DNA vaccines for HIV: challenges and opportunities.

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🔗 View Article (PMID 17031649)

Published in Springer Semin Immunopathol on October 10, 2006

Authors

David A Hokey1, David B Weiner

Author Affiliations

1: Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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Dendritic cells and the control of immunity. Nature (1998) 56.54

Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04

The dendritic cell system and its role in immunogenicity. Annu Rev Immunol (1991) 23.09

Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science (2000) 9.92

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature (1998) 9.77

Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science (2001) 9.09

Molecular identification of a danger signal that alerts the immune system to dying cells. Nature (2003) 8.90

Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell (1988) 8.01

Natural adjuvants: endogenous activators of dendritic cells. Nat Med (1999) 7.10

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol (2005) 6.81

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem (2002) 6.16

Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med (2000) 5.62

Genetic immunization is a simple method for eliciting an immune response. Nature (1992) 5.30

Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov (2006) 5.19

Helping the CD8(+) T-cell response. Nat Rev Immunol (2004) 4.90

Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing Gag. J Virol (2005) 4.78

A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science (1995) 4.64

DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol (2000) 4.51

T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today (1999) 4.49

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci U S A (1993) 4.49

Microneedles for transdermal drug delivery. Adv Drug Deliv Rev (2004) 4.37

Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science (2000) 4.03

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo. J Exp Med (1990) 3.73

DNA-based immunization by in vivo transfection of dendritic cells. Nat Med (1996) 3.62

A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med (2005) 3.59

Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat Immunol (2006) 3.57

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem (1994) 3.41

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A (1993) 3.27

Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function. J Exp Med (2003) 3.21

Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med (1998) 2.84

Codon optimization of the HIV-1 vpu and vif genes stabilizes their mRNA and allows for highly efficient Rev-independent expression. Virology (2004) 2.80

Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med (2006) 2.70

Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates. J Virol (2005) 2.61

Increased DNA vaccine delivery and immunogenicity by electroporation in vivo. J Immunol (2000) 2.54

Advances in vaccine adjuvants. Nat Biotechnol (1999) 2.18

Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat Med (1997) 2.12

Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. J Immunol (2005) 2.01

In vivo electroporation and stable transformation of skin cells of newborn mice by plasmid DNA. Biochim Biophys Acta (1991) 2.00

Transcutaneous immunization: a human vaccine delivery strategy using a patch. Nat Med (2000) 1.98

In vivo electroporation for gene therapy. Hum Gene Ther (2006) 1.92

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Enhancement of DNA vaccine potency in rhesus macaques by electroporation. Vaccine (2004) 1.74

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Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration. J Immunol (1998) 1.32

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Adjuvant activity of CpG oligodeoxynucleotides. Int Rev Immunol (2006) 1.28

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Relative contributions of codon usage, promoter efficiency and leader sequence to the antigen expression and immunogenicity of HIV-1 Env DNA vaccine. Vaccine (2005) 1.23

Protective immunity induced by oral immunization with a rotavirus DNA vaccine encapsulated in microparticles. J Virol (1998) 1.18

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The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses. Immunol Rev (2004) 1.15

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Cytotoxic T lymphocyte activation by cross-priming. Curr Opin Immunol (1999) 1.07

DNA vaccines against human immunodeficiency virus type 1 in the past decade. Clin Microbiol Rev (2004) 1.06

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Dead or alive: immunogenicity of human melanoma cells when presented by dendritic cells. Cancer Res (2000) 1.01

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Intradermal DNA immunization by using jet-injectors in mice and monkeys. Vaccine (1999) 0.84

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