Published in Nature on June 25, 2008
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17
Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res (2009) 3.66
Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nat Rev Genet (2009) 2.67
Tissue remodelling through branching morphogenesis. Nat Rev Mol Cell Biol (2009) 2.06
Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy. Genes Dev (2014) 1.57
FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell (2009) 1.53
Activation of host wound responses in breast cancer microenvironment. Clin Cancer Res (2009) 1.45
Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system. Cold Spring Harb Perspect Biol (2009) 1.31
LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth. Development (2009) 1.13
Temporal control of self-organized pattern formation without morphogen gradients in bacteria. Mol Syst Biol (2013) 1.11
Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B. Hum Mol Genet (2010) 1.07
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell (2012) 1.07
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00
SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development (2011) 0.95
Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs. Am J Respir Cell Mol Biol (2010) 0.92
Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A (2010) 0.92
Tgfbeta2 and 3 are coexpressed with their extracellular regulator Ltbp1 in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos. BMC Dev Biol (2010) 0.92
Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds. BMC Dev Biol (2012) 0.90
Biological determinants of bladder cancer gene expression subtypes. Sci Rep (2015) 0.90
The interplay between morphogens and tissue growth. EMBO Rep (2011) 0.89
DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis. Development (2009) 0.89
Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth. Dev Dyn (2011) 0.89
CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1. Nat Commun (2015) 0.88
A new molecular logic for BMP-mediated dorsoventral patterning in the leech Helobdella. Curr Biol (2011) 0.87
Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet (2013) 0.86
SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res (2015) 0.85
Early dioxin exposure causes toxic effects in adult zebrafish. Toxicol Sci (2013) 0.85
Digit patterning during limb development as a result of the BMP-receptor interaction. Sci Rep (2012) 0.85
Molecular regulation of limb growth. J Bone Joint Surg Am (2009) 0.84
A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration. Mol Biol Evol (2015) 0.83
Hand/foot splitting and the 're-evolution' of mesopodial skeletal elements during the evolution and radiation of chameleons. BMC Evol Biol (2015) 0.82
Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly. Dev Biol (2014) 0.82
Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway. Dev Biol (2014) 0.81
Hedgehog Signaling during Appendage Development and Regeneration. Genes (Basel) (2015) 0.80
Molecular anatomy of the developing limb in the coquí frog, Eleutherodactylus coqui. Evol Dev (2012) 0.80
Dynamics of BMP signaling in limb bud mesenchyme and polydactyly. Dev Biol (2014) 0.80
A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud. Development (2014) 0.79
Hedgehog and Wnt coordinate signaling in myogenic progenitors and regulate limb regeneration. Dev Biol (2012) 0.77
Negative Smad expression and regulation in the developing chick limb. PLoS One (2009) 0.77
ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling. Cell Rep (2014) 0.77
Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol (2015) 0.77
Timed deletion of Twist1 in the limb bud reveals age-specific impacts on autopod and zeugopod patterning. PLoS One (2014) 0.77
Saunders's framework for understanding limb development as a platform for investigating limb evolution. Dev Biol (2016) 0.76
Attenuation of bone morphogenetic protein signaling during amphibian limb development results in the generation of stage-specific defects. J Anat (2013) 0.76
Sonic Hedgehog Signaling in Limb Development. Front Cell Dev Biol (2017) 0.75
Transcriptomic insights into the genetic basis of mammalian limb diversity. BMC Evol Biol (2017) 0.75
Different regulation of limb development by p63 transcript variants. PLoS One (2017) 0.75
Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet (2016) 0.75
Intrinsic properties of limb bud cells can be differentially reset. Development (2017) 0.75
Fundamental ratios and logarithmic periodicity in human limb bones. J Anat (2013) 0.75
Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin. PLoS One (2015) 0.75
John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work? Dev Biol (2017) 0.75
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development (1999) 3.84
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82
Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature (2002) 3.47
Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet (2006) 3.27
Generation of Bmpr/Alk3 conditional knockout mice. Genesis (2002) 2.71
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature (1999) 2.69
On the mechanism of wing size determination in fly development. Proc Natl Acad Sci U S A (2007) 2.62
Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet (2000) 2.59
Fgf8 signalling from the AER is essential for normal limb development. Nat Genet (2000) 2.44
Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development (2004) 2.39
Measuring dimensions: the regulation of size and shape. Development (2000) 2.33
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet (2003) 2.31
Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet (2000) 2.18
The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development (2002) 2.04
The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. Development (1999) 1.96
Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. Mol Cell (1999) 1.81
Model for the regulation of size in the wing imaginal disc of Drosophila. Mech Dev (2006) 1.76
Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. Dev Biol (2004) 1.41
The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science (2004) 1.40
BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling. Development (2007) 1.35
Fgf signaling controls the number of phalanges and tip formation in developing digits. Curr Biol (2003) 1.35
BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development (1999) 1.29
Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function. Development (2005) 1.24
Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling. Development (2006) 1.22
BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning. Dev Biol (2006) 1.20
Generation of Fgfr1 conditional knockout mice. Genesis (2002) 1.18
Regulation of Gremlin expression in the posterior limb bud. Dev Biol (2006) 1.12
Cell proliferation in the attainment of constant sizes and shapes: the Entelechia model. Int J Dev Biol (1998) 1.10
Interplay between the molecular signals that control vertebrate limb development. Int J Dev Biol (2002) 1.07
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus. Nat Genet (2009) 5.75
A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds. N Engl J Med (2015) 5.28
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid. J Clin Epidemiol (2011) 2.69
The setpoint study (ACTG A5217): effect of immediate versus deferred antiretroviral therapy on virologic set point in recently HIV-1-infected individuals. J Infect Dis (2011) 2.26
Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell (2013) 2.16
Sleep-induced hypoxaemia in patients with chronic obstructive pulmonary disease. Br J Hosp Med (Lond) (2013) 2.04
Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells. Cancer Res (2003) 2.00
Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Med (2011) 1.96
Potential impact on estimated treatment effects of information lost to follow-up in randomised controlled trials (LOST-IT): systematic review. BMJ (2012) 1.85
Identification of transcriptional regulators in the mouse immune system. Nat Immunol (2013) 1.79
beta-Catenin promotes respiratory progenitor identity in mouse foregut. Proc Natl Acad Sci U S A (2009) 1.75
Mortality and treatment outcomes of China's National Pediatric antiretroviral therapy program. Clin Infect Dis (2012) 1.61
FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell (2009) 1.53
A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Genes Dev (2004) 1.42
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development (2011) 1.37
Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev (2011) 1.36
Recent advances in the genetics of systemic lupus erythematosus. Expert Rev Clin Immunol (2010) 1.35
LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact. Trials (2009) 1.32
Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet (2009) 1.31
Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development (2005) 1.27
Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci U S A (2007) 1.26
Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats. Arthritis Rheum (2003) 1.26
Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse brain neurons. Int J Biochem Cell Biol (2007) 1.22
Addressing continuous data for participants excluded from trial analysis: a guide for systematic reviewers. J Clin Epidemiol (2013) 1.14
Assessment of atrial electromechanical coupling and influential factors in nonrheumatic paroxysmal atrial fibrillation. Clin Cardiol (2008) 1.13
Immunoglobulin gene transcripts have distinct VHDJH recombination characteristics in human epithelial cancer cells. J Biol Chem (2009) 1.13
Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn (2009) 1.11
The GRADE approach is reproducible in assessing the quality of evidence of quantitative evidence syntheses. J Clin Epidemiol (2013) 1.11
Learning from failure--rationale and design for a study about discontinuation of randomized trials (DISCO study). BMC Med Res Methodol (2012) 1.10
Immunoglobulin mRNA and protein expression in human oral epithelial tumor cells. Appl Immunohistochem Mol Morphol (2008) 1.09
The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies. Front Genet (2013) 1.08
Consensus-based recommendations for investigating clinical heterogeneity in systematic reviews. BMC Med Res Methodol (2013) 1.07
Hepatitis B and hepatitis C seroprevalence in children receiving antiretroviral therapy for human immunodeficiency virus-1 infection in China, 2005-2009. J Acquir Immune Defic Syndr (2010) 1.06
Completion and Publication Rates of Randomized Controlled Trials in Surgery: An Empirical Study. Ann Surg (2015) 1.06
CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer. Cancer Res (2013) 1.05
Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK. Am J Physiol Endocrinol Metab (2007) 1.05
Patterning and plasticity in development of the respiratory lineage. Dev Dyn (2010) 1.05
HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles. Genes Dev (2014) 1.03
Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications. BMJ (2014) 1.03
Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development (2010) 1.02
Histidine-tryptophan-ketoglutarate solution vs. University of Wisconsin solution for liver transplantation: a systematic review. Liver Transpl (2007) 1.01
Postpartum viral load rebound in HIV-1-infected women treated with highly active antiretroviral therapy: AIDS Clinical Trials Group Protocol A5150. HIV Clin Trials (2011) 1.01
Progress of the National Pediatric Free Antiretroviral Therapy program in China. AIDS Care (2010) 1.00
Collagen XVIII, a basement membrane heparan sulfate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1. J Biol Chem (2003) 1.00
Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus. Bioresour Technol (2008) 0.99
Roundabout receptors are critical for foregut separation from the body wall. Dev Cell (2013) 0.98
Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein. Mol Biol Cell (2006) 0.98
The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS One (2012) 0.98
A comparison of job satisfaction of community health workers before and after local comprehensive medical care reform: a typical field investigation in Central China. PLoS One (2013) 0.98
A p50-like Y-box protein with a putative translational role becomes associated with pre-mRNA concomitant with transcription. J Cell Sci (2003) 0.97
Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn (2009) 0.97
Analysis of patient dose in full field digital mammography. Eur J Radiol (2011) 0.96
Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning. Dev Biol (2013) 0.96
Drug resistance profiles among HIV-1-infected children experiencing delayed switch and 12-month efficacy after using second-line antiretroviral therapy: an observational cohort study in rural China. J Acquir Immune Defic Syndr (2011) 0.95
Differentiation of human bone marrow mesenchymal stem cells into neuron-like cells in vitro. Spine (Phila Pa 1976) (2011) 0.95
Opaque7 encodes an acyl-activating enzyme-like protein that affects storage protein synthesis in maize endosperm. Genetics (2011) 0.95
Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein. J Cell Mol Med (2013) 0.94
Phototoxicity and environmental transformation of polycyclic aromatic hydrocarbons (PAHs)-light-induced reactive oxygen species, lipid peroxidation, and DNA damage. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev (2012) 0.93
The long-term effects of bariatric surgery for type 2 diabetes: systematic review and meta-analysis of randomized and non-randomized evidence. Obes Surg (2015) 0.93
Detection and photodynamic therapy of inflamed atherosclerotic plaques in the carotid artery of rabbits. J Photochem Photobiol B (2010) 0.93
Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway. Brain Res (2011) 0.92
Protective effect of tetrahydroxystilbene glucoside on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway. PLoS One (2011) 0.92
Outcome of surgical treatment of pelvic osteosarcoma. J Surg Oncol (2012) 0.92
Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn (2012) 0.91
Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia (2014) 0.91
Crosstalk between ABA and auxin signaling pathways in roots of Arabidopsis thaliana (L.) Heynh. Planta (2005) 0.91
Tensile strain switched ferromagnetism in layered NbS2 and NbSe2. ACS Nano (2012) 0.91
G-protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nat Commun (2010) 0.91
Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells. Nat Commun (2013) 0.90
Transcriptome-wide analysis of dynamic variations in regulation modes of grapevine microRNAs on their target genes during grapevine development. Plant Mol Biol (2013) 0.89
The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol (2011) 0.89
Identification of an N-terminal truncation of the NF-κB p65 subunit that specifically modulates ribosomal protein S3-dependent NF-κB gene expression. J Biol Chem (2012) 0.89
Molecular determinants of lung development. Ann Am Thorac Soc (2013) 0.89
Isolation and molecular characterization of GmERF7, a soybean ethylene-response factor that increases salt stress tolerance in tobacco. Gene (2012) 0.89
Purification, chemical characterization and radical scavenging activities of alkali-extracted polysaccharide fractions isolated from the fruit bodies of Tricholoma matsutake. World J Microbiol Biotechnol (2012) 0.89
Establishment of smooth muscle and cartilage juxtaposition in the developing mouse upper airways. Proc Natl Acad Sci U S A (2013) 0.88
The value of serum Cyfra21-1 as a biomarker in the diagnosis of patients with non-small cell lung cancer: a meta-analysis. J Cancer Res Ther (2014) 0.88
Hydrogen sulfide improves wound healing via restoration of endothelial progenitor cell functions and activation of angiopoietin-1 in type 2 diabetes. Diabetes (2014) 0.88
Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis. J Biol Chem (2006) 0.88
Expression of the apoptosis-related genes BCL-2 and BAD in human breast carcinoma and their associated relationship with chemosensitivity. J Exp Clin Cancer Res (2010) 0.88
Tissue crosstalk in lung development. J Cell Biochem (2014) 0.88
The accuracy of echocardiography versus surgical and pathological classification of patients with ruptured mitral chordae tendineae: a large study in a Chinese cardiovascular center. J Cardiothorac Surg (2011) 0.88
Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-α. J Exp Clin Cancer Res (2011) 0.88
Comparison of different threshold values r for approximate entropy: application to investigate the heart rate variability between heart failure and healthy control groups. Physiol Meas (2010) 0.87
A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol. Syst Rev (2013) 0.87
Intralesional excision versus wide resection for giant cell tumor involving the acetabulum: which is better? Clin Orthop Relat Res (2011) 0.87
Reconstruction with constrained prosthesis after total scapulectomy. J Shoulder Elbow Surg (2011) 0.87
Pathologic fracture does not influence local recurrence and survival in high-grade extremity osteosarcoma with adequate surgical margins. J Surg Oncol (2012) 0.87
Immunomodulatory and antitumor activities of grape seed proanthocyanidins. J Agric Food Chem (2011) 0.87
Effect of low-molecular-weight heparin and urokinase on pulmonary arteries involved in pulmonary embolism. Chin Med J (Engl) (2013) 0.86
Semi-recumbent position versus supine position for the prevention of ventilator-associated pneumonia in adults requiring mechanical ventilation. Cochrane Database Syst Rev (2016) 0.86
Grapevine microRNAs responsive to exogenous gibberellin. BMC Genomics (2014) 0.85
Interventions to enhance self management support. BMJ (2013) 0.85
Prevalence of dyssynchrony derived from echocardiographic criteria in heart failure patients with normal or prolonged QRS duration. Echocardiography (2007) 0.85
Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry. Methods Mol Biol (2011) 0.85
Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers. Chem Pharm Bull (Tokyo) (2010) 0.84
Randomized trials published in higher vs. lower impact journals differ in design, conduct, and analysis. J Clin Epidemiol (2013) 0.84
Apoptosis of THP-1 macrophages induced by protoporphyrin IX-mediated sonodynamic therapy. Int J Nanomedicine (2013) 0.84