Published in N Engl J Med on September 01, 1983
Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest (1985) 2.00
IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci U S A (2007) 1.77
Evidence that upregulation of serum IGF-1 concentration can trigger acceleration of diabetic retinopathy. Br J Ophthalmol (1998) 1.62
Biometry of the crystalline lens in early-onset diabetes. Br J Ophthalmol (1990) 1.47
One hundred pancreas transplants at a single institution. Ann Surg (1984) 1.20
Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease. J Clin Invest (2004) 1.16
Analysis of the Zucker Diabetic Fatty (ZDF) type 2 diabetic rat model suggests a neurotrophic role for insulin/IGF-I in diabetic autonomic neuropathy. Am J Pathol (2003) 1.13
Regulation of lipoprotein lipase in primary cultures of isolated human adipocytes. J Clin Invest (1985) 0.98
Human growth hormone stimulates proliferation of human retinal microvascular endothelial cells in vitro. Proc Natl Acad Sci U S A (1991) 0.93
Proliferative retinopathy in a woman with growth hormone deficiency and diabetes mellitus. BMJ (1990) 0.92
Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown. J Biol Chem (2009) 0.90
Serum insulin-like growth factor-I in diabetic retinopathy. Mol Vis (2011) 0.89
TGF-β1 and IGF-I gene variations in type 1 diabetes microangiopathic complications. J Diabetes Metab Disord (2014) 0.85
Gene expression of IGF1, IGF1R, and IGFBP3 in epiretinal membranes of patients with proliferative diabetic retinopathy: preliminary study. Mediators Inflamm (2013) 0.83
Lens thickness and insulin dependent diabetes mellitus: a population based twin study. Br J Ophthalmol (1996) 0.81
Insulin exerts metabolic and growth-promoting effects by a direct action on the liver in vivo: clarification of the functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver. Proc Natl Acad Sci U S A (1987) 0.79
The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both? Diabetes Metab J (2016) 0.79
An ocular view of the IGF-IGFBP system. Growth Horm IGF Res (2013) 0.78
Pancreas transplantation--registry report and a commentary. West J Med (1985) 0.77
Actions of insulin-like growth factors. Annu Rev Physiol (1985) 3.80
Insulin-like growth factor I stimulates growth in hypophysectomized rats. Nature (1982) 2.79
Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia. J Clin Invest (1981) 2.52
Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med (1987) 2.00
Insulin-like growth factors I and II: some biological actions and receptor binding characteristics of two purified constituents of nonsuppressible insulin-like activity of human serum. Eur J Biochem (1978) 1.88
Insulin-like growth factors I and II in healthy man. Estimations of half-lives and production rates. Acta Endocrinol (Copenh) (1989) 1.83
Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: dependence on growth hormone status. Endocrinology (1983) 1.72
Effect of arginine on serum-levels of human growth-hormone. Lancet (1965) 1.65
Genetic aspects of clinical endocrinology. Recent Prog Horm Res (1968) 1.64
The insulin-like growth factors (IGF) of human serum: chemical and biological characterization and aspects of their possible physiological role. Curr Top Cell Regul (1981) 1.63
Insulin-like growth factors in vitreous. Studies in control and diabetic subjects with neovascularization. Diabetes (1986) 1.62
Can "big" insulin-like growth factor II in serum of tumor patients account for the development of extrapancreatic tumor hypoglycemia? J Clin Invest (1992) 1.58
Insulin-like growth factors in pygmies. The role of puberty in determining final stature. N Engl J Med (1987) 1.55
Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats. Proc Natl Acad Sci U S A (1988) 1.55
Binding of nonsuppressible insulinlike activity to human serum. Evidence for a carrier protein. Arch Biochem Biophys (1975) 1.52
Growth-hormone deficiency in man: an isolated, recessively inherited defect. Science (1966) 1.51
Interactions of insulin-like growth factors I and II and multiplication-stimulating activity with receptors and serum carrier proteins. Endocrinology (1980) 1.48
Insulin-like growth factor II in human adrenal pheochromocytomas and Wilms tumors: expression at the mRNA and protein level. Proc Natl Acad Sci U S A (1987) 1.47
Nonsuppressible insulin-like activity and thyroid hormones: major pituitary-dependent sulfation factors for chick embryo cartilage. Proc Natl Acad Sci U S A (1976) 1.45
Improvement of lipid profile in type 2 (non-insulin-dependent) diabetes mellitus by insulin-like growth factor I. Diabetologia (1993) 1.45
Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity. Acta Endocrinol (Copenh) (1984) 1.43
Nonsuppressible insulin-like activity (NSILA) from human serum: recent accomplishments and their physiologic implications. Metabolism (1978) 1.40
Growth restoration of insulin-deficient diabetic rats by recombinant human insulin-like growth factor I. Nature (1986) 1.37
Biological and immunological properties of insulin-like growth factors (IGF) I and II. Clin Endocrinol Metab (1984) 1.35
Acute metabolic effects and half-lives of intravenously administered insulinlike growth factors I and II in normal and hypophysectomized rats. J Clin Invest (1986) 1.35
Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects. Proc Natl Acad Sci U S A (1989) 1.33
Effects and binding of insulin-like growth factor I in the isolated soleus muscle of lean and obese mice: comparison with insulin. Endocrinology (1979) 1.32
Patterns of hormonal release after glucose, protein, and glucose plus protein. Lancet (1966) 1.31
Fibroblasts as an experimental tool in metabolic and hormone studies. II. Effects of insulin and nonsuppressible insulin-like activity (NSILA-S) on fibroblasts in culture. Eur J Clin Invest (1973) 1.29
Inhibition of the action of nonsuppressible insulin-like activity on isolated rat fat cells by binding to its carrier protein. J Clin Invest (1979) 1.28
Growth hormone and insulin release after arginine: indifference to hyperglycemia and epinephrine. J Clin Endocrinol Metab (1966) 1.27
Direct effects of leptin on brown and white adipose tissue. J Clin Invest (1997) 1.22
Non-suppressible insulin-like activity of human serum. I. Physicochemical properties, extraction and partial purification. Biochim Biophys Acta (1966) 1.20
Insulin-like growth factors and insulin: comparative aspects. Diabetologia (1985) 1.20
Effect of trypsin treatment of rat adipocytes on biological effects and binding of insulin and insulin-like growth factors: further evidence for the action of insulin-like growth factors through the insulin receptor. Eur J Biochem (1981) 1.18
A metabolic and hormonal basis for classifying ateliotic dwarfs. Lancet (1969) 1.17
Arginine-initiated release of human growth hormone. Factors modifying the response in normal man. N Engl J Med (1969) 1.17
Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats. Acta Endocrinol (Copenh) (1985) 1.16
Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion. J Clin Invest (1992) 1.15
Studies of the sex based variation of human growth hormone secretion. J Clin Endocrinol Metab (1971) 1.14
Dwarfism in the pygmy. An isolated deficiency of insulin-like growth factor I. N Engl J Med (1981) 1.13
Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies. J Clin Invest (1993) 1.13
Crystal structure of a phosphatase-resistant mutant of sporulation response regulator Spo0F from Bacillus subtilis. Structure (1996) 1.13
Non-suppressible insulin-like activity and sulphaton activity in serum extracts of normal subjects, acromegalics and pituitary dwarfs. Acta Endocrinol (Copenh) (1976) 1.12
Activity in fetal bovine serum that stimulates erythroid colony formation in fetal mouse livers is insulinlike growth factor I. J Clin Invest (1985) 1.12
The NSILA-s receptor in liver plasma membranes. Characterization and comparison with the insulin receptor. J Biol Chem (1975) 1.11
Peripheral subresponsiveness to human growth hormone in the African pygmies. N Engl J Med (1969) 1.11
Plasma growth hormone after arginine infusion. Clinical experiences. N Engl J Med (1967) 1.11
Enhanced osteoblast proliferation and collagen gene expression by estradiol. Proc Natl Acad Sci U S A (1988) 1.11
Insulin-like growth factors I and II, prolactin, and insulin in 19 growth hormone-deficient children with excessive, normal, or decreased longitudinal growth after operation for craniopharyngioma. N Engl J Med (1983) 1.10
Insulin and non-suppressible insulin-like activity (NSILA-s): evidence for separate plasma membrane receptor sites. Biochem Biophys Res Commun (1974) 1.09
Serum levels of insulin-like growth factor (IGF) and its carrier protein in various metabolic disorders. Acta Endocrinol (Copenh) (1980) 1.09
Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia. J Clin Invest (1990) 1.09
Insulin removal by isolated perfused rat liver. Am J Physiol (1976) 1.08
Insulin-like growth factors in the fed and fasted states. J Clin Endocrinol Metab (1982) 1.08
Differential effects of insulin-like growth factor I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo. J Clin Invest (1994) 1.08
Nonsuppressible insulin-like activity in human serum. 3. Differentiation of two distinct molecules with nonsuppressible ILA. J Clin Invest (1968) 1.07
Insulin-like growth factors (IGF) 1 and 2 in human foetal plasma and relationship to gestational age and foetal size during midpregnancy. Acta Endocrinol (Copenh) (1985) 1.07
Role of muscle insulin-like growth factors in nerve sprouting: suppression of terminal sprouting in paralyzed muscle by IGF-binding protein 4. J Cell Biol (1994) 1.07
Isolated human growth hormone deficiency. 3. Insulin secretion in sexual ateliotic dwarfism. Metabolism (1968) 1.05
Insulin-like growth factor-I improves glucose and lipid metabolism in type 2 diabetes mellitus. J Clin Invest (1992) 1.04
Is extrapancreatic tumor hypoglycemia associated with elevated levels of insulin-like growth factor II? J Clin Endocrinol Metab (1982) 1.03
NSILA-carrier protein abolishes the action of nonsuppressible insulin-like activity (NSILA-S) on perfused rat heart. Diabetologia (1978) 1.03
Repopulation of the atrophied thymus in diabetic rats by insulin-like growth factor I. Proc Natl Acad Sci U S A (1990) 1.03
Glycosylated serum protein and hemoglobin A1 levels to measure control of glycemia. Ann Intern Med (1981) 1.03
Preferential enhancement of myoblast differentiation by insulin-like growth factors (IGF I and IGF II) in primary cultures of chicken embryonic cells. FEBS Lett (1983) 1.03