectomy Registry. Stroke (2003) 2.28
Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease: a population-based study. Arch Intern Med (2011) 2.27
Variation in the practice of preoperative medical consultation for major elective noncardiac surgery: a population-based study. Anesthesiology (2012) 2.26
Continuity of care and patient outcomes after hospital discharge. J Gen Intern Med (2004) 2.26
Comparison of provincial prescription drug plans and the impact on patients' annual drug expenditures. CMAJ (2008) 2.23
Preadmission antithrombotic treatment and stroke severity in patients with atrial fibrillation and acute ischaemic stroke: an observational study. Lancet Neurol (2006) 2.23
The potential economic impact of restricted access to angiotensin-receptor blockers. CMAJ (2011) 2.22
Myocarditis. Lancet (2011) 2.21
Angiotensin receptor blockers in heart failure: meta-analysis of randomized controlled trials. J Am Coll Cardiol (2002) 2.19
Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly. Arch Intern Med (2003) 2.18
Trends in risk factors for cardiovascular disease in Canada: temporal, socio-demographic and geographic factors. CMAJ (2009) 2.16
Effect of cardiac and noncardiac conditions on survival after defibrillator implantation. J Am Coll Cardiol (2007) 2.15
Intensive hemodialysis associates with improved survival compared with conventional hemodialysis. J Am Soc Nephrol (2012) 2.15
Surgical outcomes and transfusion of minimal amounts of blood in the operating room. Arch Surg (2012) 2.08
Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke (2005) 2.08