Published in Cell Cycle on March 14, 2007
Regulation of APC/C activators in mitosis and meiosis. Annu Rev Cell Dev Biol (2008) 2.46
The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC. Mol Cell (2008) 1.52
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. Proc Natl Acad Sci U S A (2007) 1.09
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases. J Biol Chem (2011) 0.94
Punctuated cyclin synthesis drives early embryonic cell cycle oscillations. Mol Biol Cell (2011) 0.84
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol (2005) 14.53
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell (2007) 10.75
Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science (2005) 6.88
A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature (2003) 6.25
Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol (2007) 6.11
Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol (2003) 5.86
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature (2011) 5.32
Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems. Proc Natl Acad Sci U S A (2004) 4.63
Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science (2008) 4.45
Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA. PLoS Biol (2009) 4.32
Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet (2010) 3.99
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev Cell (2003) 3.62
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev Cell (2003) 3.53
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Nat Cell Biol (2002) 3.46
Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS One (2008) 3.38
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A (2012) 3.21
A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Dev Cell (2008) 3.17
Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol (2003) 3.17
Systems-level dissection of the cell-cycle oscillator: bypassing positive feedback produces damped oscillations. Cell (2005) 3.10
Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell (2007) 2.88
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Mol Biol Cell (2004) 2.48
Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc Natl Acad Sci U S A (2011) 2.44
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell (2013) 2.42
Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron (2003) 2.36
Ultrasensitivity in the Regulation of Cdc25C by Cdk1. Mol Cell (2011) 2.27
Emi1 is required for cytostatic factor arrest in vertebrate eggs. Nature (2002) 2.16
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev (2006) 2.16
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Tuning the activation threshold of a kinase network by nested feedback loops. Science (2009) 2.03
An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes Dev (2011) 2.00
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Nat Cell Biol (2002) 1.99
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Mol Cell (2011) 1.92
The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses. Curr Biol (2003) 1.87
Tuning bulk electrostatics to regulate protein function. Cell (2007) 1.85
Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. Mol Biol Cell (2002) 1.81
Dual degradation signals control Gli protein stability and tumor formation. Genes Dev (2006) 1.75
Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol (2004) 1.74
High-throughput generation of tagged stable cell lines for proteomic analysis. Proteomics (2009) 1.68
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol (2013) 1.65
Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol (2007) 1.63
APC/C(Cdc20) targets E2F1 for degradation in prometaphase. Cell Cycle (2010) 1.62
Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1). J Cell Biol (2007) 1.58
Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Curr Biol (2008) 1.57
Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis. J Cell Biol (2006) 1.55
The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. Oncogene (2003) 1.55
The unique N terminus of the UbcH10 E2 enzyme controls the threshold for APC activation and enhances checkpoint regulation of the APC. Mol Cell (2008) 1.52
Spongiform degeneration in mahoganoid mutant mice. Science (2003) 1.51
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling. Cell (2007) 1.51
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. Cell (2006) 1.47
A mechanism for the evolution of phosphorylation sites. Cell (2011) 1.47
The Cdk1-APC/C cell cycle oscillator circuit functions as a time-delayed, ultrasensitive switch. Nat Cell Biol (2013) 1.46
A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs. Proc Natl Acad Sci U S A (2005) 1.45
Simple, realistic models of complex biological processes: positive feedback and bistability in a cell fate switch and a cell cycle oscillator. FEBS Lett (2009) 1.38
Multisite M-phase phosphorylation of Xenopus Wee1A. Mol Cell Biol (2005) 1.37
The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells. Cell Cycle (2008) 1.33
Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene. Proc Natl Acad Sci U S A (2007) 1.32
The roles of cyclin A2, B1, and B2 in early and late mitotic events. Mol Biol Cell (2010) 1.29
Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Am J Pathol (2007) 1.28
A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest. Curr Biol (2007) 1.27
Rapid cycling and precocious termination of G1 phase in cells expressing CDK1AF. Mol Biol Cell (2008) 1.27
Spatial positive feedback at the onset of mitosis. Cell (2012) 1.26
A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium. Hum Mutat (2014) 1.21
CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit. Proc Natl Acad Sci U S A (2006) 1.20
Minimizing off-target effects by using diced siRNAs for RNA interference. J RNAi Gene Silencing (2006) 1.20
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest (2010) 1.20
Accessory proteins for melanocortin signaling: attractin and mahogunin. Ann N Y Acad Sci (2003) 1.17
Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy. Nat Protoc (2006) 1.16
The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Dev Cell (2007) 1.16
Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). J Cell Biol (2006) 1.16
The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. Cell (2011) 1.16
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. Carcinogenesis (2003) 1.13
Wagging the dogma; tissue-specific cell cycle control in the mouse embryo. Cell (2004) 1.09
Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. J Cell Biol (2005) 1.09
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. Proc Natl Acad Sci U S A (2007) 1.09
The tubby family proteins. Genome Biol (2011) 1.07
Systems biology: On the cell cycle and its switches. Nature (2008) 1.02
A novel acetylation of β-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation. Mol Biol Cell (2010) 1.02
Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships. J Med Chem (2013) 1.02
Picking a winner: new mechanistic insights into the design of effective siRNAs. Trends Biotechnol (2004) 1.00
Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle. Nature (2013) 1.00
Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cell Cycle (2005) 0.99
A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles. Mol Biol Cell (2010) 0.98
Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor. Mol Cancer Ther (2013) 0.97
Activation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytes. Mol Biol Cell (2002) 0.97
Do cilia put brakes on the cell cycle? Nat Cell Biol (2011) 0.97