Published in Trends Cell Biol on July 01, 2002
Targeting TGF-β signaling in cancer. Expert Opin Ther Targets (2013) 1.16
Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis. Mol Pain (2012) 0.99
A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor. BMC Biol (2006) 0.95
Transforming growth factor-beta signaling and ubiquitinators in cancer. Endocr Relat Cancer (2008) 0.93
Dentin phosphophoryn activates Smad protein signaling through Ca2+-calmodulin-dependent protein kinase II in undifferentiated mesenchymal cells. J Biol Chem (2013) 0.85
A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer. Oncotarget (2016) 0.77
Possible Involvement of Smad Signaling Pathways in Induction of Odontoblastic Properties in KN-3 Cells by Bone Morphogenetic Protein-2: A Growth Factor to Induce Dentin Regeneration. Int J Dent (2012) 0.77
Non-Smad TGF-beta signals. J Cell Sci (2005) 6.06
The regulation of TGFbeta signal transduction. Development (2009) 4.59
Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci (2007) 4.07
Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr Opin Cell Biol (2009) 3.94
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell (2005) 3.75
Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta (2006) 3.64
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol (2006) 3.44
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol (2008) 3.31
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol (2009) 3.12
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res (2002) 2.70
PDGF receptors as cancer drug targets. Cancer Cell (2003) 2.66
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein. Mol Cell Biol (2004) 2.53
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell (2002) 2.27
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J Biol Chem (2008) 2.22
Control of Smad7 stability by competition between acetylation and ubiquitination. Mol Cell (2002) 2.18
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet (2008) 2.13
Regulation of EMT by TGFβ in cancer. FEBS Lett (2012) 2.11
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. Mol Biol Cell (2003) 2.03
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. J Biol Chem (2002) 1.89
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am J Pathol (2009) 1.81
PDGF receptors as targets in tumor treatment. Adv Cancer Res (2007) 1.76
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate. Cancer Res (2004) 1.72
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest (2008) 1.68
Regulating the stability of TGFbeta receptors and Smads. Cell Res (2009) 1.67
Role of Smads in TGFβ signaling. Cell Tissue Res (2011) 1.62
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J Biol Chem (2005) 1.60
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res (2011) 1.55
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest (2005) 1.55
Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation. Mol Cell Biol (2003) 1.50
Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. J Exp Med (2010) 1.48
Activation of bone morphogenetic protein/Smad signaling in bronchial epithelial cells during airway inflammation. Am J Respir Cell Mol Biol (2002) 1.45
Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21(WAF1/Cip1). J Cell Physiol (2005) 1.44
LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta. J Biol Chem (2005) 1.42
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. Mol Cell Biol (2006) 1.42
Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. Mol Cell Biol (2005) 1.41
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem (2004) 1.38
Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol (2007) 1.36
Deletion of exon I of SMAD7 in mice results in altered B cell responses. J Immunol (2006) 1.36
Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins. J Biol Chem (2004) 1.33
Differential ubiquitination defines the functional status of the tumor suppressor Smad4. J Biol Chem (2003) 1.33
Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2004) 1.33
Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes. J Biol Chem (2002) 1.32
PARP-1 attenuates Smad-mediated transcription. Mol Cell (2010) 1.32
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. Mol Biol Cell (2005) 1.29
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun (2011) 1.28
STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake. Clin Cancer Res (2003) 1.27
Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol (2004) 1.24
The balance between acetylation and deacetylation controls Smad7 stability. J Biol Chem (2005) 1.24
Induction of epithelial-mesenchymal transition by transforming growth factor β. Semin Cancer Biol (2012) 1.21
Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition. J Biol Chem (2012) 1.16
The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter. Biochemistry (2002) 1.16
Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation. J Biol Chem (2008) 1.16
Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling. Int J Cancer (2007) 1.15
Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom. BMC Evol Biol (2009) 1.14
The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation. J Biol Chem (2006) 1.14
The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma. PLoS One (2011) 1.11
Dynamic control of TGF-beta signaling and its links to the cytoskeleton. FEBS Lett (2008) 1.10
Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. Biochem J (2003) 1.10
TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1. Cell Cycle (2014) 1.09
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem J (2007) 1.08
Control of transforming growth factor beta signal transduction by small GTPases. FEBS J (2009) 1.07
Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner. J Biol Chem (2005) 1.06
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol (2004) 1.06
SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma. J Lipid Res (2007) 1.05
Filamin a mediates HGF/c-MET signaling in tumor cell migration. Int J Cancer (2011) 1.05
Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma. PLoS One (2009) 1.05
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. J Cell Biol (2011) 1.04
Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration. Arterioscler Thromb Vasc Biol (2002) 1.04
The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination. J Biol Chem (2010) 1.04
From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction. Genes Dev (2002) 1.03
Quantitative analysis of transient and sustained transforming growth factor-β signaling dynamics. Mol Syst Biol (2011) 1.03
Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail. J Biol Chem (2004) 1.03
TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage. Oncogene (2005) 1.03
Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42. J Cell Sci (2004) 0.99
TGFbeta induces SIK to negatively regulate type I receptor kinase signaling. J Cell Biol (2008) 0.99
Inhibition of platelet-derived growth factor-BB-induced receptor activation and fibroblast migration by hyaluronan activation of CD44. J Biol Chem (2006) 0.99
Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor. Mol Biol Cell (2006) 0.99
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor. J Biol Chem (2008) 0.97
Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair. EMBO J (2002) 0.97
Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription. Mol Biol Cell (2005) 0.96
Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro. Biochem Biophys Res Commun (2010) 0.96
SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor. Oncogene (2002) 0.96
APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration. Mol Biol Cell (2012) 0.95
Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor. J Biol Chem (2004) 0.94
PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4. Circ Res (2002) 0.93