Published in Development on August 01, 2002
Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol (2011) 3.51
Lamin B1 is required for mouse development and nuclear integrity. Proc Natl Acad Sci U S A (2004) 2.89
Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies. J Anat (2005) 2.58
Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud. Dev Biol (2004) 2.39
FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev (2005) 1.99
Development of the endochondral skeleton. Cold Spring Harb Perspect Biol (2013) 1.89
Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms. J Clin Invest (2008) 1.87
A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A (2004) 1.71
Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci (2007) 1.61
An essential role for FGF receptor signaling in lens development. Semin Cell Dev Biol (2006) 1.58
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol (2008) 1.58
Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly. J Cell Biol (2003) 1.55
An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature (2008) 1.55
FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell (2009) 1.53
A dosage-dependent role for Spry2 in growth and patterning during palate development. Mech Dev (2007) 1.51
Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. Proc Natl Acad Sci U S A (2007) 1.44
Development and tissue origins of the mammalian cranial base. Dev Biol (2008) 1.36
Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation. Dev Biol (2006) 1.35
Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol (2009) 1.24
Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr (2009) 1.11
Comprehensive functional annotation of seventy-one breast cancer risk Loci. PLoS One (2013) 1.10
Fgf-9 is required for angiogenesis and osteogenesis in long bone repair. Proc Natl Acad Sci U S A (2010) 1.07
Growth of cranial synchondroses and sutures requires polycystin-1. Dev Biol (2008) 1.06
Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway. Mol Cell Biol (2007) 1.05
Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Dev Dyn (2011) 1.04
Fibroblast growth factor signaling in skeletal development and disease. Genes Dev (2015) 1.04
Brain phenotypes in two FGFR2 mouse models for Apert syndrome. Dev Dyn (2010) 1.02
Roles of FGF signaling in stem cell self-renewal, senescence and aging. Aging (Albany NY) (2011) 1.02
Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Am J Hum Genet (2012) 1.02
FGF-10 and specific structural elements of dermatan sulfate size and sulfation promote maximal keratinocyte migration and cellular proliferation. Wound Repair Regen (2009) 0.99
Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3. Proc Natl Acad Sci U S A (2007) 0.99
Identification of mechanosensitive genes during embryonic bone formation. PLoS Comput Biol (2008) 0.99
Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn (2009) 0.97
FGF9 can induce endochondral ossification in cranial mesenchyme. BMC Dev Biol (2006) 0.96
Nuclear factor Y is required for basal activation and chromatin accessibility of fibroblast growth factor receptor 2 promoter in osteoblast-like cells. J Biol Chem (2008) 0.95
Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models. Bone Res (2014) 0.95
Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones. Cells Tissues Organs (2009) 0.95
Epithelial mesenchymal interactions, the ECM and limb development. J Anat (2003) 0.94
Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription. Hum Mol Genet (2014) 0.92
Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection. PLoS One (2010) 0.91
A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage. Development (2014) 0.90
p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice. J Clin Invest (2012) 0.90
Adipose-derived stem cells: a review of signaling networks governing cell fate and regenerative potential in the context of craniofacial and long bone skeletal repair. Int J Mol Sci (2014) 0.87
Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer. J Nucleic Acids (2011) 0.86
Cranial bone morphometric study among mouse strains. BMC Evol Biol (2008) 0.86
Postnatal brain and skull growth in an Apert syndrome mouse model. Am J Med Genet A (2013) 0.86
Delineation of in vitro chondrogenesis of human synovial stem cells following preconditioning using decellularized matrix. Acta Biomater (2015) 0.84
The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells. Oncotarget (2015) 0.84
Alternative splicing in oncogenic kinases: from physiological functions to cancer. J Nucleic Acids (2011) 0.83
The Fgfr2 W290R mouse model of Crouzon syndrome. Childs Nerv Syst (2012) 0.83
Exogenous addition of a C-xylopyranoside derivative stimulates keratinocyte dermatan sulfate synthesis and promotes migration. PLoS One (2011) 0.82
The role of vertebrate models in understanding craniosynostosis. Childs Nerv Syst (2012) 0.82
Roles of FGFR3 during morphogenesis of Meckel's cartilage and mandibular bones. Dev Biol (2008) 0.81
Developmental Regulation of the Growth Plate and Cranial Synchondrosis. J Dent Res (2016) 0.81
Frontal nasal prominence expression driven by Tcfap2a relies on a conserved binding site for STAT proteins. Dev Dyn (2006) 0.80
Alternative splicing in bone following mechanical loading. Bone (2010) 0.80
FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth. Development (2016) 0.80
Localization of Thy-1-positive cells in the perichondrium during endochondral ossification. J Histochem Cytochem (2010) 0.79
Genetic insights into the mechanisms of Fgf signaling. Genes Dev (2016) 0.79
Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation. Dev Dyn (2015) 0.78
Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation. PLoS One (2015) 0.78
Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time. Curr Top Dev Biol (2015) 0.77
Controlled release of growth factors on allograft bone in vitro. Clin Orthop Relat Res (2008) 0.77
The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling. Development (2014) 0.77
Wnt/β-catenin signaling and Msx1 promote outgrowth of the maxillary prominences. Front Physiol (2012) 0.76
Gene-set based genome-wide association analysis for the speed of sound in two skeletal sites of Korean women. BMB Rep (2014) 0.75
Signaling networks in joint development. Dev Dyn (2016) 0.75
Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme. Biol Open (2017) 0.75
FGFR2 mutation in 46,XY sex reversal with craniosynostosis. Hum Mol Genet (2015) 0.75
Targeted sequencing in FGF/FGFR genes and association analysis of variants for mandibular prognathism. Medicine (Baltimore) (2017) 0.75
Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions. PLoS One (2017) 0.75
Tissue origins and interactions in the mammalian skull vault. Dev Biol (2002) 3.95
Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proc Natl Acad Sci U S A (2004) 2.01
Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone. Am J Physiol Heart Circ Physiol (2008) 1.79
A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A (2004) 1.71
Bone Gla protein increases HIF-1alpha-dependent glucose metabolism and induces cartilage and vascular calcification. Arterioscler Thromb Vasc Biol (2011) 1.69
The influence of severe prolonged exercise restriction on the mechanical and structural properties of bone in an avian model. Vet J (2009) 1.47
Expression and biological role of laminin-1. Matrix Biol (2003) 1.45
Computational mouse atlases and their application to automatic assessment of craniofacial dysmorphology caused by the Crouzon mutation Fgfr2(C342Y). J Anat (2007) 1.15
Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone. Neuromuscul Disord (2008) 1.15
Th17 cells and IL-17 in protective immunity to vaginal candidiasis. PLoS One (2011) 1.12
Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome. Dev Dyn (2009) 1.11
Distinct GATA6- and laminin-dependent mechanisms regulate endodermal and ectodermal embryonic stem cell fates. Development (2004) 1.08
Growth inhibition of prostate cancer xenografts by halofuginone. Prostate (2002) 1.07
Differential activation of cysteine-substitution mutants of fibroblast growth factor receptor 3 is determined by cysteine localization. J Bone Miner Res (2002) 1.07
Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly. Proc Natl Acad Sci U S A (2005) 1.07
Prevention of liver cirrhosis in rats by curcumin. Liver Int (2007) 1.05
A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression. Blood (2007) 1.04
Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation. J Anat (2004) 1.02
Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. J Cell Sci (2006) 1.00
Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev (2008) 0.99
Prevention of fibrosis in experimental colitis by captopril: the role of tgf-beta1. Inflamm Bowel Dis (2004) 0.98
Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: effect on myotube fusion. Exp Cell Res (2010) 0.98
A point-wise quantification of asymmetry using deformation fields: application to the study of the Crouzon mouse model. Med Image Comput Comput Assist Interv (2007) 0.97
Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention. Pancreas (2009) 0.96
Expression of the ERK-specific MAP kinase phosphatase PYST1/MKP3 in mouse embryos during morphogenesis and early organogenesis. Mech Dev (2002) 0.95
Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect. Mol Cancer Ther (2007) 0.93
Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development. Pancreas (2010) 0.93
Mechanism of skull suture maintenance and interdigitation. J Anat (2009) 0.91
Nprl3 is required for normal development of the cardiovascular system. Mamm Genome (2012) 0.90
Effect of peripherally administered leptin antagonist on whole body metabolism and bone microarchitecture and biomechanical properties in the mouse. Am J Physiol Endocrinol Metab (2013) 0.87
Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. Neoplasia (2006) 0.87
Novel roles of Fgfr2 in AER differentiation and positioning of the dorsoventral limb interface. Development (2003) 0.87
Interleukin-1β promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving down-regulation of FGFR-3 and p21. Endocrinology (2012) 0.87
Treatment with halofuginone results in marked growth inhibition of a von Hippel-Lindau pheochromocytoma in vivo. Clin Cancer Res (2003) 0.86
Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. Dig Dis Sci (2008) 0.86
The role of intravenous immunoglobulin therapy in mediating skin fibrosis in tight skin mice. Arthritis Rheum (2002) 0.85
Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression. J Urol (2005) 0.85
Fibrosis inhibition and muscle histopathology improvement in laminin-alpha2-deficient mice. Muscle Nerve (2010) 0.85
Hydrodynamics based transfection in normal and fibrotic rats. World J Gastroenterol (2006) 0.85
Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors. Anat Embryol (Berl) (2004) 0.85
The involvement of collagen triple helix repeat containing 1 in muscular dystrophies. Am J Pathol (2012) 0.85
Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents. Br J Haematol (2012) 0.85
Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats. Lab Invest (2008) 0.84
Comparison of structural, architectural and mechanical aspects of cellular and acellular bone in two teleost fish. J Exp Biol (2012) 0.84
Prevention of esophageal strictures in a caustic burn model using halofuginone, an inhibitor of collagen type I synthesis. Laryngoscope (2005) 0.83
The effect of weight loading and subsequent release from loading on the postnatal skeleton. Bone (2008) 0.83
Enhancement of oligodendrocyte differentiation from murine embryonic stem cells by an activator of gp130 signaling. Stem Cells (2004) 0.83
Mechanical strain regulation of the chicken glypican-4 gene expression in the avian eggshell gland. Am J Physiol Regul Integr Comp Physiol (2002) 0.83
Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment? Neoplasia (2008) 0.83
Involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis effect of halofuginone. Cell Tissue Res (2006) 0.82
Halofuginone inhibits tumor growth in the polyoma middle T antigen mouse via a thrombospondin-1 independent mechanism. Cancer Biol Ther (2006) 0.82
A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint. Cell Mol Life Sci (2013) 0.82
Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats. Can J Gastroenterol (2012) 0.82
Involvement of host stroma cells and tissue fibrosis in pancreatic tumor development in transgenic mice. PLoS One (2012) 0.81
Inhibition of muscle fibrosis and improvement of muscle histopathology in dysferlin knock-out mice treated with halofuginone. Histol Histopathol (2013) 0.81
Developmental mechanisms underlying polydactyly in the mouse mutant Doublefoot. J Anat (2003) 0.81
Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism. Arthritis Rheum (2002) 0.81
Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats. J Hepatol (2002) 0.81
Effect of halofuginone on the development of tight skin (TSK) syndrome. Autoimmunity (2002) 0.80
A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis. Liver Int (2004) 0.79
1,25(OH)2D3 alters growth plate maturation and bone architecture in young rats with normal renal function. PLoS One (2011) 0.79
Halofuginone prevents subglottic stenosis in a canine model. Ann Otol Rhinol Laryngol (2006) 0.78
The growth plate's response to load is partially mediated by mechano-sensing via the chondrocytic primary cilium. Cell Mol Life Sci (2014) 0.78
Inhibition of rat renal fibroblast proliferation by halofuginone. Nephron Exp Nephrol (2006) 0.78
IL-1RI participates in normal growth plate development and bone modeling. Am J Physiol Endocrinol Metab (2013) 0.78
Hsp90 and angiogenesis in bone disorders--lessons from the avian growth plate. Am J Physiol Regul Integr Comp Physiol (2011) 0.78
Halofuginone, an inhibitor of collagen synthesis by rat stellate cells, stimulates insulin-like growth factor binding protein-1 synthesis by hepatocytes. J Hepatol (2004) 0.78
Generation and phenotypic analysis of CHIF knockout mice. Am J Physiol Renal Physiol (2002) 0.77
Growth hormone (GH) action in the brain: neural expression of a GH-response gene. J Mol Neurosci (2002) 0.77
Acidic peptide hydrogel scaffolds enhance calcium phosphate mineral turnover into bone tissue. Acta Biomater (2012) 0.77
The role of matrix gla protein in ossification and recovery of the avian growth plate. Front Endocrinol (Lausanne) (2012) 0.76
Expression of hindbrain boundary markers is regulated by FGF3. Biol Open (2011) 0.76
Leptin administration affects growth and skeletal development in a rat intrauterine growth restriction model: preliminary study. Nutrition (2011) 0.75
A new role of the membrane-type matrix metalloproteinase 16 (MMP16/MT3-MMP) in neural crest cell migration. Int J Dev Biol (2017) 0.75
Validation of a Nutritional Screening Tool for Ambulatory Use in Pediatrics. J Pediatr Gastroenterol Nutr (2016) 0.75