Published in Circ Res on July 26, 2002
Lipid-lowering drug use is associated with reduced prevalence of atrial fibrillation in patients with left ventricular systolic dysfunction. Heart Rhythm (2006) 2.81
Effect of long- and short-term treatments with pravastatin on diabetes mellitus and pancreatic fibrosis in the Otsuka-Long-Evans-Tokushima fatty rat. Br J Pharmacol (2009) 1.45
Statins and the vascular endothelial inflammatory response. Trends Immunol (2007) 1.43
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med (2005) 1.27
Good stress, bad stress--the delicate balance in the vasculature. Dtsch Arztebl Int (2009) 1.23
Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol (2007) 1.09
Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering. Antioxid Redox Signal (2014) 1.08
NOX1, 2, 4, 5: counting out oxidative stress. Br J Pharmacol (2011) 1.08
Endothelium and its alterations in cardiovascular diseases: life style intervention. Biomed Res Int (2014) 1.03
Renoprotection by statins is linked to a decrease in renal oxidative stress, TGF-beta, and fibronectin with concomitant increase in nitric oxide bioavailability. Am J Physiol Renal Physiol (2008) 1.01
Statins and brain dysfunction: a hypothesis to reduce the burden of cognitive impairment in patients who are critically ill. Chest (2011) 0.96
Statins and the role of nitric oxide in chronic heart failure. Heart Fail Rev (2003) 0.92
Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2. Antioxid Redox Signal (2012) 0.91
Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways. Br J Pharmacol (2005) 0.87
Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress. Int J Mol Sci (2014) 0.87
Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity. PLoS One (2013) 0.86
The "Mevalonate hypothesis": a cholesterol-independent alternative for the etiology of atherosclerosis. Lipids Health Dis (2012) 0.84
Nitric oxide dysregulation in platelets from patients with advanced Huntington disease. PLoS One (2014) 0.81
Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiation. Int J Nanomedicine (2015) 0.78
Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin. PLoS One (2015) 0.77
The Jeremiah Metzger Lecture. Pathogenesis of atherosclerosis: redox as a unifying mechanism. Trans Am Clin Climatol Assoc (2003) 0.76
"Non alcoholic fatty liver disease and eNOS dysfunction in humans". BMC Gastroenterol (2017) 0.75
Anticoagulants and Statins As Pharmacological Agents in Free Flap Surgery: Current Rationale. Eplasty (2015) 0.75
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension (2007) 5.80
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res (2012) 4.19
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem (2004) 3.37
Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation (2003) 2.69
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. J Clin Invest (2013) 2.48
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature (2011) 2.47
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A (2010) 2.36
Nox4 acts as a switch between differentiation and proliferation in preadipocytes. Arterioscler Thromb Vasc Biol (2008) 2.21
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem (2011) 2.20
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation (2003) 2.15
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke (2007) 2.13
L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension (2013) 2.05
Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension (2005) 2.01
MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res (2011) 2.01
Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress. Blood (2004) 1.96
Cell-to-cell connection of endothelial progenitor cells with cardiac myocytes by nanotubes: a novel mechanism for cell fate changes? Circ Res (2005) 1.95
Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice. Circ Res (2003) 1.89
NADPH oxidases as therapeutic targets in ischemic stroke. Cell Mol Life Sci (2012) 1.87
CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization. J Am Coll Cardiol (2008) 1.82
p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling. Circ Res (2005) 1.81
Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Free Radic Biol Med (2006) 1.78
Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties. Circ Res (2004) 1.72
Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res (2003) 1.69
Inactivation of extracellular superoxide dismutase contributes to the development of high-volume hypertension. Arterioscler Thromb Vasc Biol (2006) 1.66
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.65
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol Cell Biol (2003) 1.57
Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free Radic Biol Med (2012) 1.54
NADPH oxidase mediates tissue factor-dependent surface procoagulant activity by thrombin in human vascular smooth muscle cells. Circulation (2002) 1.52
Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid Redox Signal (2009) 1.51
Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema. Am J Respir Crit Care Med (2014) 1.48
Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. Proc Natl Acad Sci U S A (2006) 1.48
Role of p22phox in angiotensin II and platelet-derived growth factor AA induced activator protein 1 activation in vascular smooth muscle cells. J Mol Med (Berl) (2003) 1.45
Cellular properties of C-terminal KCNH2 long QT syndrome mutations: description and divergence from clinical phenotypes. Heart Rhythm (2008) 1.43
Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells. J Biol Chem (2005) 1.40
Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia. Br J Pharmacol (2006) 1.35
First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction. Antioxid Redox Signal (2008) 1.34
Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. J Biol Chem (2005) 1.30
Role of Nox4 in murine models of kidney disease. Free Radic Biol Med (2012) 1.28
Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension (2006) 1.26
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling. FASEB J (2005) 1.21
The Nox family of NADPH oxidases: friend or foe of the vascular system? Curr Hypertens Rep (2012) 1.17
Triggering mitochondrial radical release: a new function for NADPH oxidases. Hypertension (2005) 1.12
Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. J Hypertens (2009) 1.11
Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. PLoS One (2010) 1.11
NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells. Circ Res (2009) 1.10
Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition. Hypertension (2004) 1.08
Targeting inflammation and oxidative stress in atrial fibrillation: role of 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibition with statins. Antioxid Redox Signal (2013) 1.07
Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species. Free Radic Res (2004) 1.07
Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid. Circ Res (2002) 1.06
NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice. Neurobiol Dis (2010) 1.05
Regulation of proliferation of skeletal muscle precursor cells by NADPH oxidase. Antioxid Redox Signal (2008) 1.05
Aged spontaneously hypertensive rats exhibit a selective loss of EDHF-mediated relaxation in the renal artery. Hypertension (2003) 1.04
Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha. Cardiovasc Res (2005) 1.03
Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX. Basic Res Cardiol (2005) 1.02
Role of Src tyrosine kinases in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol (2012) 1.01
Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet. Free Radic Biol Med (2006) 0.99
No superoxide--no stress?: Nox4, the good NADPH oxidase! Arterioscler Thromb Vasc Biol (2011) 0.99
Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction. Heart Rhythm (2009) 0.98
Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arterioscler Thromb Vasc Biol (2010) 0.98
Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. FASEB J (2005) 0.98
Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide. Am J Physiol Heart Circ Physiol (2007) 0.95
Hepatocyte growth factor induces a proangiogenic phenotype and mobilizes endothelial progenitor cells by activating Nox2. Antioxid Redox Signal (2011) 0.93
Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction. Circulation (2011) 0.92
The polarity protein Scrib is essential for directed endothelial cell migration. Circ Res (2013) 0.91
Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2. Antioxid Redox Signal (2012) 0.91
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease. PLoS One (2013) 0.90
Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis. Infect Immun (2003) 0.90
Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling. Antioxid Redox Signal (2013) 0.89
Native LDL induces proliferation of human vascular smooth muscle cells via redox-mediated activation of ERK 1/2 mitogen-activated protein kinases. Hypertension (2002) 0.88
Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta. Hypertension (2013) 0.88
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation. Mol Pain (2011) 0.88
Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species. Free Radic Biol Med (2011) 0.87
NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury. J Neurosci (2012) 0.86
Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation. Cardiovasc Res (2006) 0.85
Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J Biol Chem (2009) 0.85
Activating SIRT1: a new strategy to prevent atherosclerosis? Cardiovasc Res (2008) 0.85
Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells. J Immunol (2009) 0.84
Evidence against a role for NADPH oxidase modulating hepatic vascular tone in cirrhosis. Gastroenterology (2007) 0.83
A radical adventure: the quest for specific functions and inhibitors of vascular NAPDH oxidases. Circ Res (2003) 0.83
Leptin potentiates endothelium-dependent relaxation by inducing endothelial expression of neuronal NO synthase. Arterioscler Thromb Vasc Biol (2012) 0.83
Statin-mediated inhibition of Rho: only to get more NO? Circ Res (2005) 0.83
Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor. J Biol Chem (2003) 0.83
Endo-PDI is required for TNFα-induced angiogenesis. Free Radic Biol Med (2013) 0.82
Hypoxia-dependent reactive oxygen species signaling in the pulmonary circulation: focus on ion channels. Antioxid Redox Signal (2015) 0.81
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension. Respir Res (2011) 0.81
Vascular peroxidase 1/peroxidasin: a complex protein with a simple function? Cardiovasc Res (2011) 0.81
SYNCRIP-dependent Nox2 mRNA destabilization impairs ROS formation in M2-polarized macrophages. Antioxid Redox Signal (2014) 0.80
Intracellular localization of RORalpha is isoform and cell line-dependent. Biochim Biophys Acta (2006) 0.80
Anti-atherosclerotic mechanisms of statin therapy. Curr Opin Pharmacol (2013) 0.80
Activation of thromboxane receptor modulates interleukin-1β-induced monocyte adhesion--a novel role of Nox1. Free Radic Biol Med (2012) 0.78
Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res Cardiol (2014) 0.77
Endothelial progenitor cells=EPC=elemental pernicious complexity. Antioxid Redox Signal (2011) 0.76
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia. Am J Respir Cell Mol Biol (2013) 0.76
Roads to dysfunction: argininase II contributes to oxidized low-density lipoprotein-induced attenuation of endothelial NO production. Circ Res (2006) 0.76
Avoiding vicious circles: mineralocorticoid receptor antagonism prevents vascular oxidative stress early after myocardial infarction. Hypertension (2007) 0.75
Response to Sympathoinhibitory effect of diltiazem and prevention of aneurysm formation. Hypertension (2014) 0.75
A new PIXel in the puzzle: how increased vascular pressure induces oxidative stress. Hypertension (2009) 0.75
Sympathoactivation and rho-kinase-dependent baroreflex function in experimental renovascular hypertension with reduced kidney mass. BMC Physiol (2014) 0.75
Novel faces to old friends: a central role of inducible NO synthase for progenitor cell recruitment and a new antiinflammatory mechanisms of statins. Circ Res (2006) 0.75