Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death.

PubWeight™: 0.93‹?›

🔗 View Article (PMC 151103)

Published in J Clin Invest on September 01, 2002

Authors

Min Li-Weber1, Markus A Weigand, Marco Giaisi, Dorothee Süss, Monika K Treiber, Sven Baumann, Elena Ritsou, Raoul Breitkreutz, Peter H Krammer

Author Affiliations

1: Tumor Immunology G0300, German Cancer Research Center, Heidelberg, Germany.

Articles citing this

Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol (2008) 5.37

The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile. Nutr J (2008) 1.04

Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death. Cancer Res (2009) 1.03

Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity. Br J Cancer (2003) 1.01

Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.01

Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J (2010) 1.00

T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules. Cytokine (2011) 0.92

T cells and reactive oxygen species. J Biomed Sci (2015) 0.89

Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation. PLoS One (2011) 0.89

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment. Oxid Med Cell Longev (2016) 0.84

Haptoglobin genotype-dependent differences in macrophage lysosomal oxidative injury. J Biol Chem (2014) 0.83

Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. PLoS One (2011) 0.81

Race differences in the association between multivitamin exposure and wheezing in preterm infants. J Perinatol (2014) 0.78

The Maternal Diet, Gut Bacteria, and Bacterial Metabolites during Pregnancy Influence Offspring Asthma. Front Immunol (2017) 0.75

Articles cited by this

Real time quantitative PCR. Genome Res (1996) 35.79

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell (1993) 9.06

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) Nature (1995) 8.23

Fas ligand-induced apoptosis as a mechanism of immune privilege. Science (1995) 8.23

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature (1995) 7.52

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature (1995) 6.85

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med (1995) 6.50

CD95's deadly mission in the immune system. Nature (2000) 5.55

PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature (2000) 5.48

Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (1995) 5.26

Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene (1999) 4.76

Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med (1995) 4.34

Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science (1995) 3.46

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity (2000) 2.99

Activation interferes with the APO-1 pathway in mature human T cells. Int Immunol (1993) 2.45

NF-kappaB as a primary regulator of the stress response. Oncogene (1999) 2.29

Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection. J Exp Med (1997) 1.89

Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes. Mol Cell Biol (1996) 1.86

Mechanisms of HIV-associated lymphocyte apoptosis. Blood (2000) 1.75

Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1. Toxicol Lett (1999) 1.48

Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children. Blood (1996) 1.46

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids. J Exp Med (1995) 1.45

Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. J Biol Chem (1991) 1.41

Role of Fas ligand and receptor in the mechanism of T-cell depletion in acquired immunodeficiency syndrome: effect on CD4+ lymphocyte depletion and human immunodeficiency virus replication. Blood (1997) 1.26

The role of metabolism in the antioxidant function of vitamin E. Crit Rev Toxicol (1993) 1.22

Association between serum vitamin A and E levels and HIV-1 disease progression. AIDS (1997) 1.19

Programmed cell death as a mechanism of CD4 and CD8 T cell deletion in AIDS. Molecular control and effect of highly active anti-retroviral therapy. Ann N Y Acad Sci (1999) 1.14

A prospective study of dietary intake and acquired immune deficiency syndrome in HIV-seropositive homosexual men. J Acquir Immune Defic Syndr (1993) 1.08

Surface T cell Fas receptor/CD95 regulation, in vivo activation, and apoptosis. Activation-induced death can occur without Fas receptor. J Immunol (1996) 1.08

Antioxidant status and lipid peroxidation in patients infected with HIV. Chem Biol Interact (1994) 1.06

9-cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation. Mol Cell Biol (1995) 1.05

Vitamin E and immunity. Vitam Horm (2000) 1.00

Inhibition of NF-kappa B activation by vitamin E derivatives. Biochem Biophys Res Commun (1993) 0.97

Decreased antioxidant defence in individuals infected by the human immunodeficiency virus. Eur J Clin Invest (2000) 0.96

Vitamins and immunomodulation in AIDS. Nutrition (1996) 0.96

Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 disease. J Virol (1998) 0.96

A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol Cell Biol (2000) 0.96

Influence of HIV infection on vitamin status and requirements. Ann N Y Acad Sci (1992) 0.93

Vitamin E: a sensor and an information transducer of the cell oxidation state. Am J Clin Nutr (1995) 0.93

Comparison of plasma cytokine levels in African patients with HIV-1 and HIV-2 infection. AIDS (1994) 0.91

Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells. Proc Natl Acad Sci U S A (1995) 0.90

CD95(APO-1/Fas)-mediated apoptosis in normal and malignant liver, colon, and hematopoietic cells. Adv Cancer Res (1998) 0.90

Raised levels of tumour necrosis factor-alpha and neopterin, but not interferon-alpha, in serum of HIV-1-infected patients from Ethiopia. Clin Exp Immunol (1993) 0.90

Nutritional status and immune responses in mice with murine AIDS are normalized by vitamin E supplementation. J Nutr (1994) 0.88

T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB. Eur J Immunol (2000) 0.85

Fas/Fas ligand on the road: an apoptotic pathway common to AIDS, autoimmunity, lymphoproliferation and transplantation. Med Hypotheses (1999) 0.85

Vitamin E status and immune function. Methods Enzymol (1997) 0.83

The death of a T-cell: expression of the CD95 ligand. Cell Death Differ (2002) 0.82

Integration of receptor-mediated signals in T cells by transmembrane adaptor proteins. Immunol Today (1999) 0.81

All-trans retinoic acid modulates Fas antigen expression and affects cell proliferation and apoptosis in combination with anti-Fas monoclonal antibody in the human myeloma cell line, U266B1. Exp Hematol (1998) 0.79

Potential therapeutics of vitamin E (tocopherol) in AIDS and HIV. Drugs (1994) 0.78

Vitamin E is an important factor in T cell differentiation in thymus of F344 rats. J Nutr Sci Vitaminol (Tokyo) (1993) 0.78

Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in human embryonal carcinoma cells by interferon gamma and all-trans retinoic acid. Biol Chem (1998) 0.78

Selective upregulation of fibroblast Fas ligand expression, and prolongation of Fas/Fas ligand-mediated skin allograft survival, by retinoic acid: the skin as a retinoide-inducible immune privilege site. J Invest Dermatol (2000) 0.77

Vitamin E deficiency: its effect on platelet-vascular interaction in various pathologic states. Ann N Y Acad Sci (1982) 0.76

The potential role of vitamin E in the treatment of immunologic abnormalities during acquired immune deficiency syndrome. Prog Food Nutr Sci (1991) 0.76

Alteration of Fas/FasL expression of oral squamous cell carcinoma cell line Tca83 induced by retinoic acid. Chin J Dent Res (2000) 0.76

[Retinoic acid inducing Fas expression in HL-60 cells]. Zhonghua Xue Ye Xue Za Zhi (1998) 0.76

Articles by these authors

Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer (2002) 5.87

International evidence-based recommendations for point-of-care lung ultrasound. Intensive Care Med (2012) 5.42

Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. J Clin Invest (2004) 3.89

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin. J Clin Invest (2005) 3.19

Analgesia and sedation for painful interventions in children and adolescents. Dtsch Arztebl Int (2010) 2.82

Death receptors in chemotherapy and cancer. Oncogene (2004) 2.64

Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis. Eur J Immunol (2005) 2.28

Death receptor signaling. J Cell Sci (2005) 2.21

Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit Care Med (2008) 2.18

Standardized peptidome profiling of human urine by magnetic bead separation and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Clin Chem (2007) 2.11

Caspases: pharmacological manipulation of cell death. J Clin Invest (2005) 2.10

Immune escape of tumors: apoptosis resistance and tumor counterattack. J Leukoc Biol (2002) 2.04

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury. Nat Med (2004) 1.95

c-FLIPR, a new regulator of death receptor-induced apoptosis. J Biol Chem (2005) 1.93

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation. J Exp Med (2006) 1.91

Sustained low efficiency dialysis using a single-pass batch system in acute kidney injury - a randomized interventional trial: the REnal Replacement Therapy Study in Intensive Care Unit PatiEnts. Crit Care (2012) 1.90

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J (2005) 1.90

TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle (2007) 1.84

Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum (2006) 1.83

Brief report: tracheal intubation using the Bonfils intubation fibrescope or direct laryngoscopy for patients with a simulated difficult airway. Can J Anaesth (2008) 1.82

Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res (2006) 1.82

The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2. Chem Biol (2012) 1.82

Infrahepatic inferior vena cava clamping for reduction of central venous pressure and blood loss during hepatic resection: a randomized controlled trial. Ann Surg (2011) 1.81

Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice. Hepatology (2010) 1.75

Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J Immunol (2007) 1.74

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. EMBO J (2002) 1.69

Focused echocardiographic evaluation in life support and peri-resuscitation of emergency patients: a prospective trial. Resuscitation (2010) 1.66

In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand- but not to TCR-mediated cell death. J Immunol (2005) 1.58

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells. Mol Syst Biol (2010) 1.57

Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model. Mol Cell (2012) 1.57

Alterations in intracellular Ca2+-homeostasis of skeletal muscle fibers during sepsis. Crit Care Med (2008) 1.57

Echocardiography practice, training and accreditation in the intensive care: document for the World Interactive Network Focused on Critical Ultrasound (WINFOCUS). Cardiovasc Ultrasound (2008) 1.55

Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling. J Biol Chem (2007) 1.55

Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. Nat Med (2004) 1.54

Thioredoxin in human and experimental sepsis. Crit Care Med (2009) 1.51

Effects of physostigmine on microcirculatory alterations during experimental endotoxemia. Shock (2010) 1.48

sRAGE is elevated in septic patients and associated with patients outcome. J Surg Res (2007) 1.47

Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. Int J Cancer (2002) 1.46

The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities. Int J Cancer (2007) 1.45

AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis. J Leukoc Biol (2009) 1.45

Initiation of risk management: incidence of failures in simulated Emergency Medical Service scenarios. Resuscitation (2010) 1.43

Pillars article: T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells. J. Exp. Med. 1982. 155: 734-748. J Immunol (2013) 1.43

p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun (2005) 1.42

Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas. Cancer Res (2003) 1.42

Prospective evaluation of regional oxygen saturation to estimate central venous saturation in sepsis. J Clin Monit Comput (2015) 1.42

Ultrasound instead of capnometry for confirming tracheal tube placement in an emergency? Resuscitation (2011) 1.41

One, two, three--p53, p63, p73 and chemosensitivity. Drug Resist Updat (2007) 1.41

The role of CD95 in the regulation of peripheral T-cell apoptosis. Immunol Rev (2003) 1.41

Molecular mechanisms of treg-mediated T cell suppression. Front Immunol (2012) 1.41

Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PLoS One (2007) 1.40

Patients suffering due to complicated peritonitis may not benefit from splenectomy: clinical data from a retrospective study. J Surg Res (2010) 1.38

Central sympatholytics prolong survival in experimental sepsis. Crit Care (2009) 1.37

Midline versus transverse incision in major abdominal surgery: a randomized, double-blind equivalence trial (POVATI: ISRCTN60734227). Ann Surg (2009) 1.35

Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction. BMC Cancer (2006) 1.35

Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis. Crit Care (2008) 1.34

Concepts of activated T cell death. Crit Rev Oncol Hematol (2008) 1.33

Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression. J Immunol (2010) 1.33

Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol (2003) 1.32

IFN-gamma represses IL-4 expression via IRF-1 and IRF-2. Immunity (2002) 1.32

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes. Hepatology (2009) 1.31

Sepsis and major abdominal surgery lead to flaking of the endothelial glycocalix. J Surg Res (2009) 1.31

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. J Cell Biol (2010) 1.30

New insights into paracrine mechanisms of human cardiac progenitor cells. Eur J Heart Fail (2010) 1.29

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants. Oncogene (2003) 1.28

High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade. Blood (2011) 1.28

Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt. Hepatology (2004) 1.28

Apoptosis in cancer--implications for therapy. Semin Oncol (2004) 1.27

Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells. J Immunol (2005) 1.26

Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancer. Clin Cancer Res (2009) 1.25

Diagnosis and management for urosepsis. Int J Urol (2013) 1.24

Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity. J Virol (2003) 1.23

Guidelines for the Appropriate Use of Bedside General and Cardiac Ultrasonography in the Evaluation of Critically Ill Patients-Part I: General Ultrasonography. Crit Care Med (2015) 1.21

Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma. Int J Oncol (2006) 1.20

Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling. J Immunol (2007) 1.20

Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Blood (2007) 1.20

How T lymphocytes switch between life and death. Eur J Immunol (2006) 1.20

T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. Cell Rep (2012) 1.16

Predictors of survival in sepsis: what is the best inflammatory marker to measure? Curr Opin Infect Dis (2012) 1.16

Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol (2007) 1.14

Comparison of the confusion assessment method for the intensive care unit (CAM-ICU) with the Intensive Care Delirium Screening Checklist (ICDSC) for delirium in critical care patients gives high agreement rate(s). Intensive Care Med (2007) 1.13

Primary human hepatocytes--a valuable tool for investigation of apoptosis and hepatitis B virus infection. J Hepatol (2003) 1.11

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J (2011) 1.10

HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP). Blood (2006) 1.10

CD4(+)CD25 (+) regulatory T cells in human lupus erythematosus. Arch Dermatol Res (2008) 1.10

Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci (2002) 1.09