Published in J Infect Dis on July 24, 2002
Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun (2005) 2.32
Epithelial cells are sensitive detectors of bacterial pore-forming toxins. J Biol Chem (2006) 1.90
The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun (2005) 1.86
CD4-T-lymphocyte interactions with pneumolysin and pneumococci suggest a crucial protective role in the host response to pneumococcal infection. Infect Immun (2004) 1.70
The role of pneumolysin in pneumococcal pneumonia and meningitis. Clin Exp Immunol (2004) 1.57
Membrane assembly of the cholesterol-dependent cytolysin pore complex. Biochim Biophys Acta (2011) 1.39
THP-1 monocytes up-regulate intercellular adhesion molecule 1 in response to pneumolysin from Streptococcus pneumoniae. Infect Immun (2005) 1.20
Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease. Mediators Inflamm (2013) 1.01
Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci. Cell Microbiol (2007) 1.01
The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model. Respir Res (2007) 1.00
Subterfuge and sabotage: evasion of host innate defenses by invasive gram-positive bacterial pathogens. Annu Rev Microbiol (2014) 1.00
The role of toll-like receptors in acute and chronic lung inflammation. J Inflamm (Lond) (2010) 0.97
Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice. PLoS One (2009) 0.96
Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infect Immun (2004) 0.94
Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infect Immun (2006) 0.94
Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid. Clin Exp Immunol (2005) 0.89
Pharmacological approaches to regulate neutrophil activity. Semin Immunopathol (2013) 0.78
Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils. Infect Immun (2004) 0.77
Neutrophil responses to CRP are not dependent on polymorphism of human FcgammaRIIA (R131H). Clin Exp Immunol (2004) 0.76
Effects of streptolysin o on extracellular matrix gene expression in normal human epidermal keratinocytes. Dose Response (2011) 0.75
Rapid pneumococcal evolution in response to clinical interventions. Science (2011) 9.09
Incidence and risk factors for the immune reconstitution inflammatory syndrome in HIV patients in South Africa: a prospective study. AIDS (2008) 4.36
Characteristics and outcomes of adult patients lost to follow-up at an antiretroviral treatment clinic in johannesburg, South Africa. J Acquir Immune Defic Syndr (2008) 3.99
An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome. Clin Infect Dis (2003) 3.93
Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am J Respir Crit Care Med (2004) 3.49
Immune reconstitution inflammatory syndrome (IRIS): review of common infectious manifestations and treatment options. AIDS Res Ther (2007) 2.65
Community-Acquired Pneumonia: Pathogenesis of Acute Cardiac Events and Potential Adjunctive Therapies. Chest (2015) 2.01
Causes of death on antiretroviral therapy: a post-mortem study from South Africa. PLoS One (2012) 1.99
Pneumolysin: a double-edged sword during the host-pathogen interaction. Curr Mol Med (2008) 1.61
Global strategies to prevent bacterial pneumonia in adults with HIV disease. Lancet Infect Dis (2004) 1.57
The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol (2011) 1.54
The biology of Gram-positive sortase enzymes. Trends Microbiol (2004) 1.53
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. Crit Care Med (2009) 1.46
Clofazimine: current status and future prospects. J Antimicrob Chemother (2011) 1.41
Febrile neutropenia: a prospective study to validate the Multinational Association of Supportive Care of Cancer (MASCC) risk-index score. Support Care Cancer (2004) 1.38
Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states. J Bacteriol (2004) 1.36
Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status. Eur J Immunol (2006) 1.34
HIV and pneumococcal disease. Curr Opin Infect Dis (2007) 1.30
Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching. J Clin Microbiol (2004) 1.29
Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol Dis (2002) 1.28
Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone. Antimicrob Agents Chemother (2003) 1.25
Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia. Crit Care Med (2006) 1.23
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin. Proc Natl Acad Sci U S A (2007) 1.19
Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination. J Neuroimmunol (2004) 1.16
Primary care physician perceptions on the diagnosis and management of chronic obstructive pulmonary disease in diverse regions of the world. Int J Chron Obstruct Pulmon Dis (2012) 1.13
Sensitivities of human monocytes and epithelial cells to pneumolysin are different. Infect Immun (2002) 1.12
Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages. Infect Immun (2011) 1.11
Emergence of OXA-48 and OXA-181 carbapenemases among Enterobacteriaceae in South Africa and evidence of in vivo selection of colistin resistance as a consequence of selective decontamination of the gastrointestinal tract. J Clin Microbiol (2012) 1.10
The solution structure and oligomerization behavior of two bacterial toxins: pneumolysin and perfringolysin O. Biophys J (2004) 1.08
T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease. J Infect Dis (2009) 1.08
The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infection. Curr Opin Infect Dis (2002) 1.06
Cigarette smoking and mechanisms of susceptibility to infections of the respiratory tract and other organ systems. J Infect (2013) 1.06
The human-specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein. Microbiol Immunol (2004) 1.04
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. PLoS Pathog (2011) 1.02
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathog (2011) 1.02
Effects of cigarette smoke condensate on pneumococcal biofilm formation and pneumolysin. Eur Respir J (2012) 1.01
Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model. FEMS Microbiol Lett (2005) 1.01
Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol (2012) 0.99
Pneumococcal pneumonia: mechanisms of infection and resolution. Chest (2012) 0.97
Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics. Mediators Inflamm (2012) 0.95
Gender as a risk factor for both antibiotic resistance and infection with pediatric serogroups/serotypes, in HIV-infected and -uninfected adults with pneumococcal bacteremia. J Infect Dis (2004) 0.94
Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infect Immun (2006) 0.94
Bacteraemic pneumococcal pneumonia: current therapeutic options. Drugs (2011) 0.93
Polychromatic immunophenotypic characterization of T cell profiles among HIV-infected patients experiencing immune reconstitution inflammatory syndrome (IRIS). AIDS Res Ther (2009) 0.92
Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking. Mol Microbiol (2008) 0.92
Increased risk of death in human immunodeficiency virus-infected children with pneumococcal meningitis in South Africa, 2003-2005. Pediatr Infect Dis J (2011) 0.91
Pharmacological control of neutrophil-mediated inflammation: strategies targeting calcium handling by activated polymorphonuclear leukocytes. Drug Des Devel Ther (2009) 0.90
Antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in South African hospitals (SMART Study 2004-2009): impact of the new carbapenem breakpoints. Surg Infect (Larchmt) (2012) 0.90
Clinical outcomes of HIV-infected patients hospitalized with bacterial community-acquired pneumonia. Int J Infect Dis (2009) 0.90
The spread of carbapenem-resistant Enterobacteriaceae in South Africa: risk factors for acquisition and prevention. S Afr Med J (2012) 0.90
Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone. PLoS One (2011) 0.89
Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity. Toxins (Basel) (2011) 0.89
Serum matrix metalloproteinase-3 in comparison with acute phase proteins as a marker of disease activity and radiographic damage in early rheumatoid arthritis. Mediators Inflamm (2013) 0.89
Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysin. J Mol Biol (2012) 0.88
Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathog (2012) 0.88
Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59. Mol Immunol (2009) 0.88
Childhood acute lymphoblastic leukemia (ALL) presenting with severe osteolysis: a model to study leukemia-bone interactions and potential targeted therapeutics. Pediatr Hematol Oncol (2010) 0.87
Evaluating the ability to detect change of health-related quality of life in children with Hodgkin disease. Cancer (2010) 0.87
Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4. Microbes Infect (2010) 0.87
Introduction of the AmpliChip CYP450 Test to a South African cohort: a platform comparative prospective cohort study. BMC Med Genet (2013) 0.87
Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis. Mediators Inflamm (2011) 0.86
Liver involvement in Langerhans cell histiocytosis. Pediatr Radiol (2006) 0.86
Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting? Drug Des Devel Ther (2013) 0.86
Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody. Infect Immun (2004) 0.86
Altered PBP 2A and its role in the development of penicillin, cefotaxime, and ceftriaxone resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob Agents Chemother (2005) 0.86
Antibiotic resistance of pathogens causing community-acquired pneumonia. Semin Respir Crit Care Med (2012) 0.86
Montelukast: more than a cysteinyl leukotriene receptor antagonist? ScientificWorldJournal (2010) 0.86
HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients. Arthritis Res Ther (2011) 0.85
CURB-65, PSI, and APACHE II to assess mortality risk in patients with severe sepsis and community acquired pneumonia in PROWESS. J Intensive Care Med (2011) 0.85
The role of appropriate diagnostic testing in acute respiratory tract infections: An antibiotic stewardship strategy to minimise diagnostic uncertainty in primary care. S Afr Med J (2016) 0.84
A detailed characterisation of the distribution and presentation of DNA vaccine encoded antigen. Vaccine (2009) 0.84
Guideline for the management of nosocomial infections in South Africa. S Afr Med J (2006) 0.84
HIV-associated bacterial pneumonia. Clin Chest Med (2013) 0.84
Nutritional quality of organic, conventional, and seasonally grown broccoli using vitamin C as a marker. Int J Food Sci Nutr (2008) 0.84
Changes in serum cytokines after repeated bouts of downhill running. Appl Physiol Nutr Metab (2007) 0.83
New insights into pneumococcal disease. Respirology (2009) 0.83
The prevalence of smoking and the knowledge of smoking hazards and smoking cessation strategies among HIV- positive patients in Johannesburg, South Africa. S Afr Med J (2013) 0.83
Pneumolysin in the immunopathogenesis and treatment of pneumococcal disease. Expert Rev Anti Infect Ther (2003) 0.83
Montelukast inhibits neutrophil pro-inflammatory activity by a cyclic AMP-dependent mechanism. Br J Pharmacol (2008) 0.83
Systems for the management of respiratory disease in primary care--an international series: South Africa. Prim Care Respir J (2009) 0.82
Reactive oxidants regulate membrane repolarization and store-operated uptake of calcium by formyl peptide-activated human neutrophils. Free Radic Biol Med (2007) 0.82
Role of platelet-activating factor in pneumolysin-induced acute lung injury. Crit Care Med (2007) 0.82
Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure. Chem Biol Drug Des (2008) 0.82
Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice. Antimicrob Agents Chemother (2012) 0.82
Emergence of extensive drug resistance (XDR) among Gram-negative bacilli in South Africa looms nearer. S Afr Med J (2008) 0.81
Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage. PLoS Pathog (2013) 0.81
Purification, crystallization and preliminary X-ray diffraction analysis of RafE, a sugar-binding lipoprotein from Streptococcus pneumoniae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.81
Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema. Glia (2011) 0.81
The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis. Clin Rheumatol (2010) 0.80
Nurses provide valuable proxy assessment of the health-related quality of life of children with Hodgkin disease. Cancer (2010) 0.80
Counteracting effects of NADPH oxidase and the Na+/Ca2+ exchanger on membrane repolarisation and store-operated uptake of Ca2+ by chemoattractant-activated human neutrophils. Biochem Pharmacol (2004) 0.80
Differentiation of human monocytes in vitro following exposure to Canova in the absence of cytokines. Ultrastruct Pathol (2008) 0.80