Published in Naunyn Schmiedebergs Arch Pharmacol on April 01, 2006
"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev (2008) 3.80
Regulation and functional roles of sphingosine kinases. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.38
Protection against myocardial ischemia/reperfusion injury by short-term diabetes: enhancement of VEGF formation, capillary density, and activation of cell survival signaling. Naunyn Schmiedebergs Arch Pharmacol (2006) 0.99
The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. Lymphat Res Biol (2012) 0.92
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The impact of bioactive lipids on cardiovascular development. Stem Cells Int (2011) 0.85
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. Br J Pharmacol (2010) 0.85
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Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. Mol Cells (2013) 0.77
A Dormant Microbial Component in the Development of Preeclampsia. Front Med (Lausanne) (2016) 0.76
Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? Invest Ophthalmol Vis Sci (2015) 0.76
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev (2003) 9.32
Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol (2005) 3.59
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci (2001) 3.32
The regulation and pharmacology of endothelial nitric oxide synthase. Annu Rev Pharmacol Toxicol (2006) 2.68
Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther (2004) 2.42
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest (2004) 2.36
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science (2001) 2.17
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J (2003) 2.10
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J Cell Sci (2005) 2.07
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Emerging medicinal roles for lysophospholipid signaling. Trends Mol Med (2006) 2.01
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Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem (2001) 1.97
Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev (2002) 1.97
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. J Biol Chem (2005) 1.95
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Sphingosylphosphorylcholine is a novel messenger for Rho-kinase-mediated Ca2+ sensitization in the bovine cerebral artery: unimportant role for protein kinase C. Circ Res (2002) 1.87
Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J (2005) 1.83
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Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. Cancer Res (2003) 1.73
Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta (2002) 1.72
Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. J Biol Chem (2001) 1.72
Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem (2002) 1.68
Targeting Rho and Rho-kinase in the treatment of cardiovascular disease. Trends Pharmacol Sci (2005) 1.60
Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J Biol Chem (2002) 1.57
Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J (2001) 1.55
Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. Cardiovasc Res (2005) 1.55
Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J Biol Chem (2001) 1.50
Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites. Br J Pharmacol (2004) 1.48
Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Cardiovasc Res (2003) 1.46
Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. Am Heart J (2003) 1.43
Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis. Arterioscler Thromb Vasc Biol (2002) 1.42
Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? Biochim Biophys Acta (2002) 1.39
Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase. Circulation (2003) 1.37
Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. Biochem Soc Trans (2003) 1.33
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol (2005) 1.33
Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium. Arterioscler Thromb Vasc Biol (2005) 1.31
Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem (2000) 1.27
Sphingosine kinase: a mediator of vital cellular functions. Prostaglandins Other Lipid Mediat (2001) 1.26
The role of sphingosine-1-phosphate in smooth muscle contraction. Cell Signal (2005) 1.26
Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. Biochem J (2001) 1.25
Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production. J Biol Chem (2000) 1.24
Prostaglandin H synthase and vascular function. Circ Res (2001) 1.23
Sphingosylphosphorylcholine-biological functions and mechanisms of action. Biochim Biophys Acta (2002) 1.23
Photolysis of intracellular caged sphingosine-1-phosphate causes Ca2+ mobilization independently of G-protein-coupled receptors. FEBS Lett (2003) 1.21
Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. Circulation (2003) 1.20
Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem (2001) 1.19
Thrombogenic and atherogenic activities of lysophosphatidic acid. J Cell Biochem (2004) 1.19
Sphingosine 1-phosphate-related metabolism in the blood vessel. J Biochem (2005) 1.18
Sphingosine 1-phosphate and control of vascular tone. Am J Physiol Heart Circ Physiol (2003) 1.18
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. Br J Pharmacol (2000) 1.16
S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate. Eur J Pharmacol (2003) 1.16
HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI-dependent manner. J Clin Invest (2003) 1.15
Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3. Circ Res (2005) 1.14
Lysophosphatidic acid alters cerebrovascular reactivity in piglets. Am J Physiol (1995) 1.12
Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. Circ Res (2002) 1.09
Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J (2005) 1.09
Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels. Am J Physiol Heart Circ Physiol (2005) 1.07
Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm. Stroke (2001) 1.06
Lysophospholipid receptor-dependent and -independent calcium signaling. J Cell Biochem (2004) 1.06
Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway. Circ Res (2002) 1.05
Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. Br J Pharmacol (2000) 1.03
Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. J Biol Chem (2004) 1.02
Regulation of vascular reactivity by established and emerging GPCRs. Trends Pharmacol Sci (2005) 1.02
Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart. Cardiovasc Res (2000) 1.01
Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. J Biol Chem (2000) 0.98
Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. Eur J Pharmacol (2001) 0.97
High-density lipoprotein stimulates myocardial perfusion in vivo. Circulation (2004) 0.96
Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. J Biol Chem (2003) 0.96
Evidence that estrogen suppresses rho-kinase function in the cerebral circulation in vivo. Stroke (2004) 0.96
Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. Br J Pharmacol (2006) 0.95
Sphingosine 1-phosphate induces CREB activation in rat cerebral artery via a protein kinase C-mediated inhibition of voltage-gated K+ channels. Biochem Pharmacol (2003) 0.94
Atheroprotective effects of high-density lipoprotein-associated lysosphingolipids. Trends Cardiovasc Med (2005) 0.94
Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. FASEB J (2005) 0.92
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Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. J Biol Chem (2000) 0.91
Sphingosine-1-phosphate receptor expression and signaling correlate with uterine prostaglandin-endoperoxide synthase 2 expression and angiogenesis during early pregnancy. Biol Reprod (2005) 0.91
HDL action on the vascular wall: is the answer NO? J Clin Invest (2004) 0.90
Sphingosylphosphorylcholine induces Ca(2+)-sensitization of vascular smooth muscle contraction: possible involvement of rho-kinase. FEBS Lett (2000) 0.89
Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats. Br J Pharmacol (2001) 0.89
GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. FASEB J (2005) 0.89
Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells? FASEB J (2002) 0.89
Sphingosine 1-phosphate receptors mediate the lipid-induced cAMP accumulation through cyclooxygenase-2/prostaglandin I2 pathway in human coronary artery smooth muscle cells. Mol Pharmacol (2004) 0.88
Sphingosine-1-phosphate activates BKCa channels independently of G protein-coupled receptor in human endothelial cells. Am J Physiol Cell Physiol (2005) 0.87
Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol (2001) 0.87
Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. Br J Pharmacol (2003) 0.85
Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. J Cell Biochem (2003) 0.85
Effects of neutral sphingomyelinase on phenylephrine-induced vasoconstriction and Ca(2+) mobilization in rat aortic smooth muscle. Eur J Pharmacol (2000) 0.85
Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. Cell Signal (2005) 0.84
Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells. Br J Pharmacol (2000) 0.84
Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. Br J Pharmacol (2004) 0.84
Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). Cell Signal (2003) 0.84
Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation. Biochem Biophys Res Commun (2004) 0.83
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Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone. Biol Reprod (2005) 0.83
Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. Toxicol Sci (2005) 0.82
Sphingosylphosphorylcholine-induced contraction of feline ileal smooth muscle cells is mediated by Galphai3 protein and MAPK. Cell Signal (2002) 0.81
Sphingosylphosphorylcholine stimulates mitogen-activated protein kinase via a Ca2+-dependent pathway. Am J Physiol (1998) 0.80
Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. Auton Autacoid Pharmacol (2004) 0.80
Upregulation of endothelin-1 production by lysophosphatidic acid in rat aortic endothelial cells. Biochim Biophys Acta (1998) 0.80