Published in Microbiol Immunol on January 01, 2004
Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect Immun (2005) 3.39
Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolysin from Gardnerella vaginalis. J Bacteriol (2008) 1.93
Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions. Proc Natl Acad Sci U S A (2007) 1.57
Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin. J Biol Chem (2007) 1.44
Crystal structure of cytotoxin protein suilysin from Streptococcus suis. Protein Cell (2010) 1.23
Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem (2011) 1.12
Structural basis for recognition of the pore-forming toxin intermedilysin by human complement receptor CD59. Cell Rep (2013) 0.88
Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59. Mol Immunol (2009) 0.88
A novel cholesterol-insensitive mode of membrane binding promotes cytolysin-mediated translocation by Streptolysin O. Mol Microbiol (2014) 0.81
Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins. Structure (2016) 0.75
Rapid pneumococcal evolution in response to clinical interventions. Science (2011) 9.09
Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron (2009) 1.85
Pneumolysin: a double-edged sword during the host-pathogen interaction. Curr Mol Med (2008) 1.61
The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol (2011) 1.54
The biology of Gram-positive sortase enzymes. Trends Microbiol (2004) 1.53
Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. Crit Care Med (2009) 1.46
Method of cell transplantation promoting the organization of intraarterial thrombus. Circulation (2005) 1.40
Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states. J Bacteriol (2004) 1.36
Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status. Eur J Immunol (2006) 1.34
Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching. J Clin Microbiol (2004) 1.29
Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. Neurobiol Dis (2002) 1.28
Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone. Antimicrob Agents Chemother (2003) 1.25
Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia. Crit Care Med (2006) 1.23
Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast. J Biol Chem (2003) 1.20
Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin. Proc Natl Acad Sci U S A (2007) 1.19
Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro. J Infect Dis (2002) 1.17
Dose-dependent activation of microglial cells by Toll-like receptor agonists alone and in combination. J Neuroimmunol (2004) 1.16
Sensitivities of human monocytes and epithelial cells to pneumolysin are different. Infect Immun (2002) 1.12
Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages. Infect Immun (2011) 1.11
Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice. J Allergy Clin Immunol (2009) 1.11
The solution structure and oligomerization behavior of two bacterial toxins: pneumolysin and perfringolysin O. Biophys J (2004) 1.08
T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease. J Infect Dis (2009) 1.08
Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci (2008) 1.07
Analysis of structural features of bis-quaternary ammonium antimicrobial agents 4,4'-(alpha,omega-polymethylenedithio)bis (1-alkylpyridinium iodide)s using computational simulation. Bioorg Med Chem (2003) 1.07
Primary CNS lymphoma arising in the region of the optic nerve presenting as loss of vision: 2 case reports, including a patient with a massive intracerebral hemorrhage. Brain Tumor Pathol (2013) 1.05
A case of Nocardia asteroides infection in a patient with HIV/AIDS diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Intern Med (2012) 1.04
Role for rpoS gene of Pseudomonas aeruginosa in antibiotic tolerance. FEMS Microbiol Lett (2005) 1.04
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci. PLoS Pathog (2011) 1.02
Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathog (2011) 1.02
Effect of Varidase (streptodornase) on biofilm formed by Pseudomonas aeruginosa. Chemotherapy (2003) 1.01
Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model. FEMS Microbiol Lett (2005) 1.01
Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. Antimicrob Agents Chemother (2009) 1.00
Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability. Am J Respir Cell Mol Biol (2012) 0.99
Pirfenidone modulates airway responsiveness, inflammation, and remodeling after repeated challenge. Am J Respir Cell Mol Biol (2006) 0.99
Intermedilysin is essential for the invasion of hepatoma HepG2 cells by Streptococcus intermedius. Microbiol Immunol (2005) 0.98
Effect of substrate surface hydrophobicity on the adherence of yeast and hyphal Candida. Mycoses (2009) 0.98
Pneumococcal pneumonia: mechanisms of infection and resolution. Chest (2012) 0.97
Dual-site recognition of different extracellular matrix components by anti-angiogenic/neurotrophic serpin, PEDF. Biochemistry (2003) 0.97
Rapid identification of Streptococcus intermedius by PCR with the ily gene as a species marker gene. J Med Microbiol (2002) 0.96
Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae. Vaccine (2010) 0.96
Retinoic acids are potent inhibitors of spontaneous human eosinophil apoptosis. J Immunol (2008) 0.95
The role of rpoS gene and quorum-sensing system in ofloxacin tolerance in Pseudomonas aeruginosa. FEMS Microbiol Lett (2009) 0.95
Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infect Immun (2006) 0.94
Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis. Int Arch Allergy Immunol (2011) 0.94
Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria. Parasitology (2011) 0.93
C-reactive protein levels in the serum of asthmatic patients. Ann Allergy Asthma Immunol (2007) 0.93
The action of D-dopachrome tautomerase as an adipokine in adipocyte lipid metabolism. PLoS One (2012) 0.92
Functional analysis of spoT, relA and dksA genes on quinolone tolerance in Pseudomonas aeruginosa under nongrowing condition. Microbiol Immunol (2006) 0.92
Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking. Mol Microbiol (2008) 0.92
YKL-40 secreted from adipose tissue inhibits degradation of type I collagen. Biochem Biophys Res Commun (2009) 0.90
Usefulness of preoperative intraaortic balloon pump therapy during off-pump coronary artery bypass grafting in high-risk patients. Ann Thorac Surg (2004) 0.89
Selective suppression of plasticity in amygdala inputs from temporal association cortex by the external capsule. J Neurosci (2011) 0.89
Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone. PLoS One (2011) 0.89
Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity. Toxins (Basel) (2011) 0.89
Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysin. J Mol Biol (2012) 0.88
Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation. Lab Invest (2010) 0.88
Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection. PLoS Pathog (2012) 0.88
Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator CD59. Mol Immunol (2009) 0.88
Human trichinosis after consumption of soft-shelled turtles, Taiwan. Emerg Infect Dis (2009) 0.88
The essentiality and involvement of Streptococcus intermedius histone-like DNA-binding protein in bacterial viability and normal growth. Mol Microbiol (2008) 0.87
Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4. Microbes Infect (2010) 0.87
Correlation between resistance of Pseudomonas aeruginosa to quaternary ammonium compounds and expression of outer membrane protein OprR. Antimicrob Agents Chemother (2003) 0.87
Reduced carnitine level causes death from hypoglycemia: possible involvement of suppression of hypothalamic orexin expression during weaning period. Endocr J (2007) 0.87
Draft Genome Sequence of Porphyromonas gingivalis Strain SJD2, Isolated from the Periodontal Pocket of a Patient with Periodontitis in China. Genome Announc (2014) 0.87
Characterisation of hexokinase in Toxoplasma gondii tachyzoites. Int J Parasitol (2002) 0.87
Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex. Neurosci Res (2007) 0.87
Streptococcus pneumoniae-induced inhibition of rat ependymal cilia is attenuated by antipneumolysin antibody. Infect Immun (2004) 0.86
Co-existence of Mycobacterium tuberculosis and Mycobacterium intracellulare in one sputum sample. Intern Med (2008) 0.86
Syntheses and antimicrobial activities of a series of new bis-quaternary ammonium compounds. Eur J Med Chem (2006) 0.86
Aortic valve destruction and pseudoaneurysm of the sinus of Valsalva associated with infective endocarditis. Ann Thorac Cardiovasc Surg (2010) 0.86
Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. Int Arch Allergy Immunol (2007) 0.86
A novel GDP-dependent pyruvate kinase isozyme from Toxoplasma gondii localizes to both the apicoplast and the mitochondrion. J Biol Chem (2008) 0.86
Coating of a surface with 2-methacryloyloxyethyl phosphorylcholine (MPC) co-polymer significantly reduces retention of human pathogenic microorganisms. FEMS Microbiol Lett (2005) 0.85
The mode of the antifungal activity of gemini-pyridinium salt against yeast. Biocontrol Sci (2009) 0.85
[Development of a microbiology data warehouse (Akita-ReNICS) for networking hospitals in a medical region]. Rinsho Byori (2011) 0.85
EG2 expressed by eosinophils as a clinically useful indicator of asthma. Allergy Asthma Proc (2009) 0.85
Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development. Eur J Neurosci (2006) 0.85
Coronary lumen and plaque segmentation from CTA using higher-order shape prior. Med Image Comput Comput Assist Interv (2014) 0.85
Adiponectin attenuates human eosinophil adhesion and chemotaxis: implications in allergic inflammation. J Asthma (2013) 0.84