Published in Circ Res on August 21, 2003
Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal (2011) 2.66
Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension (2007) 2.20
Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension (2009) 1.86
Oxidative stress as a mediator of cardiovascular disease. Oxid Med Cell Longev (2010) 1.58
Protective effect of extracellular superoxide dismutase on endothelial function during aging. Am J Physiol Heart Circ Physiol (2009) 1.57
Evidence of increased oxidative stress in aged mesenteric lymphatic vessels. Lymphat Res Biol (2012) 1.50
Cardiac-selective expression of extracellular superoxide dismutase after systemic injection of adeno-associated virus 9 protects the heart against post-myocardial infarction left ventricular remodeling. Circ Cardiovasc Imaging (2013) 1.46
NOX and inflammation in the vascular adventitia. Free Radic Biol Med (2009) 1.37
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
Reduction of renal superoxide dismutase in progressive diabetic nephropathy. J Am Soc Nephrol (2009) 1.23
Extracellular superoxide dismutase and oxidant damage in osteoarthritis. Arthritis Rheum (2005) 1.22
Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function. Hypertension (2008) 1.19
Superoxide dismutase 1 limits renal microvascular remodeling and attenuates arteriole and blood pressure responses to angiotensin II via modulation of nitric oxide bioavailability. Hypertension (2010) 1.18
Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16
Oxidative stress in hypertension: role of the kidney. Antioxid Redox Signal (2013) 1.13
Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell (2013) 1.11
Novel mechanism for regulation of extracellular SOD transcription and activity by copper: role of antioxidant-1. Free Radic Biol Med (2008) 1.10
Mitochondrial redox signaling: Interaction of mitochondrial reactive oxygen species with other sources of oxidative stress. Antioxid Redox Signal (2012) 1.10
Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension. Antioxid Redox Signal (2011) 1.05
Increased p22(phox)/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn. Antioxid Redox Signal (2013) 1.04
You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda) (2014) 1.04
The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation. Free Radic Biol Med (2010) 1.04
Vascular inflammation and endothelial dysfunction in experimental hypertension. Int J Hypertens (2011) 1.03
Redox modulation of the fetal cardiovascular defence to hypoxaemia. J Physiol (2010) 1.00
Extracellular superoxide dismutase (ecSOD) in vascular biology: an update on exogenous gene transfer and endogenous regulators of ecSOD. Transl Res (2007) 0.98
Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis. Mol Vis (2007) 0.98
Role of copper transport protein antioxidant 1 in angiotensin II-induced hypertension: a key regulator of extracellular superoxide dismutase. Hypertension (2012) 0.96
Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa. PLoS One (2013) 0.96
Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis. Mol Cancer Res (2011) 0.95
Role of glycocalyx in flow-induced production of nitric oxide and reactive oxygen species. Free Radic Biol Med (2009) 0.90
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. Am J Physiol Heart Circ Physiol (2010) 0.90
Effects of a common human gene variant of extracellular superoxide dismutase on endothelial function after endotoxin in mice. J Physiol (2007) 0.90
Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation. Proc Natl Acad Sci U S A (2012) 0.90
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality. Nat Rev Cardiol (2017) 0.90
TLR4 is a critical regulator of angiotensin II-induced vascular remodeling: the roles of extracellular SOD and NADPH oxidase. Hypertens Res (2015) 0.89
Extracellular superoxide dismutase inhibits innate immune responses and clearance of an intracellular bacterial infection. J Immunol (2012) 0.89
Bang-bang model for regulation of local blood flow. Microcirculation (2013) 0.87
The role of genetic polymorphisms in antioxidant enzymes and potential antioxidant therapies in neonatal lung disease. Antioxid Redox Signal (2014) 0.84
Imbalance between pro and anti-oxidant mechanisms in perivascular adipose tissue aggravates long-term high-fat diet-derived endothelial dysfunction. PLoS One (2014) 0.84
Adeno-associated virus serotype 9-mediated overexpression of extracellular superoxide dismutase improves recovery from surgical hind-limb ischemia in BALB/c mice. J Vasc Surg (2011) 0.84
Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia, and exercise intolerance in mice with congestive heart failure. Circ Heart Fail (2014) 0.84
A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution. Circ Cardiovasc Genet (2014) 0.84
Role of EC-SOD overexpression in preserving pulmonary angiogenesis inhibited by oxidative stress. PLoS One (2012) 0.83
Reduction of C-reactive protein and the use of anti-hypertensives. Vasc Health Risk Manag (2007) 0.82
Characterization of blood pressure and endothelial function in TRPV4-deficient mice with l-NAME- and angiotensin II-induced hypertension. Physiol Rep (2014) 0.81
Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo. J Cell Mol Med (2008) 0.81
Stimulation of endothelial progenitor cells: a new putative effect of several cardiovascular drugs. Eur J Clin Pharmacol (2009) 0.81
Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. Am J Physiol Heart Circ Physiol (2005) 0.80
Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. Clin Cancer Res (2015) 0.80
Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. Int J Hypertens (2012) 0.80
Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model. BMC Res Notes (2014) 0.80
Antioxidant enzymes as potential targets in cardioprotection and treatment of cardiovascular diseases. Enzyme antioxidants: the next stage of pharmacological counterwork to the oxidative stress. Heart Int (2012) 0.79
Extracellular superoxide dismutase polymorphism in mice: Allele-specific effects on phenotype. Free Radic Biol Med (2009) 0.79
Aged lymphatic contractility: recent answers and new questions. Lymphat Res Biol (2013) 0.79
Phosphodiesterase 5 attenuates the vasodilatory response in renovascular hypertension. PLoS One (2013) 0.79
Superoxide dismutase as a novel macromolecular nitric oxide carrier: preparation and characterization. Int J Mol Sci (2012) 0.78
Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase. Diabetes (2013) 0.77
N-n-butyl Haloperidol Iodide Protects against Hypoxia/Reoxygenation Injury in Cardiac Microvascular Endothelial Cells by Regulating the ROS/MAPK/Egr-1 Pathway. Front Pharmacol (2017) 0.77
N-Glycosylation profiling of recombinant mouse extracellular superoxide dismutase produced in Chinese hamster ovary cells. Glycoconj J (2011) 0.77
Cardiological biopharmaceuticals in the conception of drug targeting delivery: practical results and research perspectives. Acta Naturae (2012) 0.77
Sulfhydryl-dependent dimerization of soluble guanylyl cyclase modulates the relaxation of porcine pulmonary arteries to nitric oxide. Pflugers Arch (2012) 0.76
Clinical effects of an oral supplement rich in antioxidants on skin radiance in women. Clin Cosmet Investig Dermatol (2016) 0.75
Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. Am J Physiol Heart Circ Physiol (2013) 0.75
The fetal circulation, pathophysiology of hypoxemic respiratory failure and pulmonary hypertension in neonates, and the role of oxygen therapy. J Perinatol (2016) 0.75
Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome. Mediators Inflamm (2016) 0.75
Copper trafficking and extracellular superoxide dismutase activity: kinky hair, kinky vessels. Hypertension (2008) 0.75
Intravenous superoxide dismutase as a protective agent to prevent impairment of lung function induced by high tidal volume ventilation. BMC Pulm Med (2017) 0.75
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension (2007) 5.80
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res (2012) 4.19
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet (2003) 4.19
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol (2003) 3.44
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem (2004) 3.37
From blood monocytes to adipose tissue-resident macrophages: induction of diapedesis by human mature adipocytes. Diabetes (2004) 3.13
Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation (2003) 2.69
Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens (2013) 2.69
Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models. Brain (2005) 2.64
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. J Clin Invest (2013) 2.48
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature (2011) 2.47
Endothelial aging. Cardiovasc Res (2005) 2.46
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A (2010) 2.36
Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosis. Brain (2003) 2.30
Nox4 acts as a switch between differentiation and proliferation in preadipocytes. Arterioscler Thromb Vasc Biol (2008) 2.21
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem (2011) 2.20
Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscler Thromb Vasc Biol (2007) 2.17
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidase. Circulation (2003) 2.15
Extraction and GC/MS analysis of the human blood plasma metabolome. Anal Chem (2005) 2.13
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke (2007) 2.13
Plasma bilirubin and UGT1A1*28 are not protective factors against first-time myocardial infarction in a prospective, nested case-referent setting. Circ Cardiovasc Genet (2010) 2.06
L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects. Hypertension (2013) 2.05
Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension (2005) 2.01
MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res (2011) 2.01
Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress. Blood (2004) 1.96
Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells. J Cell Sci (2005) 1.95
Cell-to-cell connection of endothelial progenitor cells with cardiac myocytes by nanotubes: a novel mechanism for cell fate changes? Circ Res (2005) 1.95
Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models. Proc Natl Acad Sci U S A (2007) 1.95
Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients. PLoS One (2010) 1.89
NADPH oxidases as therapeutic targets in ischemic stroke. Cell Mol Life Sci (2012) 1.87
Role of macrophage tissue infiltration in metabolic diseases. Curr Opin Clin Nutr Metab Care (2005) 1.83
CD40 ligand+ microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis a potential mechanism for intraplaque neovascularization. J Am Coll Cardiol (2008) 1.82
p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling. Circ Res (2005) 1.81
Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem (2003) 1.80
11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1. J Biol Chem (2003) 1.78
Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Free Radic Biol Med (2006) 1.78
Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin. Circ Res (2006) 1.76
Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res (2006) 1.75
Prediction of acute renal allograft rejection by urinary monokine induced by IFN-gamma (MIG). J Am Soc Nephrol (2005) 1.72
Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties. Circ Res (2004) 1.72
Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease. Brain (2002) 1.71
Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab (2009) 1.69
Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res (2003) 1.69
Amlodipine activates the endothelial nitric oxide synthase by altering phosphorylation on Ser1177 and Thr495. Cardiovasc Res (2003) 1.67
Inactivation of extracellular superoxide dismutase contributes to the development of high-volume hypertension. Arterioscler Thromb Vasc Biol (2006) 1.66
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.65
Adipose-derived mesenchymal stromal/stem cells: tissue localization, characterization, and heterogeneity. Stem Cells Int (2012) 1.63
Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes. J Biol Chem (2003) 1.62
Preadipocytes in the human subcutaneous adipose tissue display distinct features from the adult mesenchymal and hematopoietic stem cells. J Cell Physiol (2005) 1.60
Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. Genes Dev (2012) 1.59
Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci (2005) 1.59
Candesartan improves blood pressure control and reduces proteinuria in renal transplant recipients: results from SECRET. Nephrol Dial Transplant (2009) 1.58
Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Mol Cell Biol (2003) 1.57
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation (2011) 1.57
Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free Radic Biol Med (2012) 1.54
Overexpression of angiotensinogen in the myocardium induces downregulation of the fatty acid oxidation pathway. J Mol Cell Cardiol (2006) 1.53
NADPH oxidase mediates tissue factor-dependent surface procoagulant activity by thrombin in human vascular smooth muscle cells. Circulation (2002) 1.52
Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid Redox Signal (2009) 1.51
Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema. Am J Respir Crit Care Med (2014) 1.48
Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. Proc Natl Acad Sci U S A (2006) 1.48
Long-term consequences of live kidney donation follow-up in 93% of living kidney donors in a single transplant center. Am J Transplant (2005) 1.47
Potassium supplementation reduces cardiac and renal hypertrophy independent of blood pressure in DOCA/salt mice. Hypertension (2005) 1.46
FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. J Clin Invest (2005) 1.46
Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR). FASEB J (2003) 1.46
Role of p22phox in angiotensin II and platelet-derived growth factor AA induced activator protein 1 activation in vascular smooth muscle cells. J Mol Med (Berl) (2003) 1.45
Epithelial differentiation of human adipose tissue-derived adult stem cells. Biochem Biophys Res Commun (2005) 1.43
Cellular properties of C-terminal KCNH2 long QT syndrome mutations: description and divergence from clinical phenotypes. Heart Rhythm (2008) 1.43
Valproic acid inhibits angiogenesis in vitro and in vivo. Mol Pharmacol (2004) 1.41
Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells. J Biol Chem (2005) 1.40
Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia. Br J Pharmacol (2006) 1.35
Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension (2006) 1.34
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. Am J Physiol Heart Circ Physiol (2002) 1.34
Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase. J Biol Chem (2005) 1.34
First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction. Antioxid Redox Signal (2008) 1.34
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.34
Endothelium-derived epoxyeicosatrienoic acids and vascular function. Hypertension (2006) 1.33
Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc Res (2006) 1.31
Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. J Biol Chem (2005) 1.30
Role of Nox4 in murine models of kidney disease. Free Radic Biol Med (2012) 1.28
The coupling between disulphide status, metallation and dimer interface strength in Cu/Zn superoxide dismutase. J Mol Biol (2006) 1.28
Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J (2008) 1.28
Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension (2006) 1.26
Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure. Hypertension (2005) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
Control of the adaptive response of the heart to stress via the Notch1 receptor pathway. J Exp Med (2008) 1.24
Motor neuron disease in mice expressing the wild type-like D90A mutant superoxide dismutase-1. J Neuropathol Exp Neurol (2006) 1.23
Direct acute tubular damage contributes to Shigatoxin-mediated kidney failure. J Pathol (2014) 1.22
ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation. J Am Soc Nephrol (2005) 1.21
20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. Hypertension (2002) 1.21