Regulation of type I interferon responses.

Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol (2015) 2.74

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science (2017) 2.70

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell (2015) 2.60

Type I interferons in infectious disease. Nat Rev Immunol (2015) 2.37

AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell (2016) 2.19

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med (2016) 1.96

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells. Cancer Cell (2015) 1.74

A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus. Immunity (2016) 1.59

Type I interferons link viral infection to enhanced epithelial turnover and repair. Cell Host Microbe (2014) 1.53

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes. Diabetes (2014) 1.50

Sall1 is a transcriptional regulator defining microglia identity and function. Nat Immunol (2016) 1.48

IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function. Nat Immunol (2017) 1.45

Functional Analysis of Chicken IRF7 in Response to dsRNA Analog Poly(I:C) by Integrating Overexpression and Knockdown. PLoS One (2015) 1.44

Optineurin regulates the interferon response in a cell cycle-dependent manner. PLoS Pathog (2015) 1.42

Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation. Nat Immunol (2017) 1.40

Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome. J Clin Invest (2014) 1.29

Cardiac Fibrosis: The Fibroblast Awakens. Circ Res (2016) 1.21

Molecular mechanisms in genetically defined autoinflammatory diseases: disorders of amplified danger signaling. Annu Rev Immunol (2015) 1.08

Camouflage and misdirection: the full-on assault of ebola virus disease. Cell (2014) 1.07

RIG-I-like receptor regulation in virus infection and immunity. Curr Opin Virol (2015) 1.07

Interferons and their stimulated genes in the tumor microenvironment. Semin Oncol (2014) 1.07

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol (2015) 1.06

Multifaceted activities of type I interferon are revealed by a receptor antagonist. Sci Signal (2014) 1.04

ISG15 deficiency and increased viral resistance in humans but not mice. Nat Commun (2016) 1.03

Negative regulation of the interferon response by an interferon-induced long non-coding RNA. Nucleic Acids Res (2014) 1.02

Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell (2016) 1.01

RNA degradation in antiviral immunity and autoimmunity. Trends Immunol (2015) 1.01

Molecular control of activation and priming in macrophages. Nat Immunol (2015) 1.00

Molecular mechanisms of Ebola virus pathogenesis: focus on cell death. Cell Death Differ (2015) 1.00

Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes. Mol Cancer Res (2014) 0.99

Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor. J Virol (2014) 0.99

Combinatorial strategies for the induction of immunogenic cell death. Front Immunol (2015) 0.98

Interferons: Success in anti-viral immunotherapy. Cytokine Growth Factor Rev (2014) 0.98

Intersection of mTOR and STAT signaling in immunity. Trends Immunol (2014) 0.97

HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity. Cells (2014) 0.96

Long Non-Coding RNA BST2/BISPR is Induced by IFN and Regulates the Expression of the Antiviral Factor Tetherin. Front Immunol (2015) 0.96

Selective Blockade of Interferon-α and -β Reveals Their Non-Redundant Functions in a Mouse Model of West Nile Virus Infection. PLoS One (2015) 0.95

A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages. Genes Dev (2015) 0.94

Designing DNA nanodevices for compatibility with the immune system of higher organisms. Nat Nanotechnol (2015) 0.92

Ubiquitination in the antiviral immune response. Virology (2015) 0.92

Regulation of Interferon-Stimulated Gene BST2 by a lncRNA Transcribed from a Shared Bidirectional Promoter. Front Immunol (2015) 0.90

Central role of ULK1 in type I interferon signaling. Cell Rep (2015) 0.90

Disease-promoting effects of type I interferons in viral, bacterial, and coinfections. J Interferon Cytokine Res (2015) 0.90

Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs. Front Immunol (2015) 0.90

Control of cytokine production by human fc gamma receptors: implications for pathogen defense and autoimmunity. Front Immunol (2015) 0.89

The role of type I interferons in intestinal infection, homeostasis, and inflammation. Immunol Rev (2014) 0.89

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity. Eur J Immunol (2015) 0.89

Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus. Arthritis Rheumatol (2017) 0.89

Liver immunology and its role in inflammation and homeostasis. Cell Mol Immunol (2016) 0.88

Intracellular detection of viral nucleic acids. Curr Opin Microbiol (2015) 0.88

Approved Antiviral Drugs over the Past 50 Years. Clin Microbiol Rev (2016) 0.88

Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proc Natl Acad Sci U S A (2015) 0.88

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression. Ann Rheum Dis (2014) 0.87

Insights into cytokine-receptor interactions from cytokine engineering. Annu Rev Immunol (2014) 0.87

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1. Genes Dev (2017) 0.87

Unraveling the convoluted biological roles of type I interferons in infection and immunity: a way forward for therapeutics and vaccine design. Front Immunol (2014) 0.87

BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes. Eur J Immunol (2014) 0.86

Modulation of TNF-induced macrophage polarization by synovial fibroblasts. J Immunol (2014) 0.86

Immunologic characterization of a rhesus macaque H1N1 challenge model for candidate influenza virus vaccine assessment. Clin Vaccine Immunol (2014) 0.86

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation. Cell Rep (2016) 0.85

Identification of context-dependent expression quantitative trait loci in whole blood. Nat Genet (2016) 0.85

Interferon-induced protein Ifit2 protects mice from infection of the peripheral nervous system by vesicular stomatitis virus. J Virol (2014) 0.85

Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types. Front Immunol (2014) 0.85

Sendai virus pathogenesis in mice is prevented by Ifit2 and exacerbated by interferon. J Virol (2014) 0.85

Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27. Cell Res (2015) 0.85

An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival. Oncotarget (2014) 0.84

IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus. Ann Rheum Dis (2016) 0.83

Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases. Front Immunol (2017) 0.83

Type I interferon contributes to noncanonical inflammasome activation, mediates immunopathology, and impairs protective immunity during fatal infection with lipopolysaccharide-negative ehrlichiae. Am J Pathol (2014) 0.83

Bacterial programming of host responses: coordination between type I interferon and cell death. Front Microbiol (2014) 0.83

Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses. Cell Mol Immunol (2016) 0.83

Type I Interferon Regulates the Expression of Long Non-Coding RNAs. Front Immunol (2014) 0.83

De novo assembly and transcriptome analysis of Atlantic salmon macrophage/dendritic-like TO cells following type I IFN treatment and Salmonid alphavirus subtype-3 infection. BMC Genomics (2015) 0.83

Innate immune evasion by filoviruses. Virology (2015) 0.82

Against Ebola: type I interferon guard risk and mesenchymal stromal cell combat sepsis. J Zhejiang Univ Sci B (2015) 0.82

Macrophage Polarization in Virus-Host Interactions. J Clin Cell Immunol (2015) 0.82

New insights into type I interferon and the immunopathogenesis of persistent viral infections. Curr Opin Immunol (2015) 0.81

Effect of prednisone on type I interferon signature in rheumatoid arthritis: consequences for response prediction to rituximab. Arthritis Res Ther (2015) 0.81

Short peptide type I interferon mimetics: therapeutics for experimental allergic encephalomyelitis, melanoma, and viral infections. J Interferon Cytokine Res (2014) 0.81

Innate Immune Signaling Activated by MDR Bacteria in the Airway. Physiol Rev (2016) 0.81

Interferon regulatory factors: critical mediators of human lupus. Transl Res (2014) 0.80

Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms. PLoS Pathog (2015) 0.80

Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Mol Cell Endocrinol (2015) 0.80

The type I interferon signature in leukocyte subsets from peripheral blood of patients with early arthritis: a major contribution by granulocytes. Arthritis Res Ther (2016) 0.79

The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development. Sci Signal (2015) 0.79

HIV: The mixed blessing of interferon. Nature (2014) 0.79

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype. Acta Neuropathol Commun (2016) 0.79

Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion. MBio (2016) 0.79

High-risk human papillomavirus targets crossroads in immune signaling. Viruses (2015) 0.79

Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis. PLoS One (2014) 0.79

Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila. Proc Natl Acad Sci U S A (2014) 0.79

A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin. Mucosal Immunol (2015) 0.79

Molecular evolution of the porcine type I interferon family: subtype-specific expression and antiviral activity. PLoS One (2014) 0.79

Age-Associated Failure To Adjust Type I IFN Receptor Signaling Thresholds after T Cell Activation. J Immunol (2015) 0.79

A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women-A Randomized Controlled Trial. Nutrients (2016) 0.79

The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation. Cell Commun Signal (2017) 0.78

Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus. PLoS Negl Trop Dis (2017) 0.78

Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to Activated Neutrophils during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol (2016) 0.78

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection. PLoS Pathog (2016) 0.78

Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity. Sci Rep (2016) 0.78

Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33

Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47

A diverse range of gene products are effectors of the type I interferon antiviral response. Nature (2011) 12.86

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature (2010) 10.37

Suppression of inflammation by a synthetic histone mimic. Nature (2010) 8.80

Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol (2007) 8.05

SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol (2007) 6.89

The IRF family transcription factors in immunity and oncogenesis. Annu Rev Immunol (2008) 6.60

Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature (2013) 6.50

A unifying model for mTORC1-mediated regulation of mRNA translation. Nature (2012) 6.44

A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell (2009) 6.26

Interferons, interferon-like cytokines, and their receptors. Immunol Rev (2004) 6.21

The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61

Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci U S A (2002) 5.28

The JAK-STAT signaling pathway: input and output integration. J Immunol (2007) 4.92

Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev (2006) 4.61

Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell (2010) 4.57

Complex modulation of cell type-specific signaling in response to type I interferons. Immunity (2006) 4.48

The JAK-STAT pathway at twenty. Immunity (2012) 4.41

Type I interferon: friend or foe? J Exp Med (2010) 4.40

Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science (2013) 4.18

Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science (2013) 4.14

Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell (2012) 4.10

The immune response in tuberculosis. Annu Rev Immunol (2013) 3.91

Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol (2006) 3.84

Standardizing immunophenotyping for the Human Immunology Project. Nat Rev Immunol (2012) 3.81

Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity (2008) 3.67

Cytosolic sensing of viruses. Immunity (2013) 3.54

Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity (2009) 3.51

Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity (2012) 3.47

Latent enhancers activated by stimulation in differentiated cells. Cell (2013) 3.44

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science (2007) 3.16

Determinants and dynamics of genome accessibility. Nat Rev Genet (2011) 3.15

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science (2002) 3.05

Immune sensing of DNA. Immunity (2013) 2.96

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75

Selective transcription in response to an inflammatory stimulus. Cell (2010) 2.75

Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol (2013) 2.71

PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes. Genes Dev (2005) 2.70

Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat Rev Immunol (2005) 2.59

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes. Nat Immunol (2008) 2.49

Autoimmunity through cytokine-induced dendritic cell activation. Immunity (2004) 2.46

STATs shape the active enhancer landscape of T cell populations. Cell (2012) 2.45

Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science (2013) 2.34

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J (2000) 2.33

The ISG56/IFIT1 gene family. J Interferon Cytokine Res (2010) 2.32

Translational control of the innate immune response through IRF-7. Nature (2008) 2.30

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium. Nat Immunol (2012) 2.25

Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity (2012) 2.23

Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota. Immunity (2012) 2.23

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population. J Clin Invest (2010) 2.22

Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol (2012) 2.21

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity (2011) 2.19

Histone deacetylases as regulators of inflammation and immunity. Trends Immunol (2011) 2.18

Suppression of the antiviral response by an influenza histone mimic. Nature (2012) 2.18

Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. J Biol Chem (2006) 2.15

Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation. J Biol Chem (2006) 2.15

Interferome v2.0: an updated database of annotated interferon-regulated genes. Nucleic Acids Res (2012) 2.08

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A (2010) 2.06

Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol (2011) 2.01

Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks. Genes Dev (2012) 1.91

Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat Cell Biol (2002) 1.91

Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity (2010) 1.90

OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7. Nat Immunol (2013) 1.87

Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation. Nat Immunol (2002) 1.83

Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A (2008) 1.81

Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity (2010) 1.78

Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex. Mol Cell Biol (2002) 1.73

Type I interferons: crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol (2010) 1.73

Interferon-ε protects the female reproductive tract from viral and bacterial infection. Science (2013) 1.73

Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback. J Interferon Cytokine Res (2002) 1.68

The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming. Mol Cell Biol (2004) 1.64

Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol (2009) 1.61

The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. Nat Immunol (2013) 1.60

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe (2010) 1.56

Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling. Immunity (2013) 1.55

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A (2012) 1.53

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity (2013) 1.49

Stochastic expression of the interferon-β gene. PLoS Biol (2012) 1.47

Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe (2009) 1.46

The genomic landscapes of inflammation. Genes Dev (2011) 1.45

A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature (2012) 1.44

Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci U S A (2008) 1.43

Emerging roles for lipid droplets in immunity and host-pathogen interactions. Annu Rev Cell Dev Biol (2012) 1.42

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1. Nat Immunol (2013) 1.41

The interferons and their receptors--distribution and regulation. Immunol Cell Biol (2012) 1.41

'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages. Nat Immunol (2007) 1.40

Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol (2004) 1.39

Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function. Nucleic Acids Res (2013) 1.38

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nat Immunol (2011) 1.36

Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response. J Exp Med (2012) 1.36

BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes. Mol Cell Biol (2013) 1.35

Apical role for BRG1 in cytokine-induced promoter assembly. Proc Natl Acad Sci U S A (2005) 1.30

CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity (2013) 1.28

Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation. Proc Natl Acad Sci U S A (2007) 1.28

Post-transcriptional control of the interferon system. Biochimie (2007) 1.28

The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression. Science (2010) 1.27

STAT3 negatively regulates type I IFN-mediated antiviral response. J Immunol (2011) 1.27

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. EMBO J (2013) 1.26