Published in Schweiz Med Wochenschr on October 11, 1975
Actions of insulin-like growth factors. Annu Rev Physiol (1985) 3.80
Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature (1982) 2.79
Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest (1981) 2.52
Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med (1987) 2.00
Insulin-like growth factors I and II: some biological actions and receptor binding characteristics of two purified constituents of nonsuppressible insulin-like activity of human serum. Eur J Biochem (1978) 1.88
Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinol (Copenh) (1989) 1.83
Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: dependence on growth hormone status. Endocrinology (1983) 1.72
The insulin-like growth factors (IGF) of human serum: chemical and biological characterization and aspects of their possible physiological role. Curr Top Cell Regul (1981) 1.63
Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia? J Clin Invest (1992) 1.58
Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc Natl Acad Sci U S A (1988) 1.55
Binding of nonsuppressible insulinlike activity to human serum. Evidence for a carrier protein. Arch Biochem Biophys (1975) 1.52
Interactions of insulin-like growth factors I and II and multiplication-stimulating activity with receptors and serum carrier proteins. Endocrinology (1980) 1.48
Nonsuppressible insulin-like activity and thyroid hormones: major pituitary-dependent sulfation factors for chick embryo cartilage. Proc Natl Acad Sci U S A (1976) 1.45
Improvement of lipid profile in type 2 (non-insulin-dependent) diabetes mellitus by insulin-like growth factor I. Diabetologia (1993) 1.45
Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity. Acta Endocrinol (Copenh) (1984) 1.43
Nonsuppressible insulin-like activity (NSILA) from human serum: recent accomplishments and their physiologic implications. Metabolism (1978) 1.40
Insulin-like growth factors. Studies in diabetics with and without retinopathy. N Engl J Med (1983) 1.38
Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I. Nature (1986) 1.37
Biological and immunological properties of insulin-like growth factors (IGF) I and II. Clin Endocrinol Metab (1984) 1.35
Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats. J Clin Invest (1986) 1.35
Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects. Proc Natl Acad Sci U S A (1989) 1.33
Effects and binding of insulin-like growth factor I in the isolated soleus muscle of lean and obese mice: comparison with insulin. Endocrinology (1979) 1.32
Fibroblasts as an experimental tool in metabolic and hormone studies. II. Effects of insulin and nonsuppressible insulin-like activity (NSILA-S) on fibroblasts in culture. Eur J Clin Invest (1973) 1.29
Inhibition of the action of nonsuppressible insulin-like activity on isolated rat fat cells by binding to its carrier protein. J Clin Invest (1979) 1.28
Non-suppressible insulin-like activity of human serum. I. Physicochemical properties, extraction and partial purification. Biochim Biophys Acta (1966) 1.20
Insulin-like growth factors and insulin: comparative aspects. Diabetologia (1985) 1.20
Effect of trypsin treatment of rat adipocytes on biological effects and binding of insulin and insulin-like growth factors: further evidence for the action of insulin-like growth factors through the insulin receptor. Eur J Biochem (1981) 1.18
Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats. Acta Endocrinol (Copenh) (1985) 1.16
Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion. J Clin Invest (1992) 1.15
Dwarfism in the pygmy. An isolated deficiency of insulin-like growth factor I. N Engl J Med (1981) 1.13
Non-suppressible insulin-like activity and sulphaton activity in serum extracts of normal subjects, acromegalics and pituitary dwarfs. Acta Endocrinol (Copenh) (1976) 1.12
The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor. J Biol Chem (1975) 1.11
Enhanced osteoblast proliferation and collagen gene expression by estradiol. Proc Natl Acad Sci U S A (1988) 1.11
Insulin-like growth factors I and II, prolactin, and insulin in 19 growth hormone-deficient children with excessive, normal, or decreased longitudinal growth after operation for craniopharyngioma. N Engl J Med (1983) 1.10
Serum levels of insulin-like growth factor (IGF) and its carrier protein in various metabolic disorders. Acta Endocrinol (Copenh) (1980) 1.09
Insulin and non-suppressible insulin-like activity (NSILA-s): evidence for separate plasma membrane receptor sites. Biochem Biophys Res Commun (1974) 1.09
Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia. J Clin Invest (1990) 1.09
Insulin-like growth factors in the fed and fasted states. J Clin Endocrinol Metab (1982) 1.08
Nonsuppressible insulin-like activity in human serum. 3. Differentiation of two distinct molecules with nonsuppressible ILA. J Clin Invest (1968) 1.07
Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus. J Clin Invest (1992) 1.04
Is extrapancreatic tumor hypoglycemia associated with elevated levels of insulin-like growth factor II? J Clin Endocrinol Metab (1982) 1.03
NSILA-carrier protein abolishes the action of nonsuppressible insulin-like activity (NSILA-S) on perfused rat heart. Diabetologia (1978) 1.03
Repopulation of the atrophied thymus in diabetic rats by insulin-like growth factor I. Proc Natl Acad Sci U S A (1990) 1.03
Preferential enhancement of myoblast differentiation by insulin-like growth factors (IGF I and IGF II) in primary cultures of chicken embryonic cells. FEBS Lett (1983) 1.03
Insulin regulates insulin-like growth factor I mRNA in rat hepatocytes. Am J Physiol (1991) 1.00
Recombinant human insulin-like growth factor I (rhIGF I) reduces hyperglycaemia in patients with extreme insulin resistance. Diabetologia (1991) 0.99
Nonsuppressible insulinlike activity of human serum: purification, physiochemical and biological properties and its relation to total serum ILA. Recent Prog Horm Res (1967) 0.99
Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats. Proc Natl Acad Sci U S A (1989) 0.99
Human fetal and adult chondrocytes. Effect of insulinlike growth factors I and II, insulin, and growth hormone on clonal growth. J Clin Invest (1986) 0.98
Specific binding of nonsupressible insulinlike activity to chicken embryo fibroblasts and to a solubilized fibroblast receptor. Arch Biochem Biophys (1975) 0.97
Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes. Proc Natl Acad Sci U S A (1994) 0.97
Insulin-like growth factor I stimulates lipid oxidation, reduces protein oxidation, and enhances insulin sensitivity in humans. J Clin Invest (1993) 0.97
Effects of partially purified preparations with nonsuppressible insulin-like activity (NSILA-S) on sulfate incorporation into rat and chicken cartilage. Diabetologia (1973) 0.96
Effect of insulin-like growth factor on collagen and glycosaminoglycan synthesis by rabbit articular chondrocytes in culture. Experientia (1982) 0.95
Letter: Small doses of intramuscular insulin in the treatment of diabetic "coma". Lancet (1973) 0.95
Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by growth hormone in rat white adipose tissue. Endocrinology (1993) 0.94
Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I. Biochem Biophys Res Commun (1988) 0.94
Inhibition of phosphorylase-a by fructose-1-phosphate, alpha-glycerophosphate and fructose-1,6-diphosphate: explanation for fructose-induced hypoglycaemia in hereditary fructose intolerance and fructose-1,6-diphosphatase deficiency. Eur J Clin Invest (1973) 0.94
Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats. Proc Natl Acad Sci U S A (1988) 0.93
Biological properties of NSILA-S. Adv Metab Disord (1975) 0.92
Effects of insulin and NSILA on adipocytes of normal and diabetic rats: receptor binding, glucose transport and glucose metabolism. Diabetologia (1977) 0.92
Insulin-like growth factor I increase glomerular filtration rate and renal plasma flow in man. Acta Endocrinol (Copenh) (1989) 0.92
Growth-hormone dependence of non-suppressible insulin-like activity (NSILA) and of NSILA-carrier protein in rats. Acta Endocrinol (Copenh) (1978) 0.91
Beneficial metabolic effects of insulin-like growth factor I in patients with severe insulin-resistant diabetes type A. Eur J Endocrinol (1994) 0.91
Effects of short-term insulin-like growth factor-I or growth hormone treatment on bone turnover, renal phosphate reabsorption and 1,25 dihydroxyvitamin D3 production in healthy man. J Intern Med (1997) 0.91
Demonstration of a specific serum carrier protein of nonsuppressible insulin-like activity in vivo. J Clin Endocrinol Metab (1977) 0.91
The pathogenesis of tumour hypoglycaemia: blocks of hepatic glucose release and of adipose tissue lipolysis. Diabetologia (1967) 0.91
Non-suppressible insulin-like activity of human serum. II. Biological properties of plasma extracts with non-suppressible insulin-like activity. Biochim Biophys Acta (1966) 0.91
Disorders of fructose metabolism. Clin Endocrinol Metab (1976) 0.91
Determination of nonsuppressible insulin-like activity in human serum by a sensitive protein-binding assay. Clin Chem (1977) 0.91
Progesterone-controlled growth hormone overproduction and naturally occurring canine diabetes and acromegaly. Acta Endocrinol (Copenh) (1983) 0.90
Increased sensitivity of rat adipose tissue to the lipolytic action of epinephrine during fasting and its reversal during re-feeding. FEBS Lett (1977) 0.90
Insulin and nonsuppressible insulin-like activity (NSILA-S) stimulate the same glucose transport system via two separate receptors in rat heart. Biochem Biophys Res Commun (1977) 0.90
Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. Endocrinology (1994) 0.90
Hereditary fructose intolerance. Dental status of eight patients. Br Dent J (1967) 0.90
Insulin-like growth factor I supports differentiation of cultured osteoblast-like cells. FEBS Lett (1984) 0.90
Treatment with insulin-like growth factor I alters capillary permeability in skin and retina. Diabetes (1995) 0.89
Pathophysiological and clinical aspects of the insulin-like growth factors. Horm Res (1986) 0.89
Acute cardiovascular effects of insulin-like growth factor I in patients with chronic heart failure. J Clin Endocrinol Metab (1998) 0.89
Insulin regulates the expression of the insulin-like growth factor binding protein 2 mRNA in rat hepatocytes. Mol Endocrinol (1990) 0.89
Familial Cushing's syndrome with primary adrenocortical microadenomatosis (primary adrenocortical nodular dysplasia). Acta Endocrinol (Copenh) (1980) 0.89
Insulin-like growth factors/somatomedins: structure, secretion, biological actions and physiological role. Horm Res (1986) 0.89
Insulin-like growth factors stimulate synthesis of nucleic acids and glycogen in cultured calvaria cells. Calcif Tissue Int (1983) 0.88
Receptor binding and effects of insulin and NSILA-S on glucose transport and metabolism in adipocytes from hypophysectomized rats. Diabetologia (1979) 0.88
Comparison of the effects of growth hormone and insulin-like growth factor I on substrate oxidation and on insulin sensitivity in growth hormone-deficient humans. J Clin Invest (1994) 0.87
Evidence for the existence in human serum of large molecular weight nonsuppressible insulin-like activity (NSILA) different from the small molecular weight forms. FEBS Lett (1978) 0.87
Intact but not truncated insulin-like growth factor binding protein-3 (IGFBP-3) blocks IGF I-induced stimulation of osteoblasts: control of IGF signalling to bone cells by IGFBP-3-specific proteolysis? Biochem Biophys Res Commun (1991) 0.87
Effects of insulin on glucose metabolism and glucose transport in fat cells of hormone-treated hypophysectomized rats: evidence that growth hormone restricts glucose transport. Endocrinology (1979) 0.86
Effect of glucose on spontaneous limitation of lipolysis in isolated adipose tissue: a potential regulatory mechanism. Ann N Y Acad Sci (1965) 0.86
Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. J Biol Chem (1990) 0.86
Effects of short-term insulin-like growth factor-I (IGF-I) or growth hormone (GH) treatment on bone metabolism and on production of 1,25-dihydroxycholecalciferol in GH-deficient adults. J Clin Endocrinol Metab (1998) 0.85
Reduced ob mRNA in hypophysectomised rats is not restored by growth hormone (GH), but further suppressed by exogenously administered insulin-like growth factor (IGF) I. Biochem Biophys Res Commun (1996) 0.85
Insulin-like growth factor-I stimulates myofibrillar genes and modulates atrial natriuretic factor mRNA in rat heart. Eur J Endocrinol (1997) 0.85
Immunoreactive insulin, suppressible, and non suppressible insulinlike activities in rats after administration of glucose and induction of hyperglycaemia by mannoheptulose. Diabetologia (1966) 0.85
Metabolic state, pancreatic insulin content and B-cell morphology of normoglycemie spiny mice (Acomys cahirinus): indications for an impairment of insulin secretion. Diabetologia (1970) 0.85
Isolation and NH2-terminal amino acid sequences of rat serum carrier proteins for insulin-like growth factors. Biochem Biophys Res Commun (1988) 0.84
Fibroblasts as an experimental tool in metabolic and hormone studies. I. Growth and glucose metabolism of fibroblasts in culture. Eur J Clin Invest (1973) 0.84
Effect of insulin on glucose transport and metabolism in adipose tissue and skeletal muscle of hypophysectomized rats. FEBS Lett (1981) 0.84
The physiology and pharmacology of adipose tissue lipolysis: its inhibition and implications for the treatment of diabetes. Diabetologia (1967) 0.84
The pharmacokinetics of free insulin-like growth factor-I in healthy subjects. Growth Horm IGF Res (1999) 0.84