Published in Nat Immunol on August 12, 2002
Regulation of type I interferon responses. Nat Rev Immunol (2014) 3.60
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PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci U S A (2003) 3.02
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity (2012) 2.23
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Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science (2012) 1.83
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Signaling by STATs. Arthritis Res Ther (2004) 1.35
Activation of the STAT1 pathway in rheumatoid arthritis. Ann Rheum Dis (2004) 1.26
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. J Virol (2013) 1.22
Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specimens. Arthritis Res Ther (2005) 1.13
Overview of the biology of type I interferons. Arthritis Res Ther (2010) 1.07
Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis. J Exp Med (2003) 1.03
IFN{gamma} regulates retinal pigment epithelial fluid transport. Am J Physiol Cell Physiol (2009) 1.01
Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum (2012) 1.01
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Network topologies and dynamics leading to endotoxin tolerance and priming in innate immune cells. PLoS Comput Biol (2012) 1.00
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Ultrasensitization: switch-like regulation of cellular signaling by transcriptional induction. PLoS Comput Biol (2005) 0.95
Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4. BMC Cancer (2004) 0.93
Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin. Arthritis Rheumatol (2015) 0.92
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Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections. Mucosal Immunol (2014) 0.90
CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent. Clin Exp Immunol (2004) 0.88
Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1). Arthritis Res Ther (2006) 0.87
BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes. Eur J Immunol (2014) 0.86
Modulation of TNF-induced macrophage polarization by synovial fibroblasts. J Immunol (2014) 0.86
Tumour necrosis factor receptor trafficking dysfunction opens the TRAPS door to pro-inflammatory cytokine secretion. Biosci Rep (2012) 0.85
Glycoinositolphospholipids from Leishmania braziliensis and L. infantum: modulation of innate immune system and variations in carbohydrate structure. PLoS Negl Trop Dis (2012) 0.85
Interferon-gamma reduces cell surface expression of annexin 2 and suppresses the invasive capacity of prostate cancer cells. J Biol Chem (2008) 0.85
Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2. J Leukoc Biol (2008) 0.84
Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function. J Immunol (2012) 0.83
Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance? Arthritis Res Ther (2009) 0.82
Regulation of Macrophage Polarization by RON Receptor Tyrosine Kinase Signaling. Front Immunol (2014) 0.82
Macrophages from nonobese diabetic mouse have a selective defect in IFN-γ but not IFN-α/β receptor pathway. J Clin Immunol (2012) 0.82
A strategy to study pathway cross-talks of cells under repetitive exposure to stimuli. BMC Syst Biol (2012) 0.81
Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus. Arthritis Res Ther (2014) 0.81
Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage "Switch" Phenotype. Biomed Res Int (2015) 0.80
A Cytokine Signalling Network for the Regulation of Inducible Nitric Oxide Synthase Expression in Rheumatoid Arthritis. PLoS One (2016) 0.80
Parallel Gene Expression Changes in Sarcoidosis Involving the Lacrimal Gland, Orbital Tissue, or Blood. JAMA Ophthalmol (2015) 0.80
Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome. Front Microbiol (2016) 0.79
Impaired activation of Stat1 and c-Jun as a possible defect in macrophages of patients with active tuberculosis. Clin Exp Immunol (2009) 0.79
Investigating the Role of TNF-α and IFN-γ Activation on the Dynamics of iNOS Gene Expression in LPS Stimulated Macrophages. PLoS One (2016) 0.79
Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules. J Biol Chem (2015) 0.78
Therapeutic Potential of Interferon-γ and Its Antagonists in Autoinflammation: Lessons from Murine Models of Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome. Pharmaceuticals (Basel) (2015) 0.78
Can SOCS make arthritis better? J Clin Invest (2003) 0.77
STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways. PLoS Biol (2016) 0.76
How and why do T cells and their derived cytokines affect the injured and healthy brain? Nat Rev Neurosci (2017) 0.75
Constitutive IFNα/β signaling maintains expression of signaling intermediaries for efficient cytokine responses. JAKSTAT (2016) 0.75
Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF. Immunity (2017) 0.75
Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity (2009) 3.51
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity (2006) 2.58
TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes. Nat Immunol (2008) 2.49
Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity (2008) 2.48
Macrophages and their products in rheumatoid arthritis. Curr Opin Rheumatol (2007) 2.20
Revisiting upper eyelid anatomy: introduction of the septal extension. Plast Reconstr Surg (2006) 2.18
Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation. J Biol Chem (2006) 2.15
The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model. J Exp Med (2002) 2.00
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J. J Exp Med (2012) 1.99
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Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J Leukoc Biol (2007) 1.94
Heuristic versus systematic processing of information in detecting deception: questioning the truth bias. Psychol Rep (2009) 1.94
Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. Arthritis Rheum (2006) 1.92
FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity (2007) 1.90
Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. J Virol (2007) 1.84
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol (2012) 1.81
Isolation and characterization of mesenchymal stromal cells from human degenerated nucleus pulposus: comparison with bone marrow mesenchymal stromal cells from the same subjects. Spine (Phila Pa 1976) (2010) 1.79
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity (2010) 1.78
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest (2013) 1.77
Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med (2006) 1.76
Hemolysin and the multifunctional autoprocessing RTX toxin are virulence factors during intestinal infection of mice with Vibrio cholerae El Tor O1 strains. Infect Immun (2007) 1.68
ALAS2 acts as a modifier gene in patients with congenital erythropoietic porphyria. Blood (2011) 1.68
Amelioration of rat adjuvant-induced arthritis by Met-RANTES. Arthritis Rheum (2005) 1.58
Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase. Circ Res (2003) 1.57
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling. Immunity (2013) 1.55
Citrullination of epithelial neutrophil-activating peptide 78/CXCL5 results in conversion from a non-monocyte-recruiting chemokine to a monocyte-recruiting chemokine. Arthritis Rheumatol (2014) 1.53
Vascular involvement in rheumatic diseases: 'vascular rheumatology'. Arthritis Res Ther (2008) 1.52
Chemokines and chemokine receptors in rheumatoid arthritis. Semin Immunol (2003) 1.49
Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice. Arthritis Rheum (2012) 1.48
Mechanisms of Disease: angiogenesis in inflammatory diseases. Nat Clin Pract Rheumatol (2007) 1.48
Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis. Lab Invest (2003) 1.48
The vascular system as a target of metal toxicity. Toxicol Sci (2007) 1.47
Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol (2011) 1.46
Angiogenesis and vasculogenesis in rheumatoid arthritis. Curr Opin Rheumatol (2010) 1.45
Suppression of endothelial cell activity by inhibition of TNFα. Arthritis Res Ther (2012) 1.44
New reasons for an archaic treatment: phlebotomy in sporadic porphyria cutanea tarda. Arch Dermatol (2003) 1.44
'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages. Nat Immunol (2007) 1.40
Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndrome. J Urol (2008) 1.39
Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol (2004) 1.39
Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway. Proc Natl Acad Sci U S A (2004) 1.38
IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling. Proc Natl Acad Sci U S A (2010) 1.38
IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J Immunol (2008) 1.37
Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology (2009) 1.36
Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors. Arthritis Res Ther (2011) 1.33
CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway. Cancer Res (2008) 1.33
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci U S A (2010) 1.33
Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NFkappaB. Blood (2005) 1.32
A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19. Proc Natl Acad Sci U S A (2002) 1.31
Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis. J Immunol (2008) 1.30
Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs. J Immunol (2007) 1.30
Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages. J Immunol (2010) 1.28
Regulation of macrophage phenotype by long-term exposure to IL-10. Immunobiology (2005) 1.27
TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages. Proc Natl Acad Sci U S A (2011) 1.26
IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J Immunol (2004) 1.25
Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors. J Immunol (2009) 1.25
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. J Immunol (2010) 1.25
Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues. Arthritis Res Ther (2007) 1.25
A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells. J Biol Chem (2007) 1.25
Angiogenesis and its targeting in rheumatoid arthritis. Vascul Pharmacol (2009) 1.24
Rheumatoid arthritis synoviocyte survival is dependent on Stat3. J Immunol (2002) 1.24
Reprogramming of IL-10 activity and signaling by IFN-gamma. J Immunol (2003) 1.24
The vascular endothelium as a target of cadmium toxicity. Life Sci (2006) 1.23
Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum (2006) 1.22
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. J Virol (2013) 1.22
Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis. J Orthop Res (2008) 1.21
Efficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis. J Virol (2002) 1.21
Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells. Proc Natl Acad Sci U S A (2009) 1.21
IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts. J Immunol (2003) 1.20
Macrophage migration inhibitory factor: a mediator of matrix metalloproteinase-2 production in rheumatoid arthritis. Arthritis Res Ther (2006) 1.19
IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression. J Immunol (2009) 1.19
Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue. Arthritis Res (2002) 1.19
In vivo inhibition of angiogenesis by interleukin-13 gene therapy in a rat model of rheumatoid arthritis. Arthritis Rheum (2007) 1.18
CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro. Mol Cancer Res (2008) 1.18
Mcl-1 is essential for the survival of synovial fibroblasts in rheumatoid arthritis. J Immunol (2005) 1.18
Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis. Arthritis Rheum (2012) 1.18
Inhibition of IFN-gamma signaling by glucocorticoids. J Immunol (2003) 1.17
The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. Arthritis Rheum (2007) 1.16
Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc Natl Acad Sci U S A (2008) 1.15
p21Cip1 is required for the development of monocytes and their response to serum transfer-induced arthritis. Am J Pathol (2006) 1.14
Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. J Biol Chem (2002) 1.14
The JAK/STAT pathway in rheumatoid arthritis: pathogenic or protective? Arthritis Rheum (2003) 1.14
The type I interferon signaling pathway is a target for glucocorticoid inhibition. Mol Cell Biol (2010) 1.14
CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway. Arthritis Rheum (2006) 1.13