Published in Biochem Biophys Res Commun on September 26, 2006
New properties of mitochondrial ATP-regulated potassium channels. J Bioenerg Biomembr (2008) 0.80
Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol (2004) 3.36
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell (2011) 2.31
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem (2002) 2.12
The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion. Diabetes (2002) 1.96
Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis. Am J Physiol Endocrinol Metab (2009) 1.88
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system. Cell Metab (2006) 1.76
Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes (2002) 1.74
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am J Physiol Endocrinol Metab (2008) 1.68
Disruption of pancreatic beta-cell lipid rafts modifies Kv2.1 channel gating and insulin exocytosis. J Biol Chem (2004) 1.66
Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells. J Biol Chem (2008) 1.48
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab (2009) 1.47
Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. J Biol Chem (2004) 1.46
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion. J Biol Chem (2002) 1.37
Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes. Diabetes (2009) 1.33
Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes (2005) 1.31
Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology (2005) 1.29
Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis. Diabetes (2003) 1.28
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. J Biol Chem (2010) 1.27
The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach. Mol Cell Proteomics (2008) 1.27
Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo. Diabetes (2007) 1.26
A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One (2012) 1.25
Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Mol Cell Biol (2006) 1.21
Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism. Mol Endocrinol (2002) 1.18
Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo. Diabetes (2007) 1.15
The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel. J Biol Chem (2005) 1.14
Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells. J Biol Chem (2005) 1.14
Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes (2011) 1.13
UCP2 regulates the glucagon response to fasting and starvation. Diabetes (2013) 1.13
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus. Mol Endocrinol (2002) 1.13
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J (2003) 1.10
Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release. Diabetes (2002) 1.10
Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology (2004) 1.10
UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival. Proc Natl Acad Sci U S A (2008) 1.09
Uncoupling protein 2 and islet function. Diabetes (2004) 1.08
Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment. Endocrinology (2002) 1.07
Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat. Endocrinology (2006) 1.05
Gene and protein kinase expression profiling of reactive oxygen species-associated lipotoxicity in the pancreatic beta-cell line MIN6. Diabetes (2004) 1.05
Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids. J Biol Chem (2003) 1.04
Disruption of the dopamine d2 receptor impairs insulin secretion and causes glucose intolerance. Endocrinology (2010) 1.03
Dual role of VAMP8 in regulating insulin exocytosis and islet β cell growth. Cell Metab (2012) 1.03
The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem (2006) 1.01
Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells. J Biol Chem (2012) 1.00
Expression of {beta}1 integrin receptors during rat pancreas development--sites and dynamics. Endocrinology (2004) 1.00
Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin. J Endocrinol (2007) 1.00
Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin. J Endocrinol (2009) 0.99
Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic beta-cells. J Biol Chem (2007) 0.97
Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets. J Biol Chem (2009) 0.96
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. J Biol Chem (2003) 0.95
Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism. Diabetes (2002) 0.91
Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice. J Endocrinol (2006) 0.91
Glutathionylation state of uncoupling protein-2 and the control of glucose-stimulated insulin secretion. J Biol Chem (2012) 0.89
Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids. J Endocrinol (2008) 0.88
Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells. J Physiol (2003) 0.86
Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells. Mol Endocrinol (2006) 0.85
SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells. J Cell Sci (2013) 0.85
Functional characterization of hyperpolarization-activated cyclic nucleotide-gated channels in rat pancreatic beta cells. J Endocrinol (2009) 0.84
Isolation and immortalization of MIP-GFP neurons from the hypothalamus. Endocrinology (2014) 0.83
Insulin mimetics in Urtica dioica: structural and computational analyses of Urtica dioica extracts. Phytother Res (2010) 0.82
LKB1 couples glucose metabolism to insulin secretion in mice. Diabetologia (2015) 0.79
MK-626, a dipeptidyl peptidase-4 inhibitor, does not improve the hyperglycemia or hyperinsulinemia of nonobese diabetic MKR mice. Can J Physiol Pharmacol (2012) 0.78
Thermally induced gelable polymer networks for living cell encapsulation. Biotechnol Bioeng (2007) 0.78
The characterization of mitochondrial permeability transition in clonal pancreatic beta-cells. Multiple modes and regulation. J Biol Chem (2004) 0.78
Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor. Endocrinology (2012) 0.76
Correction: A Novel Humanized GLP-1 Receptor Model Enables Both Affinity Purification and Cre-LoxP Deletion of the Receptor. PLoS One (2015) 0.75
Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets. J Mol Endocrinol (2011) 0.75
Response to Comment on: Allister et al. UCP2 regulates the glucagon response to fasting and starvation. Diabetes 2013;62:1623-1633. Diabetes (2013) 0.75
Economic evaluation of a clinical protocol for diagnosing emergency patients with suspected pulmonary embolism. Cost Eff Resour Alloc (2006) 0.75