Published in Vaccine on September 10, 2002
Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques. J Virol (2007) 1.87
Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens. PLoS One (2008) 1.80
In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers. PLoS One (2011) 1.71
Increased perfusion and angiogenesis in a hindlimb ischemia model with plasmid FGF-2 delivered by noninvasive electroporation. Gene Ther (2010) 1.56
Enhancing DNA vaccine potency by modifying the properties of antigen-presenting cells. Expert Rev Vaccines (2007) 1.50
Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment. PLoS One (2009) 1.46
The effect of the nonionic block copolymer pluronic P85 on gene expression in mouse muscle and antigen-presenting cells. Biomaterials (2008) 1.19
DNA vaccines for HIV: challenges and opportunities. Springer Semin Immunopathol (2006) 1.18
Trial watch: DNA vaccines for cancer therapy. Oncoimmunology (2013) 1.11
An electrically active microneedle array for electroporation. Biomed Microdevices (2010) 1.10
A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A. Vaccine (2009) 1.08
DNA vaccines against human immunodeficiency virus type 1 in the past decade. Clin Microbiol Rev (2004) 1.06
Tolerability of two sequential electroporation treatments using MedPulser DNA delivery system (DDS) in healthy adults. Mol Ther (2009) 1.05
Evaluation of a novel non-penetrating electrode for use in DNA vaccination. PLoS One (2011) 0.96
Human immunodeficiency virus type 1 vaccine development: recent advances in the cytotoxic T-lymphocyte platform "spotty business". J Virol (2007) 0.96
Broad humoral and cellular immunity elicited by a bivalent DNA vaccine encoding HA and NP genes from an H5N1 virus. Viral Immunol (2011) 0.93
Coadministration of telomerase genetic vaccine and a novel TLR9 agonist in nonhuman primates. Mol Ther (2009) 0.93
Synthetic DNA vaccine strategies against persistent viral infections. Expert Rev Vaccines (2013) 0.92
Optimization of electroporation-enhanced intradermal delivery of DNA vaccine using a minimally invasive surface device. Hum Gene Ther Methods (2012) 0.90
A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain. Clin Vaccine Immunol (2013) 0.88
DNA vaccine for cancer immunotherapy. Hum Vaccin Immunother (2014) 0.87
A vaccine targeting telomerase enhances survival of dogs affected by B-cell lymphoma. Mol Ther (2010) 0.85
Intracellular protein delivery and gene transfection by electroporation using a microneedle electrode array. Small (2012) 0.84
In vivo electroporation of constitutively expressed HIF-1α plasmid DNA improves neovascularization in a mouse model of limb ischemia. J Vasc Surg (2013) 0.82
Electroporation enhances immunogenicity of a DNA vaccine expressing woodchuck hepatitis virus surface antigen in woodchucks. J Virol (2011) 0.82
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire. Eur J Immunol (2008) 0.80
Chimeric DNA Vaccines against ErbB2+ Carcinomas: From Mice to Humans. Cancers (Basel) (2011) 0.80
An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinoma. Mol Ther (2011) 0.80
Dual therapeutic benefit of electroporation-mediated DNA vaccination in vivo: Enhanced gene transfer and adjuvant activity. Oncoimmunology (2014) 0.80
Cationic lipid-formulated DNA vaccine against hepatitis B virus: immunogenicity of MIDGE-Th1 vectors encoding small and large surface antigen in comparison to a licensed protein vaccine. PLoS One (2014) 0.79
Enhanced effect of DNA immunization plus in vivo electroporation with a combination of hepatitis B virus core-PreS1 and S-PreS1 plasmids. Clin Vaccine Immunol (2011) 0.79
Low concentrations of anti-Aβ antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology. Hum Gene Ther (2010) 0.78
Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology. Vet Res (2014) 0.77
Targeted Collection of Plasmid DNA in Large and Growing Animal Muscles 6 Weeks after DNA Vaccination with and without Electroporation. J Immunol Res (2015) 0.75
The catalytic A1 domains of cholera toxin and heat-labile enterotoxin are potent DNA adjuvants that evoke mixed Th1/Th17 cellular immune responses. Hum Vaccin Immunother (2015) 0.75
DNA vaccines encoding DEC205-targeted antigens: immunity or tolerance? Immunology (2015) 0.75
Coadministration of a Plasmid Encoding HIV-1 Gag Enhances the Efficacy of Cancer DNA Vaccines. Mol Ther (2016) 0.75
Swine outbreak of pandemic influenza A virus on a Canadian research farm supports human-to-swine transmission. Clin Infect Dis (2011) 2.28
Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J Hepatol (2006) 2.04
ArrayPipe: a flexible processing pipeline for microarray data. Nucleic Acids Res (2004) 2.03
Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K. J Gen Virol (2007) 1.84
Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine (2004) 1.74
Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations. Vaccine (2011) 1.48
SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation. J Virol (2007) 1.47
Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation. J Gen Virol (2007) 1.36
Non-viral nucleic acid delivery: key challenges and future directions. Curr Drug Deliv (2011) 1.25
Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides. J Control Release (2004) 1.20
Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization. Proc Natl Acad Sci U S A (2009) 1.18
ProbeLynx: a tool for updating the association of microarray probes to genes. Nucleic Acids Res (2004) 1.17
Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection. Infect Immun (2006) 1.16
Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus. J Gen Virol (2006) 1.16
Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines. J Biotechnol (2004) 1.16
Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2. J Gen Virol (2008) 1.15
Genome to kinome: species-specific peptide arrays for kinome analysis. Sci Signal (2009) 1.10
Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide. J Leukoc Biol (2006) 1.07
Mechanisms of action of adjuvants. Front Immunol (2013) 1.05
Design and delivery of a cryptic PrP(C) epitope for induction of PrP(Sc)-specific antibody responses. Vaccine (2009) 1.01
Approaches to enhance the efficacy of DNA vaccines. Crit Rev Clin Lab Sci (2004) 1.01
High transfection efficiency, gene expression, and viability of monocyte-derived human dendritic cells after nonviral gene transfer. J Leukoc Biol (2007) 1.01
Mucosal delivery of vaccines in domestic animals. Vet Res (2006) 1.01
Enhancement of antibody and cellular immune responses to malaria DNA vaccines by in vivo electroporation. Vaccine (2007) 1.00
Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization. Mol Immunol (2008) 1.00
Characterization of nuclear localization and export signals of the major tegument protein VP8 of bovine herpesvirus-1. Virology (2004) 0.99
Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides. Mol Immunol (2009) 0.98
Maternal immunity provides protection against pertussis in newborn piglets. Infect Immun (2006) 0.98
A single DNA immunization in combination with electroporation prolongs the primary immune response and maintains immune memory for six months. Vaccine (2007) 0.98
A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine (2009) 0.98
Needle-free topical electroporation improves gene expression from plasmids administered in porcine skin. Mol Ther (2003) 0.97
Elastase-dependent live attenuated swine influenza A viruses are immunogenic and confer protection against swine influenza A virus infection in pigs. J Virol (2009) 0.96
Severe acute respiratory syndrome coronavirus nucleocapsid protein expressed by an adenovirus vector is phosphorylated and immunogenic in mice. J Gen Virol (2005) 0.95
Role of bovine adenovirus-3 33K protein in viral replication. Virology (2004) 0.95
Nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of Toll-like receptor 9. J Biol Chem (2007) 0.92
Immune mechanisms and therapeutic potential of CpG oligodeoxynucleotides. Int Rev Immunol (2006) 0.92
Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: implications for a subunit vaccine. Vaccine (2006) 0.92
Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies. Vaccine (2013) 0.91
Poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) is a potent enhancer of mixed Th1/Th2 immune responses in mice immunized with influenza virus antigens. Vaccine (2006) 0.91
Transcriptional and translational expression patterns associated with immobilized growth of Campylobacter jejuni. Microbiology (2006) 0.91
Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference. FEBS Lett (2004) 0.91
Co-administration of polyphosphazenes with CpG oligodeoxynucleotides strongly enhances immune responses in mice immunized with Hepatitis B virus surface antigen. Vaccine (2008) 0.90
Transcriptional analysis of avian embryonic tissues following infection with avian infectious bronchitis virus. Virus Res (2005) 0.90
A comparison between isolated blood dendritic cells and monocyte-derived dendritic cells in pigs. Immunology (2009) 0.90
Streptococcus pneumoniae early response genes to human lung epithelial cells. BMC Res Notes (2008) 0.90
Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs. Vaccine (2010) 0.90
Use of animal models in the development of human vaccines. Future Microbiol (2007) 0.89
Topical non-invasive gene delivery using gemini nanoparticles in interferon-gamma-deficient mice. Eur J Pharm Biopharm (2007) 0.89
Differential activation and maturation of two porcine DC populations following TLR ligand stimulation. Mol Immunol (2010) 0.89
A single HBsAg DNA vaccination in combination with electroporation elicits long-term antibody responses in sheep. Bioelectrochemistry (2006) 0.89
The host defense peptide beta-defensin 1 confers protection against Bordetella pertussis in newborn piglets. Infect Immun (2006) 0.89
Intranasal immunization of mice with a bovine respiratory syncytial virus vaccine induces superior immunity and protection compared to those by subcutaneous delivery or combinations of intranasal and subcutaneous prime-boost strategies. Clin Vaccine Immunol (2009) 0.88
Intranasal immunization of mice with a formalin-inactivated bovine respiratory syncytial virus vaccine co-formulated with CpG oligodeoxynucleotides and polyphosphazenes results in enhanced protection. J Gen Virol (2008) 0.88
Effect of different nuclear localization sequences on the immune responses induced by a MIDGE vector encoding bovine herpesvirus-1 glycoprotein D. Vaccine (2005) 0.88
In vivo cutaneous interferon-gamma gene delivery using novel dicationic (gemini) surfactant-plasmid complexes. J Gene Med (2005) 0.88
Strategies for improved formulation and delivery of DNA vaccines to veterinary target species. Immunol Rev (2004) 0.88
Stability, toxicity, and biological activity of host defense peptide BMAP28 and its inversed and retro-inversed isomers. Biopolymers (2011) 0.88
Bovine polymorphonuclear cells passively acquire membrane lipids and integral membrane proteins from apoptotic and necrotic cells. J Leukoc Biol (2006) 0.87
Identification of genomic differences between Escherichia coli strains pathogenic for poultry and E. coli K-12 MG1655 using suppression subtractive hybridization analysis. Microb Pathog (2002) 0.87
Advancing nonviral gene delivery: lipid- and surfactant-based nanoparticle design strategies. Nanomedicine (Lond) (2010) 0.87
Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis. Vaccine (2011) 0.87
Comparative analysis of innate immune responses following infection of newborn calves with bovine rotavirus and bovine coronavirus. J Gen Virol (2007) 0.87
Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides. Adv Drug Deliv Rev (2009) 0.86
Augmentation of immune responses to SARS coronavirus by a combination of DNA and whole killed virus vaccines. Vaccine (2005) 0.86
Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod. Mol Immunol (2008) 0.86
Major tegument protein VP8 of bovine herpesvirus 1 is phosphorylated by viral US3 and cellular CK2 protein kinases. J Gen Virol (2009) 0.86
Topical delivery of plasmid DNA using biphasic lipid vesicles (Biphasix). J Pharm Pharmacol (2002) 0.86
Modulation of immune responses to bovine herpesvirus-1 in cattle by immunization with a DNA vaccine encoding glycoprotein D as a fusion protein with bovine CD154. Immunology (2004) 0.86
Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3. J Gen Virol (2006) 0.86
Thermodynamic and aggregation properties of aza- and imino-substituted gemini surfactants designed for gene delivery. Phys Chem Chem Phys (2006) 0.85
Targeting with bovine CD154 enhances humoral immune responses induced by a DNA vaccine in sheep. J Immunol (2003) 0.85
Combination adjuvants: the next generation of adjuvants? Expert Rev Vaccines (2011) 0.85
Oral DNA vaccination in utero induces mucosal immunity and immune memory in the neonate. J Immunol (2002) 0.85
A UL47 gene deletion mutant of bovine herpesvirus type 1 exhibits impaired growth in cell culture and lack of virulence in cattle. J Virol (2010) 0.85
Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS. Immunobiology (2010) 0.84
Formulation with CpG oligodeoxynucleotides increases cellular immunity and protection induced by vaccination of calves with formalin-inactivated bovine respiratory syncytial virus. Virology (2006) 0.84
Kinome analysis of Toll-like receptor signaling in bovine monocytes. J Recept Signal Transduct Res (2009) 0.84
Co-stimulation with TLR7/8 and TLR9 agonists induce down-regulation of innate immune responses in sheep blood mononuclear and B cells. Dev Comp Immunol (2010) 0.83
Activation and regulation of toll-like receptor 9: CpGs and beyond. Mini Rev Med Chem (2008) 0.83
Gemini surfactants: a new family of building blocks for non-viral gene delivery systems. Curr Gene Ther (2008) 0.83
CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands. Vet Immunol Immunopathol (2008) 0.83
Characterization of a bovine lactoferrin binding protein of Streptococcus uberis. Microb Pathog (2003) 0.83
Intracellular localization of the SARS coronavirus protein 9b: evidence of active export from the nucleus. Virus Res (2007) 0.83
The growth phase-dependent regulation of the pilus locus genes by two-component system TCS08 in Streptococcus pneumoniae. Microb Pathog (2008) 0.83
Efficacy of poly[di(sodium carboxylatophenoxy)phosphazene] (PCPP) as mucosal adjuvant to induce protective immunity against respiratory pathogens. Vaccine (2010) 0.83
Enhanced gene expression in epithelial cells transfected with amino acid-substituted gemini nanoparticles. Eur J Pharm Biopharm (2010) 0.82
Influence of maternal antibodies on active pertussis toxoid immunization of neonatal mice and piglets. Vaccine (2011) 0.82
Establishment of fetal bovine intestinal epithelial cell cultures susceptible to bovine rotavirus infection. J Virol Methods (2008) 0.82
Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats. Diabetes Technol Ther (2002) 0.82
Induction, regulation and physiological role of IL-17 secreting helper T-cells isolated from PBMC, thymus, and lung lymphocytes of young pigs. Vet Immunol Immunopathol (2011) 0.82
Reverse genetics-generated elastase-dependent swine influenza viruses are attenuated in pigs. J Gen Virol (2009) 0.82