T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 3595556)

Published in Cytokine on May 23, 2011

Authors

Navtej Kaur1, Osama S Naga, Håkan Norell, Amir A Al-Khami, Matthew J Scheffel, Nitya G Chakraborty, Christina Voelkel-Johnson, Bijay Mukherji, Shikhar Mehrotra

Author Affiliations

1: Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

Articles cited by this

Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer (2008) 9.82

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (1996) 8.37

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34

Adoptive immunotherapy for cancer: building on success. Nat Rev Immunol (2006) 7.76

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proc Natl Acad Sci U S A (2005) 5.21

Glutathione metabolism and its selective modification. J Biol Chem (1988) 4.89

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells. Proc Natl Acad Sci U S A (2004) 4.70

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med (2005) 4.60

Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33

Thioredoxin reductase. Biochem J (2000) 3.47

Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity (2001) 3.45

Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2',7'-dichlorofluorescin. J Leukoc Biol (1990) 3.31

Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity (1999) 2.84

IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci U S A (2000) 2.80

The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol (1998) 2.60

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J Biol Chem (1993) 2.52

Apoptosis and glutathione: beyond an antioxidant. Cell Death Differ (2009) 2.51

IL-15 promotes the survival of naive and memory phenotype CD8+ T cells. J Immunol (2003) 2.28

Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. J Immunol (2005) 2.01

Safety and immunologic effects of IL-15 administration in nonhuman primates. Blood (2009) 2.00

BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity. Free Radic Biol Med (1999) 1.95

Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling. J Immunol (1999) 1.88

Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms. Clin Sci (Lond) (2006) 1.87

CD57+ T lymphocytes and functional immune deficiency. J Leukoc Biol (2009) 1.84

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis. EMBO J (2002) 1.82

Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation. J Biol Chem (2007) 1.73

IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis. Proc Natl Acad Sci U S A (2008) 1.72

IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc Natl Acad Sci U S A (2002) 1.69

Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography. J Am Coll Cardiol (2010) 1.68

T cell surface redox levels determine T cell reactivity and arthritis susceptibility. Proc Natl Acad Sci U S A (2006) 1.63

Toll-like receptors in tumor immunotherapy. Clin Cancer Res (2007) 1.60

Lymphocyte surface thiol levels. Proc Natl Acad Sci U S A (2003) 1.52

Programming CD8+ T cells for effective immunotherapy. Curr Opin Immunol (2006) 1.51

Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis. J Clin Endocrinol Metab (2009) 1.45

IL-15 enhances survival and function of HIV-specific CD8+ T cells. Blood (2002) 1.43

CD44 regulates survival and memory development in Th1 cells. Immunity (2010) 1.37

Pharmacologic induction of CD8+ T cell memory: better living through chemistry. Sci Transl Med (2009) 1.34

MAP kinases in immune responses. Cell Mol Immunol (2005) 1.34

The IL-2/IL-15 receptor systems: targets for immunotherapy. J Clin Immunol (2002) 1.30

Control of T helper cell differentiation--in search of master genes. Sci STKE (2000) 1.30

IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest (2010) 1.28

Thioredoxin and protein kinases in redox signaling. Semin Cancer Biol (2006) 1.27

Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. Oncogene (2009) 1.26

Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family. J Biol Chem (1997) 1.25

Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci U S A (1998) 1.23

Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols. J Nutr (2010) 1.16

The thioredoxin system in retroviral infection and apoptosis. Cell Death Differ (2005) 1.14

HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL. J Immunol (2004) 1.13

Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. J Am Soc Nephrol (2007) 1.10

Redox remodeling as an immunoregulatory strategy. Biochemistry (2010) 1.08

Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine? Biochem Biophys Res Commun (2002) 1.07

Opposing effects of IL-2 in tumor immunotherapy: promoting CD8 T cell growth and inducing apoptosis. J Immunol (2002) 1.04

The contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for the immunotherapy of rheumatological diseases. Arthritis Res (2002) 1.03

The extracellular microenvironment plays a key role in regulating the redox status of cell surface proteins in HIV-infected subjects. Arch Biochem Biophys (2005) 1.03

IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells. Int Immunol (2003) 1.03

Combination of IL-21 and IL-15 enhances tumour-specific cytotoxicity and cytokine production of TCR-transduced primary T cells. Cancer Immunol Immunother (2010) 1.03

Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome. Free Radic Biol Med (2001) 1.02

ROS and innate immunity. Anticancer Res (2009) 1.00

Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes. Clin Cancer Res (2002) 1.00

Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols. J Cell Biochem (2010) 0.99

Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol (2007) 0.97

Redox aspects of Bcl-2 function. Antioxid Redox Signal (2000) 0.95

Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens: multiclonal responses that are extremely lytic if triggered and short-lived after cytokine withdrawal. Cytokine (2006) 0.95

Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal. Biochem J (1997) 0.94

Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress. J Immunol (2005) 0.94

Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death. J Clin Invest (2002) 0.93

TGFbeta, a potent regulator of tumor microenvironment and host immune response, implication for therapy. Curr Mol Med (2010) 0.93

Alleviating oxidative stress in cancer immunotherapy: a role for histamine? Med Oncol (2000) 0.90

The CD16-/CD56bright subset of NK cells is resistant to oxidant-induced cell death. J Immunol (2007) 0.90

Adoptive immunotherapy of advanced melanoma patients with interleukin-2 (IL-2) and tumor-infiltrating lymphocytes selected in vitro with low doses of IL-2. Cancer Immunol Immunother (1993) 0.89

IL-2 and IL-15 exhibit opposing effects on Fas mediated apoptosis. Cell Mol Immunol (2004) 0.88

Thyrotropin-receptor and thyroid peroxidase-specific T cell clones and their cytokine profile in autoimmune thyroid disease. J Clin Endocrinol Metab (1997) 0.87

A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). FEBS Lett (2002) 0.85

IL-15 protects antigen-specific CD8+ T cell contraction after Mycobacterium bovis bacillus Calmette-Guérin infection. J Leukoc Biol (2009) 0.85

IL-15 has innate anti-tumor activity independent of NK and CD8 T cells. J Leukoc Biol (2010) 0.83

Preventing apoptosis with thioredoxin: ASK me how. Circ Res (2002) 0.83

Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection. J Altern Complement Med (2008) 0.81

CD57 expression by T cells in the female genital tract of HIV-zx1 infected women. Clin Immunol (2010) 0.79

Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads. Retrovirology (2009) 0.78

The CD7(-) subset of CD4(+) memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15). Cell Death Differ (2001) 0.78

Chronically administered immunotherapy with low-dose IL-2 and IFN-alpha in metastatic renal cell carcinoma: a feasible option for patients with a good prognostic profile. Oncology (2008) 0.76

Articles by these authors

Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression. Cancer Biol Ther (2002) 1.96

Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma. Clin Cancer Res (2003) 1.83

Mutant HSP70 reverses autoimmune depigmentation in vitiligo. Sci Transl Med (2013) 1.66

Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus. Clin Immunol (2012) 1.53

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res (2007) 1.45

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Res (2010) 1.43

Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells. J Immunol (2009) 1.38

Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells. Mol Cancer Ther (2010) 1.31

Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms. Mol Pharmacol (2009) 1.29

IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism. J Clin Invest (2002) 1.24

Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C). J Immunol (2009) 1.20

Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas. Proc Natl Acad Sci U S A (2008) 1.18

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. EMBO Mol Med (2012) 1.16

Regulatory T cells and tumor immunity. Cancer Immunol Immunother (2005) 1.13

Inner ear supporting cells protect hair cells by secreting HSP70. J Clin Invest (2013) 1.10

MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism. Mol Cancer Ther (2009) 1.08

Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Mol Cancer Ther (2013) 1.05

Doxorubicin increases the effectiveness of Apo2L/TRAIL for tumor growth inhibition of prostate cancer xenografts. BMC Cancer (2005) 1.04

Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells. J Immunol (2010) 1.04

Detection of human perforin by ELISpot and ELISA: ex vivo identification of virus-specific cells. J Immunol Methods (2005) 1.04

Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death. Cancer Res (2009) 1.03

The role of protein synthesis in cell cycling and cancer. Mol Oncol (2009) 1.03

Human dendritic cell maturation by adenovirus transduction enhances tumor antigen-specific T-cell responses. J Immunother (2004) 1.03

Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin Cancer Res (2014) 1.01

Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.01

HER-2/neu mediated down-regulation of MHC class I antigen processing prevents CTL-mediated tumor recognition upon DNA vaccination in HLA-A2 transgenic mice. Cancer Immunol Immunother (2008) 1.00

Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress. J Immunol (2008) 0.98

The oxazolidinone derivative locostatin induces cytokine appeasement. J Immunol (2009) 0.97

Rescuing melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death, by SP600125, an inhibitor of JNK: implications in cancer immunotherapy. J Immunol (2004) 0.95

Regulatory T-cell response and tumor vaccine-induced cytotoxic T lymphocytes in human melanoma. Hum Immunol (2004) 0.94

A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice. J Immunol (2012) 0.94

Oxidative stress and lymphocyte persistence: implications in immunotherapy. Adv Cancer Res (2009) 0.93

Effect of CD4+CD25+ and CD4+CD25- T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro. J Immunol (2006) 0.93

Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-1 27-35. Clin Immunol (2008) 0.91

The CD16- CD56(bright) NK cell subset is resistant to reactive oxygen species produced by activated granulocytes and has higher antioxidative capacity than the CD16+ CD56(dim) subset. J Immunol (2007) 0.91

Regulation of melanoma epitope-specific cytolytic T lymphocyte response by immature and activated dendritic cells, in vitro. Cancer Res (2003) 0.91

Polymer-enhanced adenoviral transduction of CAR-negative bladder cancer cells. Mol Pharm (2009) 0.91

MHC-I-restricted melanoma antigen specific TCR-engineered human CD4+ T cells exhibit multifunctional effector and helper responses, in vitro. Clin Immunol (2010) 0.90

Recognition of PSA-derived peptide antigens by T cells from prostate cancer patients without any prior stimulation. Cancer Immunol Immunother (2003) 0.90

CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model. J Immunol (2008) 0.90

Cross-presentation of a human tumor antigen delivered to dendritic cells by HSV VP22-mediated protein translocation. Eur J Immunol (2004) 0.90

Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2. Free Radic Biol Med (2007) 0.90

17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen species. Mol Cancer Ther (2010) 0.86

Presence of low dose of fludarabine in cultures blocks regulatory T cell expansion and maintains tumor-specific cytotoxic T lymphocyte activity generated with peripheral blood lymphocytes. Pathobiology (2008) 0.86

Antigen presentation by MART-1 adenovirus-transduced interleukin-10-polarized human monocyte-derived dendritic cells. Immunology (2004) 0.85

Activation-induced cell death of human melanoma specific cytotoxic T lymphocytes is mediated by apoptosis-inducing factor. Eur J Immunol (2006) 0.85

Enhanced apoptosis of glioma cell lines is achieved by co-delivering FasL-GFP and TRAIL with a complex Ad5 vector. Cancer Gene Ther (2003) 0.84

Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells. Cancer Immunol Immunother (2015) 0.84

Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death. J Leukoc Biol (2006) 0.84

Continuous presence of Th1 conditions is necessary for longer lasting tumor-specific CTL activity in stimulation cultures with PBL. Hum Immunol (2005) 0.84

Targeting the short form of cFLIP by RNA interference is sufficient to enhance TRAIL sensitivity in PC3 prostate carcinoma cells. Cancer Biol Ther (2006) 0.83

Oxidative stress sensitizes bladder cancer cells to TRAIL mediated apoptosis by down-regulating anti-apoptotic proteins. J Urol (2009) 0.83

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation. J Clin Invest (2016) 0.83

Interferon-gamma renders tumors that express low levels of Her-2/neu sensitive to cytotoxic T cells. Cancer Immunol Immunother (2005) 0.81

Analyses of T cell-mediated immune response to a human melanoma-associated antigen by the young and the elderly. Hum Immunol (2013) 0.81

Dissection of adult mouse utricle and adenovirus-mediated supporting-cell infection. J Vis Exp (2012) 0.81

Obstacles to and opportunities for more effective peptide-based therapeutic immunization in human melanoma. Clin Dermatol (2009) 0.81

Histone deacetylase inhibitors restore cell surface expression of the coxsackie adenovirus receptor and enhance CMV promoter activity in castration-resistant prostate cancer cells. Prostate Cancer (2012) 0.80

Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide. Cell Immunol (2012) 0.80

Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy. Immunology (2015) 0.79

In vitro efficacy of Fas ligand gene therapy for the treatment of bladder cancer. Cancer Gene Ther (2005) 0.79

Transformation, translation and TRAIL: an unexpected intersection. Cytokine Growth Factor Rev (2008) 0.78

Adoptive immunotherapy of cancer: Gene transfer of T cell specificity. Self Nonself (2011) 0.78

Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation. Pigment Cell Melanoma Res (2014) 0.78

Metastatic melanoma in the older patient: immunologic insights and treatment outcomes. Expert Rev Pharmacoecon Outcomes Res (2011) 0.77

Death receptor-independent activation-induced cell death in human melanoma antigen-specific MHC class I-restricted TCR-engineered CD4 T cells. J Immunol (2013) 0.76

Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+)  CD25(-) and CD8(+) T cells attenuates effector function. Immunology (2015) 0.76

Dietary agents in cancer prevention: an immunological perspective. Photochem Photobiol (2012) 0.76

An orthotopic bladder cancer model for gene delivery studies. J Vis Exp (2013) 0.76

Illuminating TRAIL gene therapy. Cancer Biol Ther (2006) 0.76

GITR expression on T-cell receptor-stimulated human CD8 T cell in a JNK-dependent pathway. Indian J Hum Genet (2009) 0.76

Adenoviral infectivity of exfoliated viable cells in urine: implications for the detection of bladder cancer. BMC Cancer (2011) 0.75

Apoptosis - an Ubiquitous T cell Immunomodulator. J Clin Cell Immunol (2011) 0.75

Macrophages as stimulators of MART-1 27-35 epitope-specific human cytolytic T lymphocytes in vitro. Pathobiology (2006) 0.75