Published in Mol Endocrinol on September 01, 2002
The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev (2008) 2.73
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Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes (2004) 2.17
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells. J Physiol (2006) 1.36
Emerging role of dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes. Vasc Health Risk Manag (2008) 1.27
PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol (2007) 1.22
Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus. Curr Med Chem (2003) 1.20
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells. Prog Biophys Mol Biol (2011) 1.20
Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol (2008) 1.09
Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells. J Physiol (2008) 1.06
New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells. Horm Metab Res (2005) 1.04
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cAMP-dependent protein kinase phosphorylation produces interdomain movement in SUR2B leading to activation of the vascular KATP channel. J Biol Chem (2008) 1.00
Class II G protein-coupled receptors and their ligands in neuronal function and protection. Neuromolecular Med (2005) 0.99
Regulation of glucose homeostasis by GLP-1. Prog Mol Biol Transl Sci (2014) 0.97
ACTH inhibits bTREK-1 K+ channels through multiple cAMP-dependent signaling pathways. J Gen Physiol (2008) 0.96
Interleukin-6 enhances glucose-stimulated insulin secretion from pancreatic beta-cells: potential involvement of the PLC-IP3-dependent pathway. Diabetes (2011) 0.94
Hormonal signaling in the gut. J Biol Chem (2014) 0.93
Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass. Exp Diabetes Res (2011) 0.91
Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation. Peptides (2009) 0.90
Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac. Islets (2010) 0.89
Glucagon-like peptide 1 stimulates post-translational activation of glucokinase in pancreatic beta cells. J Biol Chem (2011) 0.88
Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. Br J Pharmacol (2014) 0.88
ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye. Invest Ophthalmol Vis Sci (2011) 0.87
The role of the Wnt signaling pathway in incretin hormone production and function. Front Physiol (2012) 0.84
Cyclic AMP dynamics in the pancreatic β-cell. Ups J Med Sci (2012) 0.84
Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacol Rev (2016) 0.78
Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling? Islets (2013) 0.78
Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytes. J Diabetes Investig (2012) 0.78
Phosphorylation-dependent changes in nucleotide binding, conformation, and dynamics of the first nucleotide binding domain (NBD1) of the sulfonylurea receptor 2B (SUR2B). J Biol Chem (2015) 0.77
PKA controls calcium influx into motor neurons during a rhythmic behavior. PLoS Genet (2013) 0.77
Anti-incretin, Anti-proliferative Action of Dopamine on β-Cells. Mol Endocrinol (2015) 0.76
Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. PLoS One (2016) 0.76
Expression and Characterization of a Potent Long-Acting GLP-1 Receptor Agonist, GLP-1-IgG2σ-Fc. PLoS One (2016) 0.75
Mechanisms of current therapies for diabetes mellitus type 2. Adv Physiol Educ (2012) 0.75
Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance. PLoS One (2016) 0.75
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol (2004) 3.36
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem (2003) 2.71
Maturation of human embryonic stem cell-derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice. Diabetes (2012) 2.40
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell (2011) 2.31
Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ Res (2008) 2.12
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem (2002) 2.12
The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes (2002) 1.96
Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis. Am J Physiol Endocrinol Metab (2009) 1.88
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab (2006) 1.76
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes (2002) 1.74
Production of functional glucagon-secreting α-cells from human embryonic stem cells. Diabetes (2010) 1.73
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am J Physiol Endocrinol Metab (2008) 1.68
Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis. J Biol Chem (2004) 1.66
Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells. J Biol Chem (2008) 1.48
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab (2009) 1.47
Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. J Biol Chem (2004) 1.46
Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease. J Clin Invest (2016) 1.39
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion. J Biol Chem (2002) 1.37
Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes (2009) 1.33
Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes (2005) 1.31
Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology (2005) 1.29
Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. Diabetes (2003) 1.28
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. J Biol Chem (2010) 1.27
The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach. Mol Cell Proteomics (2008) 1.27
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo. Diabetes (2007) 1.26
A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One (2012) 1.25
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Mol Cell Biol (2006) 1.21
Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo. Diabetes (2007) 1.15
The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel. J Biol Chem (2005) 1.14
Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells. J Biol Chem (2005) 1.14
Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes (2011) 1.13
UCP2 regulates the glucagon response to fasting and starvation. Diabetes (2013) 1.13
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. Mol Endocrinol (2002) 1.13
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. J Clin Invest (2015) 1.12
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J (2003) 1.10
Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release. Diabetes (2002) 1.10
Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology (2004) 1.10
SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans. Diabetes (2011) 1.09
UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival. Proc Natl Acad Sci U S A (2008) 1.09
Uncoupling protein 2 and islet function. Diabetes (2004) 1.08
Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells. Diabetes (2009) 1.08
Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment. Endocrinology (2002) 1.07
Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat. Endocrinology (2006) 1.05
Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6. Diabetes (2004) 1.05
Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids. J Biol Chem (2003) 1.04
Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance. Endocrinology (2010) 1.03
Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth. Cell Metab (2012) 1.03
The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem (2006) 1.01
Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells. J Biol Chem (2012) 1.00
Expression of {beta}1 integrin receptors during rat pancreas development--sites and dynamics. Endocrinology (2004) 1.00
Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin. J Endocrinol (2007) 1.00
Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin. J Endocrinol (2009) 0.99
Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells. J Biol Chem (2007) 0.97
Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets. J Biol Chem (2009) 0.96
Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion. J Biol Chem (2014) 0.96
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. J Biol Chem (2003) 0.95
Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism. Diabetes (2002) 0.91
Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia. FASEB J (2005) 0.91
Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice. J Endocrinol (2006) 0.91
Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion. J Biol Chem (2012) 0.89
In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/db mouse model of diabetes. Diabetes (2010) 0.88
Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids. J Endocrinol (2008) 0.88
Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells. J Physiol (2003) 0.86
Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels. Endocrinology (2008) 0.86
Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion. Diabetes (2010) 0.86
Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Mol Endocrinol (2006) 0.85
SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells. J Cell Sci (2013) 0.85
Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As. Mol Endocrinol (2008) 0.84
Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells. J Endocrinol (2009) 0.84
Isolation and immortalization of MIP-GFP neurons from the hypothalamus. Endocrinology (2014) 0.83
Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion. Proc Natl Acad Sci U S A (2013) 0.83
Insulin mimetics in Urtica dioica: structural and computational analyses of Urtica dioica extracts. Phytother Res (2010) 0.82
Cellular reprogramming of human amniotic fluid cells to express insulin. Differentiation (2010) 0.81
A multi-parameter, high-content, high-throughput screening platform to identify natural compounds that modulate insulin and Pdx1 expression. PLoS One (2010) 0.80
LKB1 couples glucose metabolism to insulin secretion in mice. Diabetologia (2015) 0.79
The characterization of mitochondrial permeability transition in clonal pancreatic beta-cells. Multiple modes and regulation. J Biol Chem (2004) 0.78
MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice. Can J Physiol Pharmacol (2012) 0.78
Thermally induced gelable polymer networks for living cell encapsulation. Biotechnol Bioeng (2007) 0.78
Overexpression of peroxisome proliferator-activated receptor α in pancreatic β-cells improves glucose tolerance in diet-induced obese mice. Exp Physiol (2012) 0.77
Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor. Endocrinology (2012) 0.76
Economic evaluation of a clinical protocol for diagnosing emergency patients with suspected pulmonary embolism. Cost Eff Resour Alloc (2006) 0.75
Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets. J Mol Endocrinol (2011) 0.75
Correction: A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor. PLoS One (2015) 0.75
Response to Comment on: Allister et al. UCP2 regulates the glucagon response to fasting and starvation. Diabetes 2013;62:1623-1633. Diabetes (2013) 0.75
Alkali pH directly activates ATP-sensitive K+ channels and inhibits insulin secretion in beta-cells. Biochem Biophys Res Commun (2006) 0.75