Published in Circ Res on July 26, 2002
Rho kinase in the regulation of cell death and survival. Arch Immunol Ther Exp (Warsz) (2007) 1.60
Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. Br J Pharmacol (2004) 1.48
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist (2007) 1.38
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. J Cardiovasc Pharmacol (2013) 1.24
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell (2011) 1.24
Rho kinase as a therapeutic target in cardiovascular disease. Future Cardiol (2011) 1.18
Role of rho kinase in the functional and dysfunctional tonic smooth muscles. Trends Pharmacol Sci (2011) 1.09
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells. J Anesth (2007) 1.02
Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem (2009) 1.02
Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. Br J Pharmacol (2006) 0.95
Rho-kinase in development and heart failure: insights from genetic models. Pediatr Cardiol (2011) 0.91
Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. Naunyn Schmiedebergs Arch Pharmacol (2006) 0.91
Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation. PLoS One (2010) 0.88
New roads leading to Ca2+ sensitization. Circ Res (2002) 0.88
Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C delta and Ca2+ entry. Hypertension (2007) 0.87
8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway. Exp Cell Res (2010) 0.87
Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. Br J Pharmacol (2003) 0.85
Identification of the Rock-dependent transcriptome in rodent fibroblasts. Clin Transl Oncol (2008) 0.83
A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts. J Cereb Blood Flow Metab (2015) 0.83
Human vascular endothelial cells reduce sphingosylphosphorylcholine-induced smooth muscle cell contraction in co-culture system through integrin β4 and Fyn. Acta Pharmacol Sin (2011) 0.82
Augmented sphingosylphosphorylcholine-induced Ca2+-sensitization of mesenteric artery contraction in spontaneously hypertensive rat. Naunyn Schmiedebergs Arch Pharmacol (2006) 0.79
Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. J Cereb Blood Flow Metab (2010) 0.78
Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. PLoS One (2015) 0.78
Sphingosylphosphorylcholine activates dendritic cells, stimulating the production of interleukin-12. Immunology (2007) 0.77
Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species. Cardiovasc Res (2015) 0.77
Novel Insights into the Roles of Rho Kinase in Cancer. Arch Immunol Ther Exp (Warsz) (2016) 0.76
Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function. Br J Pharmacol (2003) 0.76
The Role of Omega-3 Polyunsaturated Fatty Acids in Stroke. Oxid Med Cell Longev (2016) 0.75
Madagascine Induces Vasodilatation via Activation of AMPK. Front Pharmacol (2016) 0.75
Rho GTPases in ameloblast differentiation. Jpn Dent Sci Rev (2015) 0.75
Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med (2011) 6.89
Impact of alcohol consumption upon medical care utilization and costs in men: 4-year observation of National Health Insurance beneficiaries in Japan. Addiction (2005) 2.99
Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study. Int J Epidemiol (2007) 2.67
Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology (2007) 2.09
Cerebral hemodynamic benefits after carotid artery stenting in patients with near occlusion. J Vasc Surg (2013) 2.00
G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane. Biochem Biophys Res Commun (2006) 1.79
Impact of walking upon medical care expenditure in Japan: the Ohsaki Cohort Study. Int J Epidemiol (2003) 1.65
The sixth nationwide epidemiological survey of chronic pancreatitis in Japan. Pancreatology (2012) 1.58
Validation of the JapanSCORE versus the logistic EuroSCORE for predicting operative mortality of cardiovascular surgery in Yamaguchi University Hospital. Gen Thorac Cardiovasc Surg (2011) 1.58
Body mass index and diabetes in Asia: a cross-sectional pooled analysis of 900,000 individuals in the Asia cohort consortium. PLoS One (2011) 1.55
Risk factors for overactive bladder in the elderly population: a community-based study with face-to-face interview. Int J Urol (2010) 1.53
Mutism after evacuation of acute subdural hematoma of the posterior fossa. Childs Nerv Syst (2004) 1.52
Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene (2003) 1.49
Effective suppression of hippocampal seizures in rats by direct hippocampal cooling with a Peltier chip. J Neurosurg (2008) 1.45
Survey of current neurotrauma treatment practice in Japan. World Neurosurg (2011) 1.43
Impact of nocturia on bone fracture and mortality in older individuals: a Japanese longitudinal cohort study. J Urol (2010) 1.42
Impact of weight change since age 20 and cardiovascular disease mortality risk: the Ohsaki Cohort Study. Circ J (2012) 1.40
Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women. J Nutr (2010) 1.38
Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris. Circ J (2010) 1.36
Nationwide epidemiological survey of autoimmune pancreatitis in Japan. Pancreas (2012) 1.20
Cigarette smoking and the risk of gastric cancer: a pooled analysis of two prospective studies in Japan. Int J Cancer (2004) 1.16
Attributable risk fraction of prehypertension on cardiovascular disease mortality in the Japanese population: the Ohsaki Study. Am J Hypertens (2008) 1.14
Increased matrix metalloproteinase-9 in blood in association with activation of interleukin-6 after traumatic brain injury: influence of hypothermic therapy. J Neurotrauma (2004) 1.13
Surgery for spontaneous intracerebral hemorrhage has greater remedial value than conservative therapy. Surg Neurol (2006) 1.13
Nationwide epidemiological survey of acute pancreatitis in Japan. Pancreas (2011) 1.10
Smoking, alcohol drinking, green tea consumption and the risk of esophageal cancer in Japanese men. J Epidemiol (2006) 1.10
Coffee consumption and the risk of primary liver cancer: pooled analysis of two prospective studies in Japan. Int J Cancer (2005) 1.10
Sense of life worth living (ikigai) and mortality in Japan: Ohsaki Study. Psychosom Med (2008) 1.09
Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function. J Cell Physiol (2010) 1.08
Lower risk of death from gastric cancer among participants of gastric cancer screening in Japan: a population-based cohort study. Prev Med (2006) 1.08
High-mobility group box 1 protein in CSF of patients with subarachnoid hemorrhage. Neurocrit Care (2009) 1.06
Compliance to the recommendations on blood pressure measurements in the clinical settings. J Hypertens (2013) 1.06
Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway. Circ Res (2002) 1.05
Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products. Am J Clin Nutr (2006) 1.04
Effect of age on the association between body mass index and all-cause mortality: the Ohsaki cohort study. J Epidemiol (2010) 1.03
Factors associated with suicidal ideation in an elderly urban Japanese population: a community-based, cross-sectional study. Psychiatry Clin Neurosci (2005) 1.03
Home blood pressure is associated with depressive symptoms in an elderly population aged 70 years and over: a population-based, cross-sectional analysis. Hypertens Res (2008) 1.03
Angiogram-negative subarachnoid hemorrhage in the era of three dimensional rotational angiography. J Clin Neurosci (2007) 1.02
Seasonal variation in home blood pressure measurements and relation to outside temperature in Japan. Clin Exp Hypertens (2011) 1.02
Personality and body mass index: a cross-sectional analysis from the Miyagi Cohort Study. J Psychosom Res (2008) 1.02
Impact of obesity, overweight and underweight on life expectancy and lifetime medical expenditures: the Ohsaki Cohort Study. BMJ Open (2012) 1.02
Association between social support and depression status in the elderly: results of a 1-year community-based prospective cohort study in Japan. Psychiatry Clin Neurosci (2005) 1.01
Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft. Circ Res (2006) 1.01
Coffee consumption and the risk of oral, pharyngeal, and esophageal cancers in Japan: the Miyagi Cohort Study. Am J Epidemiol (2008) 1.00
Various magnetic resonance imaging patterns of chronic subdural hematomas: indicators of the pathogenesis? Neurol Med Chir (Tokyo) (2006) 1.00
Design of the Nationwide Nursery School Survey on Child Health Throughout the Great East Japan Earthquake. J Epidemiol (2015) 0.99
Neoplastic cells and proliferating endothelial cells express connective tissue growth factor (CTGF) in glioblastoma. Neurol Res (2002) 0.99
Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-alpha and causes motility disorders. Am J Physiol Gastrointest Liver Physiol (2007) 0.99
Green tea consumption is associated with depressive symptoms in the elderly. Am J Clin Nutr (2009) 0.97
MRI findings and pathological features in early-stage glioblastoma. J Neurooncol (2015) 0.97
The joint impact of cardiovascular risk factors upon medical costs. Prev Med (2007) 0.97
Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study. Cancer Causes Control (2009) 0.96
Age-specific interval breast cancers in Japan: estimation of the proper sensitivity of screening using a population-based cancer registry. Cancer Sci (2008) 0.96
Spinal cord infarction demonstrated by diffusion-weighted magnetic resonance imaging. J Clin Neurosci (2005) 0.95
History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study. Cancer Causes Control (2010) 0.95
Impact of walking on life expectancy and lifetime medical expenditure: the Ohsaki Cohort Study. BMJ Open (2011) 0.95
Meat consumption and risk of colorectal cancer in Japan: the Miyagi Cohort Study. Eur J Cancer Prev (2006) 0.95
[Validation of the Kihon Checklist for predicting the risk of 1-year incident long-term care insurance certification: the Ohsaki Cohort 2006 Study]. Nihon Koshu Eisei Zasshi (2011) 0.94
Long sleep duration and cause-specific mortality according to physical function and self-rated health: the Ohsaki Cohort Study. J Sleep Res (2012) 0.93
Citrus consumption and cancer incidence: the Ohsaki cohort study. Int J Cancer (2010) 0.93
Benign fibrous histiocytoma of the skull with increased intracranial pressure caused by cerebral venous sinus occlusion. J Neurosurg (2009) 0.92
Decrease in risk of lung cancer death in Japanese men after smoking cessation by age at quitting: pooled analysis of three large-scale cohort studies. Cancer Sci (2007) 0.92
ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J Biol Chem (2004) 0.92
The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen. Brain Res (2006) 0.92
Coffee consumption and the risk of colorectal cancer: a prospective cohort study in Japan. Int J Cancer (2007) 0.92
Body mass index and cardiovascular disease mortality in Japan: the Ohsaki Study. Prev Med (2008) 0.92
Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice. J Neurosurg (2010) 0.90
Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: the Miyagi Cohort Study. Eur J Cancer (2006) 0.90
Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: possible involvement of a sphingosylphosphorylcholine-rho-kinase pathway. Cerebrovasc Dis (2008) 0.90
Recurrence and extension of lobar hemorrhage related to cerebral amyloid angiopathy: multivariate analysis of clinical risk factors. Surg Neurol (2005) 0.90
Green tea consumption and hematologic malignancies in Japan: the Ohsaki study. Am J Epidemiol (2009) 0.90
Preoperative prediction of outcome in 283 poor-grade patients with subarachnoid hemorrhage: a project of the Chugoku-Shikoku Division of the Japan Neurosurgical Society. Cerebrovasc Dis (2010) 0.90
Negative psychological aspects and survival in lung cancer patients. Psychooncology (2008) 0.89
Blood pressure measured in the clinic and at home during pregnancy among nulliparous and multiparous women: the BOSHI study. Am J Hypertens (2012) 0.89
Prevalence and clinical features of Costello syndrome and cardio-facio-cutaneous syndrome in Japan: findings from a nationwide epidemiological survey. Am J Med Genet A (2012) 0.89
Brain and systemic temperature in patients with severe subarachnoid hemorrhage. Surg Neurol (2003) 0.89
Reproducibility of cerebral blood flow assessment using a quantitative SPECT reconstruction program and split-dose 123I-iodoamphetamine in institutions with different γ-cameras and collimators. J Cereb Blood Flow Metab (2012) 0.89
Identification of the active metabolite of ticlopidine from rat in vitro metabolites. Br J Pharmacol (2004) 0.88
Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma. Eur J Cancer Prev (2008) 0.88
Dietary patterns associated with fall-related fracture in elderly Japanese: a population based prospective study. BMC Geriatr (2010) 0.88
Sphingomyelinase causes endothelium-dependent vasorelaxation through endothelial nitric oxide production without cytosolic Ca(2+) elevation. FEBS Lett (2005) 0.88
Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells. FEBS Lett (2003) 0.88
Pain and risk of completed suicide in Japanese men: a population-based cohort study in Japan (Ohsaki Cohort Study). J Pain Symptom Manage (2008) 0.88
Recovered neuronal viability revealed by Iodine-123-iomazenil SPECT following traumatic brain injury. J Cereb Blood Flow Metab (2010) 0.88
Personality and gastric cancer screening attendance: a cross-sectional analysis from the Miyagi Cohort Study. J Epidemiol (2009) 0.88
Operative injury accelerates tumor growth by inducing mobilization and recruitment of bone marrow-derived stem cells. Surgery (2011) 0.87
Management of patients with cavernous angiomas presenting epileptic seizures. Surg Neurol (2005) 0.87
Fate of clots in patients with subarachnoid hemorrhage after different surgical treatment modality: a comparison between surgical clipping and Guglielmi detachable coil embolization. Neurosurgery (2011) 0.87
Evaluation of cerebral perfusion parameters measured by perfusion CT in chronic cerebral ischemia: comparison with xenon CT. J Comput Assist Tomogr (2002) 0.87