Published in Mol Cell Biol on July 01, 2003
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell (2005) 3.75
Hepatitis C virus infection protein network. Mol Syst Biol (2008) 2.91
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein. Mol Cell Biol (2004) 2.53
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol (2007) 1.68
The Yin and Yang of YY1 in the nervous system. J Neurochem (2008) 1.68
YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc Natl Acad Sci U S A (2004) 1.62
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Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. J Clin Invest (2009) 1.39
Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer. Dev Biol (2007) 1.35
Hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires transforming growth factor-beta/Smad3 signaling. J Biol Chem (2005) 1.24
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An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling. EMBO J (2008) 1.13
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Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin. J Biol Chem (2010) 0.87
Regulation of TGF-β Signal Transduction. Scientifica (Cairo) (2014) 0.84
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Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas. Onco Targets Ther (2014) 0.77
Regulation of Yin Yang 1 by Tyrosine Phosphorylation. J Biol Chem (2015) 0.76
The basic helix-loop-helix/leucine zipper transcription factor USF2 integrates serum-induced PAI-1 expression and keratinocyte growth. J Cell Biochem (2014) 0.75
A functional AT/G polymorphism in the 5'-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14. Genes Immun (2015) 0.75
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YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes. J Biol Chem (1999) 0.84
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TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell (2005) 3.75
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Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol (2006) 3.44
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A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol (2009) 3.12
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Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein. Mol Cell Biol (2004) 2.53
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology (2010) 2.48
Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev Cell (2006) 2.41
The dynamic roles of TGF-β in cancer. J Pathol (2010) 2.32
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell (2002) 2.27
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J Biol Chem (2008) 2.22
Control of Smad7 stability by competition between acetylation and ubiquitination. Mol Cell (2002) 2.18
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology (2003) 2.17
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet (2008) 2.13
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TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis. Mol Cell (2013) 2.08
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. Mol Biol Cell (2003) 2.03
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res (2008) 1.92
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses. J Biol Chem (2002) 1.89
SREBP in signal transduction: cholesterol metabolism and beyond. Curr Opin Cell Biol (2007) 1.87
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer. Am J Pathol (2009) 1.81
Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors. Mol Cell Biol (2003) 1.79
PDGF receptors as targets in tumor treatment. Adv Cancer Res (2007) 1.76
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate. Cancer Res (2004) 1.72
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats. J Clin Invest (2008) 1.68
Regulating the stability of TGFbeta receptors and Smads. Cell Res (2009) 1.67
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest (2013) 1.65
Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res (2007) 1.63
YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc Natl Acad Sci U S A (2004) 1.62
Role of Smads in TGFβ signaling. Cell Tissue Res (2011) 1.62
The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. Gastroenterology (2008) 1.61
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J Biol Chem (2005) 1.60
BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am J Pathol (2007) 1.58
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res (2011) 1.55
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest (2005) 1.55
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest (2012) 1.52
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Profiling cellular protein complexes by proximity ligation with dual tag microarray readout. PLoS One (2012) 1.47
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Exploring anti-TGF-β therapies in cancer and fibrosis. Growth Factors (2011) 1.44
LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta. J Biol Chem (2005) 1.42
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. Mol Cell Biol (2006) 1.42
Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis. Mol Cell Biol (2005) 1.41
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. J Biol Chem (2004) 1.38
Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol (2007) 1.36
Deletion of exon I of SMAD7 in mice results in altered B cell responses. J Immunol (2006) 1.36
Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J Cell Biol (2008) 1.35
Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J Biol Chem (2006) 1.35
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Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins. J Biol Chem (2004) 1.33
Differential ubiquitination defines the functional status of the tumor suppressor Smad4. J Biol Chem (2003) 1.33
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Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction. Dev Cell (2006) 1.32
Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes. J Biol Chem (2002) 1.32
PARP-1 attenuates Smad-mediated transcription. Mol Cell (2010) 1.32
A phosphorylation cascade controls the degradation of active SREBP1. J Biol Chem (2009) 1.32
Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice. J Cell Sci (2007) 1.31
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol Cell (2010) 1.30
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis. Mol Biol Cell (2005) 1.29
TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun (2011) 1.28
STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptake. Clin Cancer Res (2003) 1.27
Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues. EMBO J (2002) 1.25
Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol (2004) 1.24
Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium. FASEB J (2008) 1.24
The balance between acetylation and deacetylation controls Smad7 stability. J Biol Chem (2005) 1.24
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