Published in Mol Biol Cell on July 01, 2002
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol (2003) 2.79
A non-proteolytic function of separase links the onset of anaphase to mitotic exit. Nat Cell Biol (2003) 2.57
A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase. J Cell Biol (2003) 2.51
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol (2004) 2.44
Cdc14 phosphatases preferentially dephosphorylate a subset of cyclin-dependent kinase (Cdk) sites containing phosphoserine. J Biol Chem (2011) 1.68
The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO J (2003) 1.49
The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. Mol Cell Biol (2005) 1.49
Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation. EMBO J (2004) 1.45
Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J Cell Biol (2010) 1.44
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev (2010) 1.38
The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1. J Cell Biol (2008) 1.38
CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes. Biol Reprod (2009) 1.19
Cdc28 and Cdc14 control stability of the anaphase-promoting complex inhibitor Acm1. J Biol Chem (2008) 1.12
Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. J Cell Biol (2008) 1.09
Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Mol Biol Cell (2009) 1.04
Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription. Nat Cell Biol (2011) 1.04
The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains. BMC Genomics (2007) 1.03
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity. PLoS One (2011) 1.01
Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. Mol Cell Biol (2011) 1.00
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways. Semin Cell Dev Biol (2012) 1.00
The molecular function of the yeast polo-like kinase Cdc5 in Cdc14 release during early anaphase. Mol Biol Cell (2009) 0.99
The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability. Mol Cell (2014) 0.98
The CDC14A phosphatase regulates oocyte maturation in mouse. Cell Cycle (2009) 0.93
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1. PLoS One (2009) 0.93
Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division. BMC Cell Biol (2004) 0.92
Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin. PLoS Genet (2009) 0.92
Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B. J Biol Chem (2010) 0.91
The Cdc14B phosphatase contributes to ciliogenesis in zebrafish. Development (2011) 0.91
Regulation of APC/C-Cdh1 and its function in neuronal survival. Mol Neurobiol (2012) 0.91
A decade of Cdc14--a personal perspective. Delivered on 9 July 2007 at the 32nd FEBS Congress in Vienna, Austria. FEBS J (2008) 0.87
The non-classical MAP kinase ERK3 controls T cell activation. PLoS One (2014) 0.86
The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast. Mol Biol Cell (2007) 0.86
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers. Mol Cancer (2006) 0.86
Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation. Mol Biol Cell (2012) 0.85
Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle. J Biol Chem (2008) 0.85
Identification of Cdk targets that control cytokinesis. EMBO J (2014) 0.82
Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos. Cell Cycle (2009) 0.82
Multiple protein kinases influence the redistribution of fission yeast Clp1/Cdc14 phosphatase upon genotoxic stress. Mol Biol Cell (2012) 0.79
Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis. Dev Dyn (2012) 0.79
Cytokinesis-required Cdc14 is a signaling hub of asexual development and multi-stress tolerance in Beauveria bassiana. Sci Rep (2013) 0.78
Cdc14 phosphatase: warning, no delay allowed for chromosome segregation! Curr Genet (2015) 0.78
A general strategy for studying multisite protein phosphorylation using label-free selected reaction monitoring mass spectrometry. Anal Biochem (2011) 0.78
Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans. Mech Dev (2011) 0.78
Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. Proc Natl Acad Sci U S A (2016) 0.78
Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation. J Biochem (2012) 0.77
The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae. Genetics (2015) 0.77
How to divorce engaged chromosomes? Mol Cell Biol (2005) 0.75
Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness. Am J Hum Genet (2016) 0.75
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92
Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol (2001) 9.18
A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell (1997) 8.97
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature (1989) 8.69
The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell (1998) 6.20
Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell (1999) 5.98
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev (1995) 5.55
Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature (1999) 5.49
Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science (1999) 4.69
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J (2002) 4.54
Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell (2002) 4.16
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev (1999) 4.07
Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol Biol Cell (2000) 4.01
Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell (1999) 3.98
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell (2000) 3.91
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol (1998) 3.72
Centrosome-dependent exit of cytokinesis in animal cells. Science (2001) 3.68
A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell (1998) 3.18
Cyclin-dependent kinase control of centrosome duplication. Proc Natl Acad Sci U S A (1999) 2.85
Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. Nat Cell Biol (2000) 2.73
Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN. Trends Cell Biol (2001) 2.47
"It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle. Genes Dev (2001) 2.46
The mouse Mps1p-like kinase regulates centrosome duplication. Cell (2001) 2.44
The dynamics of postmitotic reassembly of the nucleolus. J Cell Biol (2000) 2.41
Drosophila polo kinase is required for cytokinesis. J Cell Biol (1998) 2.30
Essential function of the polo box of Cdc5 in subcellular localization and induction of cytokinetic structures. Mol Cell Biol (2000) 2.07
Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression. Curr Biol (2001) 2.04
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol (2002) 1.99
Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit. Mol Cell Biol (2001) 1.81
Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. J Biol Chem (2001) 1.80
A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J Biol Chem (1997) 1.79
Order of function of the budding-yeast mitotic exit-network proteins Tem1, Cdc15, Mob1, Dbf2, and Cdc5. Curr Biol (2001) 1.76
CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. Mol Cell (2000) 1.69
Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication. J Cell Biol (2001) 1.66
Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis. J Cell Sci (2001) 1.63
A novel function of Saccharomyces cerevisiae CDC5 in cytokinesis. J Cell Biol (2001) 1.63
The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. J Biol Chem (1997) 1.54
Tying the knot: linking cytokinesis to the nuclear cycle. J Cell Sci (2000) 1.35
Centrosome duplication. a centriolar pas de deux. Cell (2001) 1.31
Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis. Curr Biol (2001) 1.22
Dynamics of the genome during early Xenopus laevis development: karyomeres as independent units of replication. J Cell Biol (1998) 1.16
The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. J Biol Chem (2000) 1.13
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell (2007) 10.75
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature (2011) 5.32
Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet (2010) 3.99
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev Cell (2003) 3.62
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev Cell (2003) 3.53
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol (2002) 3.46
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A (2012) 3.21
A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Dev Cell (2008) 3.17
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Mol Biol Cell (2004) 2.48
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc Natl Acad Sci U S A (2011) 2.44
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell (2013) 2.42
Emi1 is required for cytostatic factor arrest in vertebrate eggs. Nature (2002) 2.16
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev (2006) 2.16
An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes Dev (2011) 2.00
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol (2002) 1.99
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Mol Cell (2011) 1.92
Dual degradation signals control Gli protein stability and tumor formation. Genes Dev (2006) 1.75
High-throughput generation of tagged stable cell lines for proteomic analysis. Proteomics (2009) 1.68
Cdc14 phosphatases preferentially dephosphorylate a subset of cyclin-dependent kinase (Cdk) sites containing phosphoserine. J Biol Chem (2011) 1.68
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol (2013) 1.65
APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle (2010) 1.62
Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1). J Cell Biol (2007) 1.58
Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis. J Cell Biol (2006) 1.55
The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC. Mol Cell (2008) 1.52
Spongiform degeneration in mahoganoid mutant mice. Science (2003) 1.51
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell (2007) 1.51
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. Cell (2006) 1.47
A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs. Proc Natl Acad Sci U S A (2005) 1.45
The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells. Cell Cycle (2008) 1.33
Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. Proc Natl Acad Sci U S A (2007) 1.32
Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am J Pathol (2007) 1.28
A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. Curr Biol (2007) 1.27
Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex. BMC Mol Biol (2002) 1.24
A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium. Hum Mutat (2014) 1.21
CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit. Proc Natl Acad Sci U S A (2006) 1.20
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest (2010) 1.20
Accessory proteins for melanocortin signaling: attractin and mahogunin. Ann N Y Acad Sci (2003) 1.17
The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Dev Cell (2007) 1.16
Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). J Cell Biol (2006) 1.16
The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. Cell (2011) 1.16
Cdc28 and Cdc14 control stability of the anaphase-promoting complex inhibitor Acm1. J Biol Chem (2008) 1.12
Wagging the dogma; tissue-specific cell cycle control in the mouse embryo. Cell (2004) 1.09
Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. J Cell Biol (2005) 1.09
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. Proc Natl Acad Sci U S A (2007) 1.09
The tubby family proteins. Genome Biol (2011) 1.07
A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation. Mol Biol Cell (2010) 1.02
Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships. J Med Chem (2013) 1.02
A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles. Mol Biol Cell (2010) 0.98
Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor. Mol Cancer Ther (2013) 0.97
Do cilia put brakes on the cell cycle? Nat Cell Biol (2011) 0.97
Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells. Cell Cycle (2006) 0.96
Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence. Mol Cell Biol (2007) 0.95
A chemosensitization screen identifies TP53RK, a kinase that restrains apoptosis after mitotic stress. Cancer Res (2010) 0.95
Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900. Mol Cancer Ther (2013) 0.94
Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618. Neoplasia (2013) 0.94
Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics. PLoS One (2011) 0.92
Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division. BMC Cell Biol (2004) 0.92
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. Mol Biol Cell (2008) 0.92
Translational unmasking of Emi2 directs cytostatic factor arrest in meiosis II. Cell Cycle (2007) 0.90
Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14. J Biol Chem (2004) 0.90
Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. Mod Pathol (2008) 0.89
Emi1 class of proteins regulate entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes. Cell Cycle (2005) 0.89
Cilia - the prodigal organelle. Cilia (2012) 0.87
A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle (2013) 0.85
Emi2 at the crossroads: where CSF meets MPF. Cell Cycle (2007) 0.84
The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Dev Biol (2002) 0.83
Control of the centriole and centrosome cycles by ubiquitination enzymes. Oncogene (2002) 0.82
Screening of tissue microarrays for ubiquitin proteasome system components in tumors. Methods Enzymol (2005) 0.81
Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Nat Cell Biol (2015) 0.80
Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis. Cell Cycle (2015) 0.79
A general strategy for studying multisite protein phosphorylation using label-free selected reaction monitoring mass spectrometry. Anal Biochem (2011) 0.78
Stopping replication, at the beginning. Nat Chem Biol (2008) 0.78
Developmental neurobiology: a destructive switch for neurons. Nature (2006) 0.77
Putting transcription repression and protein destruction in pRb's pocket. Dev Cell (2007) 0.77
Corrigendum: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery. Nat Genet (2016) 0.76
Can Fizzy fly solo? Nat Cell Biol (2003) 0.75
Our thanks to Cilia's reviewers. Cilia (2013) 0.75
Biochemical analysis of the Anaphase Promoting Complex: activities of E2 enzymes and substrate competitive (pseudosubstrate) inhibitors. Methods Mol Biol (2009) 0.75
Measuring Activity and Specificity of Protein Phosphatases. Methods Mol Biol (2016) 0.75
Acknowledgement of Cilia's reviewers in 2013. Cilia (2014) 0.75